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Fusion gene ID: 42495 |
FusionGeneSummary for ZBTB25_TPRG1 |
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Fusion gene information | Fusion gene name: ZBTB25_TPRG1 | Fusion gene ID: 42495 | Hgene | Tgene | Gene symbol | ZBTB25 | TPRG1 | Gene ID | 7597 | 285386 |
Gene name | zinc finger and BTB domain containing 25 | tumor protein p63 regulated 1 | |
Synonyms | C14orf51|KUP|ZNF46 | FAM79B | |
Cytomap | 14q23.3 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger and BTB domain-containing protein 25zinc finger protein 46zinc finger protein KUP | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180523 | 20180403 | |
UniProtAcc | P24278 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000555220, ENST00000555424, ENST00000608382, ENST00000394715, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 12 X 6 X 6=432 |
# samples | 3 | 13 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZBTB25 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-L3-A524-01A | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000555220 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-3CDS | ENST00000555220 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-intron | ENST00000555220 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-3CDS | ENST00000555424 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-3CDS | ENST00000555424 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-intron | ENST00000555424 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
5UTR-3CDS | ENST00000608382 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
5UTR-3CDS | ENST00000608382 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
5UTR-intron | ENST00000608382 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-3CDS | ENST00000394715 | ENST00000433971 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-3CDS | ENST00000394715 | ENST00000345063 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
intron-intron | ENST00000394715 | ENST00000488841 | ZBTB25 | chr14 | 64970379 | - | TPRG1 | chr3 | 188956522 | + |
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FusionProtFeatures for ZBTB25_TPRG1 |
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Hgene | Tgene |
ZBTB25 | TPRG1 |
May be involved in transcriptional regulation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ZBTB25_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ZBTB25_TPRG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ZBTB25 | TRAF2, MDFI, MAPK9, KXD1, SORBS3, HCLS1, PCBD1, ZBTB25, SSX3, ZBTB1, COIL, FCGR3A, CYP2J2, DDIT3, TNIP1, SEPHS1, APIP, TSSK3, LZTS2, PNMA5, KCTD1, SUMO2, ELP6, C9orf41, FHL2, HSPA5 | TPRG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ZBTB25_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZBTB25_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |