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Fusion gene ID: 42615 |
FusionGeneSummary for ZC3HC1_HMGCS1 |
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Fusion gene information | Fusion gene name: ZC3HC1_HMGCS1 | Fusion gene ID: 42615 | Hgene | Tgene | Gene symbol | ZC3HC1 | HMGCS1 | Gene ID | 51530 | 3157 |
Gene name | zinc finger C3HC-type containing 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | |
Synonyms | HSPC216|NIPA | HMGCS | |
Cytomap | 7q32.2 | 5p12 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear-interacting partner of ALKhematopoietic stem/progenitor cell protein 216nuclear interacting partner of anaplastic lymphoma kinase (ALK) | hydroxymethylglutaryl-CoA synthase, cytoplasmic3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | |
Modification date | 20180529 | 20180523 | |
UniProtAcc | Q86WB0 | Q01581 | |
Ensembl transtripts involved in fusion gene | ENST00000358303, ENST00000360708, ENST00000311873, ENST00000481503, | ENST00000325110, ENST00000433297, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 4 X 1=12 |
# samples | 3 | 4 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZC3HC1 [Title/Abstract] AND HMGCS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK025736 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000358303 | ENST00000325110 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000358303 | ENST00000433297 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000360708 | ENST00000325110 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000360708 | ENST00000433297 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000311873 | ENST00000325110 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000311873 | ENST00000433297 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000481503 | ENST00000325110 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
intron-3CDS | ENST00000481503 | ENST00000433297 | ZC3HC1 | chr7 | 129671759 | - | HMGCS1 | chr5 | 43294957 | - |
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FusionProtFeatures for ZC3HC1_HMGCS1 |
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Hgene | Tgene |
ZC3HC1 | HMGCS1 |
This enzyme condenses acetyl-CoA with acetoacetyl-CoA toform HMG-CoA, which is the substrate for HMG-CoA reductase. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZC3HC1_HMGCS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZC3HC1_HMGCS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZC3HC1_HMGCS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3HC1_HMGCS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZC3HC1 | C1956346 | Coronary Artery Disease | 1 | CTD_human |