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Fusion gene ID: 42610 |
FusionGeneSummary for ZC3HAV1_BRAF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3HAV1_BRAF | Fusion gene ID: 42610 | Hgene | Tgene | Gene symbol | ZC3HAV1 | BRAF | Gene ID | 56829 | 673 |
| Gene name | zinc finger CCCH-type containing, antiviral 1 | B-Raf proto-oncogene, serine/threonine kinase | |
| Synonyms | ARTD13|FLB6421|PARP13|ZAP|ZC3H2|ZC3HDC2 | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | |
| Cytomap | 7q34 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH-type antiviral protein 1ADP-ribosyltransferase diphtheria toxin-like 13zinc finger CCCH domain-containing protein 2zinc finger CCCH-type, antiviral 1 | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q7Z2W4 | P15056 | |
| Ensembl transtripts involved in fusion gene | ENST00000242351, ENST00000464606, ENST00000471652, | ENST00000288602, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 24 X 11 X 10=2640 |
| # samples | 4 | 35 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/2640*10)=-2.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZC3HAV1 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZC3HAV1 | GO:0009615 | response to virus | 21876179 |
| Hgene | ZC3HAV1 | GO:0045071 | negative regulation of viral genome replication | 21876179 |
| Hgene | ZC3HAV1 | GO:0061014 | positive regulation of mRNA catabolic process | 21876179 |
| Tgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
| Tgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
| Tgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Tgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
| Tgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Tgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
| Tgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | THCA | TCGA-KS-A4ID-01A | ZC3HAV1 | chr7 | 138758602 | - | BRAF | chr7 | 140481493 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000242351 | ENST00000288602 | ZC3HAV1 | chr7 | 138758602 | - | BRAF | chr7 | 140481493 | - |
| In-frame | ENST00000464606 | ENST00000288602 | ZC3HAV1 | chr7 | 138758602 | - | BRAF | chr7 | 140481493 | - |
| In-frame | ENST00000471652 | ENST00000288602 | ZC3HAV1 | chr7 | 138758602 | - | BRAF | chr7 | 140481493 | - |
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FusionProtFeatures for ZC3HAV1_BRAF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3HAV1 | BRAF |
| Antiviral protein which inhibits the replication ofviruses by recruiting the cellular RNA degradation machineries todegrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE)present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body fromthe 3'-end. It also recruits the decapping complex DCP1-DCP2through RNA helicase p72 (DDX17) to remove the cap structure ofthe viral mRNA to initiate its degradation from the 5'-end. Itstarget viruses belong to families which include retroviridae:human immunodeficiency virus type 1 (HIV-1), moloney and murineleukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV),filoviridae: ebola virus (EBOV) and marburg virus (MARV),togaviridae: sindbis virus (SINV) and Ross river virus (RRV).Specifically targets the multiply spliced but not unspliced orsingly spliced HIV-1 mRNAs for degradation. Isoform 1 is a morepotent viral inhibitor than isoform 2. Isoform 2 acts as apositive regulator of DDX58/RIG-I signaling resulting inactivation of the downstream effector IRF3 leading to theexpression of type I IFNs and IFN stimulated genes (ISGs).{ECO:0000269|PubMed:18225958, ECO:0000269|PubMed:21102435,ECO:0000269|PubMed:21876179, ECO:0000269|PubMed:22720057}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 285_292 | 624 | 903 | Motif | Nuclear export signal |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 69_76 | 624 | 903 | Motif | Nuclear localization signal |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 285_292 | 624 | 700 | Motif | Nuclear export signal |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 69_76 | 624 | 700 | Motif | Nuclear localization signal |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 224_254 | 624 | 903 | Region | Binding to EXOSC5 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 2_254 | 624 | 903 | Region | Note=N-terminal domain |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 224_254 | 624 | 700 | Region | Binding to EXOSC5 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 2_254 | 624 | 700 | Region | Note=N-terminal domain |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 150_172 | 624 | 903 | Zinc finger | C3H1-type 3 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 169_193 | 624 | 903 | Zinc finger | C3H1-type 4 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 73_86 | 624 | 903 | Zinc finger | C3H1-type 1 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 88_110 | 624 | 903 | Zinc finger | C3H1-type 2 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 150_172 | 624 | 700 | Zinc finger | C3H1-type 3 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 169_193 | 624 | 700 | Zinc finger | C3H1-type 4 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 73_86 | 624 | 700 | Zinc finger | C3H1-type 1 |
| Hgene | ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 88_110 | 624 | 700 | Zinc finger | C3H1-type 2 |
| Tgene | >BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 457_717 | 438 | 767 | Domain | Protein kinase |
| Tgene | >BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 463_471 | 438 | 767 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 594_681 | 624 | 903 | Domain | WWE |
| Hgene | >ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000242351 | - | 7 | 13 | 716_902 | 624 | 903 | Domain | PARP catalytic |
| Hgene | >ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 594_681 | 624 | 700 | Domain | WWE |
| Hgene | >ZC3HAV1 | chr7:138758602 | chr7:140481493 | ENST00000471652 | - | 7 | 9 | 716_902 | 624 | 700 | Domain | PARP catalytic |
| Tgene | BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 122_129 | 438 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 428_432 | 438 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 6_11 | 438 | 767 | Compositional bias | Note=Poly-Gly |
| Tgene | BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 155_227 | 438 | 767 | Domain | RBD |
| Tgene | BRAF | chr7:138758602 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 234_280 | 438 | 767 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for ZC3HAV1_BRAF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZC3HAV1_ENST00000242351_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_953aa MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKL NLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRG NCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAER SCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWK SLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKST SSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQM LIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKTLGRR DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG SSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI >In-frame_ZC3HAV1_ENST00000464606_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_1075aa MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKL NLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRG NCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAER SCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWK SLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKST SSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNGKYKGKTLWASTFVHDIPNGSSQVVDKTTDVEKTGATGFGLTMAVKAEKD MLRTGSQSLRNLVPTTPGESTAPAQVSTLPQSPAALSSSNRAAVWGAQGQNCTQVPVSSASELTRKTTGSAQYSLSDVTSTTSSRVDDHD SEEICLDHLCKGCPLNGSCSKVHFHLPYRWQMLIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKP ANSVFTTKWIWYWKNESGTWIQYGEEKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEV GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVR >In-frame_ZC3HAV1_ENST00000471652_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_953aa MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGITRSVVATTRARVCRRKYCQRPCDNLHLCKL NLLGRCNYSQSERNLCKYSHEVLSEENFKVLKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRG NCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRNMAYRARSKSRDRFFQGSQEFLASASASAER SCTPSPDQISHRASLEDAPVDDLTRKFTYLGSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWK SLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQDIQPGPLFNNNADGVATDITSTRSLNYKST SSGHREISSPRIQDAGPASRDVQATGRIADDADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQM LIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPANSVFTTKWIWYWKNESGTWIQYGEEKTLGRR DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEG SSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV IRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZC3HAV1_ENST00000242351_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_2859nt ATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGTGCGCCCACGGGGGCCGCATGGCCCTGGACGCGCTGCTCCAGGAGATC GCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCGGGCCCGACCGCTTTGTGGTGTTGGAGACCGGCGGCGAGGCCGGGATC ACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTCGCAAGTACTGCCAGAGACCCTGCGATAACCTGCATCTCTGCAAACTC AACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATTTATGCAAATATTCTCATGAGGTTCTCTCAGAAGAGAACTTCAAAGTC CTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAGCAGTGCTCCTCCTCCAAAGTGATCCTTTTTTTATGCCCGAGATATGC AAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGCAGCCACCGTGTTCAAGACTCCACATCTGTGACCACTTCACCCGAGGG AACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGGACAGAAAGGTGCTGGCCATCATGAGGGAGCACGGGCTGAACCCCGAC GTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGCAGAAGAATCCCCCAGGGCCCAGAGCTCCTTCTTCACATCGTAGAAAC ATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTCAGGGCAGCCAAGAATTTCTTGCGTCTGCTTCAGCGTCTGCTGAGAGG TCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCCTGGAGGACGCGCCTGTGGACGATCTCACCCGCAAGTTCACGTATCTG GGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGGCTACTGATCTTGGAGGAACAAGTCAGGCCGGGACAAGCCAGAGGTTT TTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAGGCAGCACTTACCTTGCTTCCAATTCAACATCAGCCCCCAACTGGAAG AGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGACTGTGTTTTCTCCCACGCTACCTGCCGCCCGCTCTTCTCTTGGCTCT CTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCTTGCTTTCCTCAGACTACAGGATCATCAATGGCAAAAGTGGAACTCAG GACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAGTGGCCACAGATATAACTTCTACCAGATCCTTAAATTACAAAAGCACT AGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATGCTGGACCTGCTTCCCGAGATGTCCAGGCCACTGGCAGAATCGCAGAT GATGCTGACCCAAGAGTAGCACTTGTTAACGATTCTTTATCTGATGTCACAAGTACCACATCTTCTAGGGTGGATGATCATGACTCAGAG GAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATGGTAGCTGCAGCAAAGTCCACTTCCATCTGCCTTACCGGTGGCAGATG CTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGATCGAGAAAGGCTACTGTAACCCCGGAATCCACCTCTGTTCTGTAGGA AGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTCCCATCCGACGCCTCTCCACTCCTTCTTCTGTCACCAAGCCAGCCAAT TCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAATCTGGCACATGGATTCAGTATGGAGAAGAGAAAACACTTGGTAGACGG GACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGA AAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTA CTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGC TCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATG GATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGAT TTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTC ATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTA CCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAAC TGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATT GAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGT >In-frame_ZC3HAV1_ENST00000464606_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_3225nt ATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGTGCGCCCACGGGGGCCGCATGGCCCTGGACGCGCTGCTCCAGGAGATC GCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCGGGCCCGACCGCTTTGTGGTGTTGGAGACCGGCGGCGAGGCCGGGATC ACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTCGCAAGTACTGCCAGAGACCCTGCGATAACCTGCATCTCTGCAAACTC AACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATTTATGCAAATATTCTCATGAGGTTCTCTCAGAAGAGAACTTCAAAGTC CTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAGCAGTGCTCCTCCTCCAAAGTGATCCTTTTTTTATGCCCGAGATATGC AAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGCAGCCACCGTGTTCAAGACTCCACATCTGTGACCACTTCACCCGAGGG AACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGGACAGAAAGGTGCTGGCCATCATGAGGGAGCACGGGCTGAACCCCGAC GTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGCAGAAGAATCCCCCAGGGCCCAGAGCTCCTTCTTCACATCGTAGAAAC ATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTCAGGGCAGCCAAGAATTTCTTGCGTCTGCTTCAGCGTCTGCTGAGAGG TCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCCTGGAGGACGCGCCTGTGGACGATCTCACCCGCAAGTTCACGTATCTG GGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGGCTACTGATCTTGGAGGAACAAGTCAGGCCGGGACAAGCCAGAGGTTT TTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAGGCAGCACTTACCTTGCTTCCAATTCAACATCAGCCCCCAACTGGAAG AGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGACTGTGTTTTCTCCCACGCTACCTGCCGCCCGCTCTTCTCTTGGCTCT CTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCTTGCTTTCCTCAGACTACAGGATCATCAATGGCAAAAGTGGAACTCAG GACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAGTGGCCACAGATATAACTTCTACCAGATCCTTAAATTACAAAAGCACT AGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATGCTGGACCTGCTTCCCGAGATGTCCAGGCCACTGGCAGAATCGCAGAT GATGCTGACCCAAGAGTAGCACTTGTTAACGGTAAATACAAAGGGAAGACACTTTGGGCTAGTACATTTGTTCATGATATACCAAATGGC TCTAGTCAAGTAGTGGATAAAACTACTGATGTAGAAAAAACTGGTGCCACTGGTTTTGGCTTAACAATGGCAGTCAAGGCAGAAAAAGAT ATGTTACGTACTGGAAGTCAGAGTCTGAGGAACCTGGTCCCCACCACACCTGGGGAATCCACTGCCCCTGCACAAGTCAGCACTCTGCCT CAGTCACCTGCTGCCCTTTCCTCAAGCAACAGAGCTGCAGTCTGGGGGGCCCAAGGGCAGAACTGCACCCAGGTTCCTGTTTCCTCTGCC AGCGAGCTCACAAGGAAGACAACAGGCTCTGCTCAGTATTCTTTATCTGATGTCACAAGTACCACATCTTCTAGGGTGGATGATCATGAC TCAGAGGAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATGGTAGCTGCAGCAAAGTCCACTTCCATCTGCCTTACCGGTGG CAGATGCTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGATCGAGAAAGGCTACTGTAACCCCGGAATCCACCTCTGTTCT GTAGGAAGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTCCCATCCGACGCCTCTCCACTCCTTCTTCTGTCACCAAGCCA GCCAATTCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAATCTGGCACATGGATTCAGTATGGAGAAGAGAAAACACTTGGT AGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTAC AAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTA GGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAG GGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATA GGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCA GAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGA CAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGG AGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCC TCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGAT >In-frame_ZC3HAV1_ENST00000471652_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_2859nt ATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGTGCGCCCACGGGGGCCGCATGGCCCTGGACGCGCTGCTCCAGGAGATC GCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCGGGCCCGACCGCTTTGTGGTGTTGGAGACCGGCGGCGAGGCCGGGATC ACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTCGCAAGTACTGCCAGAGACCCTGCGATAACCTGCATCTCTGCAAACTC AACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATTTATGCAAATATTCTCATGAGGTTCTCTCAGAAGAGAACTTCAAAGTC CTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAGCAGTGCTCCTCCTCCAAAGTGATCCTTTTTTTATGCCCGAGATATGC AAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGCAGCCACCGTGTTCAAGACTCCACATCTGTGACCACTTCACCCGAGGG AACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGGACAGAAAGGTGCTGGCCATCATGAGGGAGCACGGGCTGAACCCCGAC GTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGCAGAAGAATCCCCCAGGGCCCAGAGCTCCTTCTTCACATCGTAGAAAC ATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTCAGGGCAGCCAAGAATTTCTTGCGTCTGCTTCAGCGTCTGCTGAGAGG TCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCCTGGAGGACGCGCCTGTGGACGATCTCACCCGCAAGTTCACGTATCTG GGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGGCTACTGATCTTGGAGGAACAAGTCAGGCCGGGACAAGCCAGAGGTTT TTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAGGCAGCACTTACCTTGCTTCCAATTCAACATCAGCCCCCAACTGGAAG AGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGACTGTGTTTTCTCCCACGCTACCTGCCGCCCGCTCTTCTCTTGGCTCT CTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCTTGCTTTCCTCAGACTACAGGATCATCAATGGCAAAAGTGGAACTCAG GACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAGTGGCCACAGATATAACTTCTACCAGATCCTTAAATTACAAAAGCACT AGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATGCTGGACCTGCTTCCCGAGATGTCCAGGCCACTGGCAGAATCGCAGAT GATGCTGACCCAAGAGTAGCACTTGTTAACGATTCTTTATCTGATGTCACAAGTACCACATCTTCTAGGGTGGATGATCATGACTCAGAG GAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATGGTAGCTGCAGCAAAGTCCACTTCCATCTGCCTTACCGGTGGCAGATG CTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGATCGAGAAAGGCTACTGTAACCCCGGAATCCACCTCTGTTCTGTAGGA AGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTCCCATCCGACGCCTCTCCACTCCTTCTTCTGTCACCAAGCCAGCCAAT TCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAATCTGGCACATGGATTCAGTATGGAGAAGAGAAAACACTTGGTAGACGG GACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGA AAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTA CTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGC TCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATG GATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGAT TTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTC ATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTA CCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAAC TGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATT GAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZC3HAV1_ENST00000242351_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_3294nt GAACCGAGAGGGGGCCACCCCAGGCGGTCACCAGCAGATTTGCCCGCGCGTTCTCTTTCTTTCCACCCAGTTGCCCTTGCGGCCGGCTGT AAACCTGCCACTAGGACCCGGTCGGTGAGATCTAGCCTCTTGACCTGAGAGCCGAGAGTGGATCGCTGGGCTGGGCTAACGGCGACGGAG AGCGCGCCCTCGCTGACTCCGGGCGCGCCCAGCAGTAGCACCGCCCGCGCCCGCCCCTGGACACTTGTAAGTTTCGATTTCCGATTTCCG CGGAACCGAGTCCCGCGCCGCGGCAGAGCCAGCACAGCCAGCGCGCCATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGT GCGCCCACGGGGGCCGCATGGCCCTGGACGCGCTGCTCCAGGAGATCGCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCG GGCCCGACCGCTTTGTGGTGTTGGAGACCGGCGGCGAGGCCGGGATCACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTC GCAAGTACTGCCAGAGACCCTGCGATAACCTGCATCTCTGCAAACTCAACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATT TATGCAAATATTCTCATGAGGTTCTCTCAGAAGAGAACTTCAAAGTCCTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAG CAGTGCTCCTCCTCCAAAGTGATCCTTTTTTTATGCCCGAGATATGCAAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGC AGCCACCGTGTTCAAGACTCCACATCTGTGACCACTTCACCCGAGGGAACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGG ACAGAAAGGTGCTGGCCATCATGAGGGAGCACGGGCTGAACCCCGACGTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGC AGAAGAATCCCCCAGGGCCCAGAGCTCCTTCTTCACATCGTAGAAACATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTC AGGGCAGCCAAGAATTTCTTGCGTCTGCTTCAGCGTCTGCTGAGAGGTCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCC TGGAGGACGCGCCTGTGGACGATCTCACCCGCAAGTTCACGTATCTGGGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGG CTACTGATCTTGGAGGAACAAGTCAGGCCGGGACAAGCCAGAGGTTTTTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAG GCAGCACTTACCTTGCTTCCAATTCAACATCAGCCCCCAACTGGAAGAGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGA CTGTGTTTTCTCCCACGCTACCTGCCGCCCGCTCTTCTCTTGGCTCTCTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCT TGCTTTCCTCAGACTACAGGATCATCAATGGCAAAAGTGGAACTCAGGACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAG TGGCCACAGATATAACTTCTACCAGATCCTTAAATTACAAAAGCACTAGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATG CTGGACCTGCTTCCCGAGATGTCCAGGCCACTGGCAGAATCGCAGATGATGCTGACCCAAGAGTAGCACTTGTTAACGATTCTTTATCTG ATGTCACAAGTACCACATCTTCTAGGGTGGATGATCATGACTCAGAGGAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATG GTAGCTGCAGCAAAGTCCACTTCCATCTGCCTTACCGGTGGCAGATGCTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGA TCGAGAAAGGCTACTGTAACCCCGGAATCCACCTCTGTTCTGTAGGAAGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTC CCATCCGACGCCTCTCCACTCCTTCTTCTGTCACCAAGCCAGCCAATTCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAAT CTGGCACATGGATTCAGTATGGAGAAGAGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAG TGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAG CACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCT ATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTG AGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGA GTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATC AGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATG TATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGG TGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAA AGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCAT CAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGG GATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGC >In-frame_ZC3HAV1_ENST00000464606_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_3366nt AGAGCCAGCACAGCCAGCGCGCCATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGTGCGCCCACGGGGGCCGCATGGCCC TGGACGCGCTGCTCCAGGAGATCGCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCGGGCCCGACCGCTTTGTGGTGTTGG AGACCGGCGGCGAGGCCGGGATCACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTCGCAAGTACTGCCAGAGACCCTGCG ATAACCTGCATCTCTGCAAACTCAACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATTTATGCAAATATTCTCATGAGGTTC TCTCAGAAGAGAACTTCAAAGTCCTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAGCAGTGCTCCTCCTCCAAAGTGATC CTTTTTTTATGCCCGAGATATGCAAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGCAGCCACCGTGTTCAAGACTCCACA TCTGTGACCACTTCACCCGAGGGAACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGGACAGAAAGGTGCTGGCCATCATGA GGGAGCACGGGCTGAACCCCGACGTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGCAGAAGAATCCCCCAGGGCCCAGAG CTCCTTCTTCACATCGTAGAAACATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTCAGGGCAGCCAAGAATTTCTTGCGT CTGCTTCAGCGTCTGCTGAGAGGTCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCCTGGAGGACGCGCCTGTGGACGATC TCACCCGCAAGTTCACGTATCTGGGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGGCTACTGATCTTGGAGGAACAAGTC AGGCCGGGACAAGCCAGAGGTTTTTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAGGCAGCACTTACCTTGCTTCCAATT CAACATCAGCCCCCAACTGGAAGAGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGACTGTGTTTTCTCCCACGCTACCTG CCGCCCGCTCTTCTCTTGGCTCTCTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCTTGCTTTCCTCAGACTACAGGATCA TCAATGGCAAAAGTGGAACTCAGGACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAGTGGCCACAGATATAACTTCTACCA GATCCTTAAATTACAAAAGCACTAGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATGCTGGACCTGCTTCCCGAGATGTCC AGGCCACTGGCAGAATCGCAGATGATGCTGACCCAAGAGTAGCACTTGTTAACGGTAAATACAAAGGGAAGACACTTTGGGCTAGTACAT TTGTTCATGATATACCAAATGGCTCTAGTCAAGTAGTGGATAAAACTACTGATGTAGAAAAAACTGGTGCCACTGGTTTTGGCTTAACAA TGGCAGTCAAGGCAGAAAAAGATATGTTACGTACTGGAAGTCAGAGTCTGAGGAACCTGGTCCCCACCACACCTGGGGAATCCACTGCCC CTGCACAAGTCAGCACTCTGCCTCAGTCACCTGCTGCCCTTTCCTCAAGCAACAGAGCTGCAGTCTGGGGGGCCCAAGGGCAGAACTGCA CCCAGGTTCCTGTTTCCTCTGCCAGCGAGCTCACAAGGAAGACAACAGGCTCTGCTCAGTATTCTTTATCTGATGTCACAAGTACCACAT CTTCTAGGGTGGATGATCATGACTCAGAGGAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATGGTAGCTGCAGCAAAGTCC ACTTCCATCTGCCTTACCGGTGGCAGATGCTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGATCGAGAAAGGCTACTGTA ACCCCGGAATCCACCTCTGTTCTGTAGGAAGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTCCCATCCGACGCCTCTCCA CTCCTTCTTCTGTCACCAAGCCAGCCAATTCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAATCTGGCACATGGATTCAGT ATGGAGAAGAGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGAT CTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGT TACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAAC TGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAG ATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTC ATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTG GATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTG TTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGT CTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGAC CACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATC GGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTG TCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAAT >In-frame_ZC3HAV1_ENST00000471652_chr7_138758602_-_BRAF_ENST00000288602_chr7_140481493_-_3365nt CTTTTAGTTTCTCTTCTTTCTAAAGAAGGCTCGCGGAGCCCGGCTGGAGAACCTCACCCTCGCCGAGCCTAGAACCGAGAGGGGGCCACC CCAGGCGGTCACCAGCAGATTTGCCCGCGCGTTCTCTTTCTTTCCACCCAGTTGCCCTTGCGGCCGGCTGTAAACCTGCCACTAGGACCC GGTCGGTGAGATCTAGCCTCTTGACCTGAGAGCCGAGAGTGGATCGCTGGGCTGGGCTAACGGCGACGGAGAGCGCGCCCTCGCTGACTC CGGGCGCGCCCAGCAGTAGCACCGCCCGCGCCCGCCCCTGGACACTTGTAAGTTTCGATTTCCGATTTCCGCGGAACCGAGTCCCGCGCC GCGGCAGAGCCAGCACAGCCAGCGCGCCATGGCGGACCCGGAGGTGTGCTGCTTCATCACCAAAATCCTGTGCGCCCACGGGGGCCGCAT GGCCCTGGACGCGCTGCTCCAGGAGATCGCGCTGTCTGAGCCGCAGCTCTGTGAGGTGCTGCAGGTGGCCGGGCCCGACCGCTTTGTGGT GTTGGAGACCGGCGGCGAGGCCGGGATCACCCGATCGGTGGTGGCCACCACTCGAGCCCGGGTCTGCCGTCGCAAGTACTGCCAGAGACC CTGCGATAACCTGCATCTCTGCAAACTCAACTTGCTGGGCCGGTGCAACTATTCGCAGTCCGAGCGGAATTTATGCAAATATTCTCATGA GGTTCTCTCAGAAGAGAACTTCAAAGTCCTGAAAAATCACGAACTCTCTGGACTGAACAAAGAGGAATTAGCAGTGCTCCTCCTCCAAAG TGATCCTTTTTTTATGCCCGAGATATGCAAAAGTTATAAGGGAGAGGGTCGGCAGCAGATTTGTAACCAGCAGCCACCGTGTTCAAGACT CCACATCTGTGACCACTTCACCCGAGGGAACTGTCGTTTTCCCAACTGCCTCCGGTCCCATAACCTGATGGACAGAAAGGTGCTGGCCAT CATGAGGGAGCACGGGCTGAACCCCGACGTGGTCCAGAACATCCAGGACATCTGCAACAGCAAGCACATGCAGAAGAATCCCCCAGGGCC CAGAGCTCCTTCTTCACATCGTAGAAACATGGCATATAGGGCTAGAAGCAAGAGTAGAGATCGGTTCTTTCAGGGCAGCCAAGAATTTCT TGCGTCTGCTTCAGCGTCTGCTGAGAGGTCCTGCACACCTAGTCCAGATCAGATCAGCCACAGGGCTTCCCTGGAGGACGCGCCTGTGGA CGATCTCACCCGCAAGTTCACGTATCTGGGGAGTCAGGATCGCGCTCGGCCTCCCTCAGGCTCGTCCAAGGCTACTGATCTTGGAGGAAC AAGTCAGGCCGGGACAAGCCAGAGGTTTTTAGAGAACGGCAGTCAAGAGGACCTCTTGCATGGAAATCCAGGCAGCACTTACCTTGCTTC CAATTCAACATCAGCCCCCAACTGGAAGAGCCTCACATCCTGGACGAATGACCAAGGCGCCAGGAGAAAGACTGTGTTTTCTCCCACGCT ACCTGCCGCCCGCTCTTCTCTTGGCTCTCTGCAAACACCTGAAGCTGTGACCACCAGAAAGGGCACAGGCTTGCTTTCCTCAGACTACAG GATCATCAATGGCAAAAGTGGAACTCAGGACATCCAGCCTGGCCCTCTTTTTAATAATAATGCTGATGGAGTGGCCACAGATATAACTTC TACCAGATCCTTAAATTACAAAAGCACTAGCAGCGGTCACAGAGAAATATCATCACCTAGGATTCAGGATGCTGGACCTGCTTCCCGAGA TGTCCAGGCCACTGGCAGAATCGCAGATGATGCTGACCCAAGAGTAGCACTTGTTAACGATTCTTTATCTGATGTCACAAGTACCACATC TTCTAGGGTGGATGATCATGACTCAGAGGAAATTTGTCTTGACCATCTGTGTAAGGGTTGTCCGCTTAATGGTAGCTGCAGCAAAGTCCA CTTCCATCTGCCTTACCGGTGGCAGATGCTTATTGGTAAAACCTGGACGGACTTTGAGCACATGGAGACGATCGAGAAAGGCTACTGTAA CCCCGGAATCCACCTCTGTTCTGTAGGAAGTTATACAATCAATTTTCGGGTAATGAGTTGTGATTCCTTTCCCATCCGACGCCTCTCCAC TCCTTCTTCTGTCACCAAGCCAGCCAATTCTGTCTTCACCACCAAATGGATTTGGTATTGGAAGAATGAATCTGGCACATGGATTCAGTA TGGAGAAGAGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATC TGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTT ACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACT GGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGA TATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCA TGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGG ATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGT TCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTC TCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACC ACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCG GGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGT CCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATA |
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FusionGenePPI for ZC3HAV1_BRAF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZC3HAV1 | SAP25, PPP2R2B, HDGF, ELAVL1, SIRT7, ISG15, CUL3, COPS5, CAND1, APP, RTCA, PVR, SLTM, RAE1, USP48, SFPQ, NTHL1, ESR2, TARDBP, LIN28A, IVNS1ABP, SPRTN, AURKB, CEP250, BRCA1, EZH2, RNF2, BMI1, ILK, MAST3, WDR76, HIST1H1A, NOL12, RPL8, NIFK, NTRK1, IFI16, TMEM17, XPO1, AHSA1, SORT1, CBX8, LDHD, PES1, MIRLET7A1, MEX3C, TRIM25, CDH1, EGFR, HIST1H1D, HIST1H1C, HIST1H1T, ZNF777, RPL37A, RRP8, BAZ1B, H2AFX, PABPC4L, KHNYN, RPL26L1, ZBTB48, ZNF354A, RBM34, KIAA0020, CNBP, GNL2, NOP2, DKC1, RPL30, GLTSCR2, RBM28, LARP1, RBM19, RPS8, RPL18A, MRPS9, RPL17, ZNF574, BRIX1, YBX1, RPL10A, RPL36, ZCRB1, DHX30, RPS3A, RPS15, PRDM15, GLYR1, YBX3, GADD45GIP1, WDR46, STAU1, STAU2, NOP16, RPL18, HP1BP3, EBNA1BP2, DGCR8, NMNAT1, KRR1, ZNF2, GTPBP4, RRS1, RPL12, PPAN-P2RY11, NGRN, NSA2, DDX24, PAPD5, RPL7, RPL32, GPATCH4, RPL7A, MRPS35, DDX27, RPL13, RPS13, LIN28B, RPL26, MAK16, MOV10, UPF1, DDX10, NXF2, NIP7, RPLP0, MRPS31, LLPH, MPHOSPH10, WHSC1, RPS6, COPZ1, DRG1, NCL, COX15, DLD, PDHA1, G3BP1, TES, URI1 | BRAF | YWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZC3HAV1_BRAF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB08896 | Regorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB00398 | Sorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
| Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
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RelatedDiseases for ZC3HAV1_BRAF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | BRAF | C0025202 | melanoma | 21 | CTD_human |
| Tgene | BRAF | C1527249 | Colorectal Cancer | 8 | UNIPROT |
| Tgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
| Tgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
| Tgene | BRAF | C0040136 | Thyroid Neoplasm | 4 | CTD_human |
| Tgene | BRAF | C0024305 | Lymphoma, Non-Hodgkin | 3 | UNIPROT |
| Tgene | BRAF | C0684249 | Carcinoma of lung | 3 | UNIPROT |
| Tgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 3 | CTD_human;UNIPROT |
| Tgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
| Tgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
| Tgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0017638 | Glioma | 1 | CTD_human |
| Tgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0028326 | Noonan Syndrome | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Tgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| Tgene | BRAF | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
| Tgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
| Tgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |
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