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Fusion gene ID: 42584 |
FusionGeneSummary for ZC3H3_YY1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3H3_YY1 | Fusion gene ID: 42584 | Hgene | Tgene | Gene symbol | ZC3H3 | YY1 | Gene ID | 23144 | 7528 |
| Gene name | zinc finger CCCH-type containing 3 | YY1 transcription factor | |
| Synonyms | ZC3HDC3 | DELTA|GADEVS|INO80S|NF-E1|UCRBP|YIN-YANG-1 | |
| Cytomap | 8q24.3 | 14q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3 | transcriptional repressor protein YY1INO80 complex subunit SYY-1Yin and Yang 1 proteindelta transcription factor | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q8IXZ2 | P25490 | |
| Ensembl transtripts involved in fusion gene | ENST00000262577, | ENST00000262238, | |
| Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 6 X 4 X 5=120 |
| # samples | 7 | 7 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ZC3H3 [Title/Abstract] AND YY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9857059|16260628 |
| Tgene | YY1 | GO:0032688 | negative regulation of interferon-beta production | 16260628 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A8-A09N-01A | ZC3H3 | chr8 | 144557568 | - | YY1 | chr14 | 100728641 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000262577 | ENST00000262238 | ZC3H3 | chr8 | 144557568 | - | YY1 | chr14 | 100728641 | + |
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FusionProtFeatures for ZC3H3_YY1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3H3 | YY1 |
| Required for the export of polyadenylated mRNAs from thenucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependenttranscription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).{ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. | Multifunctional transcription factor that exhibitspositive and negative control on a large number of cellular andviral genes by binding to sites overlapping the transcriptionstart site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; somegenes have been shown to contain a longer binding motif allowingenhanced binding; the initial CG dinucleotide can be methylatedgreatly reducing the binding affinity. The effect on transcriptionregulation is depending upon the context in which it binds anddiverse mechanisms of action include direct activation orrepression, indirect activation or repression via cofactorrecruitment, or activation or repression by disruption of bindingsites