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Fusion gene ID: 42499 |
FusionGeneSummary for ZBTB33_ZBTB33 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ZBTB33_ZBTB33 | Fusion gene ID: 42499 | Hgene | Tgene | Gene symbol | ZBTB33 | ZBTB33 | Gene ID | 10009 | 10009 |
| Gene name | zinc finger and BTB domain containing 33 | zinc finger and BTB domain containing 33 | |
| Synonyms | ZNF-kaiso|ZNF348 | ZNF-kaiso|ZNF348 | |
| Cytomap | Xq24 | Xq24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcriptional regulator KaisoWUGSC:H_DJ525N14.1kaiso transcription factorzinc finger and BTB domain-containing protein 33 | transcriptional regulator KaisoWUGSC:H_DJ525N14.1kaiso transcription factorzinc finger and BTB domain-containing protein 33 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q86T24 | Q86T24 | |
| Ensembl transtripts involved in fusion gene | ENST00000326624, ENST00000557385, | ENST00000326624, ENST00000557385, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ZBTB33 [Title/Abstract] AND ZBTB33 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ZBTB33 | GO:0045892 | negative regulation of transcription, DNA-templated | 16354688 |
| Tgene | ZBTB33 | GO:0045892 | negative regulation of transcription, DNA-templated | 16354688 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA837749 | ZBTB33 | chrX | 119392125 | + | ZBTB33 | chrX | 119392203 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000326624 | ENST00000326624 | ZBTB33 | chrX | 119392125 | + | ZBTB33 | chrX | 119392203 | - |
| 3UTR-intron | ENST00000326624 | ENST00000557385 | ZBTB33 | chrX | 119392125 | + | ZBTB33 | chrX | 119392203 | - |
| intron-3UTR | ENST00000557385 | ENST00000326624 | ZBTB33 | chrX | 119392125 | + | ZBTB33 | chrX | 119392203 | - |
| intron-intron | ENST00000557385 | ENST00000557385 | ZBTB33 | chrX | 119392125 | + | ZBTB33 | chrX | 119392203 | - |
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FusionProtFeatures for ZBTB33_ZBTB33 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ZBTB33 | ZBTB33 |
| Transcriptional regulator with bimodal DNA-bindingspecificity. Binds to methylated CpG dinucleotides in theconsensus sequence 5'-CGCG-3' and also binds to the non-methylatedconsensus sequence 5'-CTGCNA-3' also known as the consensus kaisobinding site (KBS). Recruits the N-CoR repressor complex topromote histone deacetylation and the formation of repressivechromatin structures in target gene promoters. May contribute tothe repression of target genes of the Wnt signaling pathway. Mayalso activate transcription of a subset of target genes by therecruitment of CTNND2. Represses expression of MMP7 in conjunctionwith transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1(PubMed:23251453). {ECO:0000269|PubMed:11445535,ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582,ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688,ECO:0000269|PubMed:23251453}. | Transcriptional regulator with bimodal DNA-bindingspecificity. Binds to methylated CpG dinucleotides in theconsensus sequence 5'-CGCG-3' and also binds to the non-methylatedconsensus sequence 5'-CTGCNA-3' also known as the consensus kaisobinding site (KBS). Recruits the N-CoR repressor complex topromote histone deacetylation and the formation of repressivechromatin structures in target gene promoters. May contribute tothe repression of target genes of the Wnt signaling pathway. Mayalso activate transcription of a subset of target genes by therecruitment of CTNND2. Represses expression of MMP7 in conjunctionwith transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1(PubMed:23251453). {ECO:0000269|PubMed:11445535,ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:15548582,ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:16354688,ECO:0000269|PubMed:23251453}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB33_ZBTB33 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB33_ZBTB33 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB33_ZBTB33 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB33_ZBTB33 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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