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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42437

FusionGeneSummary for YY1AP1_TOMM7

check button Fusion gene summary
Fusion gene informationFusion gene name: YY1AP1_TOMM7
Fusion gene ID: 42437
HgeneTgene
Gene symbol

YY1AP1

TOMM7

Gene ID

55249

54543

Gene nameYY1 associated protein 1translocase of outer mitochondrial membrane 7
SynonymsGRNG|HCCA1|HCCA2|YY1APTOM7
Cytomap

1q22

7p15.3

Type of geneprotein-codingprotein-coding
DescriptionYY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2mitochondrial import receptor subunit TOM7 homolog6.2 kd proteintranslocase of outer membrane 7 kDa subunit homologtranslocase of outer mitochondrial membrane 7 homolog
Modification date2018052320180522
UniProtAcc

Q9H869

Q9P0U1

Ensembl transtripts involved in fusion geneENST00000311573, ENST00000368340, 
ENST00000347088, ENST00000361831, 
ENST00000355499, ENST00000404643, 
ENST00000407221, ENST00000359205, 
ENST00000295566, ENST00000368330, 
ENST00000368339, ENST00000535662, 
ENST00000405763, ENST00000438245, 
ENST00000476093, 
ENST00000463284, 
ENST00000358435, ENST00000405021, 
ENST00000372879, 
Fusion gene scores* DoF score7 X 7 X 3=1473 X 3 X 2=18
# samples 83
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: YY1AP1 [Title/Abstract] AND TOMM7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYY1AP1

GO:0051726

regulation of cell cycle

17541814


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU951526YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000311573ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000311573ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000311573ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000311573ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368340ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368340ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368340ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368340ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000347088ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000347088ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000347088ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000347088ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000361831ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000361831ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000361831ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000361831ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000355499ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000355499ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000355499ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000355499ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000404643ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000404643ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000404643ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000404643ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000407221ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000407221ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000407221ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000407221ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000359205ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000359205ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000359205ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000359205ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000295566ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000295566ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000295566ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000295566ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368330ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368330ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368330ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368330ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368339ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000368339ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368339ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000368339ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000535662ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000535662ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000535662ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000535662ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000405763ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000405763ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000405763ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000405763ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000438245ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000438245ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000438245ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000438245ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000476093ENST00000463284YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-5UTRENST00000476093ENST00000358435YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000476093ENST00000405021YY1AP1chr1

155629732

+TOMM7chr7

22862456

-
intron-intronENST00000476093ENST00000372879YY1AP1chr1

155629732

+TOMM7chr7

22862456

-

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FusionProtFeatures for YY1AP1_TOMM7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YY1AP1

Q9H869

TOMM7

Q9P0U1

Required for assembly and stability of the TOM complex.Positive regulator of PRKN translocation to damaged mitochondria.Acts probably by stabilizing PINK1 on the outer membrane ofdepolarized mitochondria. {ECO:0000269|PubMed:18331822,ECO:0000269|PubMed:24270810}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YY1AP1_TOMM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YY1AP1_TOMM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YY1AP1_TOMM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YY1AP1_TOMM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource