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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42658

FusionGeneSummary for ZCWPW2_OSBPL10

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCWPW2_OSBPL10
Fusion gene ID: 42658
HgeneTgene
Gene symbol

ZCWPW2

OSBPL10

Gene ID

152098

114884

Gene namezinc finger CW-type and PWWP domain containing 2oxysterol binding protein like 10
SynonymsZCW2ORP10|OSBP9
Cytomap

3p24.1

3p23

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CW-type PWWP domain protein 2zinc finger CW-type and PWWP domain 2zinc finger, CW type with PWWP domain 2oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10
Modification date2018051920180523
UniProtAcc

Q504Y3

Q9BXB5

Ensembl transtripts involved in fusion geneENST00000383768, ENST00000421010, 
ENST00000396556, ENST00000438237, 
ENST00000467647, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 3 X 4=72
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZCWPW2 [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-EE-A17Z-06AZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000383768ENST00000396556ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
5UTR-3CDSENST00000383768ENST00000438237ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
5UTR-intronENST00000383768ENST00000467647ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
intron-3CDSENST00000421010ENST00000396556ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
intron-3CDSENST00000421010ENST00000438237ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-
intron-intronENST00000421010ENST00000467647ZCWPW2chr3

28390694

+OSBPL10chr3

31921322

-

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FusionProtFeatures for ZCWPW2_OSBPL10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZCWPW2

Q504Y3

OSBPL10

Q9BXB5

Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZCWPW2_OSBPL10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZCWPW2_OSBPL10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZCWPW2UBCOSBPL10AP2B1, ALDOA, BBS1, GBAS, MMP2, CUL1, CLINT1, KEAP1, SAP18, SRRM2, WRNIP1, CLPB, USP11, OSBPL9, ZC3H18, PGAM5, IKBKG, VAPB, VAPA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZCWPW2_OSBPL10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZCWPW2_OSBPL10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource