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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 42461

FusionGeneSummary for ZBTB17_MTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: ZBTB17_MTOR
Fusion gene ID: 42461
HgeneTgene
Gene symbol

ZBTB17

MTOR

Gene ID

7709

2475

Gene namezinc finger and BTB domain containing 17mechanistic target of rapamycin kinase
SynonymsMIZ-1|ZNF151|ZNF60|pHZ-67FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
Cytomap

1p36.13

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger and BTB domain-containing protein 17Myc-interacting Zn finger protein-1zinc finger protein 151 (pHZ-67)zinc finger protein 60serine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o
Modification date2018052320180527
UniProtAcc

Q13105

P42345

Ensembl transtripts involved in fusion geneENST00000375743, ENST00000537142, 
ENST00000375733, ENST00000448462, 
ENST00000479282, 		ENST00000361445, 
ENST00000376838, ENST00000495435, 
Fusion gene scores* DoF score4 X 4 X 4=6411 X 12 X 7=924
# samples 416
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/924*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZBTB17 [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZBTB17

GO:0008285

negative regulation of cell proliferation

19160485

HgeneZBTB17

GO:0045944

positive regulation of transcription by RNA polymerase II

9312026

HgeneZBTB17

GO:0071158

positive regulation of cell cycle arrest

19160485

TgeneMTOR

GO:0001558

regulation of cell growth

18762023

TgeneMTOR

GO:0001934

positive regulation of protein phosphorylation

20233713

TgeneMTOR

GO:0006468

protein phosphorylation

12150926|15467718|18925875

TgeneMTOR

GO:0009267

cellular response to starvation

28223137

TgeneMTOR

GO:0016242

negative regulation of macroautophagy

25327288

TgeneMTOR

GO:0016310

phosphorylation

11853878|25327288

TgeneMTOR

GO:0034198

cellular response to amino acid starvation

22424946

TgeneMTOR

GO:0038202

TORC1 signaling

28223137

TgeneMTOR

GO:0043200

response to amino acid

18497260

TgeneMTOR

GO:0045727

positive regulation of translation

18762023

TgeneMTOR

GO:0046777

protein autophosphorylation

15467718

TgeneMTOR

GO:0071230

cellular response to amino acid stimulus

22424946

TgeneMTOR

GO:0071233

cellular response to leucine

22424946

TgeneMTOR

GO:1990253

cellular response to leucine starvation

22424946


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-BR-4357-01AZBTB17chr1

16269559

-MTORchr1

11227574

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375743ENST00000361445ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000375743ENST00000376838ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000375743ENST00000495435ZBTB17chr1

16269559

-MTORchr1

11227574

-
In-frameENST00000537142ENST00000361445ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000537142ENST00000376838ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000537142ENST00000495435ZBTB17chr1

16269559

-MTORchr1

11227574

-
In-frameENST00000375733ENST00000361445ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000375733ENST00000376838ZBTB17chr1

16269559

-MTORchr1

11227574

-
5CDS-intronENST00000375733ENST00000495435ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-3CDSENST00000448462ENST00000361445ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-intronENST00000448462ENST00000376838ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-intronENST00000448462ENST00000495435ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-3CDSENST00000479282ENST00000361445ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-intronENST00000479282ENST00000376838ZBTB17chr1

16269559

-MTORchr1

11227574

-
intron-intronENST00000479282ENST00000495435ZBTB17chr1

16269559

-MTORchr1

11227574

-

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FusionProtFeatures for ZBTB17_MTOR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ZBTB17

Q13105

MTOR

P42345

Transcription factor that can function as an activatoror repressor depending on its binding partners, and by targetingnegative regulators of cell cycle progression. Plays a criticalrole in early lymphocyte development, where it is essential toprevent apoptosis in lymphoid precursors, allowing them to survivein response to IL7 and undergo proper lineage commitment. Has beenshown to bind to the promoters of adenovirus major late proteinand cyclin D1 and activate transcription. Required for earlyembryonic development during gastrulation. Represses RB1transcription; this repression can be blocked by interaction withZBTB49 isoform 3/ZNF509S1 (PubMed:25245946).{ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:19164764,ECO:0000269|PubMed:25245946, ECO:0000269|PubMed:9308237,ECO:0000269|PubMed:9312026}. Serine/threonine protein kinase which is a centralregulator of cellular metabolism, growth and survival in responseto hormones, growth factors, nutrients, energy and stress signals.MTOR directly or indirectly regulates the phosphorylation of atleast 800 proteins. Functions as part of 2 structurally andfunctionally distinct signaling complexes mTORC1 and mTORC2 (mTORcomplex 1 and 2). Activated mTORC1 up-regulates protein synthesisby phosphorylating key regulators of mRNA translation and ribosomesynthesis. This includes phosphorylation of EIF4EBP1 and releaseof its inhibition toward the elongation initiation factor 4E(eiF4E). Moreover, phosphorylates and activates RPS6KB1 andRPS6KB2 that promote protein synthesis by modulating the activityof their downstream targets including ribosomal protein S6,eukaryotic translation initiation factor EIF4B, and the inhibitorof translation initiation PDCD4. Stimulates the pyrimidinebiosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, anddelayed regulation, through transcriptional enhancement of thepentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a laterstep in synthesis, this function is dependent on the mTORC1complex. Regulates ribosome synthesis by activating RNA polymeraseIII-dependent transcription through phosphorylation and inhibitionof MAF1 an RNA polymerase III-repressor. In parallel to proteinsynthesis, also regulates lipid synthesis through SREBF1/SREBP1and LPIN1. To maintain energy homeostasis mTORC1 may also regulatemitochondrial biogenesis through regulation of PPARGC1A. mTORC1also negatively regulates autophagy through phosphorylation ofULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventingactivation of ULK1. Also prevents autophagy throughphosphorylation of the autophagy inhibitor DAP. mTORC1 exerts afeedback control on upstream growth factor signaling that includesphosphorylation and activation of GRB10 a INSR-dependent signalingsuppressor. Among other potential targets mTORC1 may phosphorylateCLIP1 and regulate microtubules. As part of the mTORC2 complexMTOR may regulate other cellular processes including survival andorganization of the cytoskeleton. Plays a critical role in thephosphorylation at 'Ser-473' of AKT1, a pro-survival effector ofphosphoinositide 3-kinase, facilitating its activation by PDK1.mTORC2 may regulate the actin cytoskeleton, throughphosphorylation of PRKCA, PXN and activation of the Rho-typeguanine nucleotide exchange factors RHOA and RAC1A or RAC1B.mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'(PubMed:12087098, PubMed:12150925, PubMed:12150926,PubMed:12231510, PubMed:12718876, PubMed:14651849,PubMed:15268862, PubMed:15467718, PubMed:15545625,PubMed:15718470, PubMed:18497260, PubMed:18762023,PubMed:18925875, PubMed:20516213, PubMed:20537536,PubMed:21659604, PubMed:23429703, PubMed:23429704,PubMed:25799227, PubMed:26018084). Regulates osteoclastogenesis byadjusting the expression of CEBPB isoforms (By similarity).{ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098,ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926,ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876,ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862,ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625,ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:18497260,ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875,ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536,ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:23429703,ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:25799227,ECO:0000269|PubMed:26018084}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-13161_104609811DomainBTB
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-13161_104609804DomainBTB
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-12151_104527722DomainBTB
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316306_328609811Zinc fingerC2H2-type 1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316334_356609811Zinc fingerC2H2-type 2
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316362_384609811Zinc fingerC2H2-type 3
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316390_412609811Zinc fingerC2H2-type 4
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316418_440609811Zinc fingerC2H2-type 5
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316446_468609811Zinc fingerC2H2-type 6
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316474_496609811Zinc fingerC2H2-type 7
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316502_524609811Zinc fingerC2H2-type 8
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316530_552609811Zinc fingerC2H2-type 9
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316558_580609811Zinc fingerC2H2-type 10
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316586_608609811Zinc fingerC2H2-type 11
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316306_328609804Zinc fingerC2H2-type 1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316334_356609804Zinc fingerC2H2-type 2
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316362_384609804Zinc fingerC2H2-type 3
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316390_412609804Zinc fingerC2H2-type 4
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316418_440609804Zinc fingerC2H2-type 5
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316446_468609804Zinc fingerC2H2-type 6
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316474_496609804Zinc fingerC2H2-type 7
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316502_524609804Zinc fingerC2H2-type 8
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316530_552609804Zinc fingerC2H2-type 9
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316558_580609804Zinc fingerC2H2-type 10
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316586_608609804Zinc fingerC2H2-type 11
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215306_328527722Zinc fingerC2H2-type 1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215334_356527722Zinc fingerC2H2-type 2
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215362_384527722Zinc fingerC2H2-type 3
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215390_412527722Zinc fingerC2H2-type 4
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215418_440527722Zinc fingerC2H2-type 5
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215446_468527722Zinc fingerC2H2-type 6
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215474_496527722Zinc fingerC2H2-type 7
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215502_524527722Zinc fingerC2H2-type 8
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27582182_251614172550DomainPI3K/PI4K
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27582517_254914172550DomainFATC
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581443_147314172550RepeatNote=TPR 4
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581474_150714172550RepeatNote=TPR 5
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581508_154114172550RepeatNote=TPR 6
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581542_157414172550RepeatNote=TPR 7
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581575_161414172550RepeatNote=TPR 8
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581615_164914172550RepeatNote=TPR 9
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581650_169314172550RepeatNote=TPR 10
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581694_173114172550RepeatNote=TPR 11
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581732_178614172550RepeatNote=TPR 12
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581787_184614172550RepeatNote=TPR 13
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581898_193014172550RepeatNote=TPR 14
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581931_197014172550RepeatNote=TPR 15
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581971_200514172550RepeatNote=TPR 16

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316614_637609811Zinc fingerC2H2-type 12
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316717_739609811Zinc fingerC2H2-type 13
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316614_637609804Zinc fingerC2H2-type 12
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316717_739609804Zinc fingerC2H2-type 13
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215530_552527722Zinc fingerC2H2-type 9
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215558_580527722Zinc fingerC2H2-type 10
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215586_608527722Zinc fingerC2H2-type 11
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215614_637527722Zinc fingerC2H2-type 12
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215717_739527722Zinc fingerC2H2-type 13
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581382_198214172550DomainFAT
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758100_13714172550RepeatNote=HEAT 3
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581029_106814172550RepeatNote=HEAT 25
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581069_110514172550RepeatNote=HEAT 26
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581106_114414172550RepeatNote=HEAT 27
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581145_118814172550RepeatNote=HEAT 28
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581189_122514172550RepeatNote=HEAT 29
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581226_127314172550RepeatNote=HEAT 30
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581274_131114172550RepeatNote=HEAT 31
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581312_134514172550RepeatNote=HEAT 32
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581346_138214172550RepeatNote=TPR 1
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581383_140814172550RepeatNote=TPR 2
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758138_17914172550RepeatNote=HEAT 4
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581409_144214172550RepeatNote=TPR 3
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-275816_5314172550RepeatNote=HEAT 1
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758180_22014172550RepeatNote=HEAT 5
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758222_27614172550RepeatNote=HEAT 6
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758277_31314172550RepeatNote=HEAT 7
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758314_36414172550RepeatNote=HEAT 8
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758365_40914172550RepeatNote=HEAT 9
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758410_44514172550RepeatNote=HEAT 10
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758446_49414172550RepeatNote=HEAT 11
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758495_52914172550RepeatNote=HEAT 12
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758530_56314172550RepeatNote=HEAT 13
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-275855_9914172550RepeatNote=HEAT 2
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758564_59614172550RepeatNote=HEAT 14
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758597_63614172550RepeatNote=HEAT 15
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758637_68314172550RepeatNote=HEAT 16
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758686_72414172550RepeatNote=HEAT 17
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758727_76614172550RepeatNote=HEAT 18
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758769_81114172550RepeatNote=HEAT 19
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758814_85314172550RepeatNote=HEAT 20
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758857_89314172550RepeatNote=HEAT 21
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758894_94214172550RepeatNote=HEAT 22
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758943_98814172550RepeatNote=HEAT 23
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-2758989_102714172550RepeatNote=HEAT 24


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FusionGeneSequence for ZBTB17_MTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ZBTB17_ENST00000375743_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_1741aa
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVD
DVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA
EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEE
SAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK
PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPH
CDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT
QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTALIISYSSRRQRPECXNMPXN
TLESWRSRLPGMRNCTSGRMPLWPMTRKWTPTRTTQSXCWAACAASRPWGNGVNSTSSAVKSGPWLMMRPKPRWPGWLLQLHGVXVSGTA
WKNTPVXSLGTPMMGHFIELCWHCIRTSSPWHNSALTRPGTCWMLNXLRWQERVTVGHMGPWFLATCCPSWRRLSSTNLSPSDERSSARS
GGRDCRAASVSXRTGRKSLWCGPLWSALMKTXEPGSSMQACAARVAGWLLLIKLXCCSWELIRLGNLTILCQQFTLRXPMPTXKTCGRVP
ARSMPSSTCSILSRPCSNRPSMPSLLRTSSISRNCTSSWPDASXNLESGSXIYRASMRAQSPKCCSTTAPPQSTTAAGTRPGMRGQXXTS
KLCYTTNIRTKPAMRRRNCVMPAGPTSPTPPLPPPRPPLPPPLPAPRAATVRARPRAPRTAPPHRRCRRRSLRICPKPSXCTRCLPSRAS
SVPSPCHEATTSRIHSEFSPYGLIMVTGQMSMRPXWRGXKPSRLIPGYRLYLSSLQELIRPDPWWDVSFTSFSQTLVGTTPRPSSTHXQW
LLSLPRQPGTMQPTRFXRTCVSTATPWSSRPXWXARSXSEWPSSGMRCGMKAWKRHLVCTLGKGTXKACLRCWSPCMLXWNGAPRLXRKH
PLIRPMVEIXWRPKSGAGSTXNQGMSRTSPKPGTSIIMCSDESQSSCLSSHPXSCNMFPQNFXCAGTLNWLCQEHMTPTSQSFAFSPXHR
LCKSSHPSRGPGNXHLWAATDMSLFSFXKAMKICARMSVXCSSSAWLTPFWPMTQHLFGKTSASRDTLSSLYRPTRASLAGFPTVTHCTP
SSGTTGRRRRSFSTSSIASCCGWLRTMTTXLXCRRWRCLSMPSIIQLGTTWPSCCGXKAPAPRCGLTEEPIIPVLXRSCQWLGIFXAWEI
DTHPTXCWTVXVGRSCTLTLGTALRLLXPERSFQRRFHLDXQECXPMLWRLQAWMATTESHATQXWRCCESTRTVSWPCWKPLSMTPCXT
GGXWTQIPKATSDPERGRIPTLLASQSKFWTVWNLESQPIRKRGPQCQNLFILSLETVWXNQRPXIRKLSRLLTGFEISSLVGTSLMMTL

>In-frame_ZBTB17_ENST00000537142_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_1659aa
MMCWPWPLSSKCRTSSRPAMPSSHLLSRLPALGEMRRPWPQKVCPVPSPGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQ
AQSAASGAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEA
PEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAH
EKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDT
DKEHKCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQC
VMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTALIISYSSRRQRP
ECXNMPXNTLESWRSRLPGMRNCTSGRMPLWPMTRKWTPTRTTQSXCWAACAASRPWGNGVNSTSSAVKSGPWLMMRPKPRWPGWLLQLH
GVXVSGTAWKNTPVXSLGTPMMGHFIELCWHCIRTSSPWHNSALTRPGTCWMLNXLRWQERVTVGHMGPWFLATCCPSWRRLSSTNLSPS
DERSSARSGGRDCRAASVSXRTGRKSLWCGPLWSALMKTXEPGSSMQACAARVAGWLLLIKLXCCSWELIRLGNLTILCQQFTLRXPMPT
XKTCGRVPARSMPSSTCSILSRPCSNRPSMPSLLRTSSISRNCTSSWPDASXNLESGSXIYRASMRAQSPKCCSTTAPPQSTTAAGTRPG
MRGQXXTSKLCYTTNIRTKPAMRRRNCVMPAGPTSPTPPLPPPRPPLPPPLPAPRAATVRARPRAPRTAPPHRRCRRRSLRICPKPSXCT
RCLPSRASSVPSPCHEATTSRIHSEFSPYGLIMVTGQMSMRPXWRGXKPSRLIPGYRLYLSSLQELIRPDPWWDVSFTSFSQTLVGTTPR
PSSTHXQWLLSLPRQPGTMQPTRFXRTCVSTATPWSSRPXWXARSXSEWPSSGMRCGMKAWKRHLVCTLGKGTXKACLRCWSPCMLXWNG
APRLXRKHPLIRPMVEIXWRPKSGAGSTXNQGMSRTSPKPGTSIIMCSDESQSSCLSSHPXSCNMFPQNFXCAGTLNWLCQEHMTPTSQS
FAFSPXHRLCKSSHPSRGPGNXHLWAATDMSLFSFXKAMKICARMSVXCSSSAWLTPFWPMTQHLFGKTSASRDTLSSLYRPTRASLAGF
PTVTHCTPSSGTTGRRRRSFSTSSIASCCGWLRTMTTXLXCRRWRCLSMPSIIQLGTTWPSCCGXKAPAPRCGLTEEPIIPVLXRSCQWL
GIFXAWEIDTHPTXCWTVXVGRSCTLTLGTALRLLXPERSFQRRFHLDXQECXPMLWRLQAWMATTESHATQXWRCCESTRTVSWPCWKP
LSMTPCXTGGXWTQIPKATSDPERGRIPTLLASQSKFWTVWNLESQPIRKRGPQCQNLFILSLETVWXNQRPXIRKLSRLLTGFEISSLV

>In-frame_ZBTB17_ENST00000375733_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_1741aa
MDFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVHFKAHKAVLAACSEYFKMLFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVD
DVLAVATFLQMQDIITACHALKSLAEPATSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAGRSTPIGPSRDLKEERGGQAQSAASGA
EQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEEQEEEGAGPAEVKEEGSQLENGEAPEENENEE
SAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLK
PYGCEECGKSYRLISLLNLHKKRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCPH
CDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADPGALQRHVRIHTGEKPCQCVMCGKAFT
QASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTALIISYSSRRQRPECXNMPXN
TLESWRSRLPGMRNCTSGRMPLWPMTRKWTPTRTTQSXCWAACAASRPWGNGVNSTSSAVKSGPWLMMRPKPRWPGWLLQLHGVXVSGTA
WKNTPVXSLGTPMMGHFIELCWHCIRTSSPWHNSALTRPGTCWMLNXLRWQERVTVGHMGPWFLATCCPSWRRLSSTNLSPSDERSSARS
GGRDCRAASVSXRTGRKSLWCGPLWSALMKTXEPGSSMQACAARVAGWLLLIKLXCCSWELIRLGNLTILCQQFTLRXPMPTXKTCGRVP
ARSMPSSTCSILSRPCSNRPSMPSLLRTSSISRNCTSSWPDASXNLESGSXIYRASMRAQSPKCCSTTAPPQSTTAAGTRPGMRGQXXTS
KLCYTTNIRTKPAMRRRNCVMPAGPTSPTPPLPPPRPPLPPPLPAPRAATVRARPRAPRTAPPHRRCRRRSLRICPKPSXCTRCLPSRAS
SVPSPCHEATTSRIHSEFSPYGLIMVTGQMSMRPXWRGXKPSRLIPGYRLYLSSLQELIRPDPWWDVSFTSFSQTLVGTTPRPSSTHXQW
LLSLPRQPGTMQPTRFXRTCVSTATPWSSRPXWXARSXSEWPSSGMRCGMKAWKRHLVCTLGKGTXKACLRCWSPCMLXWNGAPRLXRKH
PLIRPMVEIXWRPKSGAGSTXNQGMSRTSPKPGTSIIMCSDESQSSCLSSHPXSCNMFPQNFXCAGTLNWLCQEHMTPTSQSFAFSPXHR
LCKSSHPSRGPGNXHLWAATDMSLFSFXKAMKICARMSVXCSSSAWLTPFWPMTQHLFGKTSASRDTLSSLYRPTRASLAGFPTVTHCTP
SSGTTGRRRRSFSTSSIASCCGWLRTMTTXLXCRRWRCLSMPSIIQLGTTWPSCCGXKAPAPRCGLTEEPIIPVLXRSCQWLGIFXAWEI
DTHPTXCWTVXVGRSCTLTLGTALRLLXPERSFQRRFHLDXQECXPMLWRLQAWMATTESHATQXWRCCESTRTVSWPCWKPLSMTPCXT
GGXWTQIPKATSDPERGRIPTLLASQSKFWTVWNLESQPIRKRGPQCQNLFILSLETVWXNQRPXIRKLSRLLTGFEISSLVGTSLMMTL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ZBTB17_ENST00000375743_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_5225nt
ATGGACTTTCCCCAGCACAGCCAGCATGTCTTGGAACAGCTGAACCAGCAGCGGCAGCTGGGGCTTCTCTGTGACTGCACCTTTGTGGTG
GACGGTGTTCACTTTAAGGCTCATAAAGCAGTGCTGGCGGCCTGCAGCGAGTACTTCAAGATGCTCTTCGTGGACCAGAAGGACGTGGTG
CACCTGGACATCAGTAACGCGGCAGGCCTGGGGCAGGTGCTGGAGTTTATGTACACGGCCAAGCTGAGCCTGAGCCCTGAGAACGTGGAT
GATGTGCTGGCCGTGGCCACTTTCCTCCAAATGCAGGACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCAGC
CCTGGGGGAAATGCGGAGGCCTTGGCCACAGAAGGAGGGGACAAGAGAGCCAAAGAGGAGAAGGTGGCCACCAGCACGCTGAGCAGGCTG
GAGCAGGCAGGACGCAGCACACCCATAGGCCCCAGCAGGGACCTCAAGGAGGAGCGCGGCGGTCAGGCCCAGAGTGCGGCCAGCGGTGCA
GAGCAGACAGAGAAAGCCGATGCGCCCCGGGAGCCGCCGCCTGTGGAGCTCAAGCCAGACCCCACGAGTGGCATGGCTGCTGCAGAAGCT
GAGGCCGCTTTGTCCGAGAGCTCGGAGCAAGAAATGGAGGTGGAGCCCGCCCGGAAAGGGGAAGAGGAGCAAAAGGAGCAAGAGGAGCAA
GAGGAGGAGGGCGCAGGGCCAGCTGAGGTCAAGGAGGAGGGTTCCCAGCTGGAGAACGGAGAGGCCCCCGAGGAGAACGAGAATGAGGAG
TCAGCGGGCACAGACTCGGGGCAGGAGCTCGGCTCCGAGGCCCGGGGCCTGCGCTCAGGCACCTACGGCGACCGCACGGAGTCCAAGGCC
TACGGCTCCGTCATCCACAAGTGCGAGGACTGTGGGAAGGAGTTCACGCACACGGGGAACTTCAAGCGGCACATCCGCATCCACACGGGG
GAGAAGCCCTTCTCGTGCCGGGAGTGCAGCAAGGCCTTTTCCGACCCGGCCGCGTGCAAGGCCCATGAGAAGACGCACAGCCCTCTGAAG
CCCTACGGCTGCGAGGAGTGCGGGAAGAGCTACCGCCTCATCAGCCTGCTGAACCTGCACAAGAAGCGGCACTCGGGCGAGGCGCGCTAC
CGCTGCGAGGACTGCGGCAAGCTCTTCACCACCTCGGGCAACCTCAAGCGCCACCAGCTGGTGCACAGCGGCGAGAAGCCCTACCAGTGC
GACTACTGCGGCCGCTCCTTCTCCGACCCCACTTCCAAGATGCGCCACCTGGAGACCCACGACACGGACAAGGAGCACAAGTGCCCACAC
TGCGACAAGAAGTTCAACCAGGTAGGGAACCTGAAGGCCCACCTGAAGATCCACATCGCTGACGGGCCCCTCAAGTGCCGAGAGTGTGGG
AAGCAGTTCACCACCTCAGGGAACCTGAAGCGGCACCTTCGGATCCACAGCGGGGAGAAGCCCTACGTGTGCATCCACTGCCAGCGACAG
TTTGCAGACCCCGGCGCTCTGCAGCGGCACGTCCGCATTCACACAGGTGAGAAGCCATGCCAGTGTGTGATGTGCGGTAAGGCCTTCACC
CAGGCCAGCTCCCTCATCGCCCACGTGCGCCAGCACACCGGGGAGAAGCCCTACGTCTGCGAGCGCTGCGGCAAGAGATTCGTCCAGTCC
AGCCAGTTGGCCAATCATATTCGCCACCACGACAACATCCGCCCACACAAGTGCAGCGTGTGCAGCAAGGCCTTCGTGAACGTGGGGGAC
CTGTCCAAGCACATCATCATTCACACTGCATTAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAAC
ACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTATGACAAGAAAATGGACA
CCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGTG
AAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTAGGTCAGTGGGACAGCA
TGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCT
TGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGCATATGGGG
CCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCT
GGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCCTCATGAAG
ACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAG
TTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAAGAGTGCCC
GCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGC
ATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGAGAGCACAA
TCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTCG
AAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCACCAACGCCA
CCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACA
GCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCAGGGCTTCT
TCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATG
TCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAATTGATACGC
CCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTGG
CTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGTCCAGCAGG
CCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACT
TTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAAGGAAACAT
CCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCC
AAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGTTTCCCCAA
AACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGT
CTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCTAAAAGGCC
ATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAA
ACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACTGCACGCCC
TCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTGA
CTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAAAAGCCCCA
GCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATA
GACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTATGACCCGAG
AGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATCA
CATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTTGCTGAACT
GGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTGG
ACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGGTTTGGTGA
AACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACTT
TGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTGCCCTTTCT

>In-frame_ZBTB17_ENST00000537142_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_4979nt
ATGATGTGCTGGCCGTGGCCACTTTCCTCCAAATGCAGGACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCA
GCCCTGGGGGAAATGCGGAGGCCTTGGCCACAGAAGGTCTGCCCTGTTCCATCTCCAGGAGGGGACAAGAGAGCCAAAGAGGAGAAGGTG
GCCACCAGCACGCTGAGCAGGCTGGAGCAGGCAGGACGCAGCACACCCATAGGCCCCAGCAGGGACCTCAAGGAGGAGCGCGGCGGTCAG
GCCCAGAGTGCGGCCAGCGGTGCAGAGCAGACAGAGAAAGCCGATGCGCCCCGGGAGCCGCCGCCTGTGGAGCTCAAGCCAGACCCCACG
AGTGGCATGGCTGCTGCAGAAGCTGAGGCCGCTTTGTCCGAGAGCTCGGAGCAAGAAATGGAGGTGGAGCCCGCCCGGAAAGGGGAAGAG
GAGCAAAAGGAGCAAGAGGAGCAAGAGGAGGAGGGCGCAGGGCCAGCTGAGGTCAAGGAGGAGGGTTCCCAGCTGGAGAACGGAGAGGCC
CCCGAGGAGAACGAGAATGAGGAGTCAGCGGGCACAGACTCGGGGCAGGAGCTCGGCTCCGAGGCCCGGGGCCTGCGCTCAGGCACCTAC
GGCGACCGCACGGAGTCCAAGGCCTACGGCTCCGTCATCCACAAGTGCGAGGACTGTGGGAAGGAGTTCACGCACACGGGGAACTTCAAG
CGGCACATCCGCATCCACACGGGGGAGAAGCCCTTCTCGTGCCGGGAGTGCAGCAAGGCCTTTTCCGACCCGGCCGCGTGCAAGGCCCAT
GAGAAGACGCACAGCCCTCTGAAGCCCTACGGCTGCGAGGAGTGCGGGAAGAGCTACCGCCTCATCAGCCTGCTGAACCTGCACAAGAAG
CGGCACTCGGGCGAGGCGCGCTACCGCTGCGAGGACTGCGGCAAGCTCTTCACCACCTCGGGCAACCTCAAGCGCCACCAGCTGGTGCAC
AGCGGCGAGAAGCCCTACCAGTGCGACTACTGCGGCCGCTCCTTCTCCGACCCCACTTCCAAGATGCGCCACCTGGAGACCCACGACACG
GACAAGGAGCACAAGTGCCCACACTGCGACAAGAAGTTCAACCAGGTAGGGAACCTGAAGGCCCACCTGAAGATCCACATCGCTGACGGG
CCCCTCAAGTGCCGAGAGTGTGGGAAGCAGTTCACCACCTCAGGGAACCTGAAGCGGCACCTTCGGATCCACAGCGGGGAGAAGCCCTAC
GTGTGCATCCACTGCCAGCGACAGTTTGCAGACCCCGGCGCTCTGCAGCGGCACGTCCGCATTCACACAGGTGAGAAGCCATGCCAGTGT
GTGATGTGCGGTAAGGCCTTCACCCAGGCCAGCTCCCTCATCGCCCACGTGCGCCAGCACACCGGGGAGAAGCCCTACGTCTGCGAGCGC
TGCGGCAAGAGATTCGTCCAGTCCAGCCAGTTGGCCAATCATATTCGCCACCACGACAACATCCGCCCACACAAGTGCAGCGTGTGCAGC
AAGGCCTTCGTGAACGTGGGGGACCTGTCCAAGCACATCATCATTCACACTGCATTAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCG
GAGTGTTAGAATATGCCATGAAACACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTTG
TGGCCTATGACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGG
GTCAACTCCACCAGCAGTGCTGTGAAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCAT
GGGGTTTAGGTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGG
CACTGCATCAGGACCTCTTCTCCTTGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAG
AGAGTTACAGTCGGGCATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGC
GACGAGAGATCATCCGCCAGATCTGGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGT
CCCTTGTGGTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATA
AAACTTTAGTGTTGCTCCTGGGAGTTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACA
TGAAAAACATGTGGAAGAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATG
CCATCGCTACTGAGGACCAGCAGCATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATC
TACAGGGCATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGC
ATGCGTGGGCAGTGATGAACTTCGAAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCA
GCGGGGCCAACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGA
GCGAGGCCGAGAGCACCGAGAACAGCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACA
CGGTGCCTGCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGT
TTGATTATGGTCACTGGCCAGATGTCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTC
AGCTCATTGCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGG
CCCTCATCTACCCACTGACAGTGGCTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGC
ACAGCAACACCCTGGTCCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCC
TGGAAGAGGCATCTCGTTTGTACTTTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGG
GCCCCCAGACTCTGAAGGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAAT
CAGGGAATGTCAAGGACCTCACCCAAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCT
TAGAGCTGCAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCA
TTCGCATTCAGTCCATAGCACCGTCTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATG
AGTTTGTTTTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCA
ATGACCCAACATCTCTTCGGAAAAACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTC
CCCACTGTGACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGA
TGGCTCCGGACTATGACCACTTGACTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCA
AGCTGCTGTGGCTGAAAAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTG
GGTATATTTTAGGCCTGGGAGATAGACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACT
GCTTTGAGGTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAG
GCCTGGATGGCAACTACAGAATCACATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCT
TTGTCTATGACCCCTTGCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTG
CTGGCCAGTCAGTCGAAATTTTGGACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATT
CTTTCATTGGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTC
GGGACTTCTCTCATGATGACACTTTGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGT

>In-frame_ZBTB17_ENST00000375733_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_5225nt
ATGGACTTTCCCCAGCACAGCCAGCATGTCTTGGAACAGCTGAACCAGCAGCGGCAGCTGGGGCTTCTCTGTGACTGCACCTTTGTGGTG
GACGGTGTTCACTTTAAGGCTCATAAAGCAGTGCTGGCGGCCTGCAGCGAGTACTTCAAGATGCTCTTCGTGGACCAGAAGGACGTGGTG
CACCTGGACATCAGTAACGCGGCAGGCCTGGGGCAGGTGCTGGAGTTTATGTACACGGCCAAGCTGAGCCTGAGCCCTGAGAACGTGGAT
GATGTGCTGGCCGTGGCCACTTTCCTCCAAATGCAGGACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCAGC
CCTGGGGGAAATGCGGAGGCCTTGGCCACAGAAGGAGGGGACAAGAGAGCCAAAGAGGAGAAGGTGGCCACCAGCACGCTGAGCAGGCTG
GAGCAGGCAGGACGCAGCACACCCATAGGCCCCAGCAGGGACCTCAAGGAGGAGCGCGGCGGTCAGGCCCAGAGTGCGGCCAGCGGTGCA
GAGCAGACAGAGAAAGCCGATGCGCCCCGGGAGCCGCCGCCTGTGGAGCTCAAGCCAGACCCCACGAGTGGCATGGCTGCTGCAGAAGCT
GAGGCCGCTTTGTCCGAGAGCTCGGAGCAAGAAATGGAGGTGGAGCCCGCCCGGAAAGGGGAAGAGGAGCAAAAGGAGCAAGAGGAGCAA
GAGGAGGAGGGCGCAGGGCCAGCTGAGGTCAAGGAGGAGGGTTCCCAGCTGGAGAACGGAGAGGCCCCCGAGGAGAACGAGAATGAGGAG
TCAGCGGGCACAGACTCGGGGCAGGAGCTCGGCTCCGAGGCCCGGGGCCTGCGCTCAGGCACCTACGGCGACCGCACGGAGTCCAAGGCC
TACGGCTCCGTCATCCACAAGTGCGAGGACTGTGGGAAGGAGTTCACGCACACGGGGAACTTCAAGCGGCACATCCGCATCCACACGGGG
GAGAAGCCCTTCTCGTGCCGGGAGTGCAGCAAGGCCTTTTCCGACCCGGCCGCGTGCAAGGCCCATGAGAAGACGCACAGCCCTCTGAAG
CCCTACGGCTGCGAGGAGTGCGGGAAGAGCTACCGCCTCATCAGCCTGCTGAACCTGCACAAGAAGCGGCACTCGGGCGAGGCGCGCTAC
CGCTGCGAGGACTGCGGCAAGCTCTTCACCACCTCGGGCAACCTCAAGCGCCACCAGCTGGTGCACAGCGGCGAGAAGCCCTACCAGTGC
GACTACTGCGGCCGCTCCTTCTCCGACCCCACTTCCAAGATGCGCCACCTGGAGACCCACGACACGGACAAGGAGCACAAGTGCCCACAC
TGCGACAAGAAGTTCAACCAGGTAGGGAACCTGAAGGCCCACCTGAAGATCCACATCGCTGACGGGCCCCTCAAGTGCCGAGAGTGTGGG
AAGCAGTTCACCACCTCAGGGAACCTGAAGCGGCACCTTCGGATCCACAGCGGGGAGAAGCCCTACGTGTGCATCCACTGCCAGCGACAG
TTTGCAGACCCCGGCGCTCTGCAGCGGCACGTCCGCATTCACACAGGTGAGAAGCCATGCCAGTGTGTGATGTGCGGTAAGGCCTTCACC
CAGGCCAGCTCCCTCATCGCCCACGTGCGCCAGCACACCGGGGAGAAGCCCTACGTCTGCGAGCGCTGCGGCAAGAGATTCGTCCAGTCC
AGCCAGTTGGCCAATCATATTCGCCACCACGACAACATCCGCCCACACAAGTGCAGCGTGTGCAGCAAGGCCTTCGTGAACGTGGGGGAC
CTGTCCAAGCACATCATCATTCACACTGCATTAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAAC
ACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTATGACAAGAAAATGGACA
CCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGTG
AAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTAGGTCAGTGGGACAGCA
TGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCT
TGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGCATATGGGG
CCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCT
GGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCCTCATGAAG
ACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAG
TTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAAGAGTGCCC
GCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGC
ATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGAGAGCACAA
TCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTCG
AAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCACCAACGCCA
CCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACA
GCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCAGGGCTTCT
TCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATG
TCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAATTGATACGC
CCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTGG
CTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGTCCAGCAGG
CCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACT
TTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAAGGAAACAT
CCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCC
AAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGTTTCCCCAA
AACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGT
CTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCTAAAAGGCC
ATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAA
ACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACTGCACGCCC
TCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTGA
CTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAAAAGCCCCA
GCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATA
GACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTATGACCCGAG
AGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATCA
CATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTTGCTGAACT
GGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTGG
ACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGGTTTGGTGA
AACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACTT
TGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTGCCCTTTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ZBTB17_ENST00000375743_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_6408nt
CGGAAGTTGCAGCCGGGAAGCCTGCGAGGTCGGTTCCGCCCGACTCTAACATGGCGGCGCCCTTTGTCTGCTCTGGAGTGCCGTCCCCGG
CCTTCTCGCGGCCGTGATGCACCTCCCTCTGCGGTGGGGTCCGGGACATGGCAGGTAATGAGCCGGACGAGGGGAGCCAAGCTGGAGTTT
ACACAGGCAAACTGTCAGAAAAGAGTAGCCTGGGCTGTCTGGAAATCTGAGCCATGGACTTTCCCCAGCACAGCCAGCATGTCTTGGAAC
AGCTGAACCAGCAGCGGCAGCTGGGGCTTCTCTGTGACTGCACCTTTGTGGTGGACGGTGTTCACTTTAAGGCTCATAAAGCAGTGCTGG
CGGCCTGCAGCGAGTACTTCAAGATGCTCTTCGTGGACCAGAAGGACGTGGTGCACCTGGACATCAGTAACGCGGCAGGCCTGGGGCAGG
TGCTGGAGTTTATGTACACGGCCAAGCTGAGCCTGAGCCCTGAGAACGTGGATGATGTGCTGGCCGTGGCCACTTTCCTCCAAATGCAGG
ACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCAGCCCTGGGGGAAATGCGGAGGCCTTGGCCACAGAAGGAG
GGGACAAGAGAGCCAAAGAGGAGAAGGTGGCCACCAGCACGCTGAGCAGGCTGGAGCAGGCAGGACGCAGCACACCCATAGGCCCCAGCA
GGGACCTCAAGGAGGAGCGCGGCGGTCAGGCCCAGAGTGCGGCCAGCGGTGCAGAGCAGACAGAGAAAGCCGATGCGCCCCGGGAGCCGC
CGCCTGTGGAGCTCAAGCCAGACCCCACGAGTGGCATGGCTGCTGCAGAAGCTGAGGCCGCTTTGTCCGAGAGCTCGGAGCAAGAAATGG
AGGTGGAGCCCGCCCGGAAAGGGGAAGAGGAGCAAAAGGAGCAAGAGGAGCAAGAGGAGGAGGGCGCAGGGCCAGCTGAGGTCAAGGAGG
AGGGTTCCCAGCTGGAGAACGGAGAGGCCCCCGAGGAGAACGAGAATGAGGAGTCAGCGGGCACAGACTCGGGGCAGGAGCTCGGCTCCG
AGGCCCGGGGCCTGCGCTCAGGCACCTACGGCGACCGCACGGAGTCCAAGGCCTACGGCTCCGTCATCCACAAGTGCGAGGACTGTGGGA
AGGAGTTCACGCACACGGGGAACTTCAAGCGGCACATCCGCATCCACACGGGGGAGAAGCCCTTCTCGTGCCGGGAGTGCAGCAAGGCCT
TTTCCGACCCGGCCGCGTGCAAGGCCCATGAGAAGACGCACAGCCCTCTGAAGCCCTACGGCTGCGAGGAGTGCGGGAAGAGCTACCGCC
TCATCAGCCTGCTGAACCTGCACAAGAAGCGGCACTCGGGCGAGGCGCGCTACCGCTGCGAGGACTGCGGCAAGCTCTTCACCACCTCGG
GCAACCTCAAGCGCCACCAGCTGGTGCACAGCGGCGAGAAGCCCTACCAGTGCGACTACTGCGGCCGCTCCTTCTCCGACCCCACTTCCA
AGATGCGCCACCTGGAGACCCACGACACGGACAAGGAGCACAAGTGCCCACACTGCGACAAGAAGTTCAACCAGGTAGGGAACCTGAAGG
CCCACCTGAAGATCCACATCGCTGACGGGCCCCTCAAGTGCCGAGAGTGTGGGAAGCAGTTCACCACCTCAGGGAACCTGAAGCGGCACC
TTCGGATCCACAGCGGGGAGAAGCCCTACGTGTGCATCCACTGCCAGCGACAGTTTGCAGACCCCGGCGCTCTGCAGCGGCACGTCCGCA
TTCACACAGGTGAGAAGCCATGCCAGTGTGTGATGTGCGGTAAGGCCTTCACCCAGGCCAGCTCCCTCATCGCCCACGTGCGCCAGCACA
CCGGGGAGAAGCCCTACGTCTGCGAGCGCTGCGGCAAGAGATTCGTCCAGTCCAGCCAGTTGGCCAATCATATTCGCCACCACGACAACA
TCCGCCCACACAAGTGCAGCGTGTGCAGCAAGGCCTTCGTGAACGTGGGGGACCTGTCCAAGCACATCATCATTCACACTGCATTAATAA
TAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAACACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGA
GAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTATGACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCAT
GCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGTGAAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAA
GATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTAGGTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGACACCCA
TGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCTTGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCT
GGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGCATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGA
GGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCTGGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGA
GGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGG
CAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAGTTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAAC
AGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAAGAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGT
CCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGCATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTT
CCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGA
GCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTCGAAGCTGTGCTACACTACAAACATCAGAACCAAGCCCG
CGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCACCACCAC
TGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACAGCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGA
GGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCA
GGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATGTCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCA
GATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCT
CACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTGGCTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGC
CAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGTCCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCAT
CCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACTTTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCT
GGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAAGGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGC
CCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCCAAGCCTGGGACCTCTATTATCATGTGTTCCGACGAAT
CTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCC
AGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGTCTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAA
ATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCT
CTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAAACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATC
GACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCT
CAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTGACTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGT
CAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAAAAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATAC
CCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATAGACACCCATCCAACCTGATGCTGGACCGTCTGAGTGG
GAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAG
AATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATCACATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAA
GGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTTGCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAACAAGCG
ATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTGGACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAAC
GGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTAT
TAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACTTTGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACA
AGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTGCCCTTTCTGGTAACTGGAGGCCCAGATGTGCCCATCACGTTTTTT
CTGAGGCTTTTGTACTTTAGTAAATGCTTCCACTAAACTGAAACCATGGTGAGAAAGTTTGACTTTGTTAAATATTTTGAAATGTAAATG
AAAAGAACTACTGTATATTAAAAGTTGGTTTGAACCAACTTTCTAGCTGCTGTTGAAGAATATATTGTCAGAAACACAAGGCTTGATTTG
GTTCCCAGGACAGTGAAACATAGTAATACCACGTAAATCAAGCCATTCATTTTGGGGAACAGAAGATCCATAACTTTAGAAATACGGGTT
TTGACTTAACTCACAAGAGAACTCATCATAAGTACTTGCTGATGGAAGAATGACCTAGTTGCTCCTCTCAACATGGGTACAGCAAACTCA
GCACAGCCAAGAAGCCTCAGGTCGTGGAGAACATGGATTAGGATCCTAGACTGTAAAGACACAGAAGATGCTGACCTCACCCCTGCCACC
TATCCCAAGACCTCACTGGTCTGTGGACAGCAGCAGAAATGTTTGCAAGATAGGCCAAAATGAGTACAAAAGGTCTGTCTTCCATCAGAC
CCAGTGATGCTGCGACTCACACGCTTCAATTCAAGACCTGACCGCTAGTAGGGAGGTTTATTCAGATCGCTGGCAGCCTCGGCTGAGCAG
ATGCACAGAGGGGATCACTGTGCAGTGGGACCACCCTCACTGGCCTTCTGCAGCAGGGTTCTGGGATGTTTTCAGTGGTCAAAATACTCT
GTTTAGAGCAAGGGCTCAGAAAACAGAAATACTGTCATGGAGGTGCTGAACACAGGGAAGGTCTGGTACATATTGGAAATTATGAGCAGA
ACAAATACTCAACTAAATGCACAAAGTATAAAGTGTAGCCATGTCTAGACACCATGTTGTATCAGAATAATTTTTGTGCCAATAAATGAC

>In-frame_ZBTB17_ENST00000537142_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_6176nt
AACATGGCGGCGCCCTTTGTCTGCTCTGGAGTGCCGTCCCCGGCCTTCTCGCGGCCGTGATGCACCTCCCTCTGCGGTGGGGTCCGGGAC
ATGGCAGGTAATGAGCCGGACGAGGGGAGCCAAGCTGGAGTTTACACAGGCAAACTGTCAGAAAAGAGTAGCCTGGGCTGTCTGGAAATC
TGAGGCCTGGGGCAGGTGCTGGAGTTTATGTACACGGCCAAGCTGAGCCTGAGCCCTGAGAACGTGGATGATGTGCTGGCCGTGGCCACT
TTCCTCCAAATGCAGGACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCAGCCCTGGGGGAAATGCGGAGGCC
TTGGCCACAGAAGGTCTGCCCTGTTCCATCTCCAGGAGGGGACAAGAGAGCCAAAGAGGAGAAGGTGGCCACCAGCACGCTGAGCAGGCT
GGAGCAGGCAGGACGCAGCACACCCATAGGCCCCAGCAGGGACCTCAAGGAGGAGCGCGGCGGTCAGGCCCAGAGTGCGGCCAGCGGTGC
AGAGCAGACAGAGAAAGCCGATGCGCCCCGGGAGCCGCCGCCTGTGGAGCTCAAGCCAGACCCCACGAGTGGCATGGCTGCTGCAGAAGC
TGAGGCCGCTTTGTCCGAGAGCTCGGAGCAAGAAATGGAGGTGGAGCCCGCCCGGAAAGGGGAAGAGGAGCAAAAGGAGCAAGAGGAGCA
AGAGGAGGAGGGCGCAGGGCCAGCTGAGGTCAAGGAGGAGGGTTCCCAGCTGGAGAACGGAGAGGCCCCCGAGGAGAACGAGAATGAGGA
GTCAGCGGGCACAGACTCGGGGCAGGAGCTCGGCTCCGAGGCCCGGGGCCTGCGCTCAGGCACCTACGGCGACCGCACGGAGTCCAAGGC
CTACGGCTCCGTCATCCACAAGTGCGAGGACTGTGGGAAGGAGTTCACGCACACGGGGAACTTCAAGCGGCACATCCGCATCCACACGGG
GGAGAAGCCCTTCTCGTGCCGGGAGTGCAGCAAGGCCTTTTCCGACCCGGCCGCGTGCAAGGCCCATGAGAAGACGCACAGCCCTCTGAA
GCCCTACGGCTGCGAGGAGTGCGGGAAGAGCTACCGCCTCATCAGCCTGCTGAACCTGCACAAGAAGCGGCACTCGGGCGAGGCGCGCTA
CCGCTGCGAGGACTGCGGCAAGCTCTTCACCACCTCGGGCAACCTCAAGCGCCACCAGCTGGTGCACAGCGGCGAGAAGCCCTACCAGTG
CGACTACTGCGGCCGCTCCTTCTCCGACCCCACTTCCAAGATGCGCCACCTGGAGACCCACGACACGGACAAGGAGCACAAGTGCCCACA
CTGCGACAAGAAGTTCAACCAGGTAGGGAACCTGAAGGCCCACCTGAAGATCCACATCGCTGACGGGCCCCTCAAGTGCCGAGAGTGTGG
GAAGCAGTTCACCACCTCAGGGAACCTGAAGCGGCACCTTCGGATCCACAGCGGGGAGAAGCCCTACGTGTGCATCCACTGCCAGCGACA
GTTTGCAGACCCCGGCGCTCTGCAGCGGCACGTCCGCATTCACACAGGTGAGAAGCCATGCCAGTGTGTGATGTGCGGTAAGGCCTTCAC
CCAGGCCAGCTCCCTCATCGCCCACGTGCGCCAGCACACCGGGGAGAAGCCCTACGTCTGCGAGCGCTGCGGCAAGAGATTCGTCCAGTC
CAGCCAGTTGGCCAATCATATTCGCCACCACGACAACATCCGCCCACACAAGTGCAGCGTGTGCAGCAAGGCCTTCGTGAACGTGGGGGA
CCTGTCCAAGCACATCATCATTCACACTGCATTAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAA
CACTTTGGAGAGCTGGAGATCCAGGCTACCTGGTATGAGAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTATGACAAGAAAATGGAC
ACCAACAAGGACGACCCAGAGCTGATGCTGGGCCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGT
GAAAAGTGGACCCTGGTTAATGATGAGACCCAAGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTAGGTCAGTGGGACAGC
ATGGAAGAATACACCTGTATGATCCCTCGGGACACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCC
TTGGCACAACAGTGCATTGACAAGGCCAGGGACCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGCATATGGG
GCCATGGTTTCTTGCCACATGCTGTCCGAGCTGGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATC
TGGTGGGAGAGACTGCAGGGCTGCCAGCGTATCGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCCTCATGAA
GACATGAGAACCTGGCTCAAGTATGCAAGCCTGTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGA
GTTGATCCGTCTCGGCAACTTGACCATCCTCTGCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAAGAGTGCC
CGCAAGATCGATGCCTTCCAGCACATGCAGCATTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAG
CATAAGCAGGAACTGCACAAGCTCATGGCCCGATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGAGAGCACA
ATCCCCAAAGTGCTGCAGTACTACAGCGCCGCCACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTC
GAAGCTGTGCTACACTACAAACATCAGAACCAAGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCACCAACGCC
ACCACTGCCGCCACCACGGCCGCCACTGCCACCACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAAC
AGCCCCACCCCATCGCCGCTGCAGAAGAAGGTCACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCAGGGCTTC
TTCCGTTCCATCTCCTTGTCACGAGGCAACAACCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGAT
GTCAATGAGGCCTTAGTGGAGGGGGTGAAAGCCATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAATTGATACG
CCCAGACCCTTGGTGGGACGTCTCATTCACCAGCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTG
GCTTCTAAGTCTACCACGACAGCCCGGCACAATGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGTCCAGCAG
GCCATGATGGTGAGCGAGGAGCTGATCCGAGTGGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTAC
TTTGGGGAAAGGAACGTGAAAGGCATGTTTGAGGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAAGGAAACA
TCCTTTAATCAGGCCTATGGTCGAGATTTAATGGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACC
CAAGCCTGGGACCTCTATTATCATGTGTTCCGACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGTTTCCCCA
AAACTTCTGATGTGCCGGGACCTTGAATTGGCTGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCG
TCTTTGCAAGTCATCACATCCAAGCAGAGGCCCCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCTAAAAGGC
CATGAAGATCTGCGCCAGGATGAGCGTGTGATGCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAA
AACCTCAGCATCCAGAGATACGCTGTCATCCCTTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACTGCACGCC
CTCATCCGGGACTACAGGGAGAAGAAGAAGATCCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTG
ACTCTGATGCAGAAGGTGGAGGTGTTTGAGCATGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAAAAGCCCC
AGCTCCGAGGTGTGGTTTGACCGAAGAACCAATTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGAT
AGACACCCATCCAACCTGATGCTGGACCGTCTGAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTATGACCCGA
GAGAAGTTTCCAGAGAAGATTCCATTTAGACTAACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATC
ACATGCCACACAGTGATGGAGGTGCTGCGAGAGCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTTGCTGAAC
TGGAGGCTGATGGACACAAATACCAAAGGCAACAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTG
GACGGTGTGGAACTTGGAGAGCCAGCCCATAAGAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGGTTTGGTG
AAACCAGAGGCCCTAAATAAGAAAGCTATCCAGATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACT
TTGGATGTTCCAACGCAAGTTGAGCTGCTCATCAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTGCCCTTTC
TGGTAACTGGAGGCCCAGATGTGCCCATCACGTTTTTTCTGAGGCTTTTGTACTTTAGTAAATGCTTCCACTAAACTGAAACCATGGTGA
GAAAGTTTGACTTTGTTAAATATTTTGAAATGTAAATGAAAAGAACTACTGTATATTAAAAGTTGGTTTGAACCAACTTTCTAGCTGCTG
TTGAAGAATATATTGTCAGAAACACAAGGCTTGATTTGGTTCCCAGGACAGTGAAACATAGTAATACCACGTAAATCAAGCCATTCATTT
TGGGGAACAGAAGATCCATAACTTTAGAAATACGGGTTTTGACTTAACTCACAAGAGAACTCATCATAAGTACTTGCTGATGGAAGAATG
ACCTAGTTGCTCCTCTCAACATGGGTACAGCAAACTCAGCACAGCCAAGAAGCCTCAGGTCGTGGAGAACATGGATTAGGATCCTAGACT
GTAAAGACACAGAAGATGCTGACCTCACCCCTGCCACCTATCCCAAGACCTCACTGGTCTGTGGACAGCAGCAGAAATGTTTGCAAGATA
GGCCAAAATGAGTACAAAAGGTCTGTCTTCCATCAGACCCAGTGATGCTGCGACTCACACGCTTCAATTCAAGACCTGACCGCTAGTAGG
GAGGTTTATTCAGATCGCTGGCAGCCTCGGCTGAGCAGATGCACAGAGGGGATCACTGTGCAGTGGGACCACCCTCACTGGCCTTCTGCA
GCAGGGTTCTGGGATGTTTTCAGTGGTCAAAATACTCTGTTTAGAGCAAGGGCTCAGAAAACAGAAATACTGTCATGGAGGTGCTGAACA
CAGGGAAGGTCTGGTACATATTGGAAATTATGAGCAGAACAAATACTCAACTAAATGCACAAAGTATAAAGTGTAGCCATGTCTAGACAC

>In-frame_ZBTB17_ENST00000375733_chr1_16269559_-_MTOR_ENST00000361445_chr1_11227574_-_6414nt
ATGCGCCGGAAGTTGCAGCCGGGAAGCCTGCGAGGTCGGTTCCGCCCGACTCTAACATGGCGGCGCCCTTTGTCTGCTCTGGAGTGCCGT
CCCCGGCCTTCTCGCGGCCGTGATGCACCTCCCTCTGCGGTGGGGTCCGGGACATGGCAGGTAATGAGCCGGACGAGGGGAGCCAAGCTG
GAGTTTACACAGGCAAACTGTCAGAAAAGAGTAGCCTGGGCTGTCTGGAAATCTGAGCCATGGACTTTCCCCAGCACAGCCAGCATGTCT
TGGAACAGCTGAACCAGCAGCGGCAGCTGGGGCTTCTCTGTGACTGCACCTTTGTGGTGGACGGTGTTCACTTTAAGGCTCATAAAGCAG
TGCTGGCGGCCTGCAGCGAGTACTTCAAGATGCTCTTCGTGGACCAGAAGGACGTGGTGCACCTGGACATCAGTAACGCGGCAGGCCTGG
GGCAGGTGCTGGAGTTTATGTACACGGCCAAGCTGAGCCTGAGCCCTGAGAACGTGGATGATGTGCTGGCCGTGGCCACTTTCCTCCAAA
TGCAGGACATCATCACGGCCTGCCATGCCCTCAAGTCACTTGCTGAGCCGGCTACCAGCCCTGGGGGAAATGCGGAGGCCTTGGCCACAG
AAGGAGGGGACAAGAGAGCCAAAGAGGAGAAGGTGGCCACCAGCACGCTGAGCAGGCTGGAGCAGGCAGGACGCAGCACACCCATAGGCC
CCAGCAGGGACCTCAAGGAGGAGCGCGGCGGTCAGGCCCAGAGTGCGGCCAGCGGTGCAGAGCAGACAGAGAAAGCCGATGCGCCCCGGG
AGCCGCCGCCTGTGGAGCTCAAGCCAGACCCCACGAGTGGCATGGCTGCTGCAGAAGCTGAGGCCGCTTTGTCCGAGAGCTCGGAGCAAG
AAATGGAGGTGGAGCCCGCCCGGAAAGGGGAAGAGGAGCAAAAGGAGCAAGAGGAGCAAGAGGAGGAGGGCGCAGGGCCAGCTGAGGTCA
AGGAGGAGGGTTCCCAGCTGGAGAACGGAGAGGCCCCCGAGGAGAACGAGAATGAGGAGTCAGCGGGCACAGACTCGGGGCAGGAGCTCG
GCTCCGAGGCCCGGGGCCTGCGCTCAGGCACCTACGGCGACCGCACGGAGTCCAAGGCCTACGGCTCCGTCATCCACAAGTGCGAGGACT
GTGGGAAGGAGTTCACGCACACGGGGAACTTCAAGCGGCACATCCGCATCCACACGGGGGAGAAGCCCTTCTCGTGCCGGGAGTGCAGCA
AGGCCTTTTCCGACCCGGCCGCGTGCAAGGCCCATGAGAAGACGCACAGCCCTCTGAAGCCCTACGGCTGCGAGGAGTGCGGGAAGAGCT
ACCGCCTCATCAGCCTGCTGAACCTGCACAAGAAGCGGCACTCGGGCGAGGCGCGCTACCGCTGCGAGGACTGCGGCAAGCTCTTCACCA
CCTCGGGCAACCTCAAGCGCCACCAGCTGGTGCACAGCGGCGAGAAGCCCTACCAGTGCGACTACTGCGGCCGCTCCTTCTCCGACCCCA
CTTCCAAGATGCGCCACCTGGAGACCCACGACACGGACAAGGAGCACAAGTGCCCACACTGCGACAAGAAGTTCAACCAGGTAGGGAACC
TGAAGGCCCACCTGAAGATCCACATCGCTGACGGGCCCCTCAAGTGCCGAGAGTGTGGGAAGCAGTTCACCACCTCAGGGAACCTGAAGC
GGCACCTTCGGATCCACAGCGGGGAGAAGCCCTACGTGTGCATCCACTGCCAGCGACAGTTTGCAGACCCCGGCGCTCTGCAGCGGCACG
TCCGCATTCACACAGGTGAGAAGCCATGCCAGTGTGTGATGTGCGGTAAGGCCTTCACCCAGGCCAGCTCCCTCATCGCCCACGTGCGCC
AGCACACCGGGGAGAAGCCCTACGTCTGCGAGCGCTGCGGCAAGAGATTCGTCCAGTCCAGCCAGTTGGCCAATCATATTCGCCACCACG
ACAACATCCGCCCACACAAGTGCAGCGTGTGCAGCAAGGCCTTCGTGAACGTGGGGGACCTGTCCAAGCACATCATCATTCACACTGCAT
TAATAATAAGCTACAGCAGCCGGAGGCAGCGGCCGGAGTGTTAGAATATGCCATGAAACACTTTGGAGAGCTGGAGATCCAGGCTACCTG
GTATGAGAAACTGCACGAGTGGGAGGATGCCCTTGTGGCCTATGACAAGAAAATGGACACCAACAAGGACGACCCAGAGCTGATGCTGGG
CCGCATGCGCTGCCTCGAGGCCTTGGGGGAATGGGGTCAACTCCACCAGCAGTGCTGTGAAAAGTGGACCCTGGTTAATGATGAGACCCA
AGCCAAGATGGCCCGGATGGCTGCTGCAGCTGCATGGGGTTTAGGTCAGTGGGACAGCATGGAAGAATACACCTGTATGATCCCTCGGGA
CACCCATGATGGGGCATTTTATAGAGCTGTGCTGGCACTGCATCAGGACCTCTTCTCCTTGGCACAACAGTGCATTGACAAGGCCAGGGA
CCTGCTGGATGCTGAATTAACTGCGATGGCAGGAGAGAGTTACAGTCGGGCATATGGGGCCATGGTTTCTTGCCACATGCTGTCCGAGCT
GGAGGAGGTTATCCAGTACAAACTTGTCCCCGAGCGACGAGAGATCATCCGCCAGATCTGGTGGGAGAGACTGCAGGGCTGCCAGCGTAT
CGTAGAGGACTGGCAGAAAATCCTTATGGTGCGGTCCCTTGTGGTCAGCCCTCATGAAGACATGAGAACCTGGCTCAAGTATGCAAGCCT
GTGCGGCAAGAGTGGCAGGCTGGCTCTTGCTCATAAAACTTTAGTGTTGCTCCTGGGAGTTGATCCGTCTCGGCAACTTGACCATCCTCT
GCCAACAGTTCACCCTCAGGTGACCTATGCCTACATGAAAAACATGTGGAAGAGTGCCCGCAAGATCGATGCCTTCCAGCACATGCAGCA
TTTTGTCCAGACCATGCAGCAACAGGCCCAGCATGCCATCGCTACTGAGGACCAGCAGCATAAGCAGGAACTGCACAAGCTCATGGCCCG
ATGCTTCCTGAAACTTGGAGAGTGGCAGCTGAATCTACAGGGCATCAATGAGAGCACAATCCCCAAAGTGCTGCAGTACTACAGCGCCGC
CACAGAGCACGACCGCAGCTGGTACAAGGCCTGGCATGCGTGGGCAGTGATGAACTTCGAAGCTGTGCTACACTACAAACATCAGAACCA
AGCCCGCGATGAGAAGAAGAAACTGCGTCATGCCAGCGGGGCCAACATCACCAACGCCACCACTGCCGCCACCACGGCCGCCACTGCCAC
CACCACTGCCAGCACCGAGGGCAGCAACAGTGAGAGCGAGGCCGAGAGCACCGAGAACAGCCCCACCCCATCGCCGCTGCAGAAGAAGGT
CACTGAGGATCTGTCCAAAACCCTCCTGATGTACACGGTGCCTGCCGTCCAGGGCTTCTTCCGTTCCATCTCCTTGTCACGAGGCAACAA
CCTCCAGGATACACTCAGAGTTCTCACCTTATGGTTTGATTATGGTCACTGGCCAGATGTCAATGAGGCCTTAGTGGAGGGGGTGAAAGC
CATCCAGATTGATACCTGGCTACAGGTTATACCTCAGCTCATTGCAAGAATTGATACGCCCAGACCCTTGGTGGGACGTCTCATTCACCA
GCTTCTCACAGACATTGGTCGGTACCACCCCCAGGCCCTCATCTACCCACTGACAGTGGCTTCTAAGTCTACCACGACAGCCCGGCACAA
TGCAGCCAACAAGATTCTGAAGAACATGTGTGAGCACAGCAACACCCTGGTCCAGCAGGCCATGATGGTGAGCGAGGAGCTGATCCGAGT
GGCCATCCTCTGGCATGAGATGTGGCATGAAGGCCTGGAAGAGGCATCTCGTTTGTACTTTGGGGAAAGGAACGTGAAAGGCATGTTTGA
GGTGCTGGAGCCCTTGCATGCTATGATGGAACGGGGCCCCCAGACTCTGAAGGAAACATCCTTTAATCAGGCCTATGGTCGAGATTTAAT
GGAGGCCCAAGAGTGGTGCAGGAAGTACATGAAATCAGGGAATGTCAAGGACCTCACCCAAGCCTGGGACCTCTATTATCATGTGTTCCG
ACGAATCTCAAAGCAGCTGCCTCAGCTCACATCCTTAGAGCTGCAATATGTTTCCCCAAAACTTCTGATGTGCCGGGACCTTGAATTGGC
TGTGCCAGGAACATATGACCCCAACCAGCCAATCATTCGCATTCAGTCCATAGCACCGTCTTTGCAAGTCATCACATCCAAGCAGAGGCC
CCGGAAATTGACACTTATGGGCAGCAACGGACATGAGTTTGTTTTCCTTCTAAAAGGCCATGAAGATCTGCGCCAGGATGAGCGTGTGAT
GCAGCTCTTCGGCCTGGTTAACACCCTTCTGGCCAATGACCCAACATCTCTTCGGAAAAACCTCAGCATCCAGAGATACGCTGTCATCCC
TTTATCGACCAACTCGGGCCTCATTGGCTGGGTTCCCCACTGTGACACACTGCACGCCCTCATCCGGGACTACAGGGAGAAGAAGAAGAT
CCTTCTCAACATCGAGCATCGCATCATGTTGCGGATGGCTCCGGACTATGACCACTTGACTCTGATGCAGAAGGTGGAGGTGTTTGAGCA
TGCCGTCAATAATACAGCTGGGGACGACCTGGCCAAGCTGCTGTGGCTGAAAAGCCCCAGCTCCGAGGTGTGGTTTGACCGAAGAACCAA
TTATACCCGTTCTTTAGCGGTCATGTCAATGGTTGGGTATATTTTAGGCCTGGGAGATAGACACCCATCCAACCTGATGCTGGACCGTCT
GAGTGGGAAGATCCTGCACATTGACTTTGGGGACTGCTTTGAGGTTGCTATGACCCGAGAGAAGTTTCCAGAGAAGATTCCATTTAGACT
AACAAGAATGTTGACCAATGCTATGGAGGTTACAGGCCTGGATGGCAACTACAGAATCACATGCCACACAGTGATGGAGGTGCTGCGAGA
GCACAAGGACAGTGTCATGGCCGTGCTGGAAGCCTTTGTCTATGACCCCTTGCTGAACTGGAGGCTGATGGACACAAATACCAAAGGCAA
CAAGCGATCCCGAACGAGGACGGATTCCTACTCTGCTGGCCAGTCAGTCGAAATTTTGGACGGTGTGGAACTTGGAGAGCCAGCCCATAA
GAAAACGGGGACCACAGTGCCAGAATCTATTCATTCTTTCATTGGAGACGGTTTGGTGAAACCAGAGGCCCTAAATAAGAAAGCTATCCA
GATTATTAACAGGGTTCGAGATAAGCTCACTGGTCGGGACTTCTCTCATGATGACACTTTGGATGTTCCAACGCAAGTTGAGCTGCTCAT
CAAACAAGCGACATCCCATGAAAACCTCTGCCAGTGCTATATTGGCTGGTGCCCTTTCTGGTAACTGGAGGCCCAGATGTGCCCATCACG
TTTTTTCTGAGGCTTTTGTACTTTAGTAAATGCTTCCACTAAACTGAAACCATGGTGAGAAAGTTTGACTTTGTTAAATATTTTGAAATG
TAAATGAAAAGAACTACTGTATATTAAAAGTTGGTTTGAACCAACTTTCTAGCTGCTGTTGAAGAATATATTGTCAGAAACACAAGGCTT
GATTTGGTTCCCAGGACAGTGAAACATAGTAATACCACGTAAATCAAGCCATTCATTTTGGGGAACAGAAGATCCATAACTTTAGAAATA
CGGGTTTTGACTTAACTCACAAGAGAACTCATCATAAGTACTTGCTGATGGAAGAATGACCTAGTTGCTCCTCTCAACATGGGTACAGCA
AACTCAGCACAGCCAAGAAGCCTCAGGTCGTGGAGAACATGGATTAGGATCCTAGACTGTAAAGACACAGAAGATGCTGACCTCACCCCT
GCCACCTATCCCAAGACCTCACTGGTCTGTGGACAGCAGCAGAAATGTTTGCAAGATAGGCCAAAATGAGTACAAAAGGTCTGTCTTCCA
TCAGACCCAGTGATGCTGCGACTCACACGCTTCAATTCAAGACCTGACCGCTAGTAGGGAGGTTTATTCAGATCGCTGGCAGCCTCGGCT
GAGCAGATGCACAGAGGGGATCACTGTGCAGTGGGACCACCCTCACTGGCCTTCTGCAGCAGGGTTCTGGGATGTTTTCAGTGGTCAAAA
TACTCTGTTTAGAGCAAGGGCTCAGAAAACAGAAATACTGTCATGGAGGTGCTGAACACAGGGAAGGTCTGGTACATATTGGAAATTATG
AGCAGAACAAATACTCAACTAAATGCACAAAGTATAAAGTGTAGCCATGTCTAGACACCATGTTGTATCAGAATAATTTTTGTGCCAATA


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FusionGenePPI for ZBTB17_MTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ZBTB17DIS3, DNMT3A, TOPBP1, MYC, MAX, EP300, HCFC1, IRF8, ZBTB17, MYCN, TMPRSS11A, HSP90AA1, KLF5, YWHAQ, ZBTB49, HSPB1, ZBTB4, GFI1, ITGB5, CDKN2A, TP53, BCL6, HUWE1, MAGEA4, DACT1, DVL2, ZBTB7CMTORUBQLN1, RICTOR, RPTOR, FKBP1A, ABL1, EIF4EBP1, AKT1, MTOR, IRS1, LRPAP1, PRKAA1, PRKCD, RHEB, RPS6KB1, CLIP1, STAT1, EIF3B, EIF3C, EIF3F, GPHN, MAPKAP1, GDI2P1, PA2G4, PDK1, CFP, PLD2, PPP2R2A, RAP1A, STAT3, TERT, MLST8, FBXW7, TTI1, TELO2, DEPTOR, PRR5, PRKCA, RPL23, RPS6, RPL23A, RPL26, RPL5, GSK3B, C7orf25, CDC37, SEPT2, TERF1, SIRT7, USP9X, RUVBL2, RUVBL1, SQSTM1, RRAGC, MAPK8, AKT1S1, EIF4EBP2, ULK1, RRAGD, PML, STK38, BRCA1, DDB1, VCP, METAP2, TP53, SIRT1, PREX1, PREX2, LARS, PDIA3, HSPA4, AMBRA1, TRAF6, EGFR, YWHAQ, MTA2, FKBP8, GNB1, GNG2, GNB2, GNB3, GNB5, RRAGB, PRR5L, ILK, NCBP1, EIF4E, CHUK, IKBKB, IKBKG, NFKBIA, SGK1, GADD45A, RHEBL1, SHMT2, MOV10, NXF1, MAF1, NBN, LAMTOR2, BCL2L1, SUZ12, SUMO1, GTF3C1, PRKAR1A, YWHAZ, BSG, CD274, VSIG2, CA14, NT5E, CD244, LYPD3, RP2, SCN2B, HTR6, MLXIP, MLXIPL, DIAPH1, TRMT61A, XPO1, HNRNPD, LLGL2, YEATS4, SYNCRIP, SGTB, VPS16, NAF1, ASPM, BAG6, ZSCAN26, TRAF2, TNFAIP3, RAB1A, RAP2A, PARK2, BRAT1, MAP3K3, DCP2, MTMR3, ZNRF2, FBXO8, PDGFRA, PRKDC, CHEK1, KDM5C, IGF1R, SMAD4, TOP1, CASP8, PTEN, LEFTY1, SCN3B, VIPR2, NTRK3, NPY2R, CD83, TMEM206, DPEP1, HTT, THADA, SMDT1, XPO6, XPO4, MAP2K1, MAPK1, RABGGTB, FNTA, TUBA1A, WEE1, ESR1, TRIM25, SKP2, EP300


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316269_308609811MYC
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316269_308609804MYC
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215269_308527722MYC
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27582258_229614172550MLST8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316637_803609811HCFC1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316637_803609804HCFC1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215637_803527722HCFC1
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375733-1316637_718609811MYC
HgeneZBTB17chr1:16269559chr1:11227574ENST00000375743-1316637_718609804MYC
HgeneZBTB17chr1:16269559chr1:11227574ENST00000537142-1215637_718527722MYC
TgeneMTORchr1:16269559chr1:11227574ENST00000361445-27581_65114172550NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ZBTB17_MTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMTORP42345DB01590EverolimusSerine/threonine-protein kinase mTORsmall moleculeapproved
TgeneMTORP42345DB06287TemsirolimusSerine/threonine-protein kinase mTORsmall moleculeapproved
TgeneMTORP42345DB00337PimecrolimusSerine/threonine-protein kinase mTORsmall moleculeapproved|investigational
TgeneMTORP42345DB00877SirolimusSerine/threonine-protein kinase mTORsmall moleculeapproved|investigational

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RelatedDiseases for ZBTB17_MTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMTORC0041696Unipolar Depression2PSYGENET
TgeneMTORC1269683Major Depressive Disorder2PSYGENET
TgeneMTORC0001418Adenocarcinoma1CTD_human
TgeneMTORC0007134Renal Cell Carcinoma1CTD_human
TgeneMTORC0007873Uterine Cervical Neoplasm1CTD_human
TgeneMTORC0020538Hypertensive disease1CTD_human
TgeneMTORC0025500Mesothelioma1CTD_human
TgeneMTORC0036341Schizophrenia1CTD_human
TgeneMTORC0149721Left Ventricular Hypertrophy1CTD_human
TgeneMTORC0235032Neurotoxicity Syndromes1CTD_human
TgeneMTORC0262584Carcinoma, Small Cell1CTD_human
TgeneMTORC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneMTORC0588006Mild depression1PSYGENET
TgeneMTORC0919267ovarian neoplasm1CTD_human
TgeneMTORC1955869Malformations of Cortical Development1CTD_human
TgeneMTORC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneMTORC2239176Liver carcinoma1CTD_human
TgeneMTORC4225259SMITH-KINGSMORE SYNDROME1ORPHANET;UNIPROT