or conformational DNA changes. Its activity is regulated bytranscription factors and cytoplasmic proteins that have beenshown to abrogate or completely inhibit YY1-mediated activation orrepression. For example, it acts as a repressor in absence ofadenovirus E1A protein but as an activator in its presence. Actssynergistically with the SMAD1 and SMAD4 in bone morphogeneticprotein (BMP)-mediated cardiac-specific gene expression(PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiacactivating regions. May play an important role in development anddifferentiation. Proposed to recruit the PRC2/EED-EZH2 complex totarget genes that are transcriptional repressed. Involved in DNArepair. In vitro, binds to DNA recombination intermediatestructures (Holliday junctions). Plays a role in regulatingenhancer activation (PubMed:28575647).{ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24326773,ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}. Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair; proposed to target the INO80complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:18026119}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 382_391 | 634 | 949 | Compositional bias | Note=Poly-Ser |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 257_341 | 226 | 415 | Region | Note=Involved in nuclear matrix association |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 295_414 | 226 | 415 | Region | Note=Binding to DNA |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 333_371 | 226 | 415 | Region | Note=Involved in repression of activated transcription |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 371_397 | 226 | 415 | Region | Note=Involved in masking transactivation domain |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 296_320 | 226 | 415 | Zinc finger | C2H2-type 1 |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 325_347 | 226 | 415 | Zinc finger | C2H2-type 2 |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 353_377 | 226 | 415 | Zinc finger | C2H2-type 3 |
| Tgene | >YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 383_407 | 226 | 415 | Zinc finger | C2H2-type 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 873_881 | 634 | 949 | Compositional bias | Note=Poly-Ser |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 667_695 | 634 | 949 | Zinc finger | C3H1-type 1 |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 699_722 | 634 | 949 | Zinc finger | C3H1-type 2 |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 723_749 | 634 | 949 | Zinc finger | C3H1-type 3 |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 750_777 | 634 | 949 | Zinc finger | C3H1-type 4 |
| Hgene | >ZC3H3 | chr8:144557568 | chr14:100728641 | ENST00000262577 | - | 5 | 12 | 778_800 | 634 | 949 | Zinc finger | C3H1-type 5 |
| Tgene | YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 159_170 | 226 | 415 | Compositional bias | Note=Gly/Ser-rich |
| Tgene | YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 43_53 | 226 | 415 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| Tgene | YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 54_69 | 226 | 415 | Compositional bias | Note=Gly-rich |
| Tgene | YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 70_80 | 226 | 415 | Compositional bias | Note=Poly-His |
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FusionGeneSequence for ZC3H3_YY1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ZC3H3_ENST00000262577_chr8_144557568_-_YY1_ENST00000262238_chr14_100728641_+_823aa MEEKEILRRQIRLLQGLIDDYKTLHGNAPAPGTPAASGWQPPTYHSGRAFSARYPRPSRRGYSSHHGPSWRKKYSLVNRPPGPSDPPADH AVRPLHGARGGQPPVPQQHVLERQVQLSQGQNVVIKVKPPSKSGSASASGAQRGSLEEFEETPWSDQRPREGEGEPPRGQLQPSRPTRAR GTCSVEDPLLVCQKEPGKPRMVKSVGSVGDSPREPRRTVSESVIAVKASFPSSALPPRTGVALGRKLGSHSVASCAPQLLGDRRVDAGHT DQPVPSGSVGGPARPASGPRQAREASLVVTCRTNKFRKNNYKWVAASSKSPRVARRALSPRVAAENVCKASAGMANKVEKPQLIADPEPK PRKPATSSKPGSAPSKYKWKASSPSASSSSSFRWQSEASSKDHASQLSPVLSRSPSGDRPAVGHSGLKPLSGETPLSAYKVKSRTKIIRR RSSTSLPGDKKSGTSPAATAKSHLSLRRRQALRGKSSPVLKKTPNKGLVQVTTHRLCRLPPSRAHLPTKEASSLHAVRTAPTSKVIKTRY RIVKKTPASPLSAPPFPLSLPSWRARRLSLSRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRP LLRTDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSA MRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ZC3H3_ENST00000262577_chr8_144557568_-_YY1_ENST00000262238_chr14_100728641_+_2469nt ATGGAGGAAAAGGAGATATTACGGCGGCAGATCCGCCTACTGCAGGGTCTGATTGATGACTACAAAACCCTCCACGGCAATGCCCCGGCC CCTGGTACCCCAGCAGCTTCTGGGTGGCAGCCACCCACTTACCACAGTGGCAGAGCCTTTAGTGCCCGCTACCCTCGTCCAAGCCGGAGG GGCTACTCTTCCCACCATGGGCCTTCGTGGCGCAAGAAATACTCCCTCGTGAATCGGCCCCCGGGACCCTCAGACCCTCCTGCCGACCAT GCTGTGCGGCCGTTGCACGGGGCCCGGGGGGGCCAGCCTCCTGTCCCGCAGCAGCATGTCCTTGAGAGACAGGTCCAGCTCAGTCAGGGT CAGAACGTGGTCATCAAAGTTAAACCGCCATCAAAGTCTGGCTCTGCCAGTGCCTCAGGGGCCCAGCGGGGCTCTTTGGAAGAATTTGAG GAAACCCCCTGGAGTGACCAAAGGCCCCGGGAAGGTGAAGGTGAGCCCCCTCGGGGACAGCTGCAGCCCTCGAGGCCAACAAGAGCCAGG GGGACCTGCAGTGTGGAAGATCCTCTTCTGGTCTGCCAGAAGGAGCCTGGTAAGCCCAGGATGGTGAAGTCAGTGGGCAGTGTGGGCGAC AGCCCCCGGGAGCCCCGCCGGACAGTCAGTGAGAGTGTGATTGCCGTCAAGGCGAGCTTCCCATCCTCCGCTCTGCCCCCACGCACTGGC GTGGCCCTGGGCCGGAAGCTGGGTTCTCATTCCGTGGCCAGCTGTGCTCCACAGCTCCTTGGGGACAGGAGAGTAGATGCTGGCCACACA GATCAGCCAGTTCCGTCTGGCTCAGTGGGGGGCCCCGCCAGACCGGCCTCAGGACCCAGGCAGGCCCGGGAGGCCTCGCTGGTTGTGACC TGTCGAACTAACAAGTTCCGGAAAAACAACTACAAATGGGTGGCTGCCTCCTCGAAGAGTCCCCGGGTTGCTCGGAGGGCCCTCAGTCCC AGAGTGGCTGCAGAGAATGTGTGCAAGGCCTCTGCTGGCATGGCAAACAAGGTGGAGAAGCCGCAGCTCATAGCTGACCCAGAGCCCAAG CCCAGGAAGCCAGCCACGTCCTCCAAGCCAGGGTCTGCCCCCAGCAAGTACAAGTGGAAGGCCTCCAGCCCCTCTGCCTCCTCCTCTTCC TCCTTCCGTTGGCAGTCGGAGGCCAGCAGCAAGGACCATGCCTCCCAGCTCTCCCCAGTCCTGTCTAGGTCCCCGTCGGGGGACAGACCA GCAGTAGGACACAGTGGCTTGAAGCCCCTCTCTGGGGAGACCCCGCTCTCGGCTTACAAAGTGAAGAGCCGCACCAAGATCATCCGGAGA CGCAGCAGCACAAGCCTTCCTGGAGACAAGAAAAGCGGCACCTCACCTGCCGCCACCGCCAAGAGCCACCTCAGCCTCCGGCGGAGACAG GCCCTCAGGGGGAAGAGCAGCCCTGTCCTGAAGAAGACCCCCAACAAGGGCCTGGTACAGGTCACCACGCACCGACTATGTCGCCTGCCA CCGAGCCGGGCCCACCTCCCCACCAAGGAAGCGTCCAGCCTGCATGCCGTGCGGACTGCACCCACCAGCAAGGTGATCAAGACCCGCTAC CGCATTGTCAAGAAGACGCCGGCCTCGCCTCTCAGCGCCCCGCCCTTCCCCCTGTCTCTGCCCTCCTGGCGGGCCCGGCGGCTCTCACTA TCCAGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCCAACCGGGCTCCCCTTGGTGGCGGAGCAAAGGC TACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCTCCGGCCAGCCCAGTGATGCGGGCAGCAGGCCC CTCCTGCGCACAGATGAAAAAAAAGATATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCA GAATATATGACAGGAAAGAAACTTCCTCCTGGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATG AAGCCAAGAAAAATTAAAGAAGATGATGCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCC ATGAGAAAACATCTGCACACCCACGGTCCCAGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGA CACCAACTGGTTCATACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACA CATGTGCGAATCCATACCGGAGACAGGCCCTATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ZC3H3_ENST00000262577_chr8_144557568_-_YY1_ENST00000262238_chr14_100728641_+_7693nt GGGGGCCTGGCCGGCCGTCGCGGACTCGGGAGATGGAGGAAAAGGAGATATTACGGCGGCAGATCCGCCTACTGCAGGGTCTGATTGATG ACTACAAAACCCTCCACGGCAATGCCCCGGCCCCTGGTACCCCAGCAGCTTCTGGGTGGCAGCCACCCACTTACCACAGTGGCAGAGCCT TTAGTGCCCGCTACCCTCGTCCAAGCCGGAGGGGCTACTCTTCCCACCATGGGCCTTCGTGGCGCAAGAAATACTCCCTCGTGAATCGGC CCCCGGGACCCTCAGACCCTCCTGCCGACCATGCTGTGCGGCCGTTGCACGGGGCCCGGGGGGGCCAGCCTCCTGTCCCGCAGCAGCATG TCCTTGAGAGACAGGTCCAGCTCAGTCAGGGTCAGAACGTGGTCATCAAAGTTAAACCGCCATCAAAGTCTGGCTCTGCCAGTGCCTCAG GGGCCCAGCGGGGCTCTTTGGAAGAATTTGAGGAAACCCCCTGGAGTGACCAAAGGCCCCGGGAAGGTGAAGGTGAGCCCCCTCGGGGAC AGCTGCAGCCCTCGAGGCCAACAAGAGCCAGGGGGACCTGCAGTGTGGAAGATCCTCTTCTGGTCTGCCAGAAGGAGCCTGGTAAGCCCA GGATGGTGAAGTCAGTGGGCAGTGTGGGCGACAGCCCCCGGGAGCCCCGCCGGACAGTCAGTGAGAGTGTGATTGCCGTCAAGGCGAGCT TCCCATCCTCCGCTCTGCCCCCACGCACTGGCGTGGCCCTGGGCCGGAAGCTGGGTTCTCATTCCGTGGCCAGCTGTGCTCCACAGCTCC TTGGGGACAGGAGAGTAGATGCTGGCCACACAGATCAGCCAGTTCCGTCTGGCTCAGTGGGGGGCCCCGCCAGACCGGCCTCAGGACCCA GGCAGGCCCGGGAGGCCTCGCTGGTTGTGACCTGTCGAACTAACAAGTTCCGGAAAAACAACTACAAATGGGTGGCTGCCTCCTCGAAGA GTCCCCGGGTTGCTCGGAGGGCCCTCAGTCCCAGAGTGGCTGCAGAGAATGTGTGCAAGGCCTCTGCTGGCATGGCAAACAAGGTGGAGA AGCCGCAGCTCATAGCTGACCCAGAGCCCAAGCCCAGGAAGCCAGCCACGTCCTCCAAGCCAGGGTCTGCCCCCAGCAAGTACAAGTGGA AGGCCTCCAGCCCCTCTGCCTCCTCCTCTTCCTCCTTCCGTTGGCAGTCGGAGGCCAGCAGCAAGGACCATGCCTCCCAGCTCTCCCCAG TCCTGTCTAGGTCCCCGTCGGGGGACAGACCAGCAGTAGGACACAGTGGCTTGAAGCCCCTCTCTGGGGAGACCCCGCTCTCGGCTTACA AAGTGAAGAGCCGCACCAAGATCATCCGGAGACGCAGCAGCACAAGCCTTCCTGGAGACAAGAAAAGCGGCACCTCACCTGCCGCCACCG CCAAGAGCCACCTCAGCCTCCGGCGGAGACAGGCCCTCAGGGGGAAGAGCAGCCCTGTCCTGAAGAAGACCCCCAACAAGGGCCTGGTAC AGGTCACCACGCACCGACTATGTCGCCTGCCACCGAGCCGGGCCCACCTCCCCACCAAGGAAGCGTCCAGCCTGCATGCCGTGCGGACTG CACCCACCAGCAAGGTGATCAAGACCCGCTACCGCATTGTCAAGAAGACGCCGGCCTCGCCTCTCAGCGCCCCGCCCTTCCCCCTGTCTC TGCCCTCCTGGCGGGCCCGGCGGCTCTCACTATCCAGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCC AACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCT CCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGATGAAAAAAAAGATATTGACCATGAGACAGTGGTTGAAGAACAGA TCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCTCCTGGAGGAATACCTGGCATTGACCTCTCAG ATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATTAAAGAAGATGATGCTCCAAGAACAATAGCTTGCCCTCATAAAG GCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGTCCCAGAGTCCACGTCTGTGCAGAATGTGGCA AAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCATACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAAGGCTGTGGGA AACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGGCCCTATGTGTGCCCCTTCGATGGTTGTAATA AGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACACATGCTAAGGCCAAAAACAACCAGTGAAAAGAAGAGAGAAGACCCT TCTCGACCACGGGAAGCATCTTCCAGAAGTGTGATTGGGAATAAATATGCCTCTCCTTTGTATATTATTTCTAGGAAGAATTTTAAAAAT GAATCCTACACACCTAAGGGACATGTTTTGATAAAGTAGTAAAAATTAAAAAAAAAAAACTTTACTAAGATGACATTGCTAAGATGCTCT ATCTTGCTCTGTAATCTCGTTTCAAAAACACAGTGTTTTTGTAAAGTGTGGTCCCAACAGGAGGACAATTCATGAACTTCGCATCAAAAG ACAATTCTTTATACAACAGTGCTAAAAATGGGACTTCTTTTCACATTCTTATAAATATGAAGCTCACCTGTTGCTTACAATTTTTTTAAT TTTGTATTTTCCAAGTGTGCATATTGTACACTTTTTTGGGGATATGCTTAGTAATGCTACGTGTGATTTTTCTGGAGGTTGATAACTTTG CTTGCAGTAGATTTTCTTTAAAAGAATGGGCAGTTACATGCATACTTCAAAAGTATTTTCCTGTAAAAAAAAAAAAGTTATATAGGTTTT GTTTGCTATCTTAATTTTGGTTGTATTCTTTGATGTTAACACATTTTGTATAATTGTATCGTATAGCTGTATTGAATCATGTAGTATCAA ATATTAGATGTGATTTAATAGTGTTAATCAATTTAAACCCATTTTAGTCACTTTTTTTTTCCAAAAAAATACTGCCAGATGCTGATGTTC AGTGTAATTTCTTTGCCTGTTCAGTTACAGAAAGTGGTGCTCAGTTGTAGAATGTATTGTACCTTTTAACACCTGATGTGTACATCCCAT GTAACAGAAAGGGCAACAATAAAATAGCAATCCTAAAGCAAGAATATGGCAGAACAAGATCTGTAAGCACAGTCTTATTTTCTTTTGTTG TCCAGAATACTTATAATTCTTGAGCCTCCCAGAAATTGGAAGCTAAATAAAGCAACTCAAGTTTCCTTTATTTTGCACTCAATTACAGTG ATTATTGATGAAAGCGATGCATGGATATTTTAATACTTCCTACATGTCCTGACTTCTGAAAGAGAGTAGGTAACAGGCATCCCGAGTTCA GGAACTACCTCAGAACACCCCAGGCCAGGTTGGTCATAGGCTGTGATTTTAGCCCCCGGCAAGTGTGAGTGAAGCATCTGTACCACCGCG CAGGCTGAGCGCCTGCGCAGGGTAAGGTGCCACCTGGCAGTGGGGCACACAGAGGGAAGACCAGGCCTGTCCATCAGCCGGCTGCCTTCA GAGGCAGCTCCAGCAGGACCTTGGCTTGTCTGACAGGAAATGCTTGTGGTCGTTGGTTATTTGGTTTGAGAGCCCTTGTTCCTCCATCTA GTGGAGTCCTTATTAAATGCTAGCAATGTGGCAATTGAGTGCCAGTAGCTTAATTTCATGTTTCTAAATGGACACTGGGTGCAAATCGGC AAGGTGATTAGATTATTAGAAAATTCTGCTCAATGAGTACCTCTCACATTGTAACCTCTTAAATGTACGATTATAATGTTGGATCTTAGG TCAAATAACAGACTTGAGAATACTTTATAAACTGCCATGATACAGCAAAATCTCATTTATTCAAAGTGCAAACATACTGTGTGTCTTTCT GTTTTGTGTATGCTTGACTGCAAGATAAATGACAAACTAGCTAATATCCGAGATTTATTTACAAATGGCCAGGGACCCCATCAGGTGAAA CACATAGCCCATTGTCTTAGAGCTTCTCCATCGGTCCTGTACAGGAGGATTGGTGACCTACTAACAGTGACCCTGTGGCTCTGTGGAATT TTGAAGTGCCTTTTGTGAATCATGAATGAAACATTTAACTTGAGACCCTTTAAAAAATTCATCCAGAATCTGTTACCCCTTGGGTAGTTT GATGGAACTGAGTTAAGCAGAAGACCCCAGCTGTTTTCTGGGTAAGCCAGGCTTTGCTGTATCTGGCAGTCAGGAGAGAGGTCAGCCCAT GGTGGAGGTCTTCAGTGCCGAGGGCTCGGATGAGAACGTGTAGTTCTTTGACTTGGACCTGGGCAGCGTCTTCTATGGATGCCTGCCTTG TGAGCACCCACACCTTCCCTCCCCACTGTCGGGTTGAGTAGCCCCAGCGTGGCTGTGTTAGGAGTCCTTTGCCCAACATTGTGCTGCACT GGAGCCTGGCCCTGGCACTGTCCTCAGGACCCTGCCCAAGGGCCCACCGCAGAGCACACCTATGCTATGGGGAGCCCTGCTGGCAGCCCC GAGAGCCATGCCATGGCCTGCAGGAGCCAGGCTCCTGTGTGGATGAAGTCCCTCTTCCTCTGTGCCTTGATCCCTTGGGGGTGCCTTTGG TCATCTCTTCTGTCCTTTCCTGTCTCTGAAATAGTCATCACTCCCCTTGACTCTCTCTGTTCACGTCTTCTCAGTCTGCAGAGTTAACTT CTGTAAGGAGTTTAATCTGGGGTTCCAAGAAAACAAGTTCCTTGTTAACATAGCACTGACTTTGCAACAATAGAAAACTAACAAATGAGC AACAATATAAAGAGTAGAGGTAGTTCTCATTGGGTGTAACTTCAACCCATTCTGCTTGTGGTTAGAATTTATAATTTTGCTAACGATGTA ATTTACTAAGGTTTGAAATGGTATTCTAACAGTGAGTCCATTGTCTTGAGGATTAATCTGATTTATAAGTAATACTGATAGACATATTTT CGTACATCTGAGCAGAAATAAATGCATGTTTCTAGCATATGTAATATAAAAACTCCAGAGGATAAGTTTACACTTAACAAGATGTTGTTT TCTATTTTTGAATTTCTTATTATTTCCCCCTTTTTGGTAGTGGAGTTGAGAGGGGGAGCATACTATTTGTATAAAGAACTGTCACCCCAG AGTGACATTTATTTTCCAAGATGACCCTGAACTCATGCTGTTGGTTTCATATGGTGTTTGTGTGCTTTGCCTAGATTCAAGGCCTGAGGA TTTGAGGAAAATCGGGATTTTTTTTTTCCTATTTGGTTTTCATGTAAAAGTTCTAAATGTCACTTATTTTGCTAAATAAGACCCTTTCAC AGGATAGTGTGCGCAATACCTGTCCGTGTTTCCAAGCAGAGTTCAAGTTCATGTCTTCACAAGTAGATGAGAGTCACTTCCAGTCGGGGG AAGCCCGCCTGAGCAGTGTTTTGAGAGTGCGTACATTGGAGGACTGCCCCACGTCCGTTTGCACTCTGCCTTGCAAAACTTACTGTGGAG ACGTGTCCCAGACTGGTCTCAGACCAGAGTTTGTGGCACAGGAAAACCTGGCCCCCTAAAAAGAAGTTTTGGAATTGGAAGCCTGATAAT TTCGGGAGGCTGAGGCAGGAGAACGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTG ACAGAGCAAGACTCCGTCTCCCAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAACCTGACAATTCTACCCACCTCCCCCCACCCCCGACTA TAGGCAAAGAGAGTTGATCACTTCCAGGGTCTCTGACTTCTGTGACCTGGAAATCAGCCTGGCTTGGGAAATTCATGTTGTTGATCTTTA ATTATTTAATTATTCTTTAATAATCCTTCTATTTTCTTGACATCTGACCCCCAGCAAGAGTAAGGATCCCAGAGGTCAAAACAGTGGTGA GAGCCAAGCTGCTCACAGACACCCACTTGATGCCACAGCCATGCCATGAGGCTTCCTCCCAGCTGCTCTGCTGGCTTGCTGAAGCCAGCT CTGAGTCACAGGGTTGCCTTGGACCCTCGGCTGTAGGGGGCACCTGTCTGGCTCCGGGCCCTTTGTCCTGGATACACTGACAGTAATGTG AGCGCAGCACTTCAGAGTTCAGGCCCAGCAGGTCCTGGCAAGTGCATTCCACCCGAACTTTTAACCCAAGCGGTGGGGAAGGAAGCCAAA ACTCCAAGCTGCACTTTCTTGGGGTTCTGGCCATGCACTTCTTAGCCTTCTCTCTGACTTTACAGGACAAAAGGTACCCCACGCCTTCAG AATCATGCTTACCTGCACGGCAGCATCTGACTGGATGGCTGGCTAGGTCTCATCCACCCCAAATTACTGACCCTTGATTTATGTTGTTAC TGCTCAGGTTATGCTCAGATGCCCTGGTTGCCTGAAGATGGTTTAAGTGCAGGCCCTTCAGACAAGTCACGTCAGGCAAGAGAGGGCTGG CCTCTGACCCACAAGAGGGCAGATTTGTGGCCAAGAGGCTTCCTGGCATCCACCCCCAGGCCCAAGGGATCAGTGTGGTGCCAGAGAGGA TCTTTAAGCTGGGACTGTACTGAGGCTTGATGGGAAGTATGGGCAGCATGTACTTGACACGTTATCACCCAGTCCCCTTGTAAAATCTGG AATGGAGCGTTTAAGCTGAGCGTTAGCATCAGGTCAGCAGGCAAAGCAAACCTCCCACAAACTGGGTGCCGTAAGGTGGGAGGTGACACA TGGAGAGCTTCGTCCTGGCCGAGCAGGCACCCAGCCCCATGTCCCCCGCCAGCATTCTGGATGTCAGAGGAGGGTGCGTGTGATGGCGTC ACATTCATCTGAAGCACACTGATTGATTTTCCACAAGGTGGCAAGTTTGATCAAATTGACCGCTTTTCATGAGACACCCAGATGCTGTAA AAAAAAAAAACAGCACTGGGATGTGTTGAGGAGGGGGCAGTTTGCTGTGCTCTGTTCTGTCTGCTGCTCTCTCTGGGGGCCGCACAATGT CCGCACACATCACGGAGGGGAGAAAGGCATCAGTACCAAACGGAACAACCTCTTTTTTCTACATTGTCCATACCCGGACATGTGAGGCTC TATTATCAACAGGTGGTGAGAAAAATTATGTTTTTATTCGCTTTCTGGTAACTTCTGTAGGCCCTGGCTCAAGGACTTAGCATTTCGTCT CATGTACATCTTTTTCTTAAGTGTTCTTTGCCATTTCTGGAATTGTCCTTGGTTTTTCCTTAGCTCATAGGTCATAGATGCAGAAATATA GTATTTAAGGCATCCGCATCCAGCATCAGATGGCTTTGCATCCAGAAAAACATTGATAACTCAGTTTGAAGCACCAAGCATGTGTAATAT |
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FusionGenePPI for ZC3H3_YY1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZC3H3 | HECW2, MOV10, NXF1, CTDSP2, LARP7, RPL26L1, NIP7, NOP10, RPF1, RBM28, POP1, DDX24, MRPS9, FTSJ3, MRPS26, DDX21, ANKRD17, ANKHD1, ANKHD1-EIF4EBP3, PTCD1, ZNF70, UPF1, PTCD3, RPL10A, DKC1, PABPC4, PABPC3, YARS2, ELAVL2, HIST1H1C, HIST1H1A, REXO4, TRUB2, NOP16, RBM19, RPS3A, MTERF3, MRPL32, KRI1, WHSC1, RSL1D1, MRPS10, DAP3, MRPL1, SURF6, GTPBP4, LARP1, LARP1B, FARS2, FASTKD2, NOP2, MRPS31, MRPS5, ERAL1, MRPS22, GNL2, RPL36AL, GLTSCR2, MRPL45, LLPH, RAB3IP, RBM34, MRPS25, NGRN, BRIX1, ZC3H8, MRPL9, MRPS2, PAK1IP1, MRPS33, RRS1, MRPS11, RPL15, KIAA0020, HERC5, RPL32, MRPS24, PAPD5, NMNAT1, ZCCHC9, MRPS35, DDX31, RPL13A, MRPL19, MRPS14, RPF2, AHCYL2, AHCYL1, MRPL21, MRPL13, MRPL17, PURA, PPAN-P2RY11, NSA2, MRPL30, MRPL14, MALSU1, HIST2H2AB, MRPL34, MRPS21, LTBR, APP, CTBP2, KIF3C, LGALS3BP, LLGL2, PTTG1, THOC1, SETD1B, ELMSAN1, ZFC3H1, MZT1, IKZF5, CACNG5, C11orf57, TMEM102, SSSCA1, APOBEC3D, SRSF1 | YY1 | FKBP1A, YAF2, MTA2, NOTCH1, SAP30, HDAC1, HDAC2, HDAC3, KAT2B, EP300, FKBP3, RYBP, SP1, SREBF1, MYC, ATF6, PPIA, CTCF, HDAC4, ATF2, ZNF232, HOXA11, MAX, CREBBP, HDAC5, TP53, MDM2, CDKN2A, SMAD4, SMAD1, SMAD2, SMAD3, PRMT1, ILF3, NPM1, TFAP2A, EZH2, INO80, TFCP2, PRKDC, ACTR8, HSPA4, ACTR5, ACTL6A, RUVBL1, RUVBL2, RELB, YY1, JUNB, JUND, RB1, NFE2L2, MECP2, TERF1, TERF2, INO80C, INO80E, NFRKB, TCF3, INO80B, UCHL5, INO80D, MCRS1, TFPT, HSPA5, BCL6, NEDD4, UHRF2, CREB1, ATF7, BAP1, HCFC1, NEDD4L, XRCC6, XRCC5, SMARCAD1, DDX5, DDX3X, SP3, PSMD9, SKP2, ELAVL1, EED, APP, ZNF830, NHP2L1, ZNF638, NCL, WDHD1, ZNF24, ARRB1, RING1, RNF2, PCGF2, LAMC2, GABPB1, GABPA, SLC39A7, CRKL, GRN, NFKB1, RAF1, TESK1, NR1H2, SPRY1, SHFM1, SMURF2, SUZ12, BMI1, TWIST1, PPP1R3B, TMEM150A, TRPV5, CEP164, BAX, FOXB1, FOXJ2, FOXL1, FOXN1, KMT2E, DNMT3L, AURKA, ID2, F9, TRIM25, AGO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | YY1 | chr8:144557568 | chr14:100728641 | ENST00000262238 | + | 0 | 5 | 1_170 | 226 | 415 | the SMAD1/SMAD4 complex |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZC3H3_YY1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3H3_YY1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | YY1 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
| Tgene | YY1 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | YY1 | C3714756 | Intellectual Disability | 1 | CTD_human |
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