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Fusion gene ID: 42631 |
FusionGeneSummary for ZCCHC17_TPK1 |
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Fusion gene information | Fusion gene name: ZCCHC17_TPK1 | Fusion gene ID: 42631 | Hgene | Tgene | Gene symbol | ZCCHC17 | TPK1 | Gene ID | 51538 | 27010 |
Gene name | zinc finger CCHC-type containing 17 | thiamin pyrophosphokinase 1 | |
Synonyms | HSPC251|PS1D|pNO40 | HTPK1|PP20|THMD5 | |
Cytomap | 1p35.2 | 7q35 | |
Type of gene | protein-coding | protein-coding | |
Description | nucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17 | thiamin pyrophosphokinase 1placental protein 20thiamine diphosphokinasethiamine kinase | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9NP64 | Q9H3S4 | |
Ensembl transtripts involved in fusion gene | ENST00000344147, ENST00000479629, ENST00000373714, ENST00000546109, ENST00000422613, | ENST00000360057, ENST00000538212, ENST00000549981, ENST00000378099, ENST00000547966, | |
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 2 X 3 X 2=12 |
# samples | 7 | 2 | |
** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZCCHC17 [Title/Abstract] AND TPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | EC547646 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000344147 | ENST00000360057 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000344147 | ENST00000538212 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000344147 | ENST00000549981 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000344147 | ENST00000378099 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000344147 | ENST00000547966 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
3UTR-intron | ENST00000479629 | ENST00000360057 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
3UTR-intron | ENST00000479629 | ENST00000538212 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
3UTR-intron | ENST00000479629 | ENST00000549981 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
3UTR-intron | ENST00000479629 | ENST00000378099 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
3UTR-intron | ENST00000479629 | ENST00000547966 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000373714 | ENST00000360057 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000373714 | ENST00000538212 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000373714 | ENST00000549981 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000373714 | ENST00000378099 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000373714 | ENST00000547966 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000546109 | ENST00000360057 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000546109 | ENST00000538212 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000546109 | ENST00000549981 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000546109 | ENST00000378099 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000546109 | ENST00000547966 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000422613 | ENST00000360057 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000422613 | ENST00000538212 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000422613 | ENST00000549981 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000422613 | ENST00000378099 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
5CDS-intron | ENST00000422613 | ENST00000547966 | ZCCHC17 | chr1 | 31819530 | - | TPK1 | chr7 | 144271457 | + |
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FusionProtFeatures for ZCCHC17_TPK1 |
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Hgene | Tgene |
ZCCHC17 | TPK1 |
Catalyzes the phosphorylation of thiamine to thiaminepyrophosphate. Can also catalyze the phosphorylation ofpyrithiamine to pyrithiamine pyrophosphate.{ECO:0000269|PubMed:11342111}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCCHC17_TPK1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCCHC17_TPK1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC17_TPK1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TPK1 | Q9H3S4 | DB00152 | Thiamine | Thiamin pyrophosphokinase 1 | small molecule | approved|investigational|nutraceutical|vet_approved |
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RelatedDiseases for ZCCHC17_TPK1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TPK1 | C3280866 | THIAMINE METABOLISM DYSFUNCTION SYNDROME 5 (EPISODIC ENCEPHALOPATHY TYPE) | 1 | ORPHANET;UNIPROT |