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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42690

FusionGeneSummary for ZDHHC20_MTHFD2L

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC20_MTHFD2L
Fusion gene ID: 42690
HgeneTgene
Gene symbol

ZDHHC20

MTHFD2L

Gene ID

253832

441024

Gene namezinc finger DHHC-type containing 20methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like
Synonyms4933421L13Rik|DHHC-20|DHHC20-
Cytomap

13q12.11

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC20probable palmitoyltransferase ZDHHC20zinc finger DHHC domain-containing protein 20probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2MTHFD2-likeNADP-dependent methylenetetrahydrofolate dehydrogenase 2-like proteintetrahydrofolate dehydrogenase/cyclohydrolase
Modification date2018052320180523
UniProtAcc

Q5W0Z9

Q9H903

Ensembl transtripts involved in fusion geneENST00000400590, ENST00000320220, 
ENST00000382466, ENST00000542645, 
ENST00000415724, ENST00000422251, 
ENST00000494731, 		ENST00000433372, 
ENST00000331145, ENST00000395759, 
ENST00000325278, ENST00000461101, 
Fusion gene scores* DoF score8 X 5 X 6=2405 X 4 X 4=80
# samples 106
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC20 [Title/Abstract] AND MTHFD2L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC20

GO:0018230

peptidyl-L-cysteine S-palmitoylation

29326245

HgeneZDHHC20

GO:0018345

protein palmitoylation

23034182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK023167ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
ChiTaRS3.1AX794778ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000400590ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000400590ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000400590ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000400590ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5CDS-intronENST00000400590ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000320220ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000320220ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000320220ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000320220ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5CDS-intronENST00000320220ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000382466ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000382466ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000382466ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000382466ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5CDS-intronENST00000382466ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5UTR-3CDSENST00000542645ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5UTR-3CDSENST00000542645ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5UTR-3CDSENST00000542645ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5UTR-3CDSENST00000542645ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5UTR-intronENST00000542645ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000415724ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000415724ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000415724ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000415724ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5CDS-intronENST00000415724ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000422251ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000422251ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000422251ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
Frame-shiftENST00000422251ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
5CDS-intronENST00000422251ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
intron-3CDSENST00000494731ENST00000433372ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
intron-3CDSENST00000494731ENST00000331145ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
intron-3CDSENST00000494731ENST00000395759ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
intron-3CDSENST00000494731ENST00000325278ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+
intron-intronENST00000494731ENST00000461101ZDHHC20chr13

22033193

-MTHFD2Lchr4

75065511

+

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FusionProtFeatures for ZDHHC20_MTHFD2L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZDHHC20

Q5W0Z9

MTHFD2L

Q9H903

Catalyzes palmitoylation of Cys residues on targetproteins (PubMed:27153536, PubMed:29326245). Catalyzespalmitoylation of Cys residues in the cytoplasmic C-terminus ofEGFR, and modulates the duration of EGFR signaling by modulatingpalmitoylation-dependent EGFR internalization and degradation(PubMed:27153536). Has a preference for acyl-CoA with C16 fattyacid chains (PubMed:29326245). Can also utilize acyl-CoA with C14and C18 fatty acid chains (PubMed:29326245).{ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:29326245}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZDHHC20_MTHFD2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZDHHC20_MTHFD2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZDHHC20TMEM17, MBLAC2MTHFD2LMTHFD2, HENMT1, PROSER2, SRP9, HDHD3, CST4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZDHHC20_MTHFD2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZDHHC20_MTHFD2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource