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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42381

FusionGeneSummary for YTHDF2_EYA3

check button Fusion gene summary
Fusion gene informationFusion gene name: YTHDF2_EYA3
Fusion gene ID: 42381
HgeneTgene
Gene symbol

YTHDF2

EYA3

Gene ID

51441

2140

Gene nameYTH N6-methyladenosine RNA binding protein 2EYA transcriptional coactivator and phosphatase 3
SynonymsCAHL|HGRG8|NY-REN-2-
Cytomap

1p35.3

1p35.3

Type of geneprotein-codingprotein-coding
DescriptionYTH domain-containing family protein 29430020E02RikCLL-associated antigen KW-14YTH N(6)-methyladenosine RNA binding protein 2YTH domain family, member 2high-glucose-regulated protein 8renal carcinoma antigen NY-REN-2eyes absent homolog 3eyes absent 3
Modification date2018051920180523
UniProtAcc

Q9Y5A9

Q99504

Ensembl transtripts involved in fusion geneENST00000542507, ENST00000373812, 
ENST00000541996, ENST00000478283, 
ENST00000373871, ENST00000436342, 
ENST00000373864, ENST00000540618, 
ENST00000545175, ENST00000373863, 
ENST00000471498, 
Fusion gene scores* DoF score3 X 1 X 3=92 X 2 X 2=8
# samples 32
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: YTHDF2 [Title/Abstract] AND EYA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYTHDF2

GO:1903679

positive regulation of cap-independent translational initiation

26458103

TgeneEYA3

GO:0010212

response to ionizing radiation

19234442

TgeneEYA3

GO:0016576

histone dephosphorylation

19234442|19351884


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N6-A4VG-01AYTHDF2chr1

29070498

+EYA3chr1

28304985

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000542507ENST00000373871YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000542507ENST00000436342YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000542507ENST00000373864YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000542507ENST00000540618YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000542507ENST00000545175YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000542507ENST00000373863YTHDF2chr1

29070498

+EYA3chr1

28304985

-
5CDS-intronENST00000542507ENST00000471498YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000373871YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000436342YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000373864YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000540618YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000545175YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000373812ENST00000373863YTHDF2chr1

29070498

+EYA3chr1

28304985

-
5CDS-intronENST00000373812ENST00000471498YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000373871YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000436342YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000373864YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000540618YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000545175YTHDF2chr1

29070498

+EYA3chr1

28304985

-
Frame-shiftENST00000541996ENST00000373863YTHDF2chr1

29070498

+EYA3chr1

28304985

-
5CDS-intronENST00000541996ENST00000471498YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000373871YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000436342YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000373864YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000540618YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000545175YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-3CDSENST00000478283ENST00000373863YTHDF2chr1

29070498

+EYA3chr1

28304985

-
3UTR-intronENST00000478283ENST00000471498YTHDF2chr1

29070498

+EYA3chr1

28304985

-

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FusionProtFeatures for YTHDF2_EYA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YTHDF2

Q9Y5A9

EYA3

Q99504

Specifically recognizes and binds N6-methyladenosine(m6A)-containing RNAs, and regulates mRNA stability(PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is amodification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing(PubMed:22575960, PubMed:24284625, PubMed:25412658,PubMed:25412661). Acts as a regulator of mRNA stability: bindingto m6A-containing mRNAs results in the localization to mRNA decaysites, such as processing bodies (P-bodies), leading to mRNAdegradation (PubMed:24284625, PubMed:26046440). Requiredmaternally to regulate oocyte maturation: probably acts by bindingto m6A-containing mRNAs, thereby regulating maternal transcriptdosage during oocyte maturation, which is essential for thecompetence of oocytes to sustain early zygotic development (Bysimilarity). Also involved in haematopoietic stem cellsspecification: acts by binding to m6A-containing mRNAs, leading todecrease Notch dignaling and promote endothelial to haematopoietictransition (By similarity). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: uponstress, relocalizes to the nucleus and specifically binds mRNAswith some m6A methylation mark at their 5'-UTR, protectingdemethylation of mRNAs by FTO, thereby promoting cap-independentmRNA translation (PubMed:26458103). May inhibit replication ofkaposis sarcoma-associated herpesvirus (KSHV); its role is howeverunclear and additional evidences are needed to confirm suchresults (PubMed:29109479). {ECO:0000250|UniProtKB:E7F1H9,ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960,ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658,ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440,ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103,ECO:0000269|PubMed:29109479}. (Microbial infection) Promotes viral gene expression andreplication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282).{ECO:0000269|PubMed:29447282}. (Microbial infection) Promotes viral gene expression andvirion production of kaposis sarcoma-associated herpesvirus (KSHV)at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16cells) (PubMed:29659627). Acts by binding to N6-methyladenosine(m6A)-containing viral RNAs (PubMed:29659627).{ECO:0000269|PubMed:29659627}. Tyrosine phosphatase that specifically dephosphorylates'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylationof histone H2AX plays a central role in DNA repair and acts as amark that distinguishes between apoptotic and repair responses togenotoxic stress. Promotes efficient DNA repair bydephosphorylating H2AX, promoting the recruitment of DNA repaircomplexes containing MDC1 (PubMed:19234442, PubMed:19351884). Itsfunction as histone phosphatase probably explains its role intranscription regulation during organogenesis. Coactivates SIX1,and seems to coactivate SIX2, SIX4 and SIX5. The repression ofprecursor cell proliferation in myoblasts by SIX1 is switched toactivation through recruitment of EYA3 to the SIX1-DACH1 complexand seems to be dependent on EYA3 phosphatase activity (Bysimilarity). May be involved in development of the eye.{ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442,ECO:0000269|PubMed:19351884}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YTHDF2_EYA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YTHDF2_EYA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YTHDF2HNRNPA1, HNRNPH1, MEPCE, POT1, ELAVL1, CUL3, CAND1, SMAD3, APP, ESR1, EPAS1, FN1, VCAM1, HIPK4, FBXO6, TARDBP, EIF3A, EIF3H, RPA3, RPA2, RPA1, RNF2, BMI1, RPS6KB2, AGL, HMBS, ASPSCR1, SEPT7, SFPQ, USP13, USP5, NTRK1, B9D2, DCTN1, CEP19, XPO1, RPL10, MCM2, OTUB1, G3BP1EYA3SIX5, H2AFX, SKI, ZDHHC17, TCEAL1, CRK, EWSR1, EYA3, MTMR3, SOAT1, PTRH2, MTMR2, GRPEL1, FHL2, TMEM126A, TSEN34, STIP1, NPPC, TIMM21, CACYBP, NME1, THTPA, TBP, DIS3L, CCDC28A, STX17, SIX2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YTHDF2_EYA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YTHDF2_EYA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource