	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 42436

FusionGeneSummary for YY1AP1_PRCC

Fusion gene summary

Fusion gene information	Fusion gene name: YY1AP1_PRCC
	Fusion gene ID: 42436
		Hgene	Tgene
	Gene symbol	YY1AP1	PRCC
	Gene ID	55249	5546
	Gene name	YY1 associated protein 1	papillary renal cell carcinoma (translocation-associated)
	Synonyms	GRNG\|HCCA1\|HCCA2\|YY1AP	RCCP1\|TPRC
	Cytomap	1q22	1q23.1
	Type of gene	protein-coding	protein-coding
	Description	YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2	proline-rich protein PRCCpapillary renal cell carcinoma translocation-associated gene protein
	Modification date	20180523	20180522
	UniProtAcc	Q9H869	Q92733
	Ensembl transtripts involved in fusion gene	ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093,	ENST00000271526, ENST00000353233, ENST00000491853,
Fusion gene scores	* DoF score	7 X 7 X 3=147	5 X 5 X 3=75
	# samples	8	8
	** MAII score	log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/75*10)=0.0931094043914815 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: YY1AP1 [Title/Abstract] AND PRCC [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	YY1AP1	GO:0051726	regulation of cell cycle	17541814
Tgene	PRCC	GO:0007093	mitotic cell cycle checkpoint	11717438

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BI009431	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000311573	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000311573	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000311573	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368340	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368340	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000368340	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000347088	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000347088	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000347088	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000361831	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000361831	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000361831	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000355499	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000355499	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000355499	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000404643	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000404643	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000404643	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000407221	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000407221	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000407221	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000359205	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000359205	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000359205	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000295566	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000295566	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000295566	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368330	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368330	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000368330	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368339	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000368339	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000368339	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000535662	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000535662	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000535662	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000405763	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000405763	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000405763	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000438245	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000438245	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000438245	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000476093	ENST00000271526	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-3CDS	ENST00000476093	ENST00000353233	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+
intron-intron	ENST00000476093	ENST00000491853	YY1AP1	chr1	155736379	-	PRCC	chr1	156770241	+

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FusionProtFeatures for YY1AP1_PRCC

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
YY1AP1 Q9H869	PRCC Q92733
	May regulate cell cycle progression through interactionwith MAD2L2. {ECO:0000269\|PubMed:11717438}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for YY1AP1_PRCC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YY1AP1_PRCC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for YY1AP1_PRCC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for YY1AP1_PRCC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 42436

FusionGeneSummary for YY1AP1_PRCC

FusionProtFeatures for YY1AP1_PRCC

FusionGeneSequence for YY1AP1_PRCC

FusionGenePPI for YY1AP1_PRCC

RelatedDrugs for YY1AP1_PRCC

RelatedDiseases for YY1AP1_PRCC