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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42557

FusionGeneSummary for ZC3H11A_FIP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H11A_FIP1L1
Fusion gene ID: 42557
HgeneTgene
Gene symbol

ZC3H11A

FIP1L1

Gene ID

9877

81608

Gene namezinc finger CCCH-type containing 11Afactor interacting with PAPOLA and CPSF1
SynonymsZC3HDC11AFIP1|Rhe|hFip1
Cytomap

1q32.1

4q12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 11Azinc finger CCCH-type domain containing 11Apre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia
Modification date2018052320180523
UniProtAcc

O75152

Q6UN15

Ensembl transtripts involved in fusion geneENST00000367214, ENST00000367212, 
ENST00000332127, ENST00000545588, 
ENST00000367210, ENST00000466470, 
ENST00000507166, ENST00000358575, 
ENST00000337488, ENST00000507922, 
ENST00000306932, ENST00000510668, 
Fusion gene scores* DoF score4 X 4 X 3=489 X 10 X 5=450
# samples 413
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/450*10)=-1.79141337818858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3H11A [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-E1-A7YD-01AZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000367214ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367214ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367214ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367214ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367214ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
5CDS-intronENST00000367214ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367212ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367212ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367212ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367212ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367212ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
5CDS-intronENST00000367212ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000332127ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000332127ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000332127ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000332127ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000332127ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
5CDS-intronENST00000332127ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000545588ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000545588ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000545588ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000545588ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000545588ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
5CDS-intronENST00000545588ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367210ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367210ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367210ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367210ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
Frame-shiftENST00000367210ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
5CDS-intronENST00000367210ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-3CDSENST00000466470ENST00000507166ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-3CDSENST00000466470ENST00000358575ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-3CDSENST00000466470ENST00000337488ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-3CDSENST00000466470ENST00000507922ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-3CDSENST00000466470ENST00000306932ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+
intron-intronENST00000466470ENST00000510668ZC3H11Achr1

203787817

+FIP1L1chr4

54292039

+

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FusionProtFeatures for ZC3H11A_FIP1L1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZC3H11A

O75152

FIP1L1

Q6UN15

Involved in nuclear mRNA export; probably mediated byassoociation with the TREX complex. {ECO:0000269|PubMed:22928037}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZC3H11A_FIP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZC3H11A_FIP1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZC3H11AMLH1, SIRT7, MRPL53, PQBP1, NDUFA2, SF1, SUGP1, SARNP, PPIF, SOD2, NDUFA7, RBM27, SERPINH1, UQCRFS1P1, RBMS1, NONO, PPIB, SRP19, TXLNG, SF3B4, SNX3, KIAA0101, HDAC9, TARDBP, LIN28A, RAPGEF4, BRCA1, CUL7, OBSL1, BMI1, SERPINB5, TRA2A, IER2, USP7, NTRK1, PFKFB2, XRCC3, THOC5, BCLAF1, THOC1, C17orf85, THOC2, THOC7, FOXM1, ELAVL2, C11orf57, KBTBD7, APOBEC3D, ZC3H18, GSPT2, XAGE1B, MTNR1A, SMARCB1FIP1L1CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZC3H11A_FIP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZC3H11A_FIP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZC3H11AC1458155Mammary Neoplasms1CTD_human
TgeneFIP1L1C1540912Hypereosinophilic syndrome1CTD_human