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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42615

FusionGeneSummary for ZC3HC1_HMGCS1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3HC1_HMGCS1
Fusion gene ID: 42615
HgeneTgene
Gene symbol

ZC3HC1

HMGCS1

Gene ID

51530

3157

Gene namezinc finger C3HC-type containing 13-hydroxy-3-methylglutaryl-CoA synthase 1
SynonymsHSPC216|NIPAHMGCS
Cytomap

7q32.2

5p12

Type of geneprotein-codingprotein-coding
Descriptionnuclear-interacting partner of ALKhematopoietic stem/progenitor cell protein 216nuclear interacting partner of anaplastic lymphoma kinase (ALK)hydroxymethylglutaryl-CoA synthase, cytoplasmic3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
Modification date2018052920180523
UniProtAcc

Q86WB0

Q01581

Ensembl transtripts involved in fusion geneENST00000358303, ENST00000360708, 
ENST00000311873, ENST00000481503, 
ENST00000325110, ENST00000433297, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 4 X 1=12
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZC3HC1 [Title/Abstract] AND HMGCS1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK025736ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358303ENST00000325110ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000358303ENST00000433297ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000360708ENST00000325110ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000360708ENST00000433297ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000311873ENST00000325110ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000311873ENST00000433297ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000481503ENST00000325110ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-
intron-3CDSENST00000481503ENST00000433297ZC3HC1chr7

129671759

-HMGCS1chr5

43294957

-

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FusionProtFeatures for ZC3HC1_HMGCS1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3HC1

Q86WB0

HMGCS1

Q01581

This enzyme condenses acetyl-CoA with acetoacetyl-CoA toform HMG-CoA, which is the substrate for HMG-CoA reductase.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3HC1_HMGCS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3HC1_HMGCS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3HC1_HMGCS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3HC1_HMGCS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZC3HC1C1956346Coronary Artery Disease1CTD_human