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Fusion gene ID: 42367 |
FusionGeneSummary for YPEL3_EXD3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YPEL3_EXD3 | Fusion gene ID: 42367 | Hgene | Tgene | Gene symbol | YPEL3 | EXD3 | Gene ID | 83719 | 54932 |
| Gene name | yippee like 3 | exonuclease 3'-5' domain containing 3 | |
| Synonyms | - | mut-7 | |
| Cytomap | 16p11.2 | 9q34.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein yippee-like 3 | exonuclease mut-7 homologexonuclease 3'-5' domain-containing protein 3probable exonuclease mut-7 homologtesticular tissue protein Li 125 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P61236 | Q8N9H8 | |
| Ensembl transtripts involved in fusion gene | ENST00000398841, ENST00000565479, ENST00000566134, ENST00000398838, ENST00000563788, ENST00000566595, ENST00000562641, | ENST00000342129, ENST00000340951, ENST00000479452, ENST00000475006, ENST00000465160, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 6 X 7=378 |
| # samples | 1 | 10 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: YPEL3 [Title/Abstract] AND EXD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YPEL3 | GO:2000774 | positive regulation of cellular senescence | 20388804 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ACC | TCGA-P6-A5OF-01A | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000398841 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| In-frame | ENST00000398841 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398841 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398841 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398841 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5UTR-3CDS | ENST00000565479 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5UTR-3CDS | ENST00000565479 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5UTR-intron | ENST00000565479 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5UTR-intron | ENST00000565479 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5UTR-intron | ENST00000565479 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000566134 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000566134 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566134 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566134 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566134 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000398838 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000398838 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398838 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398838 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000398838 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000563788 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000563788 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000563788 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000563788 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000563788 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000566595 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| Frame-shift | ENST00000566595 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566595 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566595 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000566595 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| In-frame | ENST00000562641 | ENST00000342129 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| In-frame | ENST00000562641 | ENST00000340951 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000562641 | ENST00000479452 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000562641 | ENST00000475006 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
| 5CDS-intron | ENST00000562641 | ENST00000465160 | YPEL3 | chr16 | 30106573 | - | EXD3 | chr9 | 140218595 | - |
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FusionProtFeatures for YPEL3_EXD3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YPEL3 | EXD3 |
| Involved in proliferation and apoptosis in myeloidprecursor cells. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >EXD3 | chr16:30106573 | chr9:140218595 | ENST00000342129 | - | 16 | 21 | 517_571 | 317 | 515 | Domain | Note=3'-5' exonuclease |
| Tgene | >EXD3 | chr16:30106573 | chr9:140218595 | ENST00000479452 | - | 0 | 8 | 517_571 | -30 | 247 | Domain | Note=3'-5' exonuclease |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >YPEL3 | chr16:30106573 | chr9:140218595 | ENST00000398838 | - | 2 | 5 | 19_116 | 39 | 120 | Domain | Yippee |
| Hgene | >YPEL3 | chr16:30106573 | chr9:140218595 | ENST00000398841 | - | 1 | 4 | 19_116 | 77 | 158 | Domain | Yippee |
| Hgene | >YPEL3 | chr16:30106573 | chr9:140218595 | ENST00000563788 | - | 2 | 5 | 19_116 | 39 | 120 | Domain | Yippee |
| Hgene | >YPEL3 | chr16:30106573 | chr9:140218595 | ENST00000566595 | - | 2 | 5 | 19_116 | 39 | 120 | Domain | Yippee |
| Tgene | EXD3 | chr16:30106573 | chr9:140218595 | ENST00000340951 | - | 16 | 22 | 517_571 | 666 | 877 | Domain | Note=3'-5' exonuclease |
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FusionGeneSequence for YPEL3_EXD3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_275aa MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAMVRISKPKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKVARQEGRIILTSG QPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGPAPDAAPEG CTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESAPSPCEPSPAPSPA >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_288aa MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAMVRISKPKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKVARQEGRIILTSG QPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGDEATQSQAV QEPGPAPDAAPEGCTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESA >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_275aa MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAMVRISKPKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKVARQEGRIILTSG QPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGPAPDAAPEG CTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESAPSPCEPSPAPSPA >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_288aa MCVAQVLTAHLLPPRQALGSLCSPWAAPRVGPLPPAPAMVRISKPKTFQAYLDDCHRRYSCAHCRAHLANHDDLISKVARQEGRIILTSG QPFHKLRAQVGAGRCLSVDCSLKAQQQAKAVLKHFNVRVTHADIFSRCQACNCDQYLKVSRDMMKQLMWLSSHQEGPRSSGDEATQSQAV QEPGPAPDAAPEGCTYDRPCRWLQMADLRAETPDMLADGTRLQLAGVPVGVLRTPGLRCFYCCTGCGKVFWDGSHLGRVATHFRDMLESA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_825nt ATGTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTG GGGCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGC TGTGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGG CAGCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCT GTGCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCC AGGGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGC TGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAG CTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGC TCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCCCAGCCCCTGCGAGCCGAGCCCAGCCCCCAGCCCGGCC >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_864nt ATGTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTG GGGCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGC TGTGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGG CAGCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCT GTGCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCC AGGGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGTGACGAGGCCACCCAGAGCCAGGCGGTG CAGGAGCCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGCTGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCG GAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAGCTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTC TACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGCTCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCC >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_825nt ATGTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTG GGGCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGC TGTGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGG CAGCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCT GTGCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCC AGGGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGC TGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAG CTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGC TCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCCCAGCCCCTGCGAGCCGAGCCCAGCCCCCAGCCCGGCC >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_864nt ATGTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTG GGGCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGC TGTGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGG CAGCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCT GTGCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCC AGGGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGTGACGAGGCCACCCAGAGCCAGGCGGTG CAGGAGCCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGCTGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCG GAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAGCTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTC TACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGCTCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_1597nt GGCGCCTGCGAACCCGGGCCCGGGGGGGACGGCGCCCGCCAGGAGCGCCCCCCACTCCCAGGCCAGCCCACCCCGGCGGACCGGGCCCCG CGCGCCCAGGCGAGGTGAGGCCCGCGCCGTCAGGGCTGCGTGTCGCCCCGCGCCCCTGCCCAGCCCGCGAGGACTGCCCCCTCCCCCGGC GCCCGCCCCCACCCCCGCGCCCCAGGTGAGCCCCGGAGTCCAGGTAAGGCTCCGCGTTGCAGGTAAGAGCCCCTGAGCGTAGAGGAGGCC TTGGCGCCCGCAGGTGAGAGCCCCTCCCCTCCTAGGTGACCCTCAACCTTCACGGCGAGGCCTCCTACCTCCTCCAGGTGGGGGACCCTC TCCCCGATGAACCCCCTAAACCACCAGTGAACCCCACTGCTCTCCAGATGAGGTCGCAAGGACCAACCAGTGCCTACCCGCCCATGCTCC CCCGAAACTGGGAACTGACAGCCCAGCCCCTCCAAAGCCCCTTCCTCCAGCTTCAGCTGCCAGGTCAGCAAGGGTGAGGCCGGAAGCAGG CGGGTGACTCACCCTGGGCACCTCCGAGCCTCAGTTTCCCCATGGATGCAACCTGAGGCCTCCTCACTGAGTCAAAACCGAGACGCCTCT GGTCCCCGGAGAGGCTGCTGGCTCTGGGGAAAGGAGAGAGCAGCCCAGTGTGACAGAGCGAGTCCCCACGGCTCTGGGAGTGCCTCGCAT GTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTGGG GCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGCTG TGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGGCA GCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCTGT GCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCCAG GGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGCTG CACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAGCT GGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGCTC CCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCCCAGCCCCTGCGAGCCGAGCCCAGCCCCCAGCCCGGCCAG >In-frame_YPEL3_ENST00000398841_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_1627nt GGCGCCTGCGAACCCGGGCCCGGGGGGGACGGCGCCCGCCAGGAGCGCCCCCCACTCCCAGGCCAGCCCACCCCGGCGGACCGGGCCCCG CGCGCCCAGGCGAGGTGAGGCCCGCGCCGTCAGGGCTGCGTGTCGCCCCGCGCCCCTGCCCAGCCCGCGAGGACTGCCCCCTCCCCCGGC GCCCGCCCCCACCCCCGCGCCCCAGGTGAGCCCCGGAGTCCAGGTAAGGCTCCGCGTTGCAGGTAAGAGCCCCTGAGCGTAGAGGAGGCC TTGGCGCCCGCAGGTGAGAGCCCCTCCCCTCCTAGGTGACCCTCAACCTTCACGGCGAGGCCTCCTACCTCCTCCAGGTGGGGGACCCTC TCCCCGATGAACCCCCTAAACCACCAGTGAACCCCACTGCTCTCCAGATGAGGTCGCAAGGACCAACCAGTGCCTACCCGCCCATGCTCC CCCGAAACTGGGAACTGACAGCCCAGCCCCTCCAAAGCCCCTTCCTCCAGCTTCAGCTGCCAGGTCAGCAAGGGTGAGGCCGGAAGCAGG CGGGTGACTCACCCTGGGCACCTCCGAGCCTCAGTTTCCCCATGGATGCAACCTGAGGCCTCCTCACTGAGTCAAAACCGAGACGCCTCT GGTCCCCGGAGAGGCTGCTGGCTCTGGGGAAAGGAGAGAGCAGCCCAGTGTGACAGAGCGAGTCCCCACGGCTCTGGGAGTGCCTCGCAT GTGTGTGGCCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTGGG GCCACTGCCCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGCTG TGCCCACTGCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGGCA GCCATTCCACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCTGT GCTCAAGCATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCCAG GGACATGATGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGTGACGAGGCCACCCAGAGCCAGGCGGTGCA GGAGCCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGCTGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGA GACACCGGACATGCTGGCCGACGGCACCCGGCTGCAGCTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTA CTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGCTCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCC CAGCCCCTGCGAGCCGAGCCCAGCCCCCAGCCCGGCCAGCAGTCCCTTCTGAGGACAGCCAGACAATAAACATGGAAAGTGCCCGACTGC >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000342129_chr9_140218595_-_1409nt CCACCCCCGCGCCCCAGGTGAGCCCCGGAGTCCAGGTAAGGCTCCGCGTTGCAGGTAAGAGCCCCTGAGCGTAGAGGAGGCCTTGGCGCC CGCAGGTGAGAGCCCCTCCCCTCCTAGGTGACCCTCAACCTTCACGGCGAGGCCTCCTACCTCCTCCAGGTGGGGGACCCTCTCCCCGAT GAACCCCCTAAACCACCAGTGAACCCCACTGCTCTCCAGATGAGGTCGCAAGGACCAACCAGTGCCTACCCGCCCATGCTCCCCCGAAAC TGGGAACTGACAGCCCAGCCCCTCCAAAGCCCCTTCCTCCAGCTTCAGCTGCCAGGTCAGCAAGGGTGAGGCCGGAAGCAGGCGGGTGAC TCACCCTGGGCACCTCCGAGCCTCAGTTTCCCCATGGATGCAACCTGAGGCCTCCTCACTGAGTCAAAACCGAGACGCCTCTGGTCCCCG GAGAGGCTGCTGGCTCTGGGGAAAGGAGAGAGCAGCCCAGTGTGACAGAGCGAGTCCCCACGGCTCTGGGAGTGCCTCGCATGTGTGTGG CCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTGGGGCCACTGC CCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGCTGTGCCCACT GCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGGCAGCCATTCC ACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCTGTGCTCAAGC ATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCCAGGGACATGA TGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGCCCAGCCCCAGACGCAGCCCCTGAGGGCTGCACCTATG ACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGAGACACCGGACATGCTGGCCGACGGCACCCGGCTGCAGCTGGCAGGGG TCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTACTGCTGCACGGGCTGTGGAAAGGTCTTCTGGGACGGCTCCCACCTGG GTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCCCAGCCCCTGCGAGCCGAGCCCAGCCCCCAGCCCGGCCAGCAGTCCCT >In-frame_YPEL3_ENST00000562641_chr16_30106573_-_EXD3_ENST00000340951_chr9_140218595_-_1439nt CCACCCCCGCGCCCCAGGTGAGCCCCGGAGTCCAGGTAAGGCTCCGCGTTGCAGGTAAGAGCCCCTGAGCGTAGAGGAGGCCTTGGCGCC CGCAGGTGAGAGCCCCTCCCCTCCTAGGTGACCCTCAACCTTCACGGCGAGGCCTCCTACCTCCTCCAGGTGGGGGACCCTCTCCCCGAT GAACCCCCTAAACCACCAGTGAACCCCACTGCTCTCCAGATGAGGTCGCAAGGACCAACCAGTGCCTACCCGCCCATGCTCCCCCGAAAC TGGGAACTGACAGCCCAGCCCCTCCAAAGCCCCTTCCTCCAGCTTCAGCTGCCAGGTCAGCAAGGGTGAGGCCGGAAGCAGGCGGGTGAC TCACCCTGGGCACCTCCGAGCCTCAGTTTCCCCATGGATGCAACCTGAGGCCTCCTCACTGAGTCAAAACCGAGACGCCTCTGGTCCCCG GAGAGGCTGCTGGCTCTGGGGAAAGGAGAGAGCAGCCCAGTGTGACAGAGCGAGTCCCCACGGCTCTGGGAGTGCCTCGCATGTGTGTGG CCCAGGTCCTGACAGCCCACCTACTCCCTCCCCGGCAGGCACTGGGCTCCCTCTGCTCCCCGTGGGCCGCTCCCCGCGTGGGGCCACTGC CCCCGGCCCCCGCCATGGTGCGGATTTCAAAGCCCAAGACGTTTCAGGCCTACTTGGATGATTGTCACCGGAGGTATAGCTGTGCCCACT GCCGCGCTCACCTGGCCAACCACGACGACCTCATCTCCAAGGTTGCCAGGCAGGAGGGGAGGATCATTCTGACGTCGGGGCAGCCATTCC ACAAGCTCCGGGCCCAGGTCGGGGCTGGGCGCTGCCTCTCGGTCGACTGCTCCCTGAAGGCCCAGCAGCAGGCCAAGGCTGTGCTCAAGC ATTTCAACGTGCGTGTCACCCACGCAGACATCTTCAGCCGCTGCCAGGCCTGTAACTGTGACCAGTACCTAAAGGTCTCCAGGGACATGA TGAAGCAGCTCATGTGGCTCAGCAGTCACCAGGAGGGGCCCAGGAGCTCAGGTGACGAGGCCACCCAGAGCCAGGCGGTGCAGGAGCCAG GCCCAGCCCCAGACGCAGCCCCTGAGGGCTGCACCTATGACCGCCCCTGCCGCTGGCTGCAGATGGCTGACCTGCGGGCGGAGACACCGG ACATGCTGGCCGACGGCACCCGGCTGCAGCTGGCAGGGGTCCCGGTGGGTGTGCTGAGGACACCTGGGCTGCGGTGCTTCTACTGCTGCA CGGGCTGTGGAAAGGTCTTCTGGGACGGCTCCCACCTGGGTCGTGTTGCCACCCACTTCCGAGACATGCTGGAGAGCGCCCCCAGCCCCT |
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FusionGenePPI for YPEL3_EXD3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| YPEL3 | APP, SRPK2, FHL3, PSMA3, TRIP6, ZYX, RBPMS, DOK7, FBXL2, FBXL20 | EXD3 | DAZAP2, PLSCR1, CUL1, EXD3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YPEL3_EXD3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YPEL3_EXD3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | YPEL3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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