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Fusion gene ID: 42534 |
FusionGeneSummary for ZBTB7A_MAP2K2 |
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Fusion gene information | Fusion gene name: ZBTB7A_MAP2K2 | Fusion gene ID: 42534 | Hgene | Tgene | Gene symbol | ZBTB7A | MAP2K2 | Gene ID | 51341 | 5605 |
Gene name | zinc finger and BTB domain containing 7A | mitogen-activated protein kinase kinase 2 | |
Synonyms | FBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemon | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | |
Cytomap | 19p13.3 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O95365 | P36507 | |
Ensembl transtripts involved in fusion gene | ENST00000322357, ENST00000601588, | ENST00000262948, ENST00000394867, ENST00000599345, | |
Fusion gene scores | * DoF score | 7 X 8 X 6=336 | 3 X 4 X 3=36 |
# samples | 8 | 5 | |
** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ZBTB7A [Title/Abstract] AND MAP2K2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
Tgene | MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-AX-A3FX-01A | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
TCGA | RV | UCEC | TCGA-EO-A22X-01A | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000322357 | ENST00000262948 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
In-frame | ENST00000322357 | ENST00000394867 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
5CDS-intron | ENST00000322357 | ENST00000599345 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
Frame-shift | ENST00000601588 | ENST00000262948 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
Frame-shift | ENST00000601588 | ENST00000394867 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
5CDS-intron | ENST00000601588 | ENST00000599345 | ZBTB7A | chr19 | 4053969 | - | MAP2K2 | chr19 | 4097341 | - |
5UTR-3CDS | ENST00000322357 | ENST00000262948 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
5UTR-3CDS | ENST00000322357 | ENST00000394867 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
5UTR-5UTR | ENST00000322357 | ENST00000599345 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
intron-3CDS | ENST00000601588 | ENST00000262948 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
intron-3CDS | ENST00000601588 | ENST00000394867 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
intron-5UTR | ENST00000601588 | ENST00000599345 | ZBTB7A | chr19 | 4066680 | - | MAP2K2 | chr19 | 4110653 | - |
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FusionProtFeatures for ZBTB7A_MAP2K2 |
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Hgene | Tgene |
ZBTB7A | MAP2K2 |
Plays a key role in the instruction of early lymphoidprogenitors to develop into B lineage by repressing T-cellinstructive Notch signals (By similarity). Specifically repressesthe transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to theconsensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).{ECO:0000250}. | Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAPkinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 175_181 | 420 | 585 | Compositional bias | Note=Poly-Ala |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 175_211 | 420 | 585 | Compositional bias | Note=Ala-rich |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 175_181 | 420 | 585 | Compositional bias | Note=Poly-Ala |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 175_211 | 420 | 585 | Compositional bias | Note=Ala-rich |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 34_101 | 420 | 585 | Domain | BTB |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 34_101 | 420 | 585 | Domain | BTB |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 382_404 | 420 | 585 | Zinc finger | C2H2-type 1 |
Hgene | ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 382_404 | 420 | 585 | Zinc finger | C2H2-type 1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 560_565 | 420 | 585 | Compositional bias | Note=Poly-Gly |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 560_565 | 420 | 585 | Compositional bias | Note=Poly-Gly |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 410_432 | 420 | 585 | Zinc finger | C2H2-type 2 |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 438_460 | 420 | 585 | Zinc finger | C2H2-type 3 |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000322357 | - | 2 | 3 | 466_490 | 420 | 585 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 410_432 | 420 | 585 | Zinc finger | C2H2-type 2 |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 438_460 | 420 | 585 | Zinc finger | C2H2-type 3 |
Hgene | >ZBTB7A | chr19:4053969 | chr19:4097341 | ENST00000601588 | - | 2 | 3 | 466_490 | 420 | 585 | Zinc finger | C2H2-type 4%3B atypical |
Tgene | MAP2K2 | chr19:4053969 | chr19:4097341 | ENST00000262948 | - | 6 | 11 | 266_315 | 306 | 401 | Compositional bias | Note=Pro-rich |
Tgene | MAP2K2 | chr19:4053969 | chr19:4097341 | ENST00000262948 | - | 6 | 11 | 72_369 | 306 | 401 | Domain | Protein kinase |
Tgene | MAP2K2 | chr19:4053969 | chr19:4097341 | ENST00000262948 | - | 6 | 11 | 78_86 | 306 | 401 | Nucleotide binding | ATP |
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FusionGeneSequence for ZBTB7A_MAP2K2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB7A_MAP2K2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZBTB7A | ZBTB7A, BCL6, TP53, HDAC1, HDAC2, HDAC3, SIRT1, NCOR1, NCOR2, SIN3A, RB1, BCOR, SP1, AR, TFAP4, EEF1A1, SREBF1, RELA, NFKBIB, NFKBIA, UTP20, SOX2, ZMYND8, ZBTB48, SOX9, HOMEZ, KHDRBS1, UBE2I, ETS1, SMAD4, TRIM25 | MAP2K2 | ARAF, MAPK3, MAPK1, MAP2K2, MEPCE, COPS5, YWHAB, MAP2K1, WDR83, RAF1, MAPK8, LIG4, BRAF, PEX14, ZNF207, FAM65B, IQGAP1, NFE2L2, EGFR, CCNDBP1, ART3, ACTL6A, TNF, PDLIM5, RPE, TXN, XPO1, SNW1, HSP90AA4P, HSP90AB3P, HSP90AB4P, HSP90AA5P, SERPINB2, HSPA8, TUBA4A, CD70, CCRN4L, DLD, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB7A_MAP2K2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MAP2K2 | P36507 | DB06616 | Bosutinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
Tgene | MAP2K2 | P36507 | DB08911 | Trametinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
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RelatedDiseases for ZBTB7A_MAP2K2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZBTB7A | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | ZBTB7A | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | ZBTB7A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | MAP2K2 | C3809007 | CARDIOFACIOCUTANEOUS SYNDROME 4 | 3 | UNIPROT |
Tgene | MAP2K2 | C1275081 | Cardio-facio-cutaneous syndrome | 2 | CTD_human;ORPHANET |
Tgene | MAP2K2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | MAP2K2 | C0025202 | melanoma | 1 | CTD_human |
Tgene | MAP2K2 | C0028326 | Noonan Syndrome | 1 | CTD_human |
Tgene | MAP2K2 | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |