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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42636

FusionGeneSummary for ZCCHC4_SMIM20

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCCHC4_SMIM20
Fusion gene ID: 42636
HgeneTgene
Gene symbol

ZCCHC4

SMIM20

Gene ID

29063

389203

Gene namezinc finger CCHC-type containing 4small integral membrane protein 20
SynonymsHSPC052|ZGRF4C4orf52|MITRAC7|PNX
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCHC domain-containing protein 4DHHC domain-containing zinc finger proteinzinc finger, CCHC domain containing 4zinc finger, GRF-type containing 4small integral membrane protein 20mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDaphoenixin
Modification date2018032920180523
UniProtAcc

Q9H5U6

Q8N5G0

Ensembl transtripts involved in fusion geneENST00000505451, ENST00000302874, 
ENST00000515764, ENST00000506197, 
ENST00000514384, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ZCCHC4 [Title/Abstract] AND SMIM20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSMIM20

GO:0033617

mitochondrial respiratory chain complex IV assembly

26321642


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6YT-01AZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000505451ENST00000515764ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
3UTR-3UTRENST00000505451ENST00000506197ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
3UTR-intronENST00000505451ENST00000514384ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
5CDS-3UTRENST00000302874ENST00000515764ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
5CDS-3UTRENST00000302874ENST00000506197ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+
5CDS-intronENST00000302874ENST00000514384ZCCHC4chr4

25317022

+SMIM20chr4

25929935

+

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FusionProtFeatures for ZCCHC4_SMIM20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZCCHC4

Q9H5U6

SMIM20

Q8N5G0

May be a methyltransferase. Component of the MITRAC (mitochondrial translationregulation assembly intermediate of cytochrome c oxidase complex)complex, that regulates cytochrome c oxidase assembly. Promotesthe progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C. Chaperone-like assembly factorrequired to stabilize newly synthesized MT-CO1/COX1 and to preventits premature turnover. {ECO:0000269|PubMed:26321642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZCCHC4_SMIM20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZCCHC4_SMIM20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZCCHC4SMIM20SF3B5, SF3B2, SRSF9, DDX46


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZCCHC4_SMIM20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZCCHC4_SMIM20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource