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Fusion gene ID: 42653 |
FusionGeneSummary for ZCCHC8_PTPN12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZCCHC8_PTPN12 | Fusion gene ID: 42653 | Hgene | Tgene | Gene symbol | ZCCHC8 | PTPN12 | Gene ID | 55596 | 5782 |
| Gene name | zinc finger CCHC-type containing 8 | protein tyrosine phosphatase, non-receptor type 12 | |
| Synonyms | - | PTP-PEST|PTPG1 | |
| Cytomap | 12q24.31 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8 | tyrosine-protein phosphatase non-receptor type 12protein-tyrosine phosphatase G1 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q6NZY4 | Q05209 | |
| Ensembl transtripts involved in fusion gene | ENST00000536306, ENST00000543897, ENST00000336229, ENST00000538116, | ENST00000248594, ENST00000415482, ENST00000435495, | |
| Fusion gene scores | * DoF score | 4 X 4 X 12=192 | 7 X 7 X 5=245 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/192*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZCCHC8 [Title/Abstract] AND PTPN12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTPN12 | GO:0006470 | protein dephosphorylation | 27134172 |
| Tgene | PTPN12 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27134172 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-3H-AB3M-01A | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000536306 | ENST00000248594 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| In-frame | ENST00000536306 | ENST00000415482 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| In-frame | ENST00000536306 | ENST00000435495 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| In-frame | ENST00000543897 | ENST00000248594 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| In-frame | ENST00000543897 | ENST00000415482 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| In-frame | ENST00000543897 | ENST00000435495 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| Frame-shift | ENST00000336229 | ENST00000248594 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| Frame-shift | ENST00000336229 | ENST00000415482 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| Frame-shift | ENST00000336229 | ENST00000435495 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| intron-3CDS | ENST00000538116 | ENST00000248594 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| intron-3CDS | ENST00000538116 | ENST00000415482 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
| intron-3CDS | ENST00000538116 | ENST00000435495 | ZCCHC8 | chr12 | 122964737 | - | PTPN12 | chr7 | 77261665 | + |
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FusionProtFeatures for ZCCHC8_PTPN12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZCCHC8 | PTPN12 |
| Scaffolding subunit of the trimeric nuclear exosometargeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosomeis fundamental for the degradation of RNA in eukaryotic nuclei.Substrate targeting is facilitated by its cofactor MTREX, whichlinks to RNA-binding protein adapters (PubMed:27871484). May beinvolved in pre-mRNA splicing (Probable).{ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:16263084}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 45_80 | 380 | 708 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 45_80 | 142 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 45_80 | 142 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 286_299 | 380 | 708 | Region | RBM7 binding |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 309_324 | 380 | 708 | Region | RBM7 binding |
| Hgene | ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 227_244 | 380 | 708 | Zinc finger | CCHC-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 516_539 | 380 | 708 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 516_539 | 142 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 516_539 | 142 | 470 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000336229 | - | 11 | 14 | 466_501 | 380 | 708 | Compositional bias | Pro-rich |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 466_501 | 142 | 470 | Compositional bias | Pro-rich |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 466_501 | 142 | 470 | Compositional bias | Pro-rich |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 286_299 | 142 | 470 | Region | RBM7 binding |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 309_324 | 142 | 470 | Region | RBM7 binding |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 286_299 | 142 | 470 | Region | RBM7 binding |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 309_324 | 142 | 470 | Region | RBM7 binding |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000536306 | - | 9 | 12 | 227_244 | 142 | 470 | Zinc finger | CCHC-type |
| Hgene | >ZCCHC8 | chr12:122964737 | chr7:77261665 | ENST00000543897 | - | 9 | 12 | 227_244 | 142 | 470 | Zinc finger | CCHC-type |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000248594 | + | 12 | 18 | 28_293 | 665 | 781 | Domain | Tyrosine-protein phosphatase |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000435495 | + | 11 | 17 | 28_293 | 535 | 651 | Domain | Tyrosine-protein phosphatase |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000248594 | + | 12 | 18 | 231_237 | 665 | 781 | Region | Substrate binding |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000248594 | + | 12 | 18 | 63_67 | 665 | 781 | Region | Substrate binding |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000435495 | + | 11 | 17 | 231_237 | 535 | 651 | Region | Substrate binding |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000435495 | + | 11 | 17 | 63_67 | 535 | 651 | Region | Substrate binding |
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FusionGeneSequence for ZCCHC8_PTPN12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_115aa MLMLVKIHLLPYLKELLNRLCXQVNIIHLXDRNGVNFKVRNDLNKKSLKAXXPLKMRNVIIQREVFTMKCAXNVHLLSVTRENKYQKIQQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_347nt ATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAA GATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATC ATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_2431nt TTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACATCCATAGATT TATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAGGAACACTGAT GCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATAAAAACCGTAC TTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGGTCTTTTGTCT TTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTCCTTAACAAAT AATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGATGGACCTATAT TACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAAAGATTTGAGG AACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCACAAAGTGGAAG AGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTACCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAA GTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGGTTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCT CGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGGAGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTA GAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGAGGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTT ATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCTCAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAA GATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACAGAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGT TTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGT TTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAG GCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTG ACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATC CACCTTCAGAATGGACATGATTCAGGGAGCTAGAAGACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGT ATTCCATCTTTAATATGTGGGACTAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACT TAGGAAAAAGTATTACATATGGTTTATTTTGAAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACA TGTTAATATAGTAATACCTTTATGATATATTGAGTTTAAGGACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACA GGGCAAGTAGGTATATAATTTGATAAAGTTGCAATTGAAATATTATTAACAGAAGATGTAAGAAATTTCTGCATGGTCTAAATCTTTGTG TACTTTATTTGTAAATTATTTGCCCTGGAGTTTTAGAAAATAGTTTCTGAATTTTAAACTTGCTGGATTCATGCAGCCAGCTTTGCAGGT TATCAGAGATCAAAGATTGTAATAATAATTTTGTAAATTGTAAGCAAAAAGTTATTTTTATATTATATACAGTCTAATTGTTCATCCTAA TTGTTCCTGTTTTCATCTAGTCAGAGATTCAGTAAGTGCCTTGGAACAATATTGAATTCTCTTAGCTTGTGTGTGTTTCTTTAATATTTG AACTCAAGTGGGATTAGAAGACTATCAAAATACATGTATGTTTCAGGATATTTGACCTGTCATTAAAAAAAACAAACAGTTTTACAGTGC >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_1640nt TTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACATCCATAGATT TATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAGGAACACTGAT GCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATAAAAACCGTAC TTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGGTCTTTTGTCT TTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTCCTTAACAAAT AATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGATGGACCTATAT TACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAAAGATTTGAGG AACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCACAAAGTGGAAG AGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTACCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAA GTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGGTTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCT CGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGGAGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTA GAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGAGGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTT ATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCTCAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAA GATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACAGAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGT TTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGT TTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAG GCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTG ACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATC >In-frame_ZCCHC8_ENST00000536306_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_1980nt TTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACATCCATAGATT TATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAGGAACACTGAT GCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATAAAAACCGTAC TTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGGTCTTTTGTCT TTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTCCTTAACAAAT AATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGATGGACCTATAT TACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAAAGATTTGAGG AACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCACAAAGTGGAAG AGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTACCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAA GTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGGTTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCT CGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGGAGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTA GAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGAGGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTT ATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCTCAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAA GATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACAGAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGT TTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGATGTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGT TTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAATGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAG GCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCGGGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTG ACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATC CACCTTCAGAATGGACATGATTCAGGGAGCTAGAAGACACTTTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGT ATTCCATCTTTAATATGTGGGACTAACAGCAGTGTAGATTGTTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACT TAGGAAAAAGTATTACATATGGTTTATTTTGAAACTTCAAGTATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACA TGTTAATATAGTAATACCTTTATGATATATTGAGTTTAAGGACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACA >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000248594_chr7_77261665_+_3920nt GGCAGCGCCAGGCGTGGGGCCGGGGCAGCGCCGGGCGAGGGCGAGGGCGCGGGCGGAAGTTCCAGGAGGGCCAGAATTCCAAGTGCTTTC TGTCACCCGCCGGCGGACCGAGAGTCTAGGGTTCGGGGCGCGCAGGCTGCCTCGGCGCAGACCTCTTCCCCTCAGGGAGGCCGTCTCCTG ACCAGACCCACTCCTGCCTCCCACCCGGGTGCCGTGTTTAGGGTTATTTTAGGCTGCTCACCTGACAGATTGTACACAAGCCCTTAATTG CCCCCCTCTGTTTGAGGTCGTGGTGAGGTTTCATATTTCGCAGCCACGCTCAAATTGTGCCGTCATGTTACAGTTGTAGGTGATGAAATA CCGGCTGCTTAGACGCGGGATCGGTTTTTATACCGGGGCAAACGCTAGTGGTCCCAGAATGCAGAGTTGGGGGCCTCAAGGAATCCGGGT GTGCTGAGATAATTGGTTAATTGCTTGATTAAAATTGGGGATTAATTTTAGAGTTCTTCCACTCGGAGCTCGCTTCTGTGCTGAAGATGC TTTGCAACGCCTTGAGGAAAACGCGCCAAAGAAGTTTCTGTTAGACTTGAGTTACAAGATTGCAGATTTTTCTTGATTTGCTAGTATGTT TTTTTTTACGTTCGTAGAGTTTTATAGGTAGATAGATAACTTTGGTTCGGGTAGTTTTCCTTTTAAAATTTGTAGAGAACTGAAAGTGGC TGATATGTTAGCTTTTTTAGGGGGACGGGGTCGGGGAATGGAGTCTCAGTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTC ACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCGCCCGCCACGGCGCCCAGT CAGTATATCAGTTTTTAAGGTTTGTGAAGCGCGATTTATTTTTTCAGAATGTCGTCTTCCTCCACATTGTGAGGAAAATTTTCAGAATAC AAAAAGTTGAGGCCGGGCGCTGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGGATCA TGAGGATCAGGTGGATCATGAGGATCAGGAGGTCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGC GTGGTGGCGCGTGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAA GATCACACCATTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACA TCCATAGATTTATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAG GAACACTGATGCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATA AAAACCGTACTTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGG TCTTTTGTCTTTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTC CTTAACAAATAATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGAT GGACCTATATTACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAA AGATTTGAGGAACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCAC AAAGTGGAAGAGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTTGTAGGAAGTGTCCTGTATTTTACTAATTTTTGCCTTGAT AAATTGGGGCAACCGCTTCTAAATGAAAACCCTCAGCTTTCCGAAGGATGGGAAATACCCAAGTATCCTACATAGTGAATGAAGATCTTT TATGCATCTTGCCACTAAGTTCACCTTTAAAACAATTTCCAAATTTTGCAGACCATGATAACTATTCCTTAATAAAATTCACTAAAGGTA CCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAAGTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGG TTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCTCGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGG AGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTAGAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGA GGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTTATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCT CAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAAGATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACA GAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGTTTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGAT GTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAA TGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCG GGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACA GATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGACATGATTCAGGGAGCTAGAAGACACT TTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAATATGTGGGACTAACAGCAGTGTAGATTG TTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTACATATGGTTTATTTTGAAACTTCAAG TATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTAATATAGTAATACCTTTATGATATATTGAGTTTAAGG ACTACTCTTTTTCTGTTTTATCATGTATGCATTATTTTGTATATGTACAGGGCAAGTAGGTATATAATTTGATAAAGTTGCAATTGAAAT ATTATTAACAGAAGATGTAAGAAATTTCTGCATGGTCTAAATCTTTGTGTACTTTATTTGTAAATTATTTGCCCTGGAGTTTTAGAAAAT AGTTTCTGAATTTTAAACTTGCTGGATTCATGCAGCCAGCTTTGCAGGTTATCAGAGATCAAAGATTGTAATAATAATTTTGTAAATTGT AAGCAAAAAGTTATTTTTATATTATATACAGTCTAATTGTTCATCCTAATTGTTCCTGTTTTCATCTAGTCAGAGATTCAGTAAGTGCCT TGGAACAATATTGAATTCTCTTAGCTTGTGTGTGTTTCTTTAATATTTGAACTCAAGTGGGATTAGAAGACTATCAAAATACATGTATGT >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000415482_chr7_77261665_+_3129nt GGCAGCGCCAGGCGTGGGGCCGGGGCAGCGCCGGGCGAGGGCGAGGGCGCGGGCGGAAGTTCCAGGAGGGCCAGAATTCCAAGTGCTTTC TGTCACCCGCCGGCGGACCGAGAGTCTAGGGTTCGGGGCGCGCAGGCTGCCTCGGCGCAGACCTCTTCCCCTCAGGGAGGCCGTCTCCTG ACCAGACCCACTCCTGCCTCCCACCCGGGTGCCGTGTTTAGGGTTATTTTAGGCTGCTCACCTGACAGATTGTACACAAGCCCTTAATTG CCCCCCTCTGTTTGAGGTCGTGGTGAGGTTTCATATTTCGCAGCCACGCTCAAATTGTGCCGTCATGTTACAGTTGTAGGTGATGAAATA CCGGCTGCTTAGACGCGGGATCGGTTTTTATACCGGGGCAAACGCTAGTGGTCCCAGAATGCAGAGTTGGGGGCCTCAAGGAATCCGGGT GTGCTGAGATAATTGGTTAATTGCTTGATTAAAATTGGGGATTAATTTTAGAGTTCTTCCACTCGGAGCTCGCTTCTGTGCTGAAGATGC TTTGCAACGCCTTGAGGAAAACGCGCCAAAGAAGTTTCTGTTAGACTTGAGTTACAAGATTGCAGATTTTTCTTGATTTGCTAGTATGTT TTTTTTTACGTTCGTAGAGTTTTATAGGTAGATAGATAACTTTGGTTCGGGTAGTTTTCCTTTTAAAATTTGTAGAGAACTGAAAGTGGC TGATATGTTAGCTTTTTTAGGGGGACGGGGTCGGGGAATGGAGTCTCAGTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTC ACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCGCCCGCCACGGCGCCCAGT CAGTATATCAGTTTTTAAGGTTTGTGAAGCGCGATTTATTTTTTCAGAATGTCGTCTTCCTCCACATTGTGAGGAAAATTTTCAGAATAC AAAAAGTTGAGGCCGGGCGCTGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGGATCA TGAGGATCAGGTGGATCATGAGGATCAGGAGGTCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGC GTGGTGGCGCGTGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAA GATCACACCATTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACA TCCATAGATTTATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAG GAACACTGATGCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATA AAAACCGTACTTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGG TCTTTTGTCTTTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTC CTTAACAAATAATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGAT GGACCTATATTACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAA AGATTTGAGGAACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCAC AAAGTGGAAGAGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTTGTAGGAAGTGTCCTGTATTTTACTAATTTTTGCCTTGAT AAATTGGGGCAACCGCTTCTAAATGAAAACCCTCAGCTTTCCGAAGGATGGGAAATACCCAAGTATCCTACATAGTGAATGAAGATCTTT TATGCATCTTGCCACTAAGTTCACCTTTAAAACAATTTCCAAATTTTGCAGACCATGATAACTATTCCTTAATAAAATTCACTAAAGGTA CCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAAGTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGG TTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCTCGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGG AGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTAGAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGA GGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTTATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCT CAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAAGATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACA GAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGTTTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGAT GTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAA TGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCG GGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACA >In-frame_ZCCHC8_ENST00000543897_chr12_122964737_-_PTPN12_ENST00000435495_chr7_77261665_+_3469nt GGCAGCGCCAGGCGTGGGGCCGGGGCAGCGCCGGGCGAGGGCGAGGGCGCGGGCGGAAGTTCCAGGAGGGCCAGAATTCCAAGTGCTTTC TGTCACCCGCCGGCGGACCGAGAGTCTAGGGTTCGGGGCGCGCAGGCTGCCTCGGCGCAGACCTCTTCCCCTCAGGGAGGCCGTCTCCTG ACCAGACCCACTCCTGCCTCCCACCCGGGTGCCGTGTTTAGGGTTATTTTAGGCTGCTCACCTGACAGATTGTACACAAGCCCTTAATTG CCCCCCTCTGTTTGAGGTCGTGGTGAGGTTTCATATTTCGCAGCCACGCTCAAATTGTGCCGTCATGTTACAGTTGTAGGTGATGAAATA CCGGCTGCTTAGACGCGGGATCGGTTTTTATACCGGGGCAAACGCTAGTGGTCCCAGAATGCAGAGTTGGGGGCCTCAAGGAATCCGGGT GTGCTGAGATAATTGGTTAATTGCTTGATTAAAATTGGGGATTAATTTTAGAGTTCTTCCACTCGGAGCTCGCTTCTGTGCTGAAGATGC TTTGCAACGCCTTGAGGAAAACGCGCCAAAGAAGTTTCTGTTAGACTTGAGTTACAAGATTGCAGATTTTTCTTGATTTGCTAGTATGTT TTTTTTTACGTTCGTAGAGTTTTATAGGTAGATAGATAACTTTGGTTCGGGTAGTTTTCCTTTTAAAATTTGTAGAGAACTGAAAGTGGC TGATATGTTAGCTTTTTTAGGGGGACGGGGTCGGGGAATGGAGTCTCAGTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTC ACTGCAACCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGATTACAGGCGCCCGCCACGGCGCCCAGT CAGTATATCAGTTTTTAAGGTTTGTGAAGCGCGATTTATTTTTTCAGAATGTCGTCTTCCTCCACATTGTGAGGAAAATTTTCAGAATAC AAAAAGTTGAGGCCGGGCGCTGTGGCTCAAGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCATGAGGTCAGGAGGATCA TGAGGATCAGGTGGATCATGAGGATCAGGAGGTCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAATTAGCCGGGC GTGGTGGCGCGTGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCCCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAA GATCACACCATTGCACTCCAGCCTGGGCGACAGGGTGAGACTGTGTCTCAAAAAAAAAAAAAAAAAGTTGAAAGGATTCTACAGTGGACA TCCATAGATTTATTCCAAATTCTAAAGTTGTTAACAGCTCGTTATACTGCATTCTCTTTATCACATAGTGGTTGTTGAAAGGTTTGACAG GAACACTGATGCTTCAATAATGGTTTTGGTTCAGTTTGTTAGTCTGTTGAACTTCAGGATCGTGTCTTAGAATATATGTTCGAAAGGATA AAAACCGTACTTTAATTTTGGGTTTCAAAAGCCTACCCCTGCAACAAAATAGAAGCTCAATAAGTGTGTCATCCTCAAAATATCCGTGGG TCTTTTGTCTTTATAATATTCTGACACCAAAAGTGAGAGAAGTAGTAGTTGAATTTTATGATTTGCATTGTTAAATGAGGGCTTATCTTC CTTAACAAATAATAACATCAAGAACTTAAACGAAAATTGAACATTCTGACTCGACCGAGTGGAATATTGGTGAACGATACTAAGTTAGAT GGACCTATATTACAGATTCTATTCATGAACAATGCTATTTCAAAGCAATATCATCAAGAAATAGAGGAATTTGTATCAAATTTAGTAAAA AGATTTGAGGAACAGCAGAAAAATGATGTGGAAAAGACTTCCTTTAATCTTTTGCCCCAGCCATCCAGTATTGTGCTAGAGGAGGACCAC AAAGTGGAAGAGTCCTGTGCCATTAAAAACAACAAGGAAGCTTTCAGTGTTGTAGGAAGTGTCCTGTATTTTACTAATTTTTGCCTTGAT AAATTGGGGCAACCGCTTCTAAATGAAAACCCTCAGCTTTCCGAAGGATGGGAAATACCCAAGTATCCTACATAGTGAATGAAGATCTTT TATGCATCTTGCCACTAAGTTCACCTTTAAAACAATTTCCAAATTTTGCAGACCATGATAACTATTCCTTAATAAAATTCACTAAAGGTA CCATCAAGTCTTCAGCCACATTGTTTCTCTAGAAGGGCAAGAAATACAAGTAAAGGCAAAAAGGCCAAAGCCTCACTGTTTCAATTGTGG TTCTGAAGAACACCAAATGAAAGATTGCCCAATGCCTCGGAATGCTGCTCGAATAAGTGAAAAGAGAAAAGAGTATATGGATGCCTGTGG AGAAGCAAACAATCAGAATTTCCAGCAGCGATACCACGCAGAAGAAGTAGAAGAAAGATTTGGAAGATTCAAGCCAGGAGTTATTAGTGA GGAACTTCAAGATGCACTAGGTGTGACAGACAAGAGTCTTCCACCTTTTATCTATCGGATGCGCCAGCTAGGGTACCCACCAGGGTGGCT CAAAGAGGCTGAATTGGAGAATTCGGGGCTTGCACTCTATGATGGAAAAGATGGCACTGATGGGGAAACAGAAGTTGGAGAAATACAACA GAATAAAAGTGTCACTTACGATCTCTCAAAATTGGTCAACTATCCTGGTTTTAATATATCTACTCCCAGAGGAATTCCAGACATGTTGAT GTTAGTGAAGATTCACCTCCTCCCCTACCTGAAAGAACTCCTGAATCGTTTGTGTTAGCAAGTGAACATAATACACCTGTAAGATCGGAA TGGAGTGAACTTCAAAGTCAGGAACGATCTGAACAAAAAAAGTCTGAAGGCTTGATAACCTCTGAAAATGAGAAATGTGATCATCCAGCG GGAGGTATTCACTATGAAATGTGCATAGAATGTCCACCTACTTTCAGTGACAAGAGAGAACAAATATCAGAAAATCCAACAGAAGCCACA GATATTGGTTTTGGTAATCGATGTGGAAAACCCAAAGGACCAAGAGATCCACCTTCAGAATGGACATGATTCAGGGAGCTAGAAGACACT TTAAGTTATACTGGAAAATTCAGGTGCCACTGAAAGCCAGATTTATAGTATTCCATCTTTAATATGTGGGACTAACAGCAGTGTAGATTG TTACCTTAATATTTTTTGCTGGGACCATCTACCTGCCTTATACTACACTTAGGAAAAAGTATTACATATGGTTTATTTTGAAACTTCAAG TATTATTGCCTTAATGTCTCTTAACCCTGTTACACGCTGCTTGTAGACATGTTAATATAGTAATACCTTTATGATATATTGAGTTTAAGG |
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FusionGenePPI for ZCCHC8_PTPN12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZCCHC8 | BRCA1, PPP2R1A, PPP2R2D, PPP2R2B, SIRT7, SKIV2L2, RBM7, CUL3, APP, U2AF1, THOC6, THOC1, U2AF2, USP7, PSMC2, MICB, TXNDC9, PSMA1, PSMC5, USP28, ZC3H15, PSMD13, PSMC4, PSMB6, PRPF40A, SOX2, CLK2, YWHAB, RPA3, RPA2, RPA1, DROSHA, RNF2, BMI1, RBM11, EXOSC3, EXOSC7, EXOSC8, RBM4B, LUC7L, PPP2R2C, INPPL1, NTRK1, XPO1, GBA, RET, SNCA, NCBP2, ZC3H18, C1D, HNRNPF, EXOSC1 | PTPN12 | PSTPIP1, SHC1, PXN, BCAR1, JAK2, NEDD9, EFS, TGFB1I1, GSN, GRB2, PTK2B, EGFR, SORBS2, WASF1, APP, STX16, CGA, CSH1, CSH2, BAG6, UTRN, PSG9, ZFP2, IFT20, THAP2, TEX10, RBM19, SMAD5, ANKS1A, EPN1, NUSAP1, PACSIN2, PLOD2, DEK, DNPEP, GANAB, TNS3, TRIM47, UGP2, VASN, NTRK1, CENPJ, NANOG, ERBB4, FGFR2, FGFR4, IGF1R, KDR, PSTPIP2, ARHGAP10, ASAP1, NCK2, CSK, LPXN, PTPN6, AIFM1, VAPA, LMTK2, AATK, ERBB3, ROR2, PTK7, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000248594 | + | 12 | 18 | 345_438 | 665 | 781 | TGFB1I1 |
| Tgene | PTPN12 | chr12:122964737 | chr7:77261665 | ENST00000435495 | + | 11 | 17 | 345_438 | 535 | 651 | TGFB1I1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC8_PTPN12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCCHC8_PTPN12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZCCHC8 | C3714756 | Intellectual Disability | 1 | CTD_human |
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