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Fusion gene ID: 42763 |
FusionGeneSummary for ZFAND6_DLEU1 |
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Fusion gene information | Fusion gene name: ZFAND6_DLEU1 | Fusion gene ID: 42763 | Hgene | Tgene | Gene symbol | ZFAND6 | DLEU1 | Gene ID | 54469 | 10301 |
Gene name | zinc finger AN1-type containing 6 | deleted in lymphocytic leukemia 1 | |
Synonyms | AWP1|ZA20D3|ZFAND5B | BCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6 | |
Cytomap | 15q25.1 | 13q14.2-q14.3 | |
Type of gene | protein-coding | ncRNA | |
Description | AN1-type zinc finger protein 6protein associated with PRK1zinc finger, A20 domain containing 3zinc finger, AN1-type domain 6 | B-cell neoplasia-associated gene with multiple splicingdeleted in lymphocytic leukemia 1 (non-protein coding)leukemia-associated protein 2long intergenic non-protein coding RNA 21 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q6FIF0 | O43261 | |
Ensembl transtripts involved in fusion gene | ENST00000261749, ENST00000561060, ENST00000559157, ENST00000558494, ENST00000559835, ENST00000559775, ENST00000558688, ENST00000558087, | ENST00000490577, ENST00000378180, | |
Fusion gene scores | * DoF score | 5 X 3 X 2=30 | 6 X 5 X 5=150 |
# samples | 4 | 6 | |
** MAII score | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZFAND6 [Title/Abstract] AND DLEU1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D3-A2J6-06A | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000261749 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000261749 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000561060 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000561060 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000559157 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000559157 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000558494 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
5UTR-intron | ENST00000558494 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000559835 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000559835 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000559775 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000559775 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000558688 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000558688 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000558087 | ENST00000490577 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
intron-intron | ENST00000558087 | ENST00000378180 | ZFAND6 | chr15 | 80352151 | + | DLEU1 | chr13 | 50657278 | + |
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FusionProtFeatures for ZFAND6_DLEU1 |
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Hgene | Tgene |
ZFAND6 | DLEU1 |
Involved in regulation of TNF-alpha induced NF-kappa-Bactivation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreasesassociation of TRAF2 with RIPK1. Required for PTS1 targetsequence-dependent protein import into peroxisomes and PEX5stability; may cooperate with PEX6. In vitro involved in PEX5export from the cytosol to peroxisomes (By similarity).{ECO:0000250, ECO:0000269|PubMed:19285159,ECO:0000269|PubMed:21810480}. | May act as a tumor suppressor. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZFAND6_DLEU1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZFAND6_DLEU1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZFAND6 | TRAF2, UBC, CDC34, USP3, WIPI2, PPP2R1A, TRAF5, CDV3, CIRBP, GSS, HNRNPA3, NONO, TXLNG, BIRC2 | DLEU1 | ABCD4, ABCF3, GDF9, CCDC90B, PSMA1, SETDB1, SHMT1, TLE1, MED31, COPS6, KAT5, KIAA1377, UTP14A, TP53, TUBB4B, UBR1, EEF1A1, EEF1G, GOPC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFAND6_DLEU1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFAND6_DLEU1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZFAND6 | C0037274 | Dermatologic disorders | 1 | CTD_human |
Hgene | ZFAND6 | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Hgene | ZFAND6 | C0520757 | Delayed Emergence from Anesthesia | 1 | CTD_human |