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Fusion gene ID: 42392 |
FusionGeneSummary for YWHAE_ERCC8 |
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Fusion gene information | Fusion gene name: YWHAE_ERCC8 | Fusion gene ID: 42392 | Hgene | Tgene | Gene symbol | YWHAE | ERCC8 | Gene ID | 7531 | 1161 |
Gene name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | |
Synonyms | 14-3-3E|HEL2|KCIP-1|MDCR|MDS | CKN1|CSA|UVSS2 | |
Cytomap | 17p13.3 | 5q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | 14-3-3 protein epsilon14-3-3 epsilonepididymis luminal protein 2mitochondrial import stimulation factor L subunitprotein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptidetyrosine | DNA excision repair protein ERCC-8Cockayne syndrome WD-repeat protein CSAcockayne syndrome WD repeat protein CSAexcision repair cross-complementation group 8excision repair cross-complementing rodent repair deficiency, complementation group 8 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P62258 | Q13216 | |
Ensembl transtripts involved in fusion gene | ENST00000264335, ENST00000571732, ENST00000573026, ENST00000575977, ENST00000498643, | ENST00000426742, ENST00000265038, ENST00000462279, ENST00000543101, | |
Fusion gene scores | * DoF score | 15 X 4 X 8=480 | 4 X 4 X 5=80 |
# samples | 15 | 6 | |
** MAII score | log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YWHAE [Title/Abstract] AND ERCC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YWHAE | GO:0000165 | MAPK cascade | 12917326 |
Hgene | YWHAE | GO:0034605 | cellular response to heat | 12917326 |
Hgene | YWHAE | GO:0046827 | positive regulation of protein export from nucleus | 12917326 |
Hgene | YWHAE | GO:0051480 | regulation of cytosolic calcium ion concentration | 18029012 |
Hgene | YWHAE | GO:0060306 | regulation of membrane repolarization | 11953308 |
Hgene | YWHAE | GO:1901016 | regulation of potassium ion transmembrane transporter activity | 11953308 |
Hgene | YWHAE | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity | 18029012 |
Hgene | YWHAE | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation | 11953308 |
Hgene | YWHAE | GO:1905913 | negative regulation of calcium ion export across plasma membrane | 18029012 |
Tgene | ERCC8 | GO:0000209 | protein polyubiquitination | 12732143 |
Tgene | ERCC8 | GO:0006283 | transcription-coupled nucleotide-excision repair | 12732143 |
Tgene | ERCC8 | GO:0006974 | cellular response to DNA damage stimulus | 11782547 |
Tgene | ERCC8 | GO:0006979 | response to oxidative stress | 11782547 |
Tgene | ERCC8 | GO:0009411 | response to UV | 12732143 |
Tgene | ERCC8 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 16751180 |
Tgene | ERCC8 | GO:0051865 | protein autoubiquitination | 12732143 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | COAD | TCGA-CM-5348-01A | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000264335 | ENST00000426742 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000264335 | ENST00000265038 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-intron | ENST00000264335 | ENST00000462279 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000264335 | ENST00000543101 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000571732 | ENST00000426742 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000571732 | ENST00000265038 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-intron | ENST00000571732 | ENST00000462279 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000571732 | ENST00000543101 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000573026 | ENST00000426742 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000573026 | ENST00000265038 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-intron | ENST00000573026 | ENST00000462279 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000573026 | ENST00000543101 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000575977 | ENST00000426742 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000575977 | ENST00000265038 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-intron | ENST00000575977 | ENST00000462279 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5CDS-5UTR | ENST00000575977 | ENST00000543101 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000498643 | ENST00000426742 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000498643 | ENST00000265038 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-intron | ENST00000498643 | ENST00000462279 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
5UTR-5UTR | ENST00000498643 | ENST00000543101 | YWHAE | chr17 | 1303341 | - | ERCC8 | chr5 | 60224786 | - |
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FusionProtFeatures for YWHAE_ERCC8 |
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Hgene | Tgene |
YWHAE | ERCC8 |
Substrate-recognition component of the CSA complex, aDCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex,involved in transcription-coupled nucleotide excision repair. TheCSA complex (DCX(ERCC8) complex) promotes the ubiquitination andsubsequent proteasomal degradation of ERCC6 in a UV-dependentmanner; ERCC6 degradation is essential for the recovery of RNAsynthesis after transcription-coupled repair. It is required forthe recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blockinglesions from the transcribed strand of active genes.{ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:16916636,ECO:0000269|PubMed:16964240}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YWHAE_ERCC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YWHAE_ERCC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YWHAE | IGF1R, GPRIN2, SORBS2, GRAP2, MAPK7, NDEL1, HDAC4, HDAC5, REM1, BAD, MAP3K10, CDC25C, MAP3K3, MAP3K1, MAP3K2, IRS1, NGFRAP1, SYN2, KCNH2, TNFAIP3, RAF1, CDC25B, TOP2A, TGFB1, CDC25A, USP43, POLR3H, HDAC7, MDM4, FOXO3, HIVEP2, LRMP, COX2, MYH10, PNLIP, SSFA2, YWHAB, YWHAZ, YWHAG, ARAF, YWHAH, HDAC9, KIAA0232, TLK1, CHAF1A, CAP2, YWHAQ, RAP1GAP2, SH3BP4, WWTR1, FAM13B, MSL2, ZNF839, RASAL3, WNK1, ENKD1, TBC1D3F, CGNL1, CEP95, ANKHD1-EIF4EBP3, ING1, SRRM2, FAN1, EMD, SAMSN1, EXO1, H2AFX, MYC, PRKAA1, PARD6G, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, DISC1, UBE3A, GAPDH, KAT8, HIST1H3A, HIST1H4A, TCEB3, BRD4, CALM1, FBXO4, CDKN1B, TRAT1, RARRES3, ARRB1, ARRB2, CBL, ACD, POT1, CUL3, CDK2, CUL1, DCUN1D1, NEDD8, PTPN14, MARK3, MARK2, MEX3B, LRRK2, AKT1, ACTA2, CBX3, HNF1A, HSP90AB1, NPM1, ATP5B, ATP5A1, STOML2, CLNS1A, IPO8, KPNB1, RPLP0, RPL6, RPL4, RPS3, RPS8, DNAJA1, EIF4B, EIF3E, EEF1G, EEF1A2, HNRNPA2B1, ILF2, RUVBL2, RCN2, TUBB, TUBB4B, TUBB2B, PRPSAP1, TUBA3E, DDX21, ADH1B, ADH4, AGXT, HIST2H4B, HNRNPA3, HNRNPC, RBMY1A1, SF3B1, PCBP1, RBM10, MAP3K7, TBK1, PPM1B, SPIN1, CDC37, PHB, PRPSAP2, PRPS1, QPCTL, TMPO, C11orf84, HDX, CFAP43, VCP, ATXN1, FN1, VCAM1, BRAF, MAP2K1, PARD3, KIF5B, KLC2, LMO7, TBC1D4, HSPA1A, KLC3, KLC4, KLC1, CLASP2, LIMA1, TSC2, CLASP1, HSPA8, PAK4, RAB11FIP2, MAST3, TBC1D1, KIF1C, OSBPL3, TIAM1, ABLIM1, LARP1, BAIAP2, IRS2, SHROOM2, LSR, KIF1B, RAB11FIP1, MLLT4, MAST2, PFKFB2, CDK18, PKP2, DENND4A, TP53BP2, CGN, ZFP36L2, TUBA1A, KSR1, RABEP1, EIF4E2, CSNK1A1, PDZD11, PRKCI, DCAF7, NADK, USP8, C1QBP, TSC1, REEP1, KIF23, SLC25A6, SRGAP2, FAM53C, TRIP11, BCAR1, CRTC1, RASSF8, CEP250, VAMP8, GRB2, TRIM32, NOS2, IL7R, UBL4A, ITGA4, CBX4, ABL1, MST1R, PAN2, RAD52, BAG3, GSTA1, FTH1, CDK11B, SRSF1, SRSF6, SRSF4, NOLC1, TRA2B, PLEKHO2, HMHA1, SRSF7, NCBP1, DOK3, VASP, KIAA0930, GAB2, KIAA0226, PIK3R4, SGK223, RCHY1, IGHG1, UVRAG, SRSF2, FBXO6, RASSF2, SAV1, YAP1, PARK2, PAFAH1B2, PPP1R2, PROSC, RAP1GDS1, TMOD3, TNFAIP8, TUBB2A, UBXN1, VCL, XPO1, ALDH7A1, ASNS, ATIC, CAPN2, CAPNS1, EIF5, FERMT2, G6PD, GSS, ISOC1, MCTS1, STK26, OGFOD1, PAK2, PDHB, PDIA4, PTMA, SCPEP1, TBCB, TWF2, UBE2R2, IRS4, SIK3, SIK2, CEP57, TP53, GRB10, DTL, HUWE1, FBXW11, CUL7, OBSL1, CCDC8, MAST1, CDK16, TNK1, BTRC, NKD2, DMTN, TEX33, EPB41L3, WWC1, HNRNPA1, HSPB1, UNK, ACAT2, CALR, CENPE, MACF1, MAPK14, MCFD2, POLR2D, PSMB2, SHMT2, SNRPD1, ACTR6, HNRNPL, NPM3, PGK1, PSMC1, ZPR1, NTRK1, LCA5, CENPJ, PRICKLE3, MYH11, TSNAX, CCDC88A, CRY1, CRY2, MCM2, CDC5L, ERRFI1, U2AF2, PRDX6, NFATC2, SNF8, ANKZF1, SMAGP, TCEANC, LCP2, METAP2, MAGEB4, CHST11, ZC3HC1, MCM10, DDX54, C8orf59, NAF1, FGF12, GSTM3, STAC, FAM64A, ATP6V0B, FLJ25758, CDC73, WWP2, CDH1, CEP131, PCM1, PPM1H, PTPN3, SSH1, TENC1, SMTNL2, PLEKHG5, SAMD4A, SPATA13, RIN1, TFEB, TESPA1, SAMD4B, FAM163A, CRTC2, FAM189A2, PAK6, RBM3, RAB3IP, CBY1, CEP170, INPP5E, CYLD, COX15, DLD, DLST, DNM1L, SDHA, SOAT1, VDAC1, TRIM25, BRCA1, BRD1, BRMS1 | ERCC8 | XAB2, COPS5, COPS6, DDB1, ERCC6, CSNK2B, POLR2A, EP300, HMGN1, DDB2, CUL4A, GPS1, RBX1, COPS2, COPS3, COPS4, COPS7A, COPS8, CUL4B, CUL5, GTF2H2, TP53, MDM2, OGG1, SSBP1, DDA1, RFWD2, TOP1, ZNF24, RUVBL2, UVSSA, PCNA, H1F0, VCP, UBXN7, PCGF1, DPPA4, BCOR, NANOG, POU5F1, PFDN4, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YWHAE_ERCC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YWHAE_ERCC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | YWHAE | C0036341 | Schizophrenia | 4 | PSYGENET |
Hgene | YWHAE | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | YWHAE | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ERCC8 | C0751039 | Cockayne Syndrome, Type I | 3 | ORPHANET;UNIPROT |
Tgene | ERCC8 | C0009207 | Cockayne Syndrome | 2 | CTD_human |
Tgene | ERCC8 | C3553298 | UV-SENSITIVE SYNDROME 2 | 1 | UNIPROT |