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Fusion gene ID: 42370 |
FusionGeneSummary for YTHDC1_ADAMTS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YTHDC1_ADAMTS3 | Fusion gene ID: 42370 | Hgene | Tgene | Gene symbol | YTHDC1 | ADAMTS3 | Gene ID | 91746 | 9508 |
| Gene name | YTH domain containing 1 | ADAM metallopeptidase with thrombospondin type 1 motif 3 | |
| Synonyms | YT521|YT521-B | ADAMTS-4 | |
| Cytomap | 4q13.2 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | YTH domain-containing protein 1putative splicing factor YT521splicing factor YT521splicing factor YT521-B | A disintegrin and metalloproteinase with thrombospondin motifs 3ADAM-TS 3ADAM-TS3ADAMTS-3PC II-NPa disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3procollagen II N-proteinaseprocollagen II amino propeptide- | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q96MU7 | O15072 | |
| Ensembl transtripts involved in fusion gene | ENST00000344157, ENST00000355665, ENST00000579690, ENST00000552105, ENST00000550485, | ENST00000286657, ENST00000505193, | |
| Fusion gene scores | * DoF score | 9 X 9 X 4=324 | 2 X 3 X 2=12 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: YTHDC1 [Title/Abstract] AND ADAMTS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YTHDC1 | GO:0006376 | mRNA splice site selection | 20167602 |
| Hgene | YTHDC1 | GO:0048024 | regulation of mRNA splicing, via spliceosome | 26876937 |
| Tgene | ADAMTS3 | GO:0010573 | vascular endothelial growth factor production | 24552833 |
| Tgene | ADAMTS3 | GO:0016485 | protein processing | 11408482|24552833 |
| Tgene | ADAMTS3 | GO:0032964 | collagen biosynthetic process | 11408482 |
| Tgene | ADAMTS3 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway | 24552833 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-66-2782-01A | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000344157 | ENST00000286657 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| 5CDS-intron | ENST00000344157 | ENST00000505193 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| In-frame | ENST00000355665 | ENST00000286657 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| 5CDS-intron | ENST00000355665 | ENST00000505193 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| In-frame | ENST00000579690 | ENST00000286657 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| 5CDS-intron | ENST00000579690 | ENST00000505193 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| intron-3CDS | ENST00000552105 | ENST00000286657 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| intron-intron | ENST00000552105 | ENST00000505193 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| intron-3CDS | ENST00000550485 | ENST00000286657 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
| intron-intron | ENST00000550485 | ENST00000505193 | YTHDC1 | chr4 | 69202745 | - | ADAMTS3 | chr4 | 73176898 | - |
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FusionProtFeatures for YTHDC1_ADAMTS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YTHDC1 | ADAMTS3 |
| Regulator of alternative splicing that specificallyrecognizes and binds N6-methyladenosine (m6A)-containing RNAs(PubMed:26318451, PubMed:26876937, PubMed:25242552,PubMed:28984244). M6A is a modification present at internal sitesof mRNAs and some non-coding RNAs and plays a role in theefficiency of mRNA splicing, processing and stability(PubMed:26318451, PubMed:25242552). Acts as a key regulator ofexon-inclusion or exon-skipping during alternative splicing viainteraction with mRNA splicing factors SRSF3 and SRSF10(PubMed:26876937). Specifically binds m6A-containing mRNAs andpromotes recruitment of SRSF3 to its mRNA-binding elementsadjacent to m6A sites, leading to exon-inclusion duringalternative splicing (PubMed:26876937). In contrast, interactionwith SRSF3 prevents interaction with SRSF10, a splicing factorthat promotes exon skipping: this prevents SRSF10 from binding toits mRNA-binding sites close to m6A-containing regions, leading toinhibit exon skipping during alternative splicing(PubMed:26876937). May also regulate alternative splice siteselection (PubMed:20167602). Also involved in nuclear export ofm6A-containing mRNAs via interaction with SRSF3: interaction withSRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 andNXF1, promoting mRNA nuclear export (PubMed:28984244). Alsorecognizes and binds m6A on other RNA molecules (PubMed:27602518).Involved in random X inactivation mediated by Xist RNA: recognizesand binds m6A-containing Xist and promotes transcriptionrepression activity of Xist (PubMed:27602518). Involved in S-adenosyl-L-methionine homeostasis by regulating expression ofMAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs(By similarity). {ECO:0000250|UniProtKB:E9Q5K9,ECO:0000269|PubMed:20167602, ECO:0000269|PubMed:25242552,ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26876937,ECO:0000269|PubMed:27602518, ECO:0000269|PubMed:28984244}. | Cleaves the propeptides of type II collagen prior tofibril assembly. Does not act on types I and III collagens. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 172_260 | 294 | 728 | Compositional bias | Note=Glu-rich |
| Hgene | YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 172_260 | 294 | 710 | Compositional bias | Note=Glu-rich |
| Tgene | >ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 1015_1054 | 640 | 1206 | Domain | PLAC |
| Tgene | >ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 845_905 | 640 | 1206 | Domain | TSP type-1 2 |
| Tgene | >ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 906_965 | 640 | 1206 | Domain | TSP type-1 3 |
| Tgene | >ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 966_1014 | 640 | 1206 | Domain | TSP type-1 4 |
| Tgene | >ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 713_844 | 640 | 1206 | Region | Note=Spacer |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 508_581 | 294 | 728 | Compositional bias | Note=Arg-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 601_643 | 294 | 728 | Compositional bias | Note=Pro-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 647_727 | 294 | 728 | Compositional bias | Note=Arg-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 508_581 | 294 | 710 | Compositional bias | Note=Arg-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 601_643 | 294 | 710 | Compositional bias | Note=Pro-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 647_727 | 294 | 710 | Compositional bias | Note=Arg-rich |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 355_492 | 294 | 728 | Domain | YTH |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 355_492 | 294 | 710 | Domain | YTH |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000344157 | - | 4 | 17 | 361_363 | 294 | 728 | Region | N6-methyladenosine binding |
| Hgene | >YTHDC1 | chr4:69202745 | chr4:73176898 | ENST00000355665 | - | 4 | 16 | 361_363 | 294 | 710 | Region | N6-methyladenosine binding |
| Tgene | ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 246_249 | 640 | 1206 | Compositional bias | Note=Poly-Arg |
| Tgene | ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 608_712 | 640 | 1206 | Compositional bias | Note=Cys-rich |
| Tgene | ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 256_460 | 640 | 1206 | Domain | Peptidase M12B |
| Tgene | ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 470_550 | 640 | 1206 | Domain | Note=Disintegrin |
| Tgene | ADAMTS3 | chr4:69202745 | chr4:73176898 | ENST00000286657 | - | 12 | 22 | 551_606 | 640 | 1206 | Domain | TSP type-1 1 |
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FusionGeneSequence for YTHDC1_ADAMTS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_YTHDC1_ENST00000344157_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_860aa MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTKGK SATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEA SDSGSESVSFTDGSVRSGSGTDGSAKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCG GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLH TDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFC EANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWS ECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAA ETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRV >In-frame_YTHDC1_ENST00000355665_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_860aa MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTKGK SATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEA SDSGSESVSFTDGSVRSGSGTDGSAKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCG GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLH TDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFC EANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWS ECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAA ETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRV >In-frame_YTHDC1_ENST00000579690_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_860aa MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTKGK SATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEA SDSGSESVSFTDGSVRSGSGTDGSAKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCG GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLH TDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFC EANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWS ECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAA ETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPTKRV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_YTHDC1_ENST00000344157_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_2580nt ATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTG TATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAA AAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAG TCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGT GCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGAT GGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGC TCTGACCATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAG GAAGATGAAGAAGTAGAAGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAG GAGGAGGAGGAGGAGGAAGAAGAAGAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCC AGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCAC CTTTACTGTCAGTCCAAGGAGACTGGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATAT AGCATATGTGTGCGAGGAGAGTGTGTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGA GGAGATAATTCCCACTGCCGAACCGTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCT GGGGCTAGACATGTGTTAATCCAAGAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAAT GGCAAAGGGGAGGAAGCCAAGTCGCGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCAC ACCGATGGACCTTTACATGATCCTGTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATC CATGAAGACTCTGTACCTACAATCAACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAG TGTTCCAAACCCTGTGGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGT GAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACAC TGCACCAAAACCTGTGGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCAC AGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGT GAGTGTTCAGTGACCTGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCG GTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATAC TGCTCCATACCAGGTTATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCT GAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACC CCTGCAAAGAAGATGTCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGT GCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTC CACCTCAGTTCAGCTTCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAG >In-frame_YTHDC1_ENST00000355665_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_2580nt ATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTG TATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAA AAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAG TCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGT GCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGAT GGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGC TCTGACCATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAG GAAGATGAAGAAGTAGAAGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAG GAGGAGGAGGAGGAGGAAGAAGAAGAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCC AGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCAC CTTTACTGTCAGTCCAAGGAGACTGGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATAT AGCATATGTGTGCGAGGAGAGTGTGTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGA GGAGATAATTCCCACTGCCGAACCGTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCT GGGGCTAGACATGTGTTAATCCAAGAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAAT GGCAAAGGGGAGGAAGCCAAGTCGCGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCAC ACCGATGGACCTTTACATGATCCTGTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATC CATGAAGACTCTGTACCTACAATCAACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAG TGTTCCAAACCCTGTGGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGT GAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACAC TGCACCAAAACCTGTGGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCAC AGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGT GAGTGTTCAGTGACCTGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCG GTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATAC TGCTCCATACCAGGTTATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCT GAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACC CCTGCAAAGAAGATGTCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGT GCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTC CACCTCAGTTCAGCTTCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAG >In-frame_YTHDC1_ENST00000579690_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_2580nt ATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTG TATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAA AAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAG TCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGT GCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGAT GGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGC TCTGACCATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAG GAAGATGAAGAAGTAGAAGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAG GAGGAGGAGGAGGAGGAAGAAGAAGAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCC AGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCAC CTTTACTGTCAGTCCAAGGAGACTGGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATAT AGCATATGTGTGCGAGGAGAGTGTGTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGA GGAGATAATTCCCACTGCCGAACCGTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCT GGGGCTAGACATGTGTTAATCCAAGAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAAT GGCAAAGGGGAGGAAGCCAAGTCGCGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCAC ACCGATGGACCTTTACATGATCCTGTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATC CATGAAGACTCTGTACCTACAATCAACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAG TGTTCCAAACCCTGTGGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGT GAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACAC TGCACCAAAACCTGTGGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCAC AGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGT GAGTGTTCAGTGACCTGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCG GTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATAC TGCTCCATACCAGGTTATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCT GAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACC CCTGCAAAGAAGATGTCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGT GCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTC CACCTCAGTTCAGCTTCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_YTHDC1_ENST00000344157_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_5083nt TTTCGGGAGCGGGATTGTTTCGCGCAGGAAGCAGGCTCCATTTTAGCGCCGCCCGCCGTCGCCATCTGTTTCCCTTCCCTCCCCCATACC TAGCCCGAGTCTGAGCCCTAACGAGAAGGCTGGGCCTAGGCCGCTGGATGCTGGAGTGAAAGGAAGGGAGAAAGGGAAAAAGCGGGAAGA GTCGAGAAGGCTGAGTGTTAAGAGGCCAAGTGCGACGCGCGTATCCGGGCAGACGGACTGACGGACGGGCCCGTGCTTCTGCCGCGGCTG CGGCGCCCGCGCGAGTCGCGTCTAAGCGGCGGCGGCGGTGGCAGCGGCGGAAACCGAAGGGGAGCCATGGCGGCTGACAGTCGGGAGGAG AAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTGTATAATCCAGAGAGTGAACAAGAT AAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAAAAGCCTTCTGTCCATTCTAGACAA CTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAGTCAGCCACAGAGTATAAAAATGAG GAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGTGCCTCCAGAGAACCTTATAAGAAT CAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGATGGTTCTGAGAGAATTGGGCTTGAA GTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGCTCTGACCATGAGACTGGCAGCAGT GGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAGGAAGATGAAGAAGTAGAAGAAGAT GCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAGGAGGAAGAAGAA GAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCCAGTGACTCTGGTTCTGAATCTGTT TCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCACCTTTACTGTCAGTCCAAGGAGACT GGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATATAGCATATGTGTGCGAGGAGAGTGT GTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGAGGAGATAATTCCCACTGCCGAACC GTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCTGGGGCTAGACATGTGTTAATCCAA GAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAATGGCAAAGGGGAGGAAGCCAAGTCG CGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCACACCGATGGACCTTTACATGATCCT GTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATCCATGAAGACTCTGTACCTACAATC AACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAGTGTTCCAAACCCTGTGGTGGAGGT TTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGTGAGGCCAACAAAAAGCCGAAACCT ATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACACTGCACCAAAACCTGTGGAAGTTCT GGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCACAGCAAATACTGCATGGGTGACCGT CCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGTGAGTGTTCAGTGACCTGCGGTGAA GGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCGGTCAGAGCCTGTCAACTGCCTCCT TGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATACTGCTCCATACCAGGTTATAACAAG TTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCTGAAACTCATGATGATGTCATCTCT AACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACCCCTGCAAAGAAGATGTCTTTGAGT AGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGTGCTAATTTACGCCAGAGGAGTGCT CAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTCCACCTCAGTTCAGCTTCACAAATG GCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAGAAAGATGGAAAGATCATTGACAAC AGACGTCCGACAAGATCATCCACCTTAGAAAGATGAGAAAGTGAACCAAAAAGGCTAGAAACCAGAGGAAAACCTGGACAACCTCTCTCT TCCCATGGTGCATATGCTTGTTTAAAGTGGAAATCTCTATAGATCGTCAGCTCATTTTATCTGTAATTGGAAGAACAGAAAGTGCTGGCT CACTTTCTAGTTGCTTTCATCCTCCTTTTGTTCTGCATTGACTCATTTACCAGAATTCATTGGAAGAAATCACCAAAGATTATTACAAAA GAAAAATATGTTGCTAAGATTGTGTTGGTCGCTCTCTGAAGCAGAAAAGGGACTGGAACCAATTGTGCATATCAGCTGACTTTTTGTTTG TTTTAGAAAAGTTACAGTAAAAATTAAAAAGAGATACCAATGGTTTACACTTTAACAAGAAATTTTGGATATGGAACAAAGAATTCTTAG ACTTGTATTCCTATTTATCTATATTAGAAATATTGTATGAGCAAATTTGCAGCTGTTGTGTAAATACTGTATATTGCAAAAATCAGTATT ATTTTAAGAGATGTGTTCTCAAATGATTGTTTACTATATTACATTTCTGGATGTTCTAGGTGCCTGTCGTTGAGTATTGCCTTGTTTGAC ATTCTATAGGTTAATTTTCAAAGCAGAGTATTACAAAAGAGAAGTTAGAATTACAGCTACTGACAATATAAAGGGTTTTGTTGAATCAAC AATGTGATACGTAAATTATAGAAAAAGAAAAGAAACACAAAAGCTATAGATATACAGATATCAGCTTACCTATTGCCTTCTATACTTATA ATTTAAAGGATTGGTGTCTTAGTACACTTGTGGTCACAGGGATCAACGAATAGTAAATAATGAACTCGTGCAAGACAAAACTGAAACCCT CTTTCCAGGACCTCAGTAGGCACCGTTGAGGTGTCCTTTGTTTTTGTGTGTGTGTGTTCTTTTTTAATTTTCGCATTGTTGACAGATACA AACAGTTATACTCAATGTACTGTAATAATCGCAAAGGAAAAAGTTTTGGGATAACTTATTTGTATGTTGGTAGCTGAGAAAAATATCATC AGTCTAGAATTGATATTTGAGTATAGTAGAGCTTTGGGGCTTTGAAGGCAGGTTCAAGAAAGCATATGTCGATGGTTGAGATATTTATTT TCCATATGGTTCATGTTCAAATGTTCACAACCACAATGCATCTGACTGCAATAATGTGCTAATAATTTATGTCAGTAGTCACCTTGCTCA CAGCAAAGCCAGAAATGCTCTCTCCAGGGAGTAGATGTAAAGTACTTGTACATAGAATTCAGAACTGAAGATATTTATTAAAAGTTGATT TTTTTTCTTGATAGTATTTTTATGTACTAAATATTTACACTAATATCAATTACATATTTTGGTAAACTAGAGAGACATAATTAGAGATGC ATGCTTTGTTCTGTGCATAGAGACCTTTAAGCAAACTACTACAGCCAACTCAAAAGCTAAAACTGAACAAATTTGATGTTATGCAAACAT CTTGCATTTTTAGTAGTTGATATTAAGTTGATGACTTGTTTCCCTTCAAGGAAACATTAAATTGTATGGACTCAGCTAGCTGTTCAATGA AATTGTGAATTAGAAACATTTTTAAAAGTTTTTGAAAGAGATAAGTGCATCATGAATTACATGTACATGAGAGGAGATAGTGATATCAGC ATAATGATTTTGAGGTCAGTACCTGAGCTGTCTAAAAATATATTATACAAACTAAAATGTAGATGAATTAACCTCTCAAAGCACAGAATG TGCAAGAACTTTTGCATTTTAATCGTTGTAAACTAACAGCTTAAACTATTGACTCTATACCTCTAAAGAATTGCTGCTACTTTGTGCAAG AACTTTGAAGGTCAAATTAGGCAAATTCCAGATAGTAAAACAATCCCTAAGCCTTAAGTCTTTTTTTTTTCCTAAAAATTCCCATAGAAT AAAATTCTCTCTAGTTTACTTGTGTGTGCATACATCTCATCCACAGGGGAAGATAAAGATGGTCACACAAACAGTTTCCATAAAGATGTA CATATTCATTATACTTCTGACCTTTGGGCTTTCTTTTCTACTAAGCTAAAAATTCCTTTTTATCAAAGTGTACACTACTGATGCTGTTTG >In-frame_YTHDC1_ENST00000355665_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_5083nt TTTCGGGAGCGGGATTGTTTCGCGCAGGAAGCAGGCTCCATTTTAGCGCCGCCCGCCGTCGCCATCTGTTTCCCTTCCCTCCCCCATACC TAGCCCGAGTCTGAGCCCTAACGAGAAGGCTGGGCCTAGGCCGCTGGATGCTGGAGTGAAAGGAAGGGAGAAAGGGAAAAAGCGGGAAGA GTCGAGAAGGCTGAGTGTTAAGAGGCCAAGTGCGACGCGCGTATCCGGGCAGACGGACTGACGGACGGGCCCGTGCTTCTGCCGCGGCTG CGGCGCCCGCGCGAGTCGCGTCTAAGCGGCGGCGGCGGTGGCAGCGGCGGAAACCGAAGGGGAGCCATGGCGGCTGACAGTCGGGAGGAG AAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTGTATAATCCAGAGAGTGAACAAGAT AAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAAAAGCCTTCTGTCCATTCTAGACAA CTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAGTCAGCCACAGAGTATAAAAATGAG GAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGTGCCTCCAGAGAACCTTATAAGAAT CAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGATGGTTCTGAGAGAATTGGGCTTGAA GTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGCTCTGACCATGAGACTGGCAGCAGT GGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAGGAAGATGAAGAAGTAGAAGAAGAT GCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAGGAGGAAGAAGAA GAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCCAGTGACTCTGGTTCTGAATCTGTT TCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCACCTTTACTGTCAGTCCAAGGAGACT GGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATATAGCATATGTGTGCGAGGAGAGTGT GTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGAGGAGATAATTCCCACTGCCGAACC GTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCTGGGGCTAGACATGTGTTAATCCAA GAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAATGGCAAAGGGGAGGAAGCCAAGTCG CGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCACACCGATGGACCTTTACATGATCCT GTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATCCATGAAGACTCTGTACCTACAATC AACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAGTGTTCCAAACCCTGTGGTGGAGGT TTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGTGAGGCCAACAAAAAGCCGAAACCT ATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACACTGCACCAAAACCTGTGGAAGTTCT GGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCACAGCAAATACTGCATGGGTGACCGT CCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGTGAGTGTTCAGTGACCTGCGGTGAA GGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCGGTCAGAGCCTGTCAACTGCCTCCT TGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATACTGCTCCATACCAGGTTATAACAAG TTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCTGAAACTCATGATGATGTCATCTCT AACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACCCCTGCAAAGAAGATGTCTTTGAGT AGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGTGCTAATTTACGCCAGAGGAGTGCT CAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTCCACCTCAGTTCAGCTTCACAAATG GCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAGAAAGATGGAAAGATCATTGACAAC AGACGTCCGACAAGATCATCCACCTTAGAAAGATGAGAAAGTGAACCAAAAAGGCTAGAAACCAGAGGAAAACCTGGACAACCTCTCTCT TCCCATGGTGCATATGCTTGTTTAAAGTGGAAATCTCTATAGATCGTCAGCTCATTTTATCTGTAATTGGAAGAACAGAAAGTGCTGGCT CACTTTCTAGTTGCTTTCATCCTCCTTTTGTTCTGCATTGACTCATTTACCAGAATTCATTGGAAGAAATCACCAAAGATTATTACAAAA GAAAAATATGTTGCTAAGATTGTGTTGGTCGCTCTCTGAAGCAGAAAAGGGACTGGAACCAATTGTGCATATCAGCTGACTTTTTGTTTG TTTTAGAAAAGTTACAGTAAAAATTAAAAAGAGATACCAATGGTTTACACTTTAACAAGAAATTTTGGATATGGAACAAAGAATTCTTAG ACTTGTATTCCTATTTATCTATATTAGAAATATTGTATGAGCAAATTTGCAGCTGTTGTGTAAATACTGTATATTGCAAAAATCAGTATT ATTTTAAGAGATGTGTTCTCAAATGATTGTTTACTATATTACATTTCTGGATGTTCTAGGTGCCTGTCGTTGAGTATTGCCTTGTTTGAC ATTCTATAGGTTAATTTTCAAAGCAGAGTATTACAAAAGAGAAGTTAGAATTACAGCTACTGACAATATAAAGGGTTTTGTTGAATCAAC AATGTGATACGTAAATTATAGAAAAAGAAAAGAAACACAAAAGCTATAGATATACAGATATCAGCTTACCTATTGCCTTCTATACTTATA ATTTAAAGGATTGGTGTCTTAGTACACTTGTGGTCACAGGGATCAACGAATAGTAAATAATGAACTCGTGCAAGACAAAACTGAAACCCT CTTTCCAGGACCTCAGTAGGCACCGTTGAGGTGTCCTTTGTTTTTGTGTGTGTGTGTTCTTTTTTAATTTTCGCATTGTTGACAGATACA AACAGTTATACTCAATGTACTGTAATAATCGCAAAGGAAAAAGTTTTGGGATAACTTATTTGTATGTTGGTAGCTGAGAAAAATATCATC AGTCTAGAATTGATATTTGAGTATAGTAGAGCTTTGGGGCTTTGAAGGCAGGTTCAAGAAAGCATATGTCGATGGTTGAGATATTTATTT TCCATATGGTTCATGTTCAAATGTTCACAACCACAATGCATCTGACTGCAATAATGTGCTAATAATTTATGTCAGTAGTCACCTTGCTCA CAGCAAAGCCAGAAATGCTCTCTCCAGGGAGTAGATGTAAAGTACTTGTACATAGAATTCAGAACTGAAGATATTTATTAAAAGTTGATT TTTTTTCTTGATAGTATTTTTATGTACTAAATATTTACACTAATATCAATTACATATTTTGGTAAACTAGAGAGACATAATTAGAGATGC ATGCTTTGTTCTGTGCATAGAGACCTTTAAGCAAACTACTACAGCCAACTCAAAAGCTAAAACTGAACAAATTTGATGTTATGCAAACAT CTTGCATTTTTAGTAGTTGATATTAAGTTGATGACTTGTTTCCCTTCAAGGAAACATTAAATTGTATGGACTCAGCTAGCTGTTCAATGA AATTGTGAATTAGAAACATTTTTAAAAGTTTTTGAAAGAGATAAGTGCATCATGAATTACATGTACATGAGAGGAGATAGTGATATCAGC ATAATGATTTTGAGGTCAGTACCTGAGCTGTCTAAAAATATATTATACAAACTAAAATGTAGATGAATTAACCTCTCAAAGCACAGAATG TGCAAGAACTTTTGCATTTTAATCGTTGTAAACTAACAGCTTAAACTATTGACTCTATACCTCTAAAGAATTGCTGCTACTTTGTGCAAG AACTTTGAAGGTCAAATTAGGCAAATTCCAGATAGTAAAACAATCCCTAAGCCTTAAGTCTTTTTTTTTTCCTAAAAATTCCCATAGAAT AAAATTCTCTCTAGTTTACTTGTGTGTGCATACATCTCATCCACAGGGGAAGATAAAGATGGTCACACAAACAGTTTCCATAAAGATGTA CATATTCATTATACTTCTGACCTTTGGGCTTTCTTTTCTACTAAGCTAAAAATTCCTTTTTATCAAAGTGTACACTACTGATGCTGTTTG >In-frame_YTHDC1_ENST00000579690_chr4_69202745_-_ADAMTS3_ENST00000286657_chr4_73176898_-_4747nt ATGGCGGCTGACAGTCGGGAGGAGAAAGATGGAGAACTTAATGTTCTGGATGATATTTTAACTGAAGTACCAGAACAAGATGATGAACTG TATAATCCAGAGAGTGAACAAGATAAAAATGAGAAAAAGGGATCAAAAAGAAAAAGTGATCGAATGGAATCTACTGATACCAAACGACAA AAGCCTTCTGTCCATTCTAGACAACTGGTTTCTAAGCCACTGAGCTCATCTGTTAGCAATAACAAAAGAATAGTTAGTACAAAAGGAAAG TCAGCCACAGAGTATAAAAATGAGGAATATCAAAGATCTGAAAGAAACAAGCGTCTAGATGCTGATCGGAAAATTCGTCTATCAAGTAGT GCCTCCAGAGAACCTTATAAGAATCAACCTGAAAAAACCTGTGTCCGGAAAAGGGATCCTGAAAGGAGGGCCAAATCTCCTACGCCAGAT GGTTCTGAGAGAATTGGGCTTGAAGTGGATAGACGTGCAAGCAGATCCAGCCAGTCTTCTAAGGAAGAAGTGAACTCTGAAGAATATGGC TCTGACCATGAGACTGGCAGCAGTGGTTCTTCTGATGAGCAAGGGAACAACACTGAGAATGAGGAGGAAGGAGTGGAAGAAGATGTGGAG GAAGATGAAGAAGTAGAAGAAGATGCAGAAGAAGATGAAGAGGTGGATGAAGATGGAGAGGAGGAGGAGGAAGAGGAGGAGGAGGAAGAG GAGGAGGAGGAGGAGGAAGAAGAAGAATATGAACAGGATGAGAGAGACCAGAAAGAGGAGGGAAATGATTATGACACTCGAAGTGAGGCC AGTGACTCTGGTTCTGAATCTGTTTCCTTCACAGATGGGTCTGTCAGATCTGGTTCAGGCACAGATGGATCAGCCAAGAAAAGATGCCAC CTTTACTGTCAGTCCAAGGAGACTGGAGATGTTGCTTACATGAAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATAT AGCATATGTGTGCGAGGAGAGTGTGTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGATAAGTGTGGTGTCTGTGGA GGAGATAATTCCCACTGCCGAACCGTGAAGGGGACATTTACCAGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCT GGGGCTAGACATGTGTTAATCCAAGAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACAGGCCATTATATTTTAAAT GGCAAAGGGGAGGAAGCCAAGTCGCGGACCTTCATAGATCTTGGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCAC ACCGATGGACCTTTACATGATCCTGTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTGACATATAAGTACATCATC CATGAAGACTCTGTACCTACAATCAACAGCAACAATGTCATCCAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAG TGTTCCAAACCCTGTGGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTCCATCGCAGCTTCTGT GAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAATATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACAC TGCACCAAAACCTGTGGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACCAACCGCTCTGTGCAC AGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCCTGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGT GAGTGTTCAGTGACCTGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGTGAAAAGCCTGAGTCG GTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGTTTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATAC TGCTCCATACCAGGTTATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATACCTTCTAGAAGCTGCT GAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCTAGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACC CCTGCAAAGAAGATGTCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAACAGTAAACCTGATGGT GCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAGACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTC CACCTCAGTTCAGCTTCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAGGCAAGAACCTCAAAG AAAGATGGAAAGATCATTGACAACAGACGTCCGACAAGATCATCCACCTTAGAAAGATGAGAAAGTGAACCAAAAAGGCTAGAAACCAGA GGAAAACCTGGACAACCTCTCTCTTCCCATGGTGCATATGCTTGTTTAAAGTGGAAATCTCTATAGATCGTCAGCTCATTTTATCTGTAA TTGGAAGAACAGAAAGTGCTGGCTCACTTTCTAGTTGCTTTCATCCTCCTTTTGTTCTGCATTGACTCATTTACCAGAATTCATTGGAAG AAATCACCAAAGATTATTACAAAAGAAAAATATGTTGCTAAGATTGTGTTGGTCGCTCTCTGAAGCAGAAAAGGGACTGGAACCAATTGT GCATATCAGCTGACTTTTTGTTTGTTTTAGAAAAGTTACAGTAAAAATTAAAAAGAGATACCAATGGTTTACACTTTAACAAGAAATTTT GGATATGGAACAAAGAATTCTTAGACTTGTATTCCTATTTATCTATATTAGAAATATTGTATGAGCAAATTTGCAGCTGTTGTGTAAATA CTGTATATTGCAAAAATCAGTATTATTTTAAGAGATGTGTTCTCAAATGATTGTTTACTATATTACATTTCTGGATGTTCTAGGTGCCTG TCGTTGAGTATTGCCTTGTTTGACATTCTATAGGTTAATTTTCAAAGCAGAGTATTACAAAAGAGAAGTTAGAATTACAGCTACTGACAA TATAAAGGGTTTTGTTGAATCAACAATGTGATACGTAAATTATAGAAAAAGAAAAGAAACACAAAAGCTATAGATATACAGATATCAGCT TACCTATTGCCTTCTATACTTATAATTTAAAGGATTGGTGTCTTAGTACACTTGTGGTCACAGGGATCAACGAATAGTAAATAATGAACT CGTGCAAGACAAAACTGAAACCCTCTTTCCAGGACCTCAGTAGGCACCGTTGAGGTGTCCTTTGTTTTTGTGTGTGTGTGTTCTTTTTTA ATTTTCGCATTGTTGACAGATACAAACAGTTATACTCAATGTACTGTAATAATCGCAAAGGAAAAAGTTTTGGGATAACTTATTTGTATG TTGGTAGCTGAGAAAAATATCATCAGTCTAGAATTGATATTTGAGTATAGTAGAGCTTTGGGGCTTTGAAGGCAGGTTCAAGAAAGCATA TGTCGATGGTTGAGATATTTATTTTCCATATGGTTCATGTTCAAATGTTCACAACCACAATGCATCTGACTGCAATAATGTGCTAATAAT TTATGTCAGTAGTCACCTTGCTCACAGCAAAGCCAGAAATGCTCTCTCCAGGGAGTAGATGTAAAGTACTTGTACATAGAATTCAGAACT GAAGATATTTATTAAAAGTTGATTTTTTTTCTTGATAGTATTTTTATGTACTAAATATTTACACTAATATCAATTACATATTTTGGTAAA CTAGAGAGACATAATTAGAGATGCATGCTTTGTTCTGTGCATAGAGACCTTTAAGCAAACTACTACAGCCAACTCAAAAGCTAAAACTGA ACAAATTTGATGTTATGCAAACATCTTGCATTTTTAGTAGTTGATATTAAGTTGATGACTTGTTTCCCTTCAAGGAAACATTAAATTGTA TGGACTCAGCTAGCTGTTCAATGAAATTGTGAATTAGAAACATTTTTAAAAGTTTTTGAAAGAGATAAGTGCATCATGAATTACATGTAC ATGAGAGGAGATAGTGATATCAGCATAATGATTTTGAGGTCAGTACCTGAGCTGTCTAAAAATATATTATACAAACTAAAATGTAGATGA ATTAACCTCTCAAAGCACAGAATGTGCAAGAACTTTTGCATTTTAATCGTTGTAAACTAACAGCTTAAACTATTGACTCTATACCTCTAA AGAATTGCTGCTACTTTGTGCAAGAACTTTGAAGGTCAAATTAGGCAAATTCCAGATAGTAAAACAATCCCTAAGCCTTAAGTCTTTTTT TTTTCCTAAAAATTCCCATAGAATAAAATTCTCTCTAGTTTACTTGTGTGTGCATACATCTCATCCACAGGGGAAGATAAAGATGGTCAC ACAAACAGTTTCCATAAAGATGTACATATTCATTATACTTCTGACCTTTGGGCTTTCTTTTCTACTAAGCTAAAAATTCCTTTTTATCAA |
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FusionGenePPI for YTHDC1_ADAMTS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| YTHDC1 | ABL1, EMD, KHDRBS1, ISG15, MAGOH, EIF4A3, KIAA0101, ADAMTS4, SOX13, GOLGA2, LAMC3, LZTS2, PLG, CFH, VPS51, KRT18, TRA2B, LAMTOR5, CORO1A, MPRIP, EDC4, TRA2A, SEPT10, PROSER2, SRPK1, SRPK2, CLK2, DVL3, HNRNPK, KHDRBS3, SDCBP2, RBMY1F, KHDRBS2, BMI1, RALYL, HNRNPA1, ILF2, RBMX, SNIP1, SRC, IFI16, CLK1, KPNB1, SLAIN2, FOXK2, ZC3H18, APOBEC3D, ELAVL2, CLK3, FBXW11, C11orf57, CDX1, SNRNP70, GSPT2, NXF2, HIST1H1T, DLST | ADAMTS3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YTHDC1_ADAMTS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YTHDC1_ADAMTS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ADAMTS3 | C0036341 | Schizophrenia | 1 | CTD_human |
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