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Fusion gene ID: 42533 |
FusionGeneSummary for ZBTB7A_DKK2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB7A_DKK2 | Fusion gene ID: 42533 | Hgene | Tgene | Gene symbol | ZBTB7A | DKK2 | Gene ID | 51341 | 27123 |
| Gene name | zinc finger and BTB domain containing 7A | dickkopf WNT signaling pathway inhibitor 2 | |
| Synonyms | FBI-1|FBI1|LRF|TIP21|ZBTB7|ZNF857A|pokemon | DKK-2 | |
| Cytomap | 19p13.3 | 4q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc finger and BTB domain-containing protein 7AHIV-1 1st-binding protein 1HIV-1 inducer of short transcripts binding proteinPOK erythroid myeloid ontogenic factorPOZ and Krueppel erythroid myeloid ontogenic factorTTF-I-interacting peptide 21factor | dickkopf-related protein 2dickkopf 2 homologdickkopf homolog 2dickkopf-2hDkk-2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95365 | Q9UBU2 | |
| Ensembl transtripts involved in fusion gene | ENST00000322357, ENST00000601588, | ENST00000513208, ENST00000510463, ENST00000285311, | |
| Fusion gene scores | * DoF score | 7 X 8 X 6=336 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZBTB7A [Title/Abstract] AND DKK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | DKK2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 11742004 |
| Tgene | DKK2 | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 12857724 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI052500 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000322357 | ENST00000513208 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| intron-intron | ENST00000322357 | ENST00000510463 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| intron-intron | ENST00000322357 | ENST00000285311 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| intron-intron | ENST00000601588 | ENST00000513208 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| intron-intron | ENST00000601588 | ENST00000510463 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
| intron-intron | ENST00000601588 | ENST00000285311 | ZBTB7A | chr19 | 4046660 | + | DKK2 | chr4 | 107945872 | + |
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FusionProtFeatures for ZBTB7A_DKK2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB7A | DKK2 |
| Plays a key role in the instruction of early lymphoidprogenitors to develop into B lineage by repressing T-cellinstructive Notch signals (By similarity). Specifically repressesthe transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to theconsensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity).{ECO:0000250}. | Antagonizes canonical Wnt signaling by inhibiting LRP5/6interaction with Wnt and by forming a ternary complex with thetransmembrane protein KREMEN that promotes internalization ofLRP5/6. DKKs play an important role in vertebrate development,where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis andeye formation. In the adult, Dkks are implicated in bone formationand bone disease, cancer and Alzheimer disease (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB7A_DKK2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB7A_DKK2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB7A_DKK2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB7A_DKK2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ZBTB7A | C0017636 | Glioblastoma | 1 | CTD_human |
| Hgene | ZBTB7A | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | ZBTB7A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | DKK2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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