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Fusion gene ID: 42705 |
FusionGeneSummary for ZDHHC2_VPS37A |
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Fusion gene information | Fusion gene name: ZDHHC2_VPS37A | Fusion gene ID: 42705 | Hgene | Tgene | Gene symbol | ZDHHC2 | VPS37A | Gene ID | 51201 | 137492 |
Gene name | zinc finger DHHC-type containing 2 | VPS37A, ESCRT-I subunit | |
Synonyms | DHHC2|ZNF372 | HCRP1|PQBP2|SPG53 | |
Cytomap | 8p22 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | palmitoyltransferase ZDHHC2DHHC-2reamrecreduced expression associated with metastasis proteinreduced expression in cancer proteintestis tissue sperm-binding protein Li 56ezinc finger DHHC domain-containing protein 2zinc finger protein 372zinc fin | vacuolar protein sorting-associated protein 37AESCRT-I complex subunit VPS37Ahepatocellular carcinoma-related protein 1polyglutamine binding protein 2vacuolar protein sorting 37 homolog A | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9UIJ5 | Q8NEZ2 | |
Ensembl transtripts involved in fusion gene | ENST00000262096, | ENST00000324849, ENST00000324815, ENST00000521829, ENST00000521005, ENST00000521162, | |
Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 4 X 4 X 3=48 |
# samples | 3 | 4 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZDHHC2 [Title/Abstract] AND VPS37A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZDHHC2 | GO:0018345 | protein palmitoylation | 23034182 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-BC-4073-01B | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262096 | ENST00000324849 | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
5CDS-intron | ENST00000262096 | ENST00000324815 | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
5CDS-intron | ENST00000262096 | ENST00000521829 | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
5CDS-intron | ENST00000262096 | ENST00000521005 | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
5CDS-intron | ENST00000262096 | ENST00000521162 | ZDHHC2 | chr8 | 17014362 | + | VPS37A | chr8 | 17143856 | + |
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FusionProtFeatures for ZDHHC2_VPS37A |
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Hgene | Tgene |
ZDHHC2 | VPS37A |
Palmitoyltransferase specific for GAP43 and DLG4/PSD95.{ECO:0000250}. | Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Required for the sorting ofendocytic ubiquitinated cargos into multivesicular bodies. May beinvolved in cell growth and differentiation.{ECO:0000269|PubMed:15240819}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZDHHC2_VPS37A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZDHHC2_VPS37A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZDHHC2 | MSX2, MAFB | VPS37A | TSG101, VPS28, MVB12A, MVB12B, ALG2, UBAP1, APP, KDM1A, TRIM42, ARRDC1, XPO1, UBC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZDHHC2_VPS37A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZDHHC2_VPS37A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZDHHC2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | ZDHHC2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | ZDHHC2 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | VPS37A | C3539494 | SPASTIC PARAPLEGIA 53, AUTOSOMAL RECESSIVE | 1 | ORPHANET;UNIPROT |