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Fusion gene ID: 42549 |
FusionGeneSummary for ZBTB8B_XYLT1 |
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Fusion gene information | Fusion gene name: ZBTB8B_XYLT1 | Fusion gene ID: 42549 | Hgene | Tgene | Gene symbol | ZBTB8B | XYLT1 | Gene ID | 728116 | 64131 |
Gene name | zinc finger and BTB domain containing 8B | xylosyltransferase 1 | |
Synonyms | ZNF916B | DBQD2|PXYLT1|XT-I|XT1|XTI|XYLTI|xylT-I | |
Cytomap | 1p35.1 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger and BTB domain-containing protein 8Bputative zinc finger and BTB domain-containing protein 8B | xylosyltransferase 1beta-D-xylosyltransferase 1peptide O-xylosyltransferase 1xylosyltransferase Ixylosyltransferase iota | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8NAP8 | Q86Y38 | |
Ensembl transtripts involved in fusion gene | ENST00000609129, | ENST00000261381, ENST00000568226, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZBTB8B [Title/Abstract] AND XYLT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV730447 | ZBTB8B | chr1 | 32931800 | + | XYLT1 | chr16 | 17272118 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000609129 | ENST00000261381 | ZBTB8B | chr1 | 32931800 | + | XYLT1 | chr16 | 17272118 | + |
intron-intron | ENST00000609129 | ENST00000568226 | ZBTB8B | chr1 | 32931800 | + | XYLT1 | chr16 | 17272118 | + |
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FusionProtFeatures for ZBTB8B_XYLT1 |
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Hgene | Tgene |
ZBTB8B | XYLT1 |
May be involved in transcriptional regulation. | Catalyzes the first step in the biosynthesis ofchondroitin sulfate and dermatan sulfate proteoglycans, such asDCN. Transfers D-xylose from UDP-D-xylose to specific serineresidues of the core protein (PubMed:15461586, PubMed:17189265,PubMed:24581741, PubMed:23982343). Required for normal embryonicand postnatal skeleton development, especially of the long bones(PubMed:24581741, PubMed:23982343). Required for normal maturationof chondrocytes during bone development, and normal onset ofossification (By similarity). {ECO:0000250|UniProtKB:Q811B1,ECO:0000269|PubMed:15461586, ECO:0000269|PubMed:17189265,ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:24581741}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB8B_XYLT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB8B_XYLT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB8B_XYLT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB8B_XYLT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | XYLT1 | C4014294 | DESBUQUOIS DYSPLASIA 2 | 2 | UNIPROT |
Tgene | XYLT1 | C0033847 | Pseudoxanthoma Elasticum | 1 | CTD_human;UNIPROT |
Tgene | XYLT1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |