	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 42489

FusionGeneSummary for ZBTB22_PLCG1

Fusion gene summary

Fusion gene information	Fusion gene name: ZBTB22_PLCG1
	Fusion gene ID: 42489
		Hgene	Tgene
	Gene symbol	ZBTB22	PLCG1
	Gene ID	9278	5335
	Gene name	zinc finger and BTB domain containing 22	phospholipase C gamma 1
	Synonyms	BING1\|ZBTB22A\|ZNF297\|ZNF297A\|fru\|fruitless	NCKAP3\|PLC-II\|PLC1\|PLC148\|PLCgamma1
	Cytomap	6p21.32	20q12
	Type of gene	protein-coding	protein-coding
	Description	zinc finger and BTB domain-containing protein 22zinc finger and BTB domain-containing protein 22Azinc finger protein 297	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-148PLC-gamma-1inositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphatidylinositol phospholipase Cphosphoinosit
	Modification date	20180522	20180522
	UniProtAcc	O15209	P19174
	Ensembl transtripts involved in fusion gene	ENST00000418724, ENST00000431845, ENST00000548019, ENST00000416097, ENST00000547592, ENST00000418540, ENST00000548484, ENST00000445320, ENST00000552144, ENST00000383196,	ENST00000244007, ENST00000373272, ENST00000373271, ENST00000608689,
Fusion gene scores	* DoF score	1 X 1 X 1=1	5 X 5 X 2=50
	# samples	1	5
	** MAII score	log2(1/1*10)=3.32192809488736	log2(5/50*10)=0
Context	PubMed: ZBTB22 [Title/Abstract] AND PLCG1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PLCG1	GO:0043536	positive regulation of blood vessel endothelial cell migration	20011604
Tgene	PLCG1	GO:0045766	positive regulation of angiogenesis	20011604
Tgene	PLCG1	GO:0071364	cellular response to epidermal growth factor stimulus	17229814

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AA018565	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000418724	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418724	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418724	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418724	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000431845	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000431845	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000431845	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000431845	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548019	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548019	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548019	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548019	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000416097	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000416097	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000416097	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000416097	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000547592	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000547592	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000547592	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000547592	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418540	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418540	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418540	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000418540	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548484	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548484	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548484	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000548484	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000445320	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000445320	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000445320	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000445320	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000552144	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000552144	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000552144	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000552144	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000383196	ENST00000244007	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000383196	ENST00000373272	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000383196	ENST00000373271	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-
intron-intron	ENST00000383196	ENST00000608689	ZBTB22	chr6	4514523	+	PLCG1	chr20	39797506	-

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FusionProtFeatures for ZBTB22_PLCG1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZBTB22 O15209	PLCG1 P19174
May be involved in transcriptional regulation.	Mediates the production of the second messengermolecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate(IP3). Plays an important role in the regulation of intracellularsignaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such asPDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role inactin reorganization and cell migration.{ECO:0000269\|PubMed:17229814}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ZBTB22_PLCG1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ZBTB22_PLCG1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ZBTB22_PLCG1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZBTB22_PLCG1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PLCG1	C0005586	Bipolar Disorder	1	PSYGENET
Tgene	PLCG1	C0018923	Hemangiosarcoma	1	CTD_human
Tgene	PLCG1	C0023493	Adult T-Cell Lymphoma/Leukemia	1	CTD_human
Tgene	PLCG1	C0036920	Sezary Syndrome	1	CTD_human
Tgene	PLCG1	C0079773	Lymphoma, T-Cell, Cutaneous	1	CTD_human

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Fusion gene ID: 42489

FusionGeneSummary for ZBTB22_PLCG1

FusionProtFeatures for ZBTB22_PLCG1

FusionGeneSequence for ZBTB22_PLCG1

FusionGenePPI for ZBTB22_PLCG1

RelatedDrugs for ZBTB22_PLCG1

RelatedDiseases for ZBTB22_PLCG1