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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42589

FusionGeneSummary for ZC3H4_PRL

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H4_PRL
Fusion gene ID: 42589
HgeneTgene
Gene symbol

ZC3H4

PRL

Gene ID

23211

5617

Gene namezinc finger CCCH-type containing 4prolactin
SynonymsC19orf7GHA1
Cytomap

19q13.32

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 4prolactindecidual prolactingrowth hormone A1
Modification date2018052320180523
UniProtAcc

Q9UPT8

P01236

Ensembl transtripts involved in fusion geneENST00000253048, ENST00000594019, 
ENST00000306482, 
Fusion gene scores* DoF score8 X 9 X 7=5042 X 2 X 2=8
# samples 102
** MAII scorelog2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ZC3H4 [Title/Abstract] AND PRL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRL

GO:0001937

negative regulation of endothelial cell proliferation

23619365

TgenePRL

GO:0046427

positive regulation of JAK-STAT cascade

12552091

TgenePRL

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

23619365


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV752015ZC3H4chr19

47588333

-PRLchr6

22294687

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000253048ENST00000306482ZC3H4chr19

47588333

-PRLchr6

22294687

-
intron-3CDSENST00000594019ENST00000306482ZC3H4chr19

47588333

-PRLchr6

22294687

-

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FusionProtFeatures for ZC3H4_PRL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H4

Q9UPT8

PRL

P01236

Prolactin acts primarily on the mammary gland bypromoting lactation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H4_PRL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H4_PRL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H4_PRL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H4_PRL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRLC0242350Erectile dysfunction5CTD_human
TgenePRLC0020514Hyperprolactinemia4CTD_human
TgenePRLC0033375Prolactinoma4CTD_human
TgenePRLC0032019Pituitary Neoplasms3CTD_human
TgenePRLC0001430Adenoma2CTD_human
TgenePRLC0018418Gynecomastia2CTD_human
TgenePRLC0020649Hypotension2CTD_human
TgenePRLC0024667Animal Mammary Neoplasms2CTD_human
TgenePRLC0033953Psychosexual Disorders2CTD_human
TgenePRLC0237873Physiological Sexual Disorders2CTD_human
TgenePRLC0001418Adenocarcinoma1CTD_human
TgenePRLC0002453Amenorrhea1CTD_human
TgenePRLC0002871Anemia1CTD_human
TgenePRLC0004352Autistic Disorder1CTD_human
TgenePRLC0004782Basal Ganglia Diseases1CTD_human
TgenePRLC0007370Catalepsy1CTD_human
TgenePRLC0014175Endometriosis1CTD_human
TgenePRLC0015951Fetal Resorption1CTD_human
TgenePRLC0015967Fever1CTD_human
TgenePRLC0018801Heart failure1CTD_human
TgenePRLC0020619Hypogonadism1CTD_human
TgenePRLC0020635Hypopituitarism1CTD_human
TgenePRLC0021308Infarction1CTD_human
TgenePRLC0021361Female infertility1CTD_human
TgenePRLC0023601Leydig Cell Tumor1CTD_human
TgenePRLC0024141Lupus Erythematosus, Systemic1CTD_human
TgenePRLC0024668Mammary Neoplasms, Experimental1CTD_human
TgenePRLC0032963Pregnancy Complications, Cardiovascular1CTD_human
TgenePRLC0034040Puerperal Disorders1CTD_human
TgenePRLC0036341Schizophrenia1PSYGENET
TgenePRLC0038587Substance Withdrawal Syndrome1CTD_human
TgenePRLC0236736Cocaine-Related Disorders1CTD_human
TgenePRLC0242422Parkinsonian Disorders1CTD_human
TgenePRLC0346302Growth Hormone-Secreting Pituitary Adenoma1CTD_human
TgenePRLC0349231Phobic anxiety disorder1CTD_human
TgenePRLC0428977Bradycardia1CTD_human
TgenePRLC0525045Mood Disorders1PSYGENET
TgenePRLC2937421Prostatic Hyperplasia1CTD_human
TgenePRLC3665358Galactorrhea1CTD_human