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Fusion gene ID: 42543 |
FusionGeneSummary for ZBTB7B_ZMPSTE24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB7B_ZMPSTE24 | Fusion gene ID: 42543 | Hgene | Tgene | Gene symbol | ZBTB7B | ZMPSTE24 | Gene ID | 51043 | 10269 |
| Gene name | zinc finger and BTB domain containing 7B | zinc metallopeptidase STE24 | |
| Synonyms | CKROX|THPOK|ZBTB15|ZFP-67|ZFP67|ZNF857B|c-KROX|hcKROX | FACE-1|FACE1|HGPS|PRO1|STE24|Ste24p | |
| Cytomap | 1q21.3 | 1p34.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 7BT-helper-inducing POZ/Krueppel-like factorkrueppel-related zinc finger protein cKroxzinc finger and BTB domain containing 15zinc finger protein 67 homologzinc finger protein 857Bzinc finger protein Th- | CAAX prenyl protease 1 homologfarnesylated proteins-converting enzyme 1prenyl protein-specific endoprotease 1zinc metallopeptidase STE24 homologzinc metalloproteinase Ste24 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15156 | O75844 | |
| Ensembl transtripts involved in fusion gene | ENST00000535420, ENST00000368426, ENST00000487542, ENST00000417934, ENST00000292176, | ENST00000372759, ENST00000479131, | |
| Fusion gene scores | * DoF score | 7 X 4 X 5=140 | 3 X 2 X 3=18 |
| # samples | 8 | 3 | |
| ** MAII score | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ZBTB7B [Title/Abstract] AND ZMPSTE24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-DD-A4NE-01A | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000535420 | ENST00000372759 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 5UTR-intron | ENST00000535420 | ENST00000479131 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 5UTR-3CDS | ENST00000368426 | ENST00000372759 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 5UTR-intron | ENST00000368426 | ENST00000479131 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 3UTR-3CDS | ENST00000487542 | ENST00000372759 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 3UTR-intron | ENST00000487542 | ENST00000479131 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 5UTR-3CDS | ENST00000417934 | ENST00000372759 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| 5UTR-intron | ENST00000417934 | ENST00000479131 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| intron-3CDS | ENST00000292176 | ENST00000372759 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
| intron-intron | ENST00000292176 | ENST00000479131 | ZBTB7B | chr1 | 154975419 | + | ZMPSTE24 | chr1 | 40733458 | + |
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FusionProtFeatures for ZBTB7B_ZMPSTE24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB7B | ZMPSTE24 |
| Transcription regulator that acts as a key regulator oflineage commitment of immature T-cell precursors. Exerts distinctbiological functions in the mammary epithelial cells and T cellsin a tissue-specific manner. Necessary and sufficient forcommitment of CD4 lineage, while its absence causes CD8commitment. Development of immature T-cell precursors (thymocytes)to either the CD4 helper or CD8 killer T-cell lineages correlatesprecisely with their T-cell receptor specificity for majorhistocompatibility complex class II or class I molecules,respectively. Cross-antagonism between ZBTB7B and CBF complexesare determinative to CD4 versus CD8 cell fate decision. SuppressesRUNX3 expression and imposes CD4+ lineage fate by inducing theSOCS suppressors of cytokine signaling. induces, as atranscriptional activator, SOCS genes expression which repressesRUNX3 expression and promotes the CD4+ lineage fate. During CD4lineage commitment, associates with multiple sites at the CD8locus, acting as a negative regulator of the CD8 promoter andenhancers by epigenetic silencing through the recruitment of classII histone deacetylases, such as HDAC4 and HDAC5, to these loci.Regulates the development of IL17-producing CD1d-restricted nauralkiller (NK) T cells. Also functions as an important metabolicregulator in the lactating mammary glands. Critical feed-forwardregulator of insulin signaling in mammary gland lactation,directly regulates expression of insulin receptor substrate-1(IRS-1) and insulin-induced Akt-mTOR-SREBP signaling (Bysimilarity). Transcriptional repressor of the collagen COL1A1 andCOL1A2 genes. May also function as a repressor of fibronectin andpossibly other extracellular matrix genes (PubMed:9370309). Potentdriver of brown fat development, thermogenesis and cold-inducedbeige fat formation. Recruits the brown fat lncRNA 1(Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenicgene expression in brown and beige adipocytes (By similarity).{ECO:0000250|UniProtKB:Q64321, ECO:0000269|PubMed:9370309}. | Proteolytically removes the C-terminal three residues offarnesylated proteins. Acts on lamin A/C. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB7B_ZMPSTE24 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB7B_ZMPSTE24 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ZBTB7B | GRAP2, ZNF277, SP1, SP3, EP300, PRPF8, MYBBP1A, CEBPZ, HSPH1, ZBTB7B, RELA, TFAP4, HDAC4, HDAC5, HDAC3, HDAC10, KPNA2, KAT5, NDN, BCL6, GRB2, PIN1, RPL9, NCK2, MORF4L2, ZBTB5, SORBS3, SH3YL1, SH3KBP1, IMP4, SYTL4, RNF2, CDK2AP1, P4HA3, TRIM25 | ZMPSTE24 | MME, ELAVL1, DDOST, S100A10, MGST3, ATP6V1H, NDUFB7, TMEM43, UQCRFS1P1, SYNJ2BP, RAB5C, GALNT2, HNRNPF, CD55, MRPS5, VDAC1, HNRNPUL1, KIAA2013, PTPN1, MRPL40, RAB10, BAG3, PMF1, RNF26, CYP1A1, CLTC, TCTN2, TCTN3, SLC18A1, TNFRSF17, GDPD5, VAC14, FDPS, MED21, DEFB4A, GPR21, GTF2E2, SLC17A2, TMPRSS12, SLC2A5, DUSP23, GJB7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB7B_ZMPSTE24 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB7B_ZMPSTE24 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ZMPSTE24 | C1837756 | MANDIBULOACRAL DYSPLASIA WITH TYPE B LIPODYSTROPHY | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | ZMPSTE24 | C0917990 | Acro-Osteolysis | 2 | CTD_human |
| Tgene | ZMPSTE24 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
| Tgene | ZMPSTE24 | C0023787 | Lipodystrophy | 1 | CTD_human |
| Tgene | ZMPSTE24 | C0024689 | Mandibular Diseases | 1 | CTD_human |
| Tgene | ZMPSTE24 | C0033300 | Progeria | 1 | CTD_human;ORPHANET |
| Tgene | ZMPSTE24 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | ZMPSTE24 | C1136321 | HIV-Associated Lipodystrophy Syndrome | 1 | CTD_human |
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