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Fusion gene ID: 42623 |
FusionGeneSummary for ZCCHC14_IMPA2 |
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Fusion gene information | Fusion gene name: ZCCHC14_IMPA2 | Fusion gene ID: 42623 | Hgene | Tgene | Gene symbol | ZCCHC14 | IMPA2 | Gene ID | 23174 | 3613 |
Gene name | zinc finger CCHC-type containing 14 | inositol monophosphatase 2 | |
Synonyms | BDG-29|BDG29 | - | |
Cytomap | 16q24.2 | 18p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14 | inositol monophosphatase 2IMP 2IMPase 2inosine monophosphatase 2inositol monophosphatase 2 variant 1inositol monophosphatase 2 variant 2inositol(myo)-1(or 4)-monophosphatase 2myo-inositol monophosphatase 2myo-inositol monophosphatase A2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8WYQ9 | O14732 | |
Ensembl transtripts involved in fusion gene | ENST00000268616, | ENST00000588752, ENST00000589238, ENST00000269159, ENST00000588927, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 6 X 5 X 5=150 |
# samples | 5 | 6 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZCCHC14 [Title/Abstract] AND IMPA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IMPA2 | GO:0046855 | inositol phosphate dephosphorylation | 17068342 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-ZG-A9M4-01A | ZCCHC14 | chr16 | 87493614 | - | IMPA2 | chr18 | 11999053 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000268616 | ENST00000588752 | ZCCHC14 | chr16 | 87493614 | - | IMPA2 | chr18 | 11999053 | + |
5CDS-5UTR | ENST00000268616 | ENST00000589238 | ZCCHC14 | chr16 | 87493614 | - | IMPA2 | chr18 | 11999053 | + |
5CDS-5UTR | ENST00000268616 | ENST00000269159 | ZCCHC14 | chr16 | 87493614 | - | IMPA2 | chr18 | 11999053 | + |
5CDS-intron | ENST00000268616 | ENST00000588927 | ZCCHC14 | chr16 | 87493614 | - | IMPA2 | chr18 | 11999053 | + |
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FusionProtFeatures for ZCCHC14_IMPA2 |
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Hgene | Tgene |
ZCCHC14 | IMPA2 |
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacologicaltarget for lithium Li(+) action in brain.{ECO:0000269|PubMed:17068342}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCCHC14_IMPA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCCHC14_IMPA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZCCHC14 | NFIC, ELAVL1, BAG3, SMAD3, RMND5A | IMPA2 | TNFRSF14, IMPA1, IMPA2, UBA3, SPACA1, A4GNT, HSF2, ALDOA, ALDOC, ARHGDIA, DUT, FSCN1, GPX4, ADSS, CARHSP1, CYCS, GLO1, HSPE1, NUDT9, PAICS, PARK7, PGLS, PLIN3, RPE, STMN1, TXN, ITPA, MSN, PABPC4, PDCD6, RDX, SCPEP1, NPPA, RBFOX1, ZIC1, AAR2, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC14_IMPA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IMPA2 | O14732 | DB01356 | Lithium | Inositol monophosphatase 2 | small molecule | approved |
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RelatedDiseases for ZCCHC14_IMPA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZCCHC14 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | IMPA2 | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | IMPA2 | C0525045 | Mood Disorders | 2 | PSYGENET |
Tgene | IMPA2 | C0009952 | Febrile Convulsions | 1 | CTD_human |
Tgene | IMPA2 | C0011570 | Mental Depression | 1 | PSYGENET |
Tgene | IMPA2 | C0011581 | Depressive disorder | 1 | PSYGENET |
Tgene | IMPA2 | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | IMPA2 | C0036341 | Schizophrenia | 1 | PSYGENET |