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Fusion gene ID: 42761 |
FusionGeneSummary for ZFAND3_THEGL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZFAND3_THEGL | Fusion gene ID: 42761 | Hgene | Tgene | Gene symbol | ZFAND3 | THEGL | Gene ID | 60685 | 100506564 |
| Gene name | zinc finger AN1-type containing 3 | theg spermatid protein like | |
| Synonyms | TEX27 | - | |
| Cytomap | 6p21.2 | 4q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AN1-type zinc finger protein 3testis expressed sequence 27testis-expressed protein 27zinc finger, AN1-type domain 3 | testicular haploid expressed gene protein-liketheg spermatid-like protein | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H8U3 | P0DJG4 | |
| Ensembl transtripts involved in fusion gene | ENST00000287218, ENST00000373391, ENST00000463847, | ENST00000512175, ENST00000510716, | |
| Fusion gene scores | * DoF score | 16 X 5 X 10=800 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/800*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZFAND3 [Title/Abstract] AND THEGL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A07G-01A | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000287218 | ENST00000512175 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| 5CDS-intron | ENST00000287218 | ENST00000510716 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| In-frame | ENST00000373391 | ENST00000512175 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| 5CDS-intron | ENST00000373391 | ENST00000510716 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| intron-3CDS | ENST00000463847 | ENST00000512175 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
| intron-intron | ENST00000463847 | ENST00000510716 | ZFAND3 | chr6 | 37897775 | + | THEGL | chr4 | 57414956 | + |
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FusionProtFeatures for ZFAND3_THEGL |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZFAND3 | THEGL |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 174_192 | 164 | 466 | Repeat | Note=THEG 1 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 214_233 | 164 | 466 | Repeat | Note=THEG 2 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 260_279 | 164 | 466 | Repeat | Note=THEG 3 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 297_316 | 164 | 466 | Repeat | Note=THEG 4 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 333_352 | 164 | 466 | Repeat | Note=THEG 5 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 373_392 | 164 | 466 | Repeat | Note=THEG 6 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 409_428 | 164 | 466 | Repeat | Note=THEG 7 |
| Tgene | >THEGL | chr6:37897775 | chr4:57414956 | ENST00000512175 | + | 0 | 9 | 446_465 | 164 | 466 | Repeat | Note=THEG 8 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZFAND3 | chr6:37897775 | chr4:57414956 | ENST00000287218 | + | 2 | 6 | 12_44 | 37 | 228 | Zinc finger | A20-type |
| Hgene | >ZFAND3 | chr6:37897775 | chr4:57414956 | ENST00000287218 | + | 2 | 6 | 154_200 | 37 | 228 | Zinc finger | AN1-type |
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FusionGeneSequence for ZFAND3_THEGL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZFAND3_ENST00000287218_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_339aa MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFAANPVSCDFVRKCFSSRKRTPNLSKPKKQWGTPDRKLFWGNQDPIRPVSQGALK AQLTKRLENLAQPKEVSCHYVPNRAQYYHSCGRESVIWEITPPALFRQPSKRIQRLSQPNGFKRQCLLNRPFSDNSARDSLRISDPSPRI LQLSVAKGTDPNYHPSKKMQTKISLSTLSAIATPRIIELAHPRIKLEGLCYERQRSELPIRPVPPAAMIAKPSPRTIALAKSKSVHQDYL >In-frame_ZFAND3_ENST00000373391_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_339aa MGDAGSERSKAPSLPPRCPCGFWGSSKTMNLCSKCFAANPVSCDFVRKCFSSRKRTPNLSKPKKQWGTPDRKLFWGNQDPIRPVSQGALK AQLTKRLENLAQPKEVSCHYVPNRAQYYHSCGRESVIWEITPPALFRQPSKRIQRLSQPNGFKRQCLLNRPFSDNSARDSLRISDPSPRI LQLSVAKGTDPNYHPSKKMQTKISLSTLSAIATPRIIELAHPRIKLEGLCYERQRSELPIRPVPPAAMIAKPSPRTIALAKSKSVHQDYL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZFAND3_ENST00000287218_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_1017nt ATGGGAGACGCTGGGAGCGAGCGCAGCAAAGCGCCCAGCCTGCCGCCTCGCTGTCCCTGCGGCTTCTGGGGGTCCAGCAAGACTATGAAT CTCTGTTCCAAATGCTTTGCTGCAAATCCTGTTTCCTGTGACTTTGTAAGGAAATGTTTTTCTTCTAGGAAGAGAACCCCAAATCTTTCA AAGCCTAAAAAGCAATGGGGAACTCCAGACAGAAAACTGTTTTGGGGAAATCAAGATCCTATTCGCCCTGTTTCCCAGGGTGCTTTGAAG GCTCAGCTGACCAAAAGACTTGAGAACCTTGCCCAGCCCAAGGAAGTTTCCTGCCACTATGTACCTAACAGGGCTCAATACTACCACAGC TGTGGAAGAGAGTCTGTAATTTGGGAGATCACTCCTCCTGCATTGTTTAGACAACCCTCCAAAAGGATCCAGAGGCTGTCACAGCCCAAT GGATTCAAAAGACAGTGTCTACTAAATAGACCCTTCAGTGATAACTCAGCAAGAGATTCTCTTCGAATCTCTGATCCTTCTCCCCGGATA TTACAACTCTCAGTAGCCAAAGGCACAGACCCAAACTATCATCCTTCAAAAAAAATGCAAACCAAGATTTCACTTTCTACCCTGAGTGCG ATTGCAACTCCAAGAATTATAGAGCTTGCCCACCCAAGGATCAAGTTAGAGGGTCTGTGCTATGAAAGACAAAGAAGTGAACTGCCCATC CGTCCTGTACCTCCTGCTGCCATGATAGCTAAACCTAGCCCCCGAACAATAGCTCTAGCGAAGTCCAAGTCTGTTCATCAAGATTATCTA