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Fusion gene ID: 42586 |
FusionGeneSummary for ZC3H4_ARHGAP35 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3H4_ARHGAP35 | Fusion gene ID: 42586 | Hgene | Tgene | Gene symbol | ZC3H4 | ARHGAP35 | Gene ID | 23211 | 2909 |
| Gene name | zinc finger CCCH-type containing 4 | Rho GTPase activating protein 35 | |
| Synonyms | C19orf7 | GRF-1|GRLF1|P190-A|P190A|p190ARhoGAP|p190RhoGAP | |
| Cytomap | 19q13.32 | 19q13.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 4 | rho GTPase-activating protein 35glucocorticoid receptor DNA-binding factor 1glucocorticoid receptor repression factor 1rho GAP p190A | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q9UPT8 | Q9NRY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000253048, ENST00000594019, | ENST00000404338, ENST00000598548, | |
| Fusion gene scores | * DoF score | 8 X 9 X 7=504 | 9 X 7 X 5=315 |
| # samples | 10 | 9 | |
| ** MAII score | log2(10/504*10)=-2.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZC3H4 [Title/Abstract] AND ARHGAP35 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARHGAP35 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 1894621 |
| Tgene | ARHGAP35 | GO:0045892 | negative regulation of transcription, DNA-templated | 1894621 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ACC | TCGA-OR-A5JP-01A | ZC3H4 | chr19 | 47614152 | - | ARHGAP35 | chr19 | 47491246 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000253048 | ENST00000404338 | ZC3H4 | chr19 | 47614152 | - | ARHGAP35 | chr19 | 47491246 | + |
| intron-intron | ENST00000253048 | ENST00000598548 | ZC3H4 | chr19 | 47614152 | - | ARHGAP35 | chr19 | 47491246 | + |
| intron-3CDS | ENST00000594019 | ENST00000404338 | ZC3H4 | chr19 | 47614152 | - | ARHGAP35 | chr19 | 47491246 | + |
| intron-intron | ENST00000594019 | ENST00000598548 | ZC3H4 | chr19 | 47614152 | - | ARHGAP35 | chr19 | 47491246 | + |
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FusionProtFeatures for ZC3H4_ARHGAP35 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3H4 | ARHGAP35 |
| Rho GTPase-activating protein (GAP) (PubMed:19673492,PubMed:28894085). Binds several acidic phospholipids whichinhibits the Rho GAP activity to promote the Rac GAP activity(PubMed:19673492). This binding is inhibited by phosphorylation byPRKCA (PubMed:19673492). Involved in cell differentiation as wellas cell adhesion and migration, plays an important role in retinaltissue morphogenesis, neural tube fusion, midline fusion of thecerebral hemispheres and mammary gland branching morphogenesis (Bysimilarity). Transduces signals from p21-ras to the nucleus,acting via the ras GTPase-activating protein (GAP) (Bysimilarity). Transduces SRC-dependent signals from cell-surfaceadhesion molecules, such as laminin, to promote neurite outgrowth.Regulates axon outgrowth, guidance and fasciculation (Bysimilarity). Modulates Rho GTPase-dependent F-actinpolymerization, organization and assembly, is involved inpolarized cell migration and in the positive regulation ofciliogenesis and cilia elongation (By similarity). During mammarygland development, is required in both the epithelial and stromalcompartments for ductal outgrowth (By similarity). Repressestranscription of the glucocorticoid receptor by binding to thecis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; thisfunction is however unclear and would need additional experimentalevidences (PubMed:1894621). {ECO:0000250|UniProtKB:P81128,ECO:0000250|UniProtKB:Q91YM2, ECO:0000269|PubMed:1894621,ECO:0000269|PubMed:19673492, ECO:0000269|PubMed:28894085}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZC3H4_ARHGAP35 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZC3H4_ARHGAP35 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZC3H4 | MRPL45, USP28, DBN1, WIZ, SDHA, FLNB, SHMT1, PSMA2, MARC1, DYNC1H1, PAF1, SLC25A10, OBSL1, RNF2, BMI1, RSPH9, ZFP41, NTRK1, CDC42, RC3H1, EGFR, CAPN13, JMJD6, HTRA4, PDGFB, MRPS11 | ARHGAP35 | RASA1, RHOA, GRB2, BCL6, RND1, RND2, RND3, KRT31, TCERG1, NTRK1, CDC42, RAC1, SERPINB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZC3H4_ARHGAP35 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3H4_ARHGAP35 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ARHGAP35 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
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