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Fusion gene ID: 4270 |
FusionGeneSummary for BNC2_ARHGAP44 |
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Fusion gene information | Fusion gene name: BNC2_ARHGAP44 | Fusion gene ID: 4270 | Hgene | Tgene | Gene symbol | BNC2 | ARHGAP44 | Gene ID | 54796 | 9912 |
Gene name | basonuclin 2 | Rho GTPase activating protein 44 | |
Synonyms | BSN2 | NPC-A-10|RICH2 | |
Cytomap | 9p22.3-p22.2 | 17p12 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein basonuclin-2 | rho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6ZN30 | Q17R89 | |
Ensembl transtripts involved in fusion gene | ENST00000380672, ENST00000380667, ENST00000545497, ENST00000380666, ENST00000471301, | ENST00000379672, ENST00000340825, ENST00000262444, ENST00000578087, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 4 X 4=64 |
# samples | 5 | 5 | |
** MAII score | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BNC2 [Title/Abstract] AND ARHGAP44 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI012359 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + | ||
ChiTaRS3.1 | BF846733 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000380672 | ENST00000379672 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000380672 | ENST00000340825 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380672 | ENST00000262444 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380672 | ENST00000578087 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000380667 | ENST00000379672 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000380667 | ENST00000340825 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380667 | ENST00000262444 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380667 | ENST00000578087 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000545497 | ENST00000379672 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000545497 | ENST00000340825 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000545497 | ENST00000262444 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000545497 | ENST00000578087 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000380666 | ENST00000379672 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000380666 | ENST00000340825 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380666 | ENST00000262444 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000380666 | ENST00000578087 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000471301 | ENST00000379672 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-3UTR | ENST00000471301 | ENST00000340825 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000471301 | ENST00000262444 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
intron-intron | ENST00000471301 | ENST00000578087 | BNC2 | chr9 | 16410473 | + | ARHGAP44 | chr17 | 12893998 | + |
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FusionProtFeatures for BNC2_ARHGAP44 |
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Hgene | Tgene |
BNC2 | ARHGAP44 |
Probable transcription factor specific for skinkeratinocytes. May play a role in the differentiation ofspermatozoa and oocytes. | GTPase-activating protein (GAP) that stimulates theGTPase activity of Rho-type GTPases. Thereby, controls Rho-typeGTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomalrecycling protein which, in association with SHANK3, is involvedin synaptic plasticity. Promotes GRIA1 exocytosis from recyclingendosomes and spine morphological changes associated to long-termpotentiation. {ECO:0000269|PubMed:11431473}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for BNC2_ARHGAP44 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for BNC2_ARHGAP44 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BNC2_ARHGAP44 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BNC2_ARHGAP44 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | BNC2 | C0008925 | Cleft Palate | 1 | CTD_human |
Hgene | BNC2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | BNC2 | C0919267 | ovarian neoplasm | 1 | CTD_human |