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Fusion gene ID: 42519 |
FusionGeneSummary for ZBTB48_TAS1R1 |
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Fusion gene information | Fusion gene name: ZBTB48_TAS1R1 | Fusion gene ID: 42519 | Hgene | Tgene | Gene symbol | ZBTB48 | TAS1R1 | Gene ID | 3104 | 80835 |
Gene name | zinc finger and BTB domain containing 48 | taste 1 receptor member 1 | |
Synonyms | HKR3|TZAP|ZNF855|pp9964 | GM148|GPR70|T1R1|TR1 | |
Cytomap | 1p36.31 | 1p36.31 | |
Type of gene | protein-coding | protein-coding | |
Description | telomere zinc finger-associated proteinGLI-Kruppel family member HKR3krueppel-related zinc finger protein 3telomeric zinc finger-associated proteinzinc finger and BTB domain-containing protein 48zinc finger protein 855 | taste receptor type 1 member 1G-protein coupled receptor 70seven transmembrane helix receptortaste receptor, type 1, member 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P10074 | Q7RTX1 | |
Ensembl transtripts involved in fusion gene | ENST00000377674, | ENST00000333172, ENST00000328191, ENST00000351136, | |
Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ZBTB48 [Title/Abstract] AND TAS1R1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TAS1R1 | GO:0050917 | sensory perception of umami taste | 11917125 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-D8-A1XK-01A | ZBTB48 | chr1 | 6648904 | + | TAS1R1 | chr1 | 6637010 | + |
TCGA | LD | BRCA | TCGA-D8-A1XK-01A | ZBTB48 | chr1 | 6649110 | + | TAS1R1 | chr1 | 6637010 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000377674 | ENST00000333172 | ZBTB48 | chr1 | 6648904 | + | TAS1R1 | chr1 | 6637010 | + |
5CDS-intron | ENST00000377674 | ENST00000328191 | ZBTB48 | chr1 | 6648904 | + | TAS1R1 | chr1 | 6637010 | + |
5CDS-intron | ENST00000377674 | ENST00000351136 | ZBTB48 | chr1 | 6648904 | + | TAS1R1 | chr1 | 6637010 | + |
Frame-shift | ENST00000377674 | ENST00000333172 | ZBTB48 | chr1 | 6649110 | + | TAS1R1 | chr1 | 6637010 | + |
5CDS-intron | ENST00000377674 | ENST00000328191 | ZBTB48 | chr1 | 6649110 | + | TAS1R1 | chr1 | 6637010 | + |
5CDS-intron | ENST00000377674 | ENST00000351136 | ZBTB48 | chr1 | 6649110 | + | TAS1R1 | chr1 | 6637010 | + |
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FusionProtFeatures for ZBTB48_TAS1R1 |
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Hgene | Tgene |
ZBTB48 | TAS1R1 |
Telomere-binding protein that acts as a regulator oftelomere length (PubMed:28500257, PubMed:28082411). Directly bindsthe telomeric double-stranded 5'-TTAGGG-3' repeat(PubMed:28500257, PubMed:28082411). Preferentially binds totelomeres that have a low concentration of shelterin complex andacts as a regulator of telomere length by initiating telomeretrimming, a process that prevents the accumulation of aberrantlylong telomeres (PubMed:28082411). Also acts as a transcriptionregulator that binds to promoter regions (PubMed:7969177,PubMed:24382891, PubMed:28500257). Regulates expression of a smallsubset of genes, including MTFP1 (PubMed:28500257). Regulatesexpression the J and/or S elements in MHC II promoter(PubMed:7969177). Acts as a negative regulator of cellproliferation by specifically activating expression of ARF, atumor suppressor isoform of CDKN2A (PubMed:24382891).{ECO:0000269|PubMed:24382891, ECO:0000269|PubMed:28082411,ECO:0000269|PubMed:28500257, ECO:0000269|PubMed:7969177}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 26_89 | 590 | 689 | Domain | BTB |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 291_313 | 590 | 689 | Zinc finger | C2H2-type 1 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 319_341 | 590 | 689 | Zinc finger | C2H2-type 2%3B degenerate |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 350_372 | 590 | 689 | Zinc finger | C2H2-type 3 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 378_401 | 590 | 689 | Zinc finger | C2H2-type 4 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 407_430 | 590 | 689 | Zinc finger | C2H2-type 5 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 436_459 | 590 | 689 | Zinc finger | C2H2-type 6 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 465_487 | 590 | 689 | Zinc finger | C2H2-type 7 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 493_515 | 590 | 689 | Zinc finger | C2H2-type 8 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 521_544 | 590 | 689 | Zinc finger | C2H2-type 9 |
Hgene | ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 550_572 | 590 | 689 | Zinc finger | C2H2-type 10 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 589_603 | 491 | 842 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 625_639 | 491 | 842 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 661_680 | 491 | 842 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 702_725 | 491 | 842 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 747_761 | 491 | 842 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 783_795 | 491 | 842 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 817_841 | 491 | 842 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 589_603 | 237 | 588 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 625_639 | 237 | 588 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 661_680 | 237 | 588 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 702_725 | 237 | 588 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 747_761 | 237 | 588 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 783_795 | 237 | 588 | Topological domain | Extracellular |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 817_841 | 237 | 588 | Topological domain | Cytoplasmic |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 568_588 | 491 | 842 | Transmembrane | Helical%3B Name%3D1 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 604_624 | 491 | 842 | Transmembrane | Helical%3B Name%3D2 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 640_660 | 491 | 842 | Transmembrane | Helical%3B Name%3D3 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 681_701 | 491 | 842 | Transmembrane | Helical%3B Name%3D4 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 726_746 | 491 | 842 | Transmembrane | Helical%3B Name%3D5 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 762_782 | 491 | 842 | Transmembrane | Helical%3B Name%3D6 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 796_816 | 491 | 842 | Transmembrane | Helical%3B Name%3D7 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 568_588 | 237 | 588 | Transmembrane | Helical%3B Name%3D1 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 604_624 | 237 | 588 | Transmembrane | Helical%3B Name%3D2 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 640_660 | 237 | 588 | Transmembrane | Helical%3B Name%3D3 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 681_701 | 237 | 588 | Transmembrane | Helical%3B Name%3D4 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 726_746 | 237 | 588 | Transmembrane | Helical%3B Name%3D5 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 762_782 | 237 | 588 | Transmembrane | Helical%3B Name%3D6 |
Tgene | >TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 796_816 | 237 | 588 | Transmembrane | Helical%3B Name%3D7 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ZBTB48 | chr1:6648904 | chr1:6637010 | ENST00000377674 | + | 10 | 11 | 578_600 | 590 | 689 | Zinc finger | C2H2-type 11 |
Tgene | TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000333172 | + | 3 | 6 | 21_567 | 491 | 842 | Topological domain | Extracellular |
Tgene | TAS1R1 | chr1:6648904 | chr1:6637010 | ENST00000351136 | + | 2 | 5 | 21_567 | 237 | 588 | Topological domain | Extracellular |
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FusionGeneSequence for ZBTB48_TAS1R1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB48_TAS1R1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZBTB48 | C7orf34, DVL3, ZBTB8A, NUDT21, ILK, PNRC2, CDKN1A, TNFRSF14, RGS2, CDK2AP2, C11orf58, UPF2, EP300, ZBTB7A, ZBTB48, NME7, GPATCH2L, KRTAP10-5, PTTG1, DVL2, TRIM41, RET, CDC23, NCBP2, FBXO7, ETAA1, HIST1H1C, NSD1, HIST1H1A, ZNF121, ZC3HAV1, MRPS34, RRP7A, MRPS35, FBXO11, APOBEC3C, NOL6, RPL26L1, PTCD3, MRPS5, RPL36AL, HIRA, MRPS31, MRPS18C, ZNF777, LTV1, DAP3, ZBTB24, MRPS11, ZSCAN25, BMS1, DDX24, TPD52, DGCR8, MRPS9, CEBPZ, MRPS2, MRPS33, RBM34, FTSJ3, RPL5, CENPB, RBM28, RPS3A, RPL3, MRPS7, PBRM1, TSR1, DDX54, GZF1, SCAF1, DKC1, SRBD1, GNL2, DHX57, LRP2, GTPBP4, RBM19, ZNF771, NSA2, MRPS24, TEX10, RPF2, MRPS10, UTP23, RPL32, MAK16, RPS15, PPAN-P2RY11, CTCF, RPS3 | TAS1R1 | TAS1R3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB48_TAS1R1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB48_TAS1R1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |