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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42546

FusionGeneSummary for ZBTB7C_SCFD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB7C_SCFD2
Fusion gene ID: 42546
HgeneTgene
Gene symbol

ZBTB7C

SCFD2

Gene ID

201501

152579

Gene namezinc finger and BTB domain containing 7Csec1 family domain containing 2
SynonymsAPM-1|APM1|ZBTB36|ZNF857CSTXBP1L1
Cytomap

18q21.1

4q12

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 7CB230208J24Rikaffected by papillomavirus DNA integration in ME180 cells protein 1zinc finger and BTB domain containing 36zinc finger and BTB domain-containing protein 36zinc finger protein 857Csec1 family domain-containing protein 2syntaxin binding protein 1-like 1
Modification date2018051920180519
UniProtAcc

A1YPR0

Q8WU76

Ensembl transtripts involved in fusion geneENST00000535628, ENST00000588982, 
ENST00000586438, ENST00000590800, 
ENST00000332053, 
ENST00000401642, 
ENST00000388940, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 8 X 10=800
# samples 311
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZBTB7C [Title/Abstract] AND SCFD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZBTB7C

GO:0008285

negative regulation of cell proliferation

9427755


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-04-1361-01AZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000535628ENST00000401642ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000535628ENST00000388940ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000588982ENST00000401642ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000588982ENST00000388940ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000586438ENST00000401642ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000586438ENST00000388940ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
5UTR-3CDSENST00000590800ENST00000401642ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
5UTR-3CDSENST00000590800ENST00000388940ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000332053ENST00000401642ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-
intron-3CDSENST00000332053ENST00000388940ZBTB7Cchr18

45712305

-SCFD2chr4

54140168

-

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FusionProtFeatures for ZBTB7C_SCFD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB7C

A1YPR0

SCFD2

Q8WU76

May be a tumor suppressor gene.{ECO:0000269|PubMed:9427755}. May be involved in protein transport.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ZBTB7C_SCFD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB7C_SCFD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB7CSREBF1, CDC5L, JUN, ZBTB17SCFD2USE1, STX12, NAPG, SIRT2, RINT1, NBAS, SEC22B, BNIP1, ZW10, C19orf25, VAMP4, STX18


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB7C_SCFD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZBTB7C_SCFD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource