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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42624

FusionGeneSummary for ZCCHC14_SNX7

check button Fusion gene summary
Fusion gene informationFusion gene name: ZCCHC14_SNX7
Fusion gene ID: 42624
HgeneTgene
Gene symbol

ZCCHC14

SNX7

Gene ID

23174

51375

Gene namezinc finger CCHC-type containing 14sorting nexin 7
SynonymsBDG-29|BDG29-
Cytomap

16q24.2

1p21.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14sorting nexin-7
Modification date2018051920180519
UniProtAcc

Q8WYQ9

Q9UNH6

Ensembl transtripts involved in fusion geneENST00000268616, ENST00000370189, 
ENST00000529992, ENST00000306121, 
ENST00000473868, 
Fusion gene scores* DoF score5 X 3 X 5=753 X 1 X 3=9
# samples 53
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZCCHC14 [Title/Abstract] AND SNX7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A18J-01AZCCHC14chr16

87493614

-SNX7chr1

99225610

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000268616ENST00000370189ZCCHC14chr16

87493614

-SNX7chr1

99225610

+
Frame-shitENST00000268616ENST00000529992ZCCHC14chr16

87493614

-SNX7chr1

99225610

+
Frame-shitENST00000268616ENST00000306121ZCCHC14chr16

87493614

-SNX7chr1

99225610

+
5CDS-intronENST00000268616ENST00000473868ZCCHC14chr16

87493614

-SNX7chr1

99225610

+

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FusionProtFeatures for ZCCHC14_SNX7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZCCHC14

Q8WYQ9

SNX7

Q9UNH6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZCCHC14_SNX7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZCCHC14_SNX7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZCCHC14NFIC, ELAVL1, BAG3, SMAD3, RMND5ASNX7MAGEA11, TEX11, HMOX2, MESDC2, BIRC3, POLR2L, HGS, ASPM, SNX4, DTNBP1, BLOC1S2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZCCHC14_SNX7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZCCHC14_SNX7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZCCHC14C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneSNX7C0023893Liver Cirrhosis, Experimental1CTD_human