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Fusion gene ID: 42520 |
FusionGeneSummary for ZBTB49_IGKJ5 |
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Fusion gene information | Fusion gene name: ZBTB49_IGKJ5 | Fusion gene ID: 42520 | Hgene | Tgene | Gene symbol | ZBTB49 | IGKJ5 | Gene ID | 166793 | 28946 |
Gene name | zinc finger and BTB domain containing 49 | immunoglobulin kappa joining 5 | |
Synonyms | ZNF509 | J5 | |
Cytomap | 4p16.3 | 2p11.2 | |
Type of gene | protein-coding | other | |
Description | zinc finger and BTB domain-containing protein 49zinc finger protein 509 | - | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q6ZSB9 | ||
Ensembl transtripts involved in fusion gene | ENST00000355834, ENST00000538529, ENST00000337872, | ENST00000390238, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZBTB49 [Title/Abstract] AND IGKJ5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZBTB49 | GO:0007050 | cell cycle arrest | 25245946 |
Hgene | ZBTB49 | GO:0008285 | negative regulation of cell proliferation | 25245946 |
Hgene | ZBTB49 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 25245946 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-P3-A6SW-01A | ZBTB49 | chr4 | 4292080 | + | IGKJ5 | chr2 | 89160115 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000355834 | ENST00000390238 | ZBTB49 | chr4 | 4292080 | + | IGKJ5 | chr2 | 89160115 | - |
5UTR-3CDS | ENST00000538529 | ENST00000390238 | ZBTB49 | chr4 | 4292080 | + | IGKJ5 | chr2 | 89160115 | - |
5UTR-3CDS | ENST00000337872 | ENST00000390238 | ZBTB49 | chr4 | 4292080 | + | IGKJ5 | chr2 | 89160115 | - |
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FusionProtFeatures for ZBTB49_IGKJ5 |
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Hgene | Tgene |
ZBTB49 | IGKJ5 |
Transcription factor. Inhibits cell proliferation byactivating either CDKN1A/p21 transcription or RB1 transcription.{ECO:0000269|PubMed:25245946}. Isoform 1: Binds CDKN1A promoter and activates itstranscription; this activity is further potentiated in thepresence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).{ECO:0000269|PubMed:25245946}. Isoform 3: Activates RB1 transcription most probably byantagonizing ZBTB17 repression of RB1. Does not bind directly RB1promoter. {ECO:0000269|PubMed:25245946}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB49_IGKJ5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB49_IGKJ5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZBTB49 | HSP90AA1, POT1, TRAF2, GOPC, CEP70, ZBTB8A, KAT5, EP300, ZBTB17, HINFP | IGKJ5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB49_IGKJ5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB49_IGKJ5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |