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Fusion gene ID: 42636 |
FusionGeneSummary for ZCCHC4_SMIM20 |
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Fusion gene information | Fusion gene name: ZCCHC4_SMIM20 | Fusion gene ID: 42636 | Hgene | Tgene | Gene symbol | ZCCHC4 | SMIM20 | Gene ID | 29063 | 389203 |
Gene name | zinc finger CCHC-type containing 4 | small integral membrane protein 20 | |
Synonyms | HSPC052|ZGRF4 | C4orf52|MITRAC7|PNX | |
Cytomap | 4p15.2 | 4p15.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger CCHC domain-containing protein 4DHHC domain-containing zinc finger proteinzinc finger, CCHC domain containing 4zinc finger, GRF-type containing 4 | small integral membrane protein 20mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDaphoenixin | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | Q9H5U6 | Q8N5G0 | |
Ensembl transtripts involved in fusion gene | ENST00000505451, ENST00000302874, | ENST00000515764, ENST00000506197, ENST00000514384, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ZCCHC4 [Title/Abstract] AND SMIM20 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SMIM20 | GO:0033617 | mitochondrial respiratory chain complex IV assembly | 26321642 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A6YT-01A | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000505451 | ENST00000515764 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
3UTR-3UTR | ENST00000505451 | ENST00000506197 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
3UTR-intron | ENST00000505451 | ENST00000514384 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
5CDS-3UTR | ENST00000302874 | ENST00000515764 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
5CDS-3UTR | ENST00000302874 | ENST00000506197 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
5CDS-intron | ENST00000302874 | ENST00000514384 | ZCCHC4 | chr4 | 25317022 | + | SMIM20 | chr4 | 25929935 | + |
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FusionProtFeatures for ZCCHC4_SMIM20 |
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Hgene | Tgene |
ZCCHC4 | SMIM20 |
May be a methyltransferase. | Component of the MITRAC (mitochondrial translationregulation assembly intermediate of cytochrome c oxidase complex)complex, that regulates cytochrome c oxidase assembly. Promotesthe progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factorrequired to stabilize newly synthesized MT-CO1/COX1 and to preventits premature turnover. {ECO:0000269|PubMed:26321642}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCCHC4_SMIM20 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCCHC4_SMIM20 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZCCHC4 | SMIM20 | SF3B5, SF3B2, SRSF9, DDX46 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC4_SMIM20 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCCHC4_SMIM20 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |