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Fusion gene ID: 4238 |
FusionGeneSummary for BMP7_EEF1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BMP7_EEF1A2 | Fusion gene ID: 4238 | Hgene | Tgene | Gene symbol | BMP7 | EEF1A2 | Gene ID | 655 | 1917 |
| Gene name | bone morphogenetic protein 7 | eukaryotic translation elongation factor 1 alpha 2 | |
| Synonyms | OP-1 | EEF1AL|EF-1-alpha-2|EF1A|EIEE33|HS1|MRD38|STN|STNL | |
| Cytomap | 20q13.31 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | bone morphogenetic protein 7osteogenic protein 1 | elongation factor 1-alpha 2eukaryotic elongation factor 1 A-2statin-S1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P18075 | Q05639 | |
| Ensembl transtripts involved in fusion gene | ENST00000395863, ENST00000395864, ENST00000450594, ENST00000460817, | ENST00000298049, ENST00000217182, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: BMP7 [Title/Abstract] AND EEF1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BMP7 | GO:0010628 | positive regulation of gene expression | 28124060 |
| Hgene | BMP7 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 19736306 |
| Hgene | BMP7 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 9311995|16049014|17244894|19736306 |
| Hgene | BMP7 | GO:0030501 | positive regulation of bone mineralization | 18436533 |
| Hgene | BMP7 | GO:0030509 | BMP signaling pathway | 16049014|18436533 |
| Hgene | BMP7 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 15100360 |
| Hgene | BMP7 | GO:0034504 | protein localization to nucleus | 17244894 |
| Hgene | BMP7 | GO:0042326 | negative regulation of phosphorylation | 17244894 |
| Hgene | BMP7 | GO:0043407 | negative regulation of MAP kinase activity | 17244894 |
| Hgene | BMP7 | GO:0045665 | negative regulation of neuron differentiation | 16325379 |
| Hgene | BMP7 | GO:0045669 | positive regulation of osteoblast differentiation | 18436533 |
| Hgene | BMP7 | GO:0045786 | negative regulation of cell cycle | 11502704 |
| Hgene | BMP7 | GO:0045839 | negative regulation of mitotic nuclear division | 17244894 |
| Hgene | BMP7 | GO:0045892 | negative regulation of transcription, DNA-templated | 15100360|17244894 |
| Hgene | BMP7 | GO:0045893 | positive regulation of transcription, DNA-templated | 14517293|15100360|16049014 |
| Hgene | BMP7 | GO:0048762 | mesenchymal cell differentiation | 9693150 |
| Hgene | BMP7 | GO:0048812 | neuron projection morphogenesis | 16325379 |
| Hgene | BMP7 | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation | 16049014 |
| Hgene | BMP7 | GO:0060395 | SMAD protein signal transduction | 17244894 |
| Hgene | BMP7 | GO:0060548 | negative regulation of cell death | 12631064 |
| Hgene | BMP7 | GO:0070487 | monocyte aggregation | 15100360 |
| Hgene | BMP7 | GO:0072125 | negative regulation of glomerular mesangial cell proliferation | 17244894 |
| Hgene | BMP7 | GO:1900006 | positive regulation of dendrite development | 11580864 |
| Hgene | BMP7 | GO:1900106 | positive regulation of hyaluranon cable assembly | 15100360 |
| Tgene | EEF1A2 | GO:0090218 | positive regulation of lipid kinase activity | 17088255 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | COAD | TCGA-DM-A0XF-01A | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000395863 | ENST00000298049 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| 5CDS-5UTR | ENST00000395863 | ENST00000217182 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| In-frame | ENST00000395864 | ENST00000298049 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| 5CDS-5UTR | ENST00000395864 | ENST00000217182 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| In-frame | ENST00000450594 | ENST00000298049 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| 5CDS-5UTR | ENST00000450594 | ENST00000217182 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| intron-3CDS | ENST00000460817 | ENST00000298049 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
| intron-5UTR | ENST00000460817 | ENST00000217182 | BMP7 | chr20 | 55840761 | - | EEF1A2 | chr20 | 62129187 | - |
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FusionProtFeatures for BMP7_EEF1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BMP7 | EEF1A2 |
| Induces cartilage and bone formation. May be theosteoinductive factor responsible for the phenomenon of epithelialosteogenesis. Plays a role in calcium regulation and bonehomeostasis. | This protein promotes the GTP-dependent binding ofaminoacyl-tRNA to the A-site of ribosomes during proteinbiosynthesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 5_242 | -24 | 464 | Domain | Note=tr-type G |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 91_95 | -24 | 464 | Nucleotide binding | GTP |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 91_95 | 48 | 464 | Nucleotide binding | GTP |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 14_21 | -24 | 464 | Region | G1 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 153_156 | -24 | 464 | Region | G4 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 194_196 | -24 | 464 | Region | G5 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 70_74 | -24 | 464 | Region | G2 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000217182 | - | 0 | 8 | 91_94 | -24 | 464 | Region | G3 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 153_156 | 48 | 464 | Region | G4 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 194_196 | 48 | 464 | Region | G5 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 70_74 | 48 | 464 | Region | G2 |
| Tgene | >EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 91_94 | 48 | 464 | Region | G3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 5_242 | 48 | 464 | Domain | Note=tr-type G |
| Tgene | EEF1A2 | chr20:55840761 | chr20:62129187 | ENST00000298049 | - | -1 | 7 | 14_21 | 48 | 464 | Region | G1 |
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FusionGeneSequence for BMP7_EEF1A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_BMP7_ENST00000395863_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_139aa MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAM >In-frame_BMP7_ENST00000395864_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_139aa MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAM >In-frame_BMP7_ENST00000450594_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_139aa MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_BMP7_ENST00000395863_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_418nt ATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGAC TTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCC ATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATG GCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGC >In-frame_BMP7_ENST00000395864_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_418nt ATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGAC TTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCC ATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATG GCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGC >In-frame_BMP7_ENST00000450594_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_418nt ATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGAC TTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCC ATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATG GCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_BMP7_ENST00000395863_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_2672nt CGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGTG GGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCGT TGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCCA AGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGC CGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCA CCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGC ACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCA TCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACC TCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGG GCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACA TGGTCATGAGCTTCGTCAACCTCGAATCACTGCAGCCCCCCTCGCCCTGAGCCAGAGCACCCCGGGTCCCGCCAGCCCCTCACACTCCCA GCAAAATGGGCAAGGAGAAGACCCACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCT ACAAATGCGGAGGTATTGACAAAAGGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGG TGCTGGACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCA TCATCGATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGG GCGTGGGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCA TCGTGGGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCA AGAAGATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGC CGTGGTTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCA CGCGCCCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGA CCGGCATCCTGCGGCCGGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTC TGAGCGAAGCTCTGCCCGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACA GCAAGTCTGACCCGCCGCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCC CGGTCATCGACTGCCACACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGG ACAACCCCAAGTCCCTGAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACC CGCCTCTCGGCCGCTTCGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCG GCAAGGTCACCAAGTCGGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGC TCCGAACCCCGGGCCCGGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTC CGCTTGCCAGAGGCCCTCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGG >In-frame_BMP7_ENST00000395864_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_2386nt CGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGGCCGGGGAGGGGCCATGT CTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCCACCTGGGGCGGTGCGGG CCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCGCACAGCTTCGTGGCGCT CTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTCATCCACCGGCGCCTCCG CAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCACCTCCAGGGCAAGCACAA CTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAGGGCTTCTCCTACCCCTA CAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGACATGGTCATGAGCTTCGT CAACCTCGAATCACTGCAGCCCCCCTCGCCCTGAGCCAGAGCACCCCGGGTCCCGCCAGCCCCTCACACTCCCAGCAAAATGGGCAAGGA GAAGACCCACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATCTACAAATGCGGAGGTAT TGACAAAAGGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGGGTGCTGGACAAGCTGAA GGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACCATCATCGATGCCCCCGG CCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCGGGCGTGGGCGAGTTCGA GGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTCATCGTGGGCGTGAACAA AATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATCAAGAAGATCGGCTACAA CCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATGCCGTGGTTCAAGGGCTG GAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCCACGCGCCCCACGGACAA GCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAGACCGGCATCCTGCGGCC GGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCTCTGAGCGAAGCTCTGCC CGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGACAGCAAGTCTGACCCGCC GCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCCCCGGTCATCGACTGCCA CACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAGGACAACCCCAAGTCCCT GAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTACCCGCCTCTCGGCCGCTT CGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCCGGCAAGGTCACCAAGTC GGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCGCTCCGAACCCCGGGCCC GGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCTCCGCTTGCCAGAGGCCC TCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAGGCTTCCGCGCCCAGCGC >In-frame_BMP7_ENST00000450594_chr20_55840761_-_EEF1A2_ENST00000298049_chr20_62129187_-_2673nt CCGAGGCGGCCTCTTGTGCGATCCAGGGCGCACAAGGCTGGGAGAGCGCCCCGGGGCCCCTGCTATCCGCGCCGGAGGTTGGAAGAGGGT GGGTTGCCGCCGCCCGAGGGCGAGAGCGCCAGAGGAGCGGGAAGAAGGAGCGCTCGCCCGCCCGCCTGCCTCCTCGCTGCCTCCCCGGCG TTGGCTCTCTGGACTCCTAGGCTTGCTGGCTGCTCCTCCCACCCGCGCCCGCCTCCTCACTCGCCTTTTCGTTCGCCGGGGCTGCTTTCC AAGCCCTGCGGTGCGCCCGGGCGAGTGCGGGGCGAGGGGCCCGGGGCCAGCACCGAGCAGGGGGCGGGGGTCCGGGCAGAGCGCGGCCGG CCGGGGAGGGGCCATGTCTGGCGCGGGCGCAGCGGGGCCCGTCTGCAGCAAGTGACCGAGCGGCGCGGACGGCCGCCTGCCCCCTCTGCC ACCTGGGGCGGTGCGGGCCCGGAGCCCGGAGCCCGGGTAGCGCGTAGAGCCGGCGCGATGCACGTGCGCTCACTGCGAGCTGCGGCGCCG CACAGCTTCGTGGCGCTCTGGGCACCCCTGTTCCTGCTGCGCTCCGCCCTGGCCGACTTCAGCCTGGACAACGAGGTGCACTCGAGCTTC ATCCACCGGCGCCTCCGCAGCCAGGAGCGGCGGGAGATGCAGCGCGAGATCCTCTCCATTTTGGGCTTGCCCCACCGCCCGCGCCCGCAC CTCCAGGGCAAGCACAACTCGGCACCCATGTTCATGCTGGACCTGTACAACGCCATGGCGGTGGAGGAGGGCGGCGGGCCCGGCGGCCAG GGCTTCTCCTACCCCTACAAGGCCGTCTTCAGTACCCAGGGCCCCCCTCTGGCCAGCCTGCAAGATAGCCATTTCCTCACCGACGCCGAC ATGGTCATGAGCTTCGTCAACCTCGAATCACTGCAGCCCCCCTCGCCCTGAGCCAGAGCACCCCGGGTCCCGCCAGCCCCTCACACTCCC AGCAAAATGGGCAAGGAGAAGACCCACATCAACATCGTGGTCATCGGCCACGTGGACTCCGGAAAGTCCACCACCACGGGCCACCTCATC TACAAATGCGGAGGTATTGACAAAAGGACCATTGAGAAGTTCGAGAAGGAGGCGGCTGAGATGGGGAAGGGATCCTTCAAGTATGCCTGG GTGCTGGACAAGCTGAAGGCGGAGCGTGAGCGCGGCATCACCATCGACATCTCCCTCTGGAAGTTCGAGACCACCAAGTACTACATCACC ATCATCGATGCCCCCGGCCACCGCGACTTCATCAAGAACATGATCACGGGTACATCCCAGGCGGACTGCGCAGTGCTGATCGTGGCGGCG GGCGTGGGCGAGTTCGAGGCGGGCATCTCCAAGAATGGGCAGACGCGGGAGCATGCCCTGCTGGCCTACACGCTGGGTGTGAAGCAGCTC ATCGTGGGCGTGAACAAAATGGACTCCACAGAGCCGGCCTACAGCGAGAAGCGCTACGACGAGATCGTCAAGGAAGTCAGCGCCTACATC AAGAAGATCGGCTACAACCCGGCCACCGTGCCCTTTGTGCCCATCTCCGGCTGGCACGGTGACAACATGCTGGAGCCCTCCCCCAACATG CCGTGGTTCAAGGGCTGGAAGGTGGAGCGTAAGGAGGGCAACGCAAGCGGCGTGTCCCTGCTGGAGGCCCTGGACACCATCCTGCCCCCC ACGCGCCCCACGGACAAGCCCCTGCGCCTGCCGCTGCAGGACGTGTACAAGATTGGCGGCATTGGCACGGTGCCCGTGGGCCGGGTGGAG ACCGGCATCCTGCGGCCGGGCATGGTGGTGACCTTTGCGCCAGTGAACATCACCACTGAGGTGAAGTCAGTGGAGATGCACCACGAGGCT CTGAGCGAAGCTCTGCCCGGCGACAACGTCGGCTTCAATGTGAAGAACGTGTCGGTGAAGGACATCCGGCGGGGCAACGTGTGTGGGGAC AGCAAGTCTGACCCGCCGCAGGAGGCTGCTCAGTTCACCTCCCAGGTCATCATCCTGAACCACCCGGGGCAGATTAGCGCCGGCTACTCC CCGGTCATCGACTGCCACACAGCCCACATCGCCTGCAAGTTTGCGGAGCTGAAGGAGAAGATTGACCGGCGCTCTGGCAAGAAGCTGGAG GACAACCCCAAGTCCCTGAAGTCTGGAGACGCGGCCATCGTGGAGATGGTGCCGGGAAAGCCCATGTGTGTGGAGAGCTTCTCCCAGTAC CCGCCTCTCGGCCGCTTCGCCGTGCGCGACATGAGGCAGACGGTGGCCGTAGGCGTCATCAAGAACGTGGAGAAGAAGAGCGGCGGCGCC GGCAAGGTCACCAAGTCGGCGCAGAAGGCGCAGAAGGCGGGCAAGTGAAGCGCGGGCGCCCGCGGCGCGACCCTCCCCGGCGGTGCCGCG CTCCGAACCCCGGGCCCGGGCCCCCGCCCCGCCCCCGCCCCGCGCGCCGGTCCGGCGCCCCGCACCCCCGCCAGGCGCATGTCTGCACCT CCGCTTGCCAGAGGCCCTCGGTCAGCGACTGGATGCTCGCCATCAAGGTCCAGTGGAAGTTCTTCAAGAGGAAAGGCGCCCCCGCCCCAG |
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FusionGenePPI for BMP7_EEF1A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| BMP7 | BMPR2, SOSTDC1, BMP7, NOG, ENG, BMPR1A, BMPR1B, ACVR1, ACVR2A, ACVR2B, SMAD1, SMAD3, ACTN4, KRTAP5-9, TRIM27, MTUS2, KRTAP10-7, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, TAZ, TRAC, ISLR, UBR1, VWA8, GSTCD, NPTX1, AMD1, CNTNAP3B, ICK, NAAA, OLFM4, PDCD10, STK26, GDF11, DKKL1, OLFM2, GNB2, BTBD1, SLAMF1, PPP2R5D, PTPRK | EEF1A2 | VARS, EEF1D, EEF1B2, MGMT, SRRM2, PTEN, MAPK6, ARRB1, ARRB2, TCF3, ISG15, FBXO25, NFX1, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, UBXN6, TTLL12, YWHAE, BTK, CD81, IGSF8, CDK3, PARK2, AHCY, SHFM1, RPA3, RPA2, RPA1, ERG, TRIM25, LGR4, UBC, AURKA, CEP57, HAUS2, CEP76, TUBG1, VCP, ABTB1, PBDC1, NXPH2, NUFIP1, DGUOK, C4orf19, HEXIM1, HOMER1, TMEM25, WDR53, DCP2, DDHD2, GJA1, RNF26, EEF1G, FAM177A1, PLK2, CDK7, ACTB, ACTG1, POLR1A, EEF2, EFTUD2, GMPPB, GORASP2, PABPC1, PABPC3, PKLR, PKM, POLR2A, PSMD1, RPL12, RPL30, RPL4, RPSA, STK11, ID2, CRY2, MCM2, MCM5, ESRRB, CDC37, CDC73, DPF3, WWP2, EEF1A1, N6AMT2, CARS, PSG1, IL36A, FGB, SNRNP27, PITHD1, RAB1A, GTF2E2, CTAGE5, ZNF490, GYPA, LRRC56, MLLT6, FUOM, CKS1B, TPT1, NCSTN, HSPB8, GJB7, SLC38A7, SLC13A5, SREK1IP1, TBXAS1, BTNL3, RPS11, PPIAL4G, DHX57, ST6GALNAC1, USP47, TLE3, DBF4, FLT4, CYLD, MTF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for BMP7_EEF1A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for BMP7_EEF1A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | BMP7 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Hgene | BMP7 | C0005974 | Bone Resorption | 1 | CTD_human |
| Hgene | BMP7 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | BMP7 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | BMP7 | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Hgene | BMP7 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | BMP7 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | BMP7 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | EEF1A2 | C4225337 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 33 | 2 | UNIPROT |
| Tgene | EEF1A2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Tgene | EEF1A2 | C4225343 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 38 | 1 | UNIPROT |
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