CCTGACCGTGATGCCCATTGGCCAGTATCTTATGCTACTACTCATTCCAAAGCATCACCTAGGATTCAGGAACTAGCTAATCCAAATAAG AGGGCTCCTGTGCGTATTGTGTATTATGATCCAGATGTCTTTAAAACCAAGCCAGCTGCTTTGAAAGCACAGTGTTCTCAAAGGATCTGG >In-frame_ZFAND3_ENST00000373391_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_1017nt ATGGGAGACGCTGGGAGCGAGCGCAGCAAAGCGCCCAGCCTGCCGCCTCGCTGTCCCTGCGGCTTCTGGGGGTCCAGCAAGACTATGAAT CTCTGTTCCAAATGCTTTGCTGCAAATCCTGTTTCCTGTGACTTTGTAAGGAAATGTTTTTCTTCTAGGAAGAGAACCCCAAATCTTTCA AAGCCTAAAAAGCAATGGGGAACTCCAGACAGAAAACTGTTTTGGGGAAATCAAGATCCTATTCGCCCTGTTTCCCAGGGTGCTTTGAAG GCTCAGCTGACCAAAAGACTTGAGAACCTTGCCCAGCCCAAGGAAGTTTCCTGCCACTATGTACCTAACAGGGCTCAATACTACCACAGC TGTGGAAGAGAGTCTGTAATTTGGGAGATCACTCCTCCTGCATTGTTTAGACAACCCTCCAAAAGGATCCAGAGGCTGTCACAGCCCAAT GGATTCAAAAGACAGTGTCTACTAAATAGACCCTTCAGTGATAACTCAGCAAGAGATTCTCTTCGAATCTCTGATCCTTCTCCCCGGATA TTACAACTCTCAGTAGCCAAAGGCACAGACCCAAACTATCATCCTTCAAAAAAAATGCAAACCAAGATTTCACTTTCTACCCTGAGTGCG ATTGCAACTCCAAGAATTATAGAGCTTGCCCACCCAAGGATCAAGTTAGAGGGTCTGTGCTATGAAAGACAAAGAAGTGAACTGCCCATC CGTCCTGTACCTCCTGCTGCCATGATAGCTAAACCTAGCCCCCGAACAATAGCTCTAGCGAAGTCCAAGTCTGTTCATCAAGATTATCTA CCTGACCGTGATGCCCATTGGCCAGTATCTTATGCTACTACTCATTCCAAAGCATCACCTAGGATTCAGGAACTAGCTAATCCAAATAAG AGGGCTCCTGTGCGTATTGTGTATTATGATCCAGATGTCTTTAAAACCAAGCCAGCTGCTTTGAAAGCACAGTGTTCTCAAAGGATCTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZFAND3_ENST00000287218_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_1648nt GTTACGGAGACAGCAGGGCCCGGGGCTTCAGAGCGGCCGCTGCGACTCCGGAGCCGGCGGGGGGCTCCGGTCCTTCCCTGCGCCACCGCA CAGGACATCTCTCTGGCTGGGGAGCGGCGGTGAGACCCGCCGAGGGCGTCTGTGTCCCTCCTCCCCCGCGGTCCTCGGTGCGTCCGCACG CCCCTCCTCCTCGGCTCCCTCCTTCTTCTCTCCGCGCCTCTCCGCCCCCTCCCCGTCTCCGCAGGCCGAGTGGTGCGGCCCGCCTCCAGC TGACCGGCCTGGAATCCCGGCTCCGAGCCCCGGACTCGCGCCCGCCCGCGCGCCCGCTCCTTCCCCCTCCCCCCGCCCCGAGCCCCCCGA CGCCGCCGCCACCGCCTCCTCAGAGCGGGGCCCGGGCCCAGCCGCCGCCACCGCTGCCGCCGCCGAGCTCCGCCGCCGCCGAGCACCATG GGAGACGCTGGGAGCGAGCGCAGCAAAGCGCCCAGCCTGCCGCCTCGCTGTCCCTGCGGCTTCTGGGGGTCCAGCAAGACTATGAATCTC TGTTCCAAATGCTTTGCTGCAAATCCTGTTTCCTGTGACTTTGTAAGGAAATGTTTTTCTTCTAGGAAGAGAACCCCAAATCTTTCAAAG CCTAAAAAGCAATGGGGAACTCCAGACAGAAAACTGTTTTGGGGAAATCAAGATCCTATTCGCCCTGTTTCCCAGGGTGCTTTGAAGGCT CAGCTGACCAAAAGACTTGAGAACCTTGCCCAGCCCAAGGAAGTTTCCTGCCACTATGTACCTAACAGGGCTCAATACTACCACAGCTGT GGAAGAGAGTCTGTAATTTGGGAGATCACTCCTCCTGCATTGTTTAGACAACCCTCCAAAAGGATCCAGAGGCTGTCACAGCCCAATGGA TTCAAAAGACAGTGTCTACTAAATAGACCCTTCAGTGATAACTCAGCAAGAGATTCTCTTCGAATCTCTGATCCTTCTCCCCGGATATTA CAACTCTCAGTAGCCAAAGGCACAGACCCAAACTATCATCCTTCAAAAAAAATGCAAACCAAGATTTCACTTTCTACCCTGAGTGCGATT GCAACTCCAAGAATTATAGAGCTTGCCCACCCAAGGATCAAGTTAGAGGGTCTGTGCTATGAAAGACAAAGAAGTGAACTGCCCATCCGT CCTGTACCTCCTGCTGCCATGATAGCTAAACCTAGCCCCCGAACAATAGCTCTAGCGAAGTCCAAGTCTGTTCATCAAGATTATCTACCT GACCGTGATGCCCATTGGCCAGTATCTTATGCTACTACTCATTCCAAAGCATCACCTAGGATTCAGGAACTAGCTAATCCAAATAAGAGG GCTCCTGTGCGTATTGTGTATTATGATCCAGATGTCTTTAAAACCAAGCCAGCTGCTTTGAAAGCACAGTGTTCTCAAAGGATCTGGGAG TTGTCACAACCTCTTACACGTTAAATACAGAAAGCCACAACAGTCAGACCCTGGTTATGTATCTAGAACACATATTAGATGACTTAGTTC CCTGTTGCGGTACTGTCAGTTTACATTCACCCCTTGCTTCCCCTCCCACAAAATGAGACCTTTAGGGAAAACCACCATGATCATTAAATA >In-frame_ZFAND3_ENST00000373391_chr6_37897775_+_THEGL_ENST00000512175_chr4_57414956_+_1349nt CCGGACTCGCGCCCGCCCGCGCGCCCGCTCCTTCCCCCTCCCCCCGCCCCGAGCCCCCCGACGCCGCCGCCACCGCCTCCTCAGAGCGGG GCCCGGGCCCAGCCGCCGCCACCGCTGCCGCCGCCGAGCTCCGCCGCCGCCGAGCACCATGGGAGACGCTGGGAGCGAGCGCAGCAAAGC GCCCAGCCTGCCGCCTCGCTGTCCCTGCGGCTTCTGGGGGTCCAGCAAGACTATGAATCTCTGTTCCAAATGCTTTGCTGCAAATCCTGT TTCCTGTGACTTTGTAAGGAAATGTTTTTCTTCTAGGAAGAGAACCCCAAATCTTTCAAAGCCTAAAAAGCAATGGGGAACTCCAGACAG AAAACTGTTTTGGGGAAATCAAGATCCTATTCGCCCTGTTTCCCAGGGTGCTTTGAAGGCTCAGCTGACCAAAAGACTTGAGAACCTTGC CCAGCCCAAGGAAGTTTCCTGCCACTATGTACCTAACAGGGCTCAATACTACCACAGCTGTGGAAGAGAGTCTGTAATTTGGGAGATCAC TCCTCCTGCATTGTTTAGACAACCCTCCAAAAGGATCCAGAGGCTGTCACAGCCCAATGGATTCAAAAGACAGTGTCTACTAAATAGACC CTTCAGTGATAACTCAGCAAGAGATTCTCTTCGAATCTCTGATCCTTCTCCCCGGATATTACAACTCTCAGTAGCCAAAGGCACAGACCC AAACTATCATCCTTCAAAAAAAATGCAAACCAAGATTTCACTTTCTACCCTGAGTGCGATTGCAACTCCAAGAATTATAGAGCTTGCCCA CCCAAGGATCAAGTTAGAGGGTCTGTGCTATGAAAGACAAAGAAGTGAACTGCCCATCCGTCCTGTACCTCCTGCTGCCATGATAGCTAA ACCTAGCCCCCGAACAATAGCTCTAGCGAAGTCCAAGTCTGTTCATCAAGATTATCTACCTGACCGTGATGCCCATTGGCCAGTATCTTA TGCTACTACTCATTCCAAAGCATCACCTAGGATTCAGGAACTAGCTAATCCAAATAAGAGGGCTCCTGTGCGTATTGTGTATTATGATCC AGATGTCTTTAAAACCAAGCCAGCTGCTTTGAAAGCACAGTGTTCTCAAAGGATCTGGGAGTTGTCACAACCTCTTACACGTTAAATACA GAAAGCCACAACAGTCAGACCCTGGTTATGTATCTAGAACACATATTAGATGACTTAGTTCCCTGTTGCGGTACTGTCAGTTTACATTCA |
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FusionGenePPI for ZFAND3_THEGL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZFAND3 | UBC, TUBG1, MAP3K1, TRIM25 | THEGL | BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZFAND3_THEGL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFAND3_THEGL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZFAND3 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | ZFAND3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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