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Fusion gene ID: 42434 |
FusionGeneSummary for YY1AP1_MLXIP |
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Fusion gene information | Fusion gene name: YY1AP1_MLXIP | Fusion gene ID: 42434 | Hgene | Tgene | Gene symbol | YY1AP1 | MLXIP | Gene ID | 55249 | 22877 |
Gene name | YY1 associated protein 1 | MLX interacting protein | |
Synonyms | GRNG|HCCA1|HCCA2|YY1AP | MIR|MONDOA|bHLHe36 | |
Cytomap | 1q22 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | YY1-associated protein 1hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-associated protein 2 | MLX-interacting proteinMlx interactorclass E basic helix-loop-helix protein 36transcriptional activator MondoA | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9H869 | Q9HAP2 | |
Ensembl transtripts involved in fusion gene | ENST00000311573, ENST00000368340, ENST00000347088, ENST00000361831, ENST00000355499, ENST00000404643, ENST00000407221, ENST00000359205, ENST00000295566, ENST00000368330, ENST00000368339, ENST00000535662, ENST00000405763, ENST00000438245, ENST00000476093, | ENST00000319080, ENST00000538698, ENST00000377037, ENST00000535996, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 7 X 6 X 4=168 |
# samples | 8 | 7 | |
** MAII score | log2(8/147*10)=-0.877744249949002 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YY1AP1 [Title/Abstract] AND MLXIP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YY1AP1 | GO:0051726 | regulation of cell cycle | 17541814 |
Tgene | MLXIP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11073985 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI004450 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000311573 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000311573 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000311573 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000311573 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000368340 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000368340 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368340 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368340 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000347088 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000347088 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000347088 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000347088 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000361831 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000361831 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000361831 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000361831 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000355499 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000355499 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000355499 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000355499 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000404643 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000404643 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000404643 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000404643 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000407221 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000407221 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000407221 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000407221 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000359205 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000359205 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000359205 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000359205 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000295566 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000295566 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000295566 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000295566 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000368330 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000368330 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368330 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368330 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000368339 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000368339 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368339 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000368339 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000535662 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000535662 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000535662 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000535662 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000405763 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000405763 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000405763 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000405763 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000438245 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000438245 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000438245 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000438245 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-3CDS | ENST00000476093 | ENST00000319080 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-5UTR | ENST00000476093 | ENST00000538698 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000476093 | ENST00000377037 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
intron-intron | ENST00000476093 | ENST00000535996 | YY1AP1 | chr1 | 155630516 | + | MLXIP | chr12 | 122617912 | - |
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FusionProtFeatures for YY1AP1_MLXIP |
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Hgene | Tgene |
YY1AP1 | MLXIP |
Binds DNA as a heterodimer with MLX and activatestranscription. Binds to the canonical E box sequence 5'-CACGTG-3'.Plays a role in transcriptional activation of glycolytic targetgenes. Involved in glucose-responsive gene regulation.{ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771,ECO:0000269|PubMed:16782875}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YY1AP1_MLXIP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YY1AP1_MLXIP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YY1AP1_MLXIP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YY1AP1_MLXIP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |