|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 42764 |
FusionGeneSummary for ZFAND6_KCNRG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFAND6_KCNRG | Fusion gene ID: 42764 | Hgene | Tgene | Gene symbol | ZFAND6 | KCNRG | Gene ID | 54469 | 283518 |
| Gene name | zinc finger AN1-type containing 6 | potassium channel regulator | |
| Synonyms | AWP1|ZA20D3|ZFAND5B | DLTET | |
| Cytomap | 15q25.1 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6 | potassium channel regulatory proteinputative potassium channel regulatory protein | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q6FIF0 | Q8N5I3 | |
| Ensembl transtripts involved in fusion gene | ENST00000261749, ENST00000561060, ENST00000559157, ENST00000558494, ENST00000559835, ENST00000559775, ENST00000558688, ENST00000558087, | ENST00000360473, ENST00000312942, | |
| Fusion gene scores | * DoF score | 5 X 3 X 2=30 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZFAND6 [Title/Abstract] AND KCNRG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KCNRG | GO:1902260 | negative regulation of delayed rectifier potassium channel activity | 19968958 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A2J6-06A | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000261749 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| 5UTR-3CDS | ENST00000261749 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000561060 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000561060 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000559157 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000559157 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558494 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558494 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000559835 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000559835 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| 5UTR-3CDS | ENST00000559775 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| 5UTR-3CDS | ENST00000559775 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558688 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558688 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558087 | ENST00000360473 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
| intron-3CDS | ENST00000558087 | ENST00000312942 | ZFAND6 | chr15 | 80390920 | + | KCNRG | chr13 | 50594350 | + |
Top |
FusionProtFeatures for ZFAND6_KCNRG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFAND6 | KCNRG |
| Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. | Inhibits potassium fluxes in cells. May regulate Kv1family channel proteins by retaining a fraction of channels inendomembranes. {ECO:0000269|PubMed:12650944,ECO:0000269|PubMed:19968958}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ZFAND6_KCNRG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ZFAND6_KCNRG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFAND6 | TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2 | KCNRG | CCNK, KCNRG, DGCR6L, FXR2, AP5B1, KCNA1, KCNA4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ZFAND6_KCNRG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ZFAND6_KCNRG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZFAND6 | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Hgene | ZFAND6 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
| Hgene | ZFAND6 | C0520757 | Delayed Emergence from Anesthesia | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|