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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42763

FusionGeneSummary for ZFAND6_DLEU1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFAND6_DLEU1
Fusion gene ID: 42763
HgeneTgene
Gene symbol

ZFAND6

DLEU1

Gene ID

54469

10301

Gene namezinc finger AN1-type containing 6deleted in lymphocytic leukemia 1
SynonymsAWP1|ZA20D3|ZFAND5BBCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6
Cytomap

15q25.1

13q14.2-q14.3

Type of geneprotein-codingncRNA
DescriptionAN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6B-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21
Modification date2018052220180519
UniProtAcc

Q6FIF0

O43261

Ensembl transtripts involved in fusion geneENST00000261749, ENST00000561060, 
ENST00000559157, ENST00000558494, 
ENST00000559835, ENST00000559775, 
ENST00000558688, ENST00000558087, 
ENST00000490577, ENST00000378180, 
Fusion gene scores* DoF score5 X 3 X 2=306 X 5 X 5=150
# samples 46
** MAII scorelog2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFAND6 [Title/Abstract] AND DLEU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A2J6-06AZFAND6chr15

80352151

+DLEU1chr13

50657278

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000261749ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000261749ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000561060ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000561060ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000559157ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000559157ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000558494ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
5UTR-intronENST00000558494ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000559835ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000559835ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000559775ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000559775ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000558688ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000558688ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000558087ENST00000490577ZFAND6chr15

80352151

+DLEU1chr13

50657278

+
intron-intronENST00000558087ENST00000378180ZFAND6chr15

80352151

+DLEU1chr13

50657278

+

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FusionProtFeatures for ZFAND6_DLEU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZFAND6

Q6FIF0

DLEU1

O43261

Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. May act as a tumor suppressor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZFAND6_DLEU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZFAND6_DLEU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZFAND6TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2DLEU1ABCD4, ABCF3, GDF9, CCDC90B, PSMA1, SETDB1, SHMT1, TLE1, MED31, COPS6, KAT5, KIAA1377, UTP14A, TP53, TUBB4B, UBR1, EEF1A1, EEF1G, GOPC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZFAND6_DLEU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZFAND6_DLEU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZFAND6C0037274Dermatologic disorders1CTD_human
HgeneZFAND6C0311375Arsenic Poisoning1CTD_human
HgeneZFAND6C0520757Delayed Emergence from Anesthesia1CTD_human