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Fusion gene ID: 4256 |
FusionGeneSummary for BMPR2_ATG4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BMPR2_ATG4B | Fusion gene ID: 4256 | Hgene | Tgene | Gene symbol | BMPR2 | ATG4B | Gene ID | 659 | 23192 |
| Gene name | bone morphogenetic protein receptor type 2 | autophagy related 4B cysteine peptidase | |
| Synonyms | BMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALK | APG4B|AUTL1 | |
| Cytomap | 2q33.1-q33.2 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bone morphogenetic protein receptor type-2BMP type II receptorBMP type-2 receptorbone morphogenetic protein receptor type IIbone morphogenetic protein receptor, type II (serine/threonine kinase)type II activin receptor-like kinasetype II receptor fo | cysteine protease ATG4BAPG4 autophagy 4 homolog BATG4 autophagy related 4 homolog BAUT-like 1 cysteine endopeptidaseautophagin-1autophagy-related cysteine endopeptidase 1autophagy-related protein 4 homolog BhAPG4B | |
| Modification date | 20180527 | 20180526 | |
| UniProtAcc | Q13873 | Q9Y4P1 | |
| Ensembl transtripts involved in fusion gene | ENST00000374580, ENST00000374574, ENST00000479069, | ENST00000405546, ENST00000402096, ENST00000404914, ENST00000491867, ENST00000396411, ENST00000474739, | |
| Fusion gene scores | * DoF score | 11 X 7 X 7=539 | 2 X 1 X 2=4 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/539*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: BMPR2 [Title/Abstract] AND ATG4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BMPR2 | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 12045205 |
| Hgene | BMPR2 | GO:0010634 | positive regulation of epithelial cell migration | 12819188 |
| Hgene | BMPR2 | GO:0030308 | negative regulation of cell growth | 12819188 |
| Hgene | BMPR2 | GO:0030509 | BMP signaling pathway | 18436533 |
| Tgene | ATG4B | GO:0006508 | proteolysis | 15169837|18387192 |
| Tgene | ATG4B | GO:0006914 | autophagy | 18387192 |
| Tgene | ATG4B | GO:0051697 | protein delipidation | 25327288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-63-6202-01A | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374580 | ENST00000405546 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374580 | ENST00000402096 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374580 | ENST00000404914 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-3UTR | ENST00000374580 | ENST00000491867 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374580 | ENST00000396411 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374580 | ENST00000474739 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| In-frame | ENST00000374574 | ENST00000405546 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374574 | ENST00000402096 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374574 | ENST00000404914 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-3UTR | ENST00000374574 | ENST00000491867 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374574 | ENST00000396411 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 5CDS-5UTR | ENST00000374574 | ENST00000474739 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-3CDS | ENST00000479069 | ENST00000405546 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-5UTR | ENST00000479069 | ENST00000402096 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-5UTR | ENST00000479069 | ENST00000404914 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-3UTR | ENST00000479069 | ENST00000491867 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-5UTR | ENST00000479069 | ENST00000396411 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
| 3UTR-5UTR | ENST00000479069 | ENST00000474739 | BMPR2 | chr2 | 203332412 | + | ATG4B | chr2 | 242590425 | + |
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FusionProtFeatures for BMPR2_ATG4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BMPR2 | ATG4B |
| On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threoninekinases. Type II receptors phosphorylate and activate type Ireceptors which autophosphorylate, then bind and activate SMADtranscriptional regulators. Binds to BMP7, BMP2 and, lessefficiently, BMP4. Binding is weak but enhanced by the presence oftype I receptors for BMPs. Mediates induction of adipogenesis byGDF6. {ECO:0000250|UniProtKB:O35607}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 547_550 | 139 | 1039 | Compositional bias | Note=Poly-Ser |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 610_618 | 139 | 1039 | Compositional bias | Note=Poly-Thr |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 901_908 | 139 | 1039 | Compositional bias | Note=Poly-Asn |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 203_504 | 139 | 1039 | Domain | Protein kinase |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 209_217 | 139 | 1039 | Nucleotide binding | ATP |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 280_282 | 139 | 1039 | Nucleotide binding | ATP |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 337_338 | 139 | 1039 | Nucleotide binding | ATP |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 172_1038 | 139 | 1039 | Topological domain | Cytoplasmic |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 27_150 | 139 | 1039 | Topological domain | Extracellular |
| Hgene | >BMPR2 | chr2:203332412 | chr2:242590425 | ENST00000374580 | + | 3 | 13 | 151_171 | 139 | 1039 | Transmembrane | Helical |
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FusionGeneSequence for BMPR2_ATG4B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BMPR2_ENST00000374580_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_517aa MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGD PQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLTTLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILS DVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVG EGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVL LIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELD >In-frame_BMPR2_ENST00000374574_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_517aa MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGD PQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLTTLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILS DVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVG EGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVL LIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BMPR2_ENST00000374580_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_1551nt ATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAA GAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGC TCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGAT CCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACA GATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCACTACTCTGACCTACGACACTCTCCGGTTTGCT GAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCT GATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGC ATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAG CCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGC GAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTG GCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCG TTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTT CTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGCACTGCTTCATGATGCCCCAGTCCCTGGGC GTCATCGGAGGGAAGCCCAACAGCGCCCACTACTTCATCGGCTACGTTGGTGAGGAGCTCATCTACCTGGACCCCCACACCACGCAGCCA GCCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACTGCCAGCACCCGCCGTGCCGCATGAGCATCGCGGAGCTTGAC CCGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGATGACTTCAATGATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGT GCCCTGCCCATGTTTGAGCTGGTGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGGTGAGAGCTGCCAA >In-frame_BMPR2_ENST00000374574_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_1551nt ATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAA GAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGC TCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGAT CCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACA GATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCACTACTCTGACCTACGACACTCTCCGGTTTGCT GAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCT GATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGC ATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAG CCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGC GAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTG GCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCG TTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTT CTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGCACTGCTTCATGATGCCCCAGTCCCTGGGC GTCATCGGAGGGAAGCCCAACAGCGCCCACTACTTCATCGGCTACGTTGGTGAGGAGCTCATCTACCTGGACCCCCACACCACGCAGCCA GCCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACTGCCAGCACCCGCCGTGCCGCATGAGCATCGCGGAGCTTGAC CCGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGATGACTTCAATGATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGT GCCCTGCCCATGTTTGAGCTGGTGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGGTGAGAGCTGCCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BMPR2_ENST00000374580_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_3739nt GGAAGCACCGAAGCGAAACTTAAGGAATCCTGCCTTCCCGGAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCC GGCTTCGTCCTTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGAATCCCCGCCCTCCGCACCCTGGATATGT TTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAACTACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCAC AGACATGCCTTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGGAGAGAAATGAAGGGAATTTCT GCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCAGCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGG GAGAGAAGACGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGA TGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAG AACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCT CGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATC CCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAG ATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCACTACTCTGACCTACGACACTCTCCGGTTTGCTG AGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTAGAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTG ATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCATTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCA TGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGCACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGC CAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACAGTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCG AAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGGTCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGG CGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAAGGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGT TTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTGAGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTC TCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGGAGACGCTGAAGCACTGCTTCATGATGCCCCAGTCCCTGGGCG TCATCGGAGGGAAGCCCAACAGCGCCCACTACTTCATCGGCTACGTTGGTGAGGAGCTCATCTACCTGGACCCCCACACCACGCAGCCAG CCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACTGCCAGCACCCGCCGTGCCGCATGAGCATCGCGGAGCTTGACC CGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGATGACTTCAATGATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGTG CCCTGCCCATGTTTGAGCTGGTGGAGCTGCAGCCTTCACATCTGGCCTGCCCCGACGTCCTGAACCTGTCCCTAGGTGAGAGCTGCCAAG TCCAGATTCTTCTGATGTAGAGCGACTGGAAAGATTCTTCGACTCAGAAGATGAAGACTTTGAAATCCTGTCCCTTTGAAAATCCTGGGG TCGGGGGTGGCACCTGTGAGAGCCTGGGGCTCCTGGTGCCGCTGCGTTTCATCCATCCCGCCCGCTCGCCTGCCGAGGGCTGCGCCCCGT GCTGCCTCCCCCCAGAGGGCCACCCGCTGTGCTCGTGGACTGAGGCTGCGCTGCCCGGGAGGCCTTACTGCTTGGTGTCAGACTGCCCAG CTCAGAGTGCCCGTCAGGGCCTGTGCATCCGCACGCGGAGCCGTCTGTTAGGAGCTTCCAGAGTGTTCTCTCGACACTGCCAGCCCCGTG TTAGCACCTGGGCCTCAGTCCCACTTGCTCCCAGGCGCCGGTTCTGTGGTTGGTTTGGAATTAAAGTCCTGTTTGAAGTTGTCAGACACA GACATGAATTTCTGGGCGCTCCCTGAGTCAGAGTCTCAGAAGACCTGTGCAGGCTGGCGTGAGAGGAGCGGCAGCCACACTGCGGCCCCA CGCCCAAGGACTGGGCTGCTCTCGAGGGGGGCGCGCCCACCGCTGTGTCCTCTCTGCCCAGCCTGGCTTACCAAGGGCTACCTCAGTGGG AGATGAGGTTGGAGGAACGAAGGCGAGGTTCCTCCTTGCTTTGGGGAGAAAAGTATTCAGGAAGTGGGTGTGTGGGAAACCTGAAGATGG CGTGCACAGGACACAGCGTGGGCGGCCTGGGCAGAAGGGCGGCTGGCTGTCCTGGAGCTGCTGCTGGAGCCTGCCCTCAGAGTGTCCCTT TCCAGTGCTGTGGCATTCTGTGGCAGCTTCCCCAGGTGTGGTGACGGGGGGGGGGCGGGGCCTCCACCTGTGACAGCCAGGCTTGAGGGT GGACGGCGTGCCTCTCCCAGGAGCCTTCCCCATGTCCTTGCCTTGCTGAGAATTGCCCTCCCATGCCGCTGAGGTGTTAGGTGGTTTAGG GCCAAAAGGGGAAAACCACTTGAGTCTTGTGGTGTGTGGTGGGCAGACACCACAGGGTGGCATCACCTGGTGGCATTTCCAGAACCTCAG CCCCGATTCCAGCACCCACCACCGCCTGACCCTGTGTAACCTGCTGTCCCGGGTCCCAGAGTGCACTCTGCCCCGCTGCTCTGCTGCCTG TCCTGGGAAAGTATCTTTGCCCCACTAGGAAATGTAAACAGGAGGGCTTGGGGAGCGTGGGCACTTTTCTCATGAGCAGCTACTGCGGCG TTGGCAGGACTCGCTGCTGCTGCTGCTGCTTGTGTAGGTCGGGGAGCCAGAGATCCCCGAGGACGCGCGCCGGACAGTCGGCACTGACCG GCCCACCTGGTAGCAGAGGACACCCCCAGCCCCCCAAGCATTGAAGACATAGTGTATTTCCTCGTATCCTTTCTCCCTTGGGTGTAGTTG GGGTGGGGAAGCAGGGAAGGCTGGTGCGATCTCCATTCCTTGGGCTCCACGTCCGAGTTCATGGTGCGCCGCTGTGCTGGGAGCTGCAGT GGTAATGTGTGGGACACCTTGACCAAAGGGGAGCTTTGTCTCGTGTGTTTTGAAAAAGGCTTAATGAAGAGAATGTTGTTCATTCTTAGT >In-frame_BMPR2_ENST00000374574_chr2_203332412_+_ATG4B_ENST00000405546_chr2_242590425_+_3241nt ATTTCTTTTCTTTGCCCTCCTGATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGA CCATCCTGCTGGTCAGCACTGCGGCTGCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTATCAGCAAGACCTTGGGATAG GTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACA TAAATCTTGTAAAACAAGGATGTTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTAGTAACTACCACTCCTCCCT CAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACAGATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAA CACCACTCACTACTCTGACCTACGACACTCTCCGGTTTGCTGAGTTTGAAGATTTTCCTGAGACCTCAGAGCCCGTTTGGATACTGGGTA GAAAATACAGCATTTTCACAGAAAAGGACGAGATCTTGTCTGATGTGGCATCTAGACTTTGGTTTACATACAGGAAAAACTTTCCAGCCA TTGGGGGGACAGGCCCCACCTCGGACACAGGCTGGGGCTGCATGCTGCGGTGTGGACAGATGATCTTTGCCCAAGCCCTGGTGTGCCGGC ACCTAGGCCGAGATTGGAGGTGGACACAAAGGAAGAGGCAGCCAGACAGCTACTTCAGCGTCCTCAACGCATTCATCGACAGGAAGGACA GTTACTACTCCATTCACCAGATAGCGCAAATGGGAGTTGGCGAAGGCAAGTCCATAGGCCAGTGGTACGGGCCCAACACTGTCGCCCAGG TCCTGAAGAAGCTTGCTGTCTTCGATACGTGGAGCTCCTTGGCGGTCCACATTGCAATGGACAACACTGTTGTGATGGAGGAAATCAGAA GGTTGTGCAGGACCAGCGTTCCCTGTGCAGGCGCCACTGCGTTTCCTGCAGATTCCGACCGGCACTGCAACGGATTCCCTGCCGGAGCTG AGGTCACCAACAGGCCGTCGCCATGGAGACCCCTGGTACTTCTCATTCCCCTGCGCCTGGGGCTCACGGACATCAACGAGGCCTACGTGG AGACGCTGAAGCACTGCTTCATGATGCCCCAGTCCCTGGGCGTCATCGGAGGGAAGCCCAACAGCGCCCACTACTTCATCGGCTACGTTG GTGAGGAGCTCATCTACCTGGACCCCCACACCACGCAGCCAGCCGTGGAGCCCACTGATGGCTGCTTCATCCCGGACGAGAGCTTCCACT GCCAGCACCCGCCGTGCCGCATGAGCATCGCGGAGCTTGACCCGTCCATCGCTGTGGGGTTTTTCTGTAAGACTGAAGATGACTTCAATG ATTGGTGCCAGCAAGTCAAAAAGCTGTCTCTGCTTGGAGGTGCCCTGCCCATGTTTGAGCTGGTGGAGCTGCAGCCTTCACATCTGGCCT GCCCCGACGTCCTGAACCTGTCCCTAGGTGAGAGCTGCCAAGTCCAGATTCTTCTGATGTAGAGCGACTGGAAAGATTCTTCGACTCAGA AGATGAAGACTTTGAAATCCTGTCCCTTTGAAAATCCTGGGGTCGGGGGTGGCACCTGTGAGAGCCTGGGGCTCCTGGTGCCGCTGCGTT TCATCCATCCCGCCCGCTCGCCTGCCGAGGGCTGCGCCCCGTGCTGCCTCCCCCCAGAGGGCCACCCGCTGTGCTCGTGGACTGAGGCTG CGCTGCCCGGGAGGCCTTACTGCTTGGTGTCAGACTGCCCAGCTCAGAGTGCCCGTCAGGGCCTGTGCATCCGCACGCGGAGCCGTCTGT TAGGAGCTTCCAGAGTGTTCTCTCGACACTGCCAGCCCCGTGTTAGCACCTGGGCCTCAGTCCCACTTGCTCCCAGGCGCCGGTTCTGTG GTTGGTTTGGAATTAAAGTCCTGTTTGAAGTTGTCAGACACAGACATGAATTTCTGGGCGCTCCCTGAGTCAGAGTCTCAGAAGACCTGT GCAGGCTGGCGTGAGAGGAGCGGCAGCCACACTGCGGCCCCACGCCCAAGGACTGGGCTGCTCTCGAGGGGGGCGCGCCCACCGCTGTGT CCTCTCTGCCCAGCCTGGCTTACCAAGGGCTACCTCAGTGGGAGATGAGGTTGGAGGAACGAAGGCGAGGTTCCTCCTTGCTTTGGGGAG AAAAGTATTCAGGAAGTGGGTGTGTGGGAAACCTGAAGATGGCGTGCACAGGACACAGCGTGGGCGGCCTGGGCAGAAGGGCGGCTGGCT GTCCTGGAGCTGCTGCTGGAGCCTGCCCTCAGAGTGTCCCTTTCCAGTGCTGTGGCATTCTGTGGCAGCTTCCCCAGGTGTGGTGACGGG GGGGGGGCGGGGCCTCCACCTGTGACAGCCAGGCTTGAGGGTGGACGGCGTGCCTCTCCCAGGAGCCTTCCCCATGTCCTTGCCTTGCTG AGAATTGCCCTCCCATGCCGCTGAGGTGTTAGGTGGTTTAGGGCCAAAAGGGGAAAACCACTTGAGTCTTGTGGTGTGTGGTGGGCAGAC ACCACAGGGTGGCATCACCTGGTGGCATTTCCAGAACCTCAGCCCCGATTCCAGCACCCACCACCGCCTGACCCTGTGTAACCTGCTGTC CCGGGTCCCAGAGTGCACTCTGCCCCGCTGCTCTGCTGCCTGTCCTGGGAAAGTATCTTTGCCCCACTAGGAAATGTAAACAGGAGGGCT TGGGGAGCGTGGGCACTTTTCTCATGAGCAGCTACTGCGGCGTTGGCAGGACTCGCTGCTGCTGCTGCTGCTTGTGTAGGTCGGGGAGCC AGAGATCCCCGAGGACGCGCGCCGGACAGTCGGCACTGACCGGCCCACCTGGTAGCAGAGGACACCCCCAGCCCCCCAAGCATTGAAGAC ATAGTGTATTTCCTCGTATCCTTTCTCCCTTGGGTGTAGTTGGGGTGGGGAAGCAGGGAAGGCTGGTGCGATCTCCATTCCTTGGGCTCC ACGTCCGAGTTCATGGTGCGCCGCTGTGCTGGGAGCTGCAGTGGTAATGTGTGGGACACCTTGACCAAAGGGGAGCTTTGTCTCGTGTGT TTTGAAAAAGGCTTAATGAAGAGAATGTTGTTCATTCTTAGTAGTATAGTTTGCAATTCTTAATGGCAAATAATAAGTTTCAGTAGAAAA |
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FusionGenePPI for BMPR2_ATG4B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BMPR2 | LIMK1, CES3, GCGR, CRYAB, FRS3, TGFBR1, ACVR1B, TSR1, ACVR1, BMPR1A, BMPR1B, BMP2, BMP7, GDF5, GDF6, BMP4, BMP6, GDF9, BMPR2, FHL2, XIAP, MAPK8, FST, TRIB3, SMAD6, SMAD7, PPP1CC, CAV1, GDF2, BMP10, PYCARD, CDH1, LRRIQ1, C16orf58, MRAP2, CD83, C14orf37, RNF11 | ATG4B | GABARAPL2, LINC00341, MAP1LC3B, GABARAP, FBXW11, AMBRA1, ATG10, ATG12, ATG3, GABARAPL1, KRT4, ANXA1, CAMKK2, MAP1LC3A, STK3, ULK1, SQSTM1, YWHAB, BAG3, SHMT2, MOV10, NXF1, FANK1, STK16, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BMPR2_ATG4B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | BMPR2 | Q13873 | DB11639 | Dibotermin alfa | Bone morphogenetic protein receptor type-2 | biotech | approved|investigational |
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RelatedDiseases for BMPR2_ATG4B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BMPR2 | C0020542 | Pulmonary Hypertension | 9 | CTD_human;HPO |
| Hgene | BMPR2 | C3203102 | Idiopathic pulmonary arterial hypertension | 7 | HPO;UNIPROT |
| Hgene | BMPR2 | C0206081 | Hyperandrogenism | 1 | CTD_human |
| Hgene | BMPR2 | C0340543 | Familial primary pulmonary hypertension | 1 | CTD_human;ORPHANET |
| Hgene | BMPR2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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