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Fusion gene ID: 42733 |
FusionGeneSummary for ZEB2_GPD1L |
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Fusion gene information | Fusion gene name: ZEB2_GPD1L | Fusion gene ID: 42733 | Hgene | Tgene | Gene symbol | ZEB2 | GPD1L | Gene ID | 9839 | 23171 |
Gene name | zinc finger E-box binding homeobox 2 | glycerol-3-phosphate dehydrogenase 1 like | |
Synonyms | HSPC082|SIP-1|SIP1|SMADIP1|ZFHX1B | GPD1-L | |
Cytomap | 2q22.3 | 3p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger E-box-binding homeobox 2SMAD interacting protein 1Smad-interacting protein 1zinc finger homeobox 1b | glycerol-3-phosphate dehydrogenase 1-like protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O60315 | Q8N335 | |
Ensembl transtripts involved in fusion gene | ENST00000558170, ENST00000409487, ENST00000303660, ENST00000539609, ENST00000493689, ENST00000470879, ENST00000465070, ENST00000462355, | ENST00000282541, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 6 X 3 X 6=108 |
# samples | 5 | 7 | |
** MAII score | log2(5/50*10)=0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZEB2 [Title/Abstract] AND GPD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZEB2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12837246|20516212 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA778688 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000558170 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000409487 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000303660 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000539609 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000493689 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000470879 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000465070 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
intron-5UTR | ENST00000462355 | ENST00000282541 | ZEB2 | chr2 | 145274917 | - | GPD1L | chr3 | 32148134 | + |
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FusionProtFeatures for ZEB2_GPD1L |
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Hgene | Tgene |
ZEB2 | GPD1L |
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. {ECO:0000269|PubMed:16061479}. | Plays a role in regulating cardiac sodium current;decreased enzymatic activity with resulting increased levels ofglycerol 3-phosphate activating the DPD1L-dependent SCN5Aphosphorylation pathway, may ultimately lead to decreased sodiumcurrent; cardiac sodium current may also be reduced due toalterations of NAD(H) balance induced by DPD1L.{ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZEB2_GPD1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZEB2_GPD1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZEB2_GPD1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZEB2_GPD1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZEB2 | C1856113 | Mowat-Wilson syndrome | 5 | CTD_human;UNIPROT |
Hgene | ZEB2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | ZEB2 | C0018798 | Congenital Heart Defects | 1 | CTD_human |
Hgene | ZEB2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ZEB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ZEB2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | GPD1L | C2673193 | Brugada Syndrome 2 | 3 | CTD_human;UNIPROT |
Tgene | GPD1L | C0038644 | Sudden infant death syndrome | 2 | UNIPROT |
Tgene | GPD1L | C0015695 | Fatty Liver | 1 | CTD_human |