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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42631

FusionGeneSummary for ZCCHC17_TPK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCCHC17_TPK1
Fusion gene ID: 42631
HgeneTgene
Gene symbol

ZCCHC17

TPK1

Gene ID

51538

27010

Gene namezinc finger CCHC-type containing 17thiamin pyrophosphokinase 1
SynonymsHSPC251|PS1D|pNO40HTPK1|PP20|THMD5
Cytomap

1p35.2

7q35

Type of geneprotein-codingprotein-coding
Descriptionnucleolar protein of 40 kDanucleolar protein 40pnn-interacting nucleolar proteinputative S1 RNA binding domain proteinzinc finger CCHC domain-containing protein 17zinc finger, CCHC domain containing 17thiamin pyrophosphokinase 1placental protein 20thiamine diphosphokinasethiamine kinase
Modification date2018052220180523
UniProtAcc

Q9NP64

Q9H3S4

Ensembl transtripts involved in fusion geneENST00000344147, ENST00000479629, 
ENST00000373714, ENST00000546109, 
ENST00000422613, 		ENST00000360057, 
ENST00000538212, ENST00000549981, 
ENST00000378099, ENST00000547966, 
Fusion gene scores* DoF score7 X 6 X 4=1682 X 3 X 2=12
# samples 72
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZCCHC17 [Title/Abstract] AND TPK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1EC547646ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000344147ENST00000360057ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000344147ENST00000538212ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000344147ENST00000549981ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000344147ENST00000378099ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000344147ENST00000547966ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
3UTR-intronENST00000479629ENST00000360057ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
3UTR-intronENST00000479629ENST00000538212ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
3UTR-intronENST00000479629ENST00000549981ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
3UTR-intronENST00000479629ENST00000378099ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
3UTR-intronENST00000479629ENST00000547966ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000373714ENST00000360057ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000373714ENST00000538212ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000373714ENST00000549981ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000373714ENST00000378099ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000373714ENST00000547966ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000546109ENST00000360057ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000546109ENST00000538212ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000546109ENST00000549981ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000546109ENST00000378099ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000546109ENST00000547966ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000422613ENST00000360057ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000422613ENST00000538212ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000422613ENST00000549981ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000422613ENST00000378099ZCCHC17chr1

31819530

-TPK1chr7

144271457

+
5CDS-intronENST00000422613ENST00000547966ZCCHC17chr1

31819530

-TPK1chr7

144271457

+

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FusionProtFeatures for ZCCHC17_TPK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZCCHC17

Q9NP64

TPK1

Q9H3S4

Catalyzes the phosphorylation of thiamine to thiaminepyrophosphate. Can also catalyze the phosphorylation ofpyrithiamine to pyrithiamine pyrophosphate.{ECO:0000269|PubMed:11342111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZCCHC17_TPK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZCCHC17_TPK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZCCHC17_TPK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPK1Q9H3S4DB00152ThiamineThiamin pyrophosphokinase 1small moleculeapproved|investigational|nutraceutical|vet_approved

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RelatedDiseases for ZCCHC17_TPK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPK1C3280866THIAMINE METABOLISM DYSFUNCTION SYNDROME 5 (EPISODIC ENCEPHALOPATHY TYPE)1ORPHANET;UNIPROT