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Fusion gene ID: 42624 |
FusionGeneSummary for ZCCHC14_SNX7 |
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Fusion gene information | Fusion gene name: ZCCHC14_SNX7 | Fusion gene ID: 42624 | Hgene | Tgene | Gene symbol | ZCCHC14 | SNX7 | Gene ID | 23174 | 51375 |
Gene name | zinc finger CCHC-type containing 14 | sorting nexin 7 | |
Synonyms | BDG-29|BDG29 | - | |
Cytomap | 16q24.2 | 1p21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14 | sorting nexin-7 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8WYQ9 | Q9UNH6 | |
Ensembl transtripts involved in fusion gene | ENST00000268616, | ENST00000370189, ENST00000529992, ENST00000306121, ENST00000473868, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 3 X 1 X 3=9 |
# samples | 5 | 3 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZCCHC14 [Title/Abstract] AND SNX7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A18J-01A | ZCCHC14 | chr16 | 87493614 | - | SNX7 | chr1 | 99225610 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000268616 | ENST00000370189 | ZCCHC14 | chr16 | 87493614 | - | SNX7 | chr1 | 99225610 | + |
Frame-shift | ENST00000268616 | ENST00000529992 | ZCCHC14 | chr16 | 87493614 | - | SNX7 | chr1 | 99225610 | + |
Frame-shift | ENST00000268616 | ENST00000306121 | ZCCHC14 | chr16 | 87493614 | - | SNX7 | chr1 | 99225610 | + |
5CDS-intron | ENST00000268616 | ENST00000473868 | ZCCHC14 | chr16 | 87493614 | - | SNX7 | chr1 | 99225610 | + |
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FusionProtFeatures for ZCCHC14_SNX7 |
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Hgene | Tgene |
ZCCHC14 | SNX7 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCCHC14_SNX7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCCHC14_SNX7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZCCHC14 | NFIC, ELAVL1, BAG3, SMAD3, RMND5A | SNX7 | MAGEA11, TEX11, HMOX2, MESDC2, BIRC3, POLR2L, HGS, ASPM, SNX4, DTNBP1, BLOC1S2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC14_SNX7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCCHC14_SNX7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZCCHC14 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | SNX7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |