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Fusion gene ID: 42579 |
FusionGeneSummary for ZC3H3_LY6H |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZC3H3_LY6H | Fusion gene ID: 42579 | Hgene | Tgene | Gene symbol | ZC3H3 | LY6H | Gene ID | 23144 | 4062 |
| Gene name | zinc finger CCCH-type containing 3 | lymphocyte antigen 6 family member H | |
| Synonyms | ZC3HDC3 | NMLY6 | |
| Cytomap | 8q24.3 | 8q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3 | lymphocyte antigen 6Hly-6Hlymphocyte antigen 6 complex, locus H | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IXZ2 | O94772 | |
| Ensembl transtripts involved in fusion gene | ENST00000262577, | ENST00000430474, ENST00000342752, ENST00000414417, | |
| Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZC3H3 [Title/Abstract] AND LY6H [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-LN-A49V-01A | ZC3H3 | chr8 | 144547887 | - | LY6H | chr8 | 144241126 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000262577 | ENST00000430474 | ZC3H3 | chr8 | 144547887 | - | LY6H | chr8 | 144241126 | - |
| 5CDS-5UTR | ENST00000262577 | ENST00000342752 | ZC3H3 | chr8 | 144547887 | - | LY6H | chr8 | 144241126 | - |
| 5CDS-5UTR | ENST00000262577 | ENST00000414417 | ZC3H3 | chr8 | 144547887 | - | LY6H | chr8 | 144241126 | - |
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FusionProtFeatures for ZC3H3_LY6H |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZC3H3 | LY6H |
| Required for the export of polyadenylated mRNAs from thenucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependenttranscription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).{ECO:0000250|UniProtKB:Q8CHP0, ECO:0000269|PubMed:19364924}. | Believed to act as a modulator of nicotinicacetylcholine receptors (nAChRs) activity. In vitro inhibitsalpha-3:beta-4-containing nAChRs maximum response. May play a rolein the intracellular trafficking of alpha-7-containing nAChRs andmay inhibit their expression at the cell surface. Seems to inhibitalpha-7/CHRNA7 signaling in hippocampal neurons.{ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZC3H3_LY6H |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZC3H3_LY6H |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZC3H3 | HECW2, MOV10, NXF1, CTDSP2, LARP7, RPL26L1, NIP7, NOP10, RPF1, RBM28, POP1, DDX24, MRPS9, FTSJ3, MRPS26, DDX21, ANKRD17, ANKHD1, ANKHD1-EIF4EBP3, PTCD1, ZNF70, UPF1, PTCD3, RPL10A, DKC1, PABPC4, PABPC3, YARS2, ELAVL2, HIST1H1C, HIST1H1A, REXO4, TRUB2, NOP16, RBM19, RPS3A, MTERF3, MRPL32, KRI1, WHSC1, RSL1D1, MRPS10, DAP3, MRPL1, SURF6, GTPBP4, LARP1, LARP1B, FARS2, FASTKD2, NOP2, MRPS31, MRPS5, ERAL1, MRPS22, GNL2, RPL36AL, GLTSCR2, MRPL45, LLPH, RAB3IP, RBM34, MRPS25, NGRN, BRIX1, ZC3H8, MRPL9, MRPS2, PAK1IP1, MRPS33, RRS1, MRPS11, RPL15, KIAA0020, HERC5, RPL32, MRPS24, PAPD5, NMNAT1, ZCCHC9, MRPS35, DDX31, RPL13A, MRPL19, MRPS14, RPF2, AHCYL2, AHCYL1, MRPL21, MRPL13, MRPL17, PURA, PPAN-P2RY11, NSA2, MRPL30, MRPL14, MALSU1, HIST2H2AB, MRPL34, MRPS21, LTBR, APP, CTBP2, KIF3C, LGALS3BP, LLGL2, PTTG1, THOC1, SETD1B, ELMSAN1, ZFC3H1, MZT1, IKZF5, CACNG5, C11orf57, TMEM102, SSSCA1, APOBEC3D, SRSF1 | LY6H | KRTAP5-9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZC3H3_LY6H |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZC3H3_LY6H |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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