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Fusion gene ID: 42622 |
FusionGeneSummary for ZCCHC14_IGHJ4 |
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Fusion gene information | Fusion gene name: ZCCHC14_IGHJ4 | Fusion gene ID: 42622 | Hgene | Tgene | Gene symbol | ZCCHC14 | IGHJ4 | Gene ID | 23174 | 28477 |
Gene name | zinc finger CCHC-type containing 14 | immunoglobulin heavy joining 4 | |
Synonyms | BDG-29|BDG29 | JH4b | |
Cytomap | 16q24.2 | 14q32.33 | |
Type of gene | protein-coding | other | |
Description | zinc finger CCHC domain-containing protein 14zinc finger, CCHC domain containing 14 | - | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q8WYQ9 | ||
Ensembl transtripts involved in fusion gene | ENST00000268616, | ENST00000461719, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 12 X 7 X 6=504 |
# samples | 5 | 12 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZCCHC14 [Title/Abstract] AND IGHJ4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | TGCT | TCGA-2X-A9D6-01A | ZCCHC14 | chr16 | 87451319 | - | IGHJ4 | chr14 | 106330464 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000268616 | ENST00000461719 | ZCCHC14 | chr16 | 87451319 | - | IGHJ4 | chr14 | 106330464 | - |
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FusionProtFeatures for ZCCHC14_IGHJ4 |
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Hgene | Tgene |
ZCCHC14 | IGHJ4 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZCCHC14_IGHJ4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZCCHC14_IGHJ4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZCCHC14 | NFIC, ELAVL1, BAG3, SMAD3, RMND5A | IGHJ4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZCCHC14_IGHJ4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZCCHC14_IGHJ4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZCCHC14 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |