	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 4254

FusionGeneSummary for BMPR1B_PDLIM5

Fusion gene summary

Fusion gene information	Fusion gene name: BMPR1B_PDLIM5
	Fusion gene ID: 4254
		Hgene	Tgene
	Gene symbol	BMPR1B	PDLIM5
	Gene ID	658	10611
	Gene name	bone morphogenetic protein receptor type 1B	PDZ and LIM domain 5
	Synonyms	ALK-6\|ALK6\|AMDD\|BDA1D\|BDA2\|CDw293	ENH\|ENH1\|L9\|LIM
	Cytomap	4q22.3	4q22.3
	Type of gene	protein-coding	protein-coding
	Description	bone morphogenetic protein receptor type-1BBMP type-1B receptorBMPR-1Bactivin receptor-like kinase 6bone morphogenetic protein receptor, type IBserine/threonine receptor kinase	PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein
	Modification date	20180523	20180522
	UniProtAcc	O00238	Q96HC4
	Ensembl transtripts involved in fusion gene	ENST00000515059, ENST00000440890, ENST00000264568, ENST00000394931, ENST00000502683,	ENST00000450793, ENST00000538141, ENST00000380180, ENST00000318007, ENST00000437932, ENST00000317968, ENST00000542407, ENST00000508216, ENST00000514743, ENST00000380176, ENST00000359265, ENST00000512274, ENST00000504489,
Fusion gene scores	* DoF score	5 X 4 X 4=80	9 X 12 X 5=540
	# samples	6	12
	** MAII score	log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BMPR1B [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BMPR1B	GO:0006468	protein phosphorylation	12065756
Hgene	BMPR1B	GO:0030509	BMP signaling pathway	18436533

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-HC-A4ZV-01A	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
TCGA	RV	PRAD	TCGA-EJ-7330-01A	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000515059	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-3CDS	ENST00000515059	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-3CDS	ENST00000515059	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-3CDS	ENST00000515059	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-3CDS	ENST00000515059	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-3CDS	ENST00000515059	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000440890	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000440890	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000264568	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000264568	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000394931	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000394931	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-3CDS	ENST00000502683	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
intron-intron	ENST00000502683	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95444875	+
5UTR-intron	ENST00000515059	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-3UTR	ENST00000515059	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
5UTR-intron	ENST00000515059	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-3UTR	ENST00000440890	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000440890	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-3UTR	ENST00000264568	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000264568	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-3UTR	ENST00000394931	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000394931	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000450793	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000538141	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000380180	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000318007	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000437932	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000317968	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000542407	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000508216	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000514743	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-3UTR	ENST00000502683	ENST00000380176	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000359265	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000512274	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+
intron-intron	ENST00000502683	ENST00000504489	BMPR1B	chr4	95679219	+	PDLIM5	chr4	95561427	+

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FusionProtFeatures for BMPR1B_PDLIM5

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BMPR1B O00238	PDLIM5 Q96HC4
On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threoninekinases. Type II receptors phosphorylate and activate type Ireceptors which autophosphorylate, then bind and activate SMADtranscriptional regulators. Receptor for BMP7/OP-1 and GDF5.Positively regulates chondrocyte differentiation through GDF5interaction. {ECO:0000250\|UniProtKB:P36898}.	May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for BMPR1B_PDLIM5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BMPR1B_PDLIM5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
BMPR1B	BMPR2, GDF5, GDF6, BMP7, BMP4, BMPR1A, BMPR1B, BMP2, SNX6, TRAF6, XIAP, TSC22D1, IGSF1, SMURF1, SMAD6, BAMBI, APP, PEG10, USP15, EVA1C, OTUB1, TPRA1	PDLIM5	TRIM39, CACNA1B, PRKCB, PRKCE, GFI1B, NDUFA7, SIN3A, ELMSAN1, DSTN, FN1, CALU, EIF4A3, METTL1, NPLOC4, PDE12, ANP32A, CBS, IPO11, PKM, PLIN3, SRP14, UBA2, RAD23B, TPD52, ZYX, COIL, CCDC136, KRT40, KRTAP10-7, SUZ12, RNF2, BMI1, SIRT6, ILK, METTL6, RWDD2B, SYT11, DNAJC8, MAP2K1, MAP2K2, ARFIP2, CAMK2G, NTRK1, BTRC, MED4, SSX2IP, CEP128, CEP19, XPO1, CDH1, PDLIM7, TULP3, PHF19, NFATC2IP, DENR, TPM2, EMILIN1, ATG14, G3BP1, BRCA1, TES

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for BMPR1B_PDLIM5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BMPR1B_PDLIM5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BMPR1B	C1832702	BRACHYDACTYLY, TYPE A2	2	CTD_human;HPO;ORPHANET;UNIPROT
Hgene	BMPR1B	C0005941	Bone Diseases, Developmental	1	CTD_human
Hgene	BMPR1B	C0015393	Eye Abnormalities	1	CTD_human
Hgene	BMPR1B	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	BMPR1B	C0376634	Craniofacial Abnormalities	1	CTD_human
Hgene	BMPR1B	C1836182	Chondrodysplasia, acromesomelic, with genital anomalies	1	CTD_human
Hgene	BMPR1B	C4225183	BRACHYDACTYLY, TYPE A1, D	1	UNIPROT
Hgene	BMPR1B	C4225404	ACROMESOMELIC DYSPLASIA, DEMIRHAN TYPE	1	UNIPROT
Tgene	PDLIM5	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	PDLIM5	C0036341	Schizophrenia	4	PSYGENET
Tgene	PDLIM5	C0041696	Unipolar Depression	4	PSYGENET
Tgene	PDLIM5	C1269683	Major Depressive Disorder	4	PSYGENET
Tgene	PDLIM5	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	PDLIM5	C0221765	Chronic schizophrenia	1	PSYGENET

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Fusion gene ID: 4254

FusionGeneSummary for BMPR1B_PDLIM5

FusionProtFeatures for BMPR1B_PDLIM5

FusionGeneSequence for BMPR1B_PDLIM5

FusionGenePPI for BMPR1B_PDLIM5

RelatedDrugs for BMPR1B_PDLIM5

RelatedDiseases for BMPR1B_PDLIM5