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Fusion gene ID: 42658 |
FusionGeneSummary for ZCWPW2_OSBPL10 |
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Fusion gene information | Fusion gene name: ZCWPW2_OSBPL10 | Fusion gene ID: 42658 | Hgene | Tgene | Gene symbol | ZCWPW2 | OSBPL10 | Gene ID | 152098 | 114884 |
Gene name | zinc finger CW-type and PWWP domain containing 2 | oxysterol binding protein like 10 | |
Synonyms | ZCW2 | ORP10|OSBP9 | |
Cytomap | 3p24.1 | 3p23 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger CW-type PWWP domain protein 2zinc finger CW-type and PWWP domain 2zinc finger, CW type with PWWP domain 2 | oxysterol-binding protein-related protein 10ORP-10OSBP-related protein 10 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q504Y3 | Q9BXB5 | |
Ensembl transtripts involved in fusion gene | ENST00000383768, ENST00000421010, | ENST00000396556, ENST00000438237, ENST00000467647, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 3 X 4=72 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZCWPW2 [Title/Abstract] AND OSBPL10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-EE-A17Z-06A | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000383768 | ENST00000396556 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
5UTR-3CDS | ENST00000383768 | ENST00000438237 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
5UTR-intron | ENST00000383768 | ENST00000467647 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
intron-3CDS | ENST00000421010 | ENST00000396556 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
intron-3CDS | ENST00000421010 | ENST00000438237 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
intron-intron | ENST00000421010 | ENST00000467647 | ZCWPW2 | chr3 | 28390694 | + | OSBPL10 | chr3 | 31921322 | - |
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FusionProtFeatures for ZCWPW2_OSBPL10 |
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Hgene | Tgene |
ZCWPW2 | OSBPL10 |
Probable lipid transporter involved in lipidcountertransport between the endoplasmic reticulum and the plasmamembrane. Its ability to bind phosphatidylserine, suggests that itspecifically exchanges phosphatidylserine withphosphatidylinositol 4-phosphate (PI4P), deliveringphosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110) (Probable). Plays a role in negative regulationof lipid biosynthesis (PubMed:19554302). Negatively regulates APOBsecretion from hepatocytes (PubMed:19554302, PubMed:22906437).Binds cholesterol and acidic phospholipids (PubMed:22906437). Alsobinds 25-hydroxycholesterol (PubMed:17428193). Bindsphosphatidylserine (PubMed:23934110).{ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302,ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110,ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCWPW2_OSBPL10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCWPW2_OSBPL10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZCWPW2 | UBC | OSBPL10 | AP2B1, ALDOA, BBS1, GBAS, MMP2, CUL1, CLINT1, KEAP1, SAP18, SRRM2, WRNIP1, CLPB, USP11, OSBPL9, ZC3H18, PGAM5, IKBKG, VAPB, VAPA |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCWPW2_OSBPL10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCWPW2_OSBPL10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |