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Fusion gene ID: 42522 |
FusionGeneSummary for ZBTB49_SUPT3H |
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Fusion gene information | Fusion gene name: ZBTB49_SUPT3H | Fusion gene ID: 42522 | Hgene | Tgene | Gene symbol | ZBTB49 | SUPT3H | Gene ID | 166793 | 8464 |
Gene name | zinc finger and BTB domain containing 49 | SPT3 homolog, SAGA and STAGA complex component | |
Synonyms | ZNF509 | SPT3|SPT3L | |
Cytomap | 4p16.3 | 6p21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger and BTB domain-containing protein 49zinc finger protein 509 | transcription initiation protein SPT3 homologSPT3-like proteinsuppressor of Ty 3 homolog | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6ZSB9 | O75486 | |
Ensembl transtripts involved in fusion gene | ENST00000355834, ENST00000538529, ENST00000337872, | ENST00000371460, ENST00000371459, ENST00000371461, ENST00000306867, ENST00000371458, ENST00000459689, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 15 X 7 X 9=945 |
# samples | 3 | 15 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/945*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZBTB49 [Title/Abstract] AND SUPT3H [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZBTB49 | GO:0007050 | cell cycle arrest | 25245946 |
Hgene | ZBTB49 | GO:0008285 | negative regulation of cell proliferation | 25245946 |
Hgene | ZBTB49 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25245946 |
Tgene | SUPT3H | GO:0016578 | histone deubiquitination | 18206972 |
Tgene | SUPT3H | GO:0043966 | histone H3 acetylation | 11564863 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-HB-A3YV-01A | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000355834 | ENST00000371460 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
intron-3CDS | ENST00000355834 | ENST00000371459 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
intron-3CDS | ENST00000355834 | ENST00000371461 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
intron-3CDS | ENST00000355834 | ENST00000306867 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
intron-intron | ENST00000355834 | ENST00000371458 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
intron-intron | ENST00000355834 | ENST00000459689 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000538529 | ENST00000371460 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000538529 | ENST00000371459 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000538529 | ENST00000371461 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000538529 | ENST00000306867 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
5CDS-intron | ENST00000538529 | ENST00000371458 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
5CDS-intron | ENST00000538529 | ENST00000459689 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000337872 | ENST00000371460 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000337872 | ENST00000371459 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000337872 | ENST00000371461 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
Frame-shift | ENST00000337872 | ENST00000306867 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
5CDS-intron | ENST00000337872 | ENST00000371458 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
5CDS-intron | ENST00000337872 | ENST00000459689 | ZBTB49 | chr4 | 4317697 | + | SUPT3H | chr6 | 44988369 | - |
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FusionProtFeatures for ZBTB49_SUPT3H |
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Hgene | Tgene |
ZBTB49 | SUPT3H |
Transcription factor. Inhibits cell proliferation byactivating either CDKN1A/p21 transcription or RB1 transcription.{ECO:0000269|PubMed:25245946}. Isoform 1: Binds CDKN1A promoter and activates itstranscription; this activity is further potentiated in thepresence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).{ECO:0000269|PubMed:25245946}. Isoform 3: Activates RB1 transcription most probably byantagonizing ZBTB17 repression of RB1. Does not bind directly RB1promoter. {ECO:0000269|PubMed:25245946}. | Probable transcriptional activator.{ECO:0000269|PubMed:9787080}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB49_SUPT3H |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB49_SUPT3H |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZBTB49 | HSP90AA1, POT1, TRAF2, GOPC, CEP70, ZBTB8A, KAT5, EP300, ZBTB17, HINFP | SUPT3H | MYC, TAF4, TAF5, KAT2A, TAF10, TRRAP, TAF6L, TAF5L, TADA3, TADA1, SF3B3, SUPT7L, TAF9, TAF12, DDB1, DDB2, ATXN7L3, USP22, ATXN7, TP53, KAT2B, MED1, MED16, MED17, MED13, MED12, PYGO2, TADA2B, CCDC101, SAP130, TADA2A, TCF3, HIST3H3, SUPT20H, SSSCA1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB49_SUPT3H |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB49_SUPT3H |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |