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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42534

FusionGeneSummary for ZBTB7A_MAP2K2

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB7A_MAP2K2
Fusion gene ID: 42534
HgeneTgene
Gene symbol

ZBTB7A

MAP2K2

Gene ID

51341

5605

Gene namezinc finger and BTB domain containing 7Amitogen-activated protein kinase kinase 2
SynonymsFBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemonCFC4|MAPKK2|MEK2|MKK2|PRKMK2
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45
Modification date2018052320180523
UniProtAcc

O95365

P36507

Ensembl transtripts involved in fusion geneENST00000322357, ENST00000601588, 
ENST00000262948, ENST00000394867, 
ENST00000599345, 
Fusion gene scores* DoF score7 X 8 X 6=3363 X 4 X 3=36
# samples 85
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ZBTB7A [Title/Abstract] AND MAP2K2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP2K2

GO:0036289

peptidyl-serine autophosphorylation

8388392

TgeneMAP2K2

GO:0071902

positive regulation of protein serine/threonine kinase activity

8388392


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3FX-01AZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
TCGARVUCECTCGA-EO-A22X-01AZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000322357ENST00000262948ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
In-frameENST00000322357ENST00000394867ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
5CDS-intronENST00000322357ENST00000599345ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
Frame-shitENST00000601588ENST00000262948ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
Frame-shitENST00000601588ENST00000394867ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
5CDS-intronENST00000601588ENST00000599345ZBTB7Achr19

4053969

-MAP2K2chr19

4097341

-
5UTR-3CDSENST00000322357ENST00000262948ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
5UTR-3CDSENST00000322357ENST00000394867ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
5UTR-5UTRENST00000322357ENST00000599345ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
intron-3CDSENST00000601588ENST00000262948ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
intron-3CDSENST00000601588ENST00000394867ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-
intron-5UTRENST00000601588ENST00000599345ZBTB7Achr19

4066680

-MAP2K2chr19

4110653

-

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FusionProtFeatures for ZBTB7A_MAP2K2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB7A

O95365

MAP2K2

P36507

Plays a key role in the instruction of early lymphoidprogenitors to develop into B lineage by repressing T-cellinstructive Notch signals (By similarity). Specifically repressesthe transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to theconsensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).{ECO:0000250}. Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAPkinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23175_181420585Compositional biasNote=Poly-Ala
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23175_211420585Compositional biasNote=Ala-rich
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23175_181420585Compositional biasNote=Poly-Ala
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23175_211420585Compositional biasNote=Ala-rich
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-2334_101420585DomainBTB
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-2334_101420585DomainBTB
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23382_404420585Zinc fingerC2H2-type 1
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23382_404420585Zinc fingerC2H2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23560_565420585Compositional biasNote=Poly-Gly
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23560_565420585Compositional biasNote=Poly-Gly
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23410_432420585Zinc fingerC2H2-type 2
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23438_460420585Zinc fingerC2H2-type 3
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000322357-23466_490420585Zinc fingerC2H2-type 4%3B atypical
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23410_432420585Zinc fingerC2H2-type 2
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23438_460420585Zinc fingerC2H2-type 3
HgeneZBTB7Achr19:4053969chr19:4097341ENST00000601588-23466_490420585Zinc fingerC2H2-type 4%3B atypical
TgeneMAP2K2chr19:4053969chr19:4097341ENST00000262948-611266_315306401Compositional biasNote=Pro-rich
TgeneMAP2K2chr19:4053969chr19:4097341ENST00000262948-61172_369306401DomainProtein kinase
TgeneMAP2K2chr19:4053969chr19:4097341ENST00000262948-61178_86306401Nucleotide bindingATP


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FusionGeneSequence for ZBTB7A_MAP2K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB7A_MAP2K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB7AZBTB7A, BCL6, TP53, HDAC1, HDAC2, HDAC3, SIRT1, NCOR1, NCOR2, SIN3A, RB1, BCOR, SP1, AR, TFAP4, EEF1A1, SREBF1, RELA, NFKBIB, NFKBIA, UTP20, SOX2, ZMYND8, ZBTB48, SOX9, HOMEZ, KHDRBS1, UBE2I, ETS1, SMAD4, TRIM25MAP2K2ARAF, MAPK3, MAPK1, MAP2K2, MEPCE, COPS5, YWHAB, MAP2K1, WDR83, RAF1, MAPK8, LIG4, BRAF, PEX14, ZNF207, FAM65B, IQGAP1, NFE2L2, EGFR, CCNDBP1, ART3, ACTL6A, TNF, PDLIM5, RPE, TXN, XPO1, SNW1, HSP90AA4P, HSP90AB3P, HSP90AB4P, HSP90AA5P, SERPINB2, HSPA8, TUBA4A, CD70, CCRN4L, DLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB7A_MAP2K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMAP2K2P36507DB06616BosutinibDual specificity mitogen-activated protein kinase kinase 2small moleculeapproved
TgeneMAP2K2P36507DB08911TrametinibDual specificity mitogen-activated protein kinase kinase 2small moleculeapproved

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RelatedDiseases for ZBTB7A_MAP2K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZBTB7AC0017636Glioblastoma1CTD_human
HgeneZBTB7AC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneZBTB7AC0033578Prostatic Neoplasms1CTD_human
TgeneMAP2K2C3809007CARDIOFACIOCUTANEOUS SYNDROME 43UNIPROT
TgeneMAP2K2C1275081Cardio-facio-cutaneous syndrome2CTD_human;ORPHANET
TgeneMAP2K2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneMAP2K2C0025202melanoma1CTD_human
TgeneMAP2K2C0028326Noonan Syndrome1CTD_human
TgeneMAP2K2C0587248Costello syndrome (disorder)1CTD_human