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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42614

FusionGeneSummary for ZC3HC1_ADAM22

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3HC1_ADAM22
Fusion gene ID: 42614
HgeneTgene
Gene symbol

ZC3HC1

ADAM22

Gene ID

51530

53616

Gene namezinc finger C3HC-type containing 1ADAM metallopeptidase domain 22
SynonymsHSPC216|NIPAADAM 22|EIEE61|MDC2
Cytomap

7q32.2

7q21.12

Type of geneprotein-codingprotein-coding
Descriptionnuclear-interacting partner of ALKhematopoietic stem/progenitor cell protein 216nuclear interacting partner of anaplastic lymphoma kinase (ALK)disintegrin and metalloproteinase domain-containing protein 22a disintegrin and metalloproteinase domain 22metalloproteinase-disintegrin ADAM22-3metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Modification date2018052920180519
UniProtAcc

Q86WB0

Q9P0K1

Ensembl transtripts involved in fusion geneENST00000358303, ENST00000360708, 
ENST00000311873, ENST00000481503, 
ENST00000398204, ENST00000439864, 
ENST00000398201, ENST00000265727, 
ENST00000315984, ENST00000398209, 
ENST00000476330, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 3 X 4=48
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3HC1 [Title/Abstract] AND ADAM22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-B9-4116-01AZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358303ENST00000398204ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000358303ENST00000439864ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000358303ENST00000398201ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000358303ENST00000265727ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000358303ENST00000315984ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000358303ENST00000398209ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
5CDS-intronENST00000358303ENST00000476330ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000398204ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000439864ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000398201ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000265727ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000315984ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000360708ENST00000398209ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
5CDS-intronENST00000360708ENST00000476330ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000398204ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000439864ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000398201ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000265727ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000315984ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000311873ENST00000398209ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
5CDS-intronENST00000311873ENST00000476330ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000398204ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000439864ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000398201ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000265727ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000315984ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
Frame-shiftENST00000481503ENST00000398209ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+
5CDS-intronENST00000481503ENST00000476330ZC3HC1chr7

129691061

-ADAM22chr7

87704941

+

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FusionProtFeatures for ZC3HC1_ADAM22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3HC1

Q86WB0

ADAM22

Q9P0K1

Probable ligand for integrin in the brain. This is a noncatalytic metalloprotease-like protein (PubMed:19692335). Involvedin regulation of cell adhesion and spreading and in inhibition ofcell proliferation. Neuronal receptor for LGI1.{ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968,ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3HC1_ADAM22


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3HC1_ADAM22


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZC3HC1CCNB1, SKP1, CUL1, RBX1, TNFSF11, PDPK1, TSC22D1, ALK, APP, EHD4, GTF3C4, AASDHPPT, HNRNPA1, PFKL, RPL38, TRIP13, FZR1, MAPK3, MAPK1, FAM188A, ATP6V1C2, GRN, HIST1H2BG, CDC5L, YWHAE, NXF2B, PLK1, SASS6, GPX7, TPR, FAM19A3, SRBD1, ETNPPL, SALL2ADAM22DLG4, LGI1, LYN, EPS8, RAC2, CSNK1E, NXF1, APP, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3HC1_ADAM22


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3HC1_ADAM22


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZC3HC1C1956346Coronary Artery Disease1CTD_human