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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42577

FusionGeneSummary for ZC3H18_ZFPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H18_ZFPM1
Fusion gene ID: 42577
HgeneTgene
Gene symbol

ZC3H18

ZFPM1

Gene ID

124245

161882

Gene namezinc finger CCCH-type containing 18zinc finger protein, FOG family member 1
SynonymsNHN1FOG|FOG1|ZC2HC11A|ZNF408|ZNF89A
Cytomap

16q24.2

16q24.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 18conserved nuclear protein NHN1nuclear protein NHN1zinc finger protein ZFPM1FOG-1friend of GATA 1friend of GATA protein 1zinc finger protein 89Azinc finger protein, multitype 1
Modification date2018051920180523
UniProtAcc

Q86VM9

Q8IX07

Ensembl transtripts involved in fusion geneENST00000301011, ENST00000452588, 
ENST00000319555, ENST00000569086, 
Fusion gene scores* DoF score6 X 6 X 4=1443 X 3 X 2=18
# samples 73
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZC3H18 [Title/Abstract] AND ZFPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZFPM1

GO:0010724

regulation of definitive erythrocyte differentiation

15920471

TgeneZFPM1

GO:0045078

positive regulation of interferon-gamma biosynthetic process

21646796

TgeneZFPM1

GO:0045403

negative regulation of interleukin-4 biosynthetic process

21646796


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A11C-01AZC3H18chr16

88644134

+ZFPM1chr16

88580795

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000301011ENST00000319555ZC3H18chr16

88644134

+ZFPM1chr16

88580795

+
5CDS-3UTRENST00000301011ENST00000569086ZC3H18chr16

88644134

+ZFPM1chr16

88580795

+
Frame-shitENST00000452588ENST00000319555ZC3H18chr16

88644134

+ZFPM1chr16

88580795

+
5CDS-3UTRENST00000452588ENST00000569086ZC3H18chr16

88644134

+ZFPM1chr16

88580795

+

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FusionProtFeatures for ZC3H18_ZFPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H18

Q86VM9

ZFPM1

Q8IX07

Transcription regulator that plays an essential role inerythroid and megakaryocytic cell differentiation. Essentialcofactor that acts via the formation of a heterodimer withtranscription factors of the GATA family GATA1, GATA2 and GATA3.Such heterodimer can both activate or repress transcriptionalactivity, depending on the cell and promoter context. Theheterodimer formed with GATA proteins is essential to activateexpression of genes such as NFE2, ITGA2B, alpha- and beta-globin,while it represses expression of KLF1. May be involved inregulation of some genes in gonads. May also be involved incardiac development, in a non-redundant way with ZFPM2/FOG2 (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H18_ZFPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H18_ZFPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZC3H18OSBPL10, SMARCAD1, SF3A2, SIRT7, TERF1, TERF2, CUL3, NHP2L1, CDC5L, UBE2S, USP10, BUD31, SAFB, SF3B3, SF3B6, S100A9, USP39, NCSTN, SEPT2, HNRNPC, SMU1, SF3A1, HNRNPU, PSIP1, TRPM8, WDR70, VASN, RBM14, RBMX, HP1BP3, LGR4, CSNK2A2, MOV10, NXF1, LUC7L, LUC7L2, C9orf41, PTGER3, EPB41L3, NTRK1, RNPS1, RPL6, RTF1, SLC3A2, SRRM2, ACIN1, BRD4, LEO1, NUMA1, PNN, SNRPD2, SRRT, SSRP1, SUPT16H, KRAS, FBXW11, SRPK2, CLK1, CCNA2, RBM7, FERMT3, MZT1, FBXW7, ZC3H13, FNBP4, KIAA1429, CLK4, CLK3, RBBP6, YTHDC1, C10orf2, PRPF38B, CLK2, PRPF40A, TOPORS, ZFC3H1, RBM15B, RBMXL1, ZCCHC8, PRPF4B, SRSF12, PPHLN1, NKTR, SRSF8, CAMKV, ZC3H14, RBM25, CPSF4, WDR33, APOBEC3F, RBM6, TRA2A, TSPYL1, ERMAP, EXOSC10, SRSF1, RSBN1, AQR, RALY, CRNKL1, ELAVL2, DHX35, XAB2, PPIG, MKRN2, WDR83, U2AF2, ZC3H11A, SYF2, ZNF816, NKAP, PIP5K1A, SRSF10, TSPYL2, RBM15, NFKBIL1, CDC40, FIP1L1, SLTM, UPF1, KEAP1, CTR9, JPH4, SRRM1, ZNF214, GSPT2, ISY1, VANGL1, PPIE, SNW1, ZCCHC3ZFPM1GATA2, GATA1, RBBP4, MTA1, TRIM21, GSK3B, CTBP2, ERP44, DEFA6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H18_ZFPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H18_ZFPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource