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Fusion gene ID: 42323 |
FusionGeneSummary for YEATS4_SLC35E3 |
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Fusion gene information | Fusion gene name: YEATS4_SLC35E3 | Fusion gene ID: 42323 | Hgene | Tgene | Gene symbol | YEATS4 | SLC35E3 | Gene ID | 8089 | 55508 |
Gene name | YEATS domain containing 4 | solute carrier family 35 member E3 | |
Synonyms | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | BLOV1 | |
Cytomap | 12q15 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | solute carrier family 35 member E3bladder cancer-overexpressed gene 1 proteinsolute carrier family 35, member E2 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O95619 | Q7Z769 | |
Ensembl transtripts involved in fusion gene | ENST00000247843, ENST00000548020, | ENST00000398004, ENST00000538043, | |
Fusion gene scores | * DoF score | 13 X 4 X 8=416 | 6 X 5 X 4=120 |
# samples | 14 | 7 | |
** MAII score | log2(14/416*10)=-1.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YEATS4 [Title/Abstract] AND SLC35E3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
Hgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-78-8662-01A | YEATS4 | chr12 | 69759664 | + | SLC35E3 | chr12 | 69152937 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000247843 | ENST00000398004 | YEATS4 | chr12 | 69759664 | + | SLC35E3 | chr12 | 69152937 | + |
5CDS-intron | ENST00000247843 | ENST00000538043 | YEATS4 | chr12 | 69759664 | + | SLC35E3 | chr12 | 69152937 | + |
intron-3CDS | ENST00000548020 | ENST00000398004 | YEATS4 | chr12 | 69759664 | + | SLC35E3 | chr12 | 69152937 | + |
intron-intron | ENST00000548020 | ENST00000538043 | YEATS4 | chr12 | 69759664 | + | SLC35E3 | chr12 | 69152937 | + |
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FusionProtFeatures for YEATS4_SLC35E3 |
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Hgene | Tgene |
YEATS4 | SLC35E3 |
Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. | Putative transporter. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 225_245 | 224 | 314 | Transmembrane | Helical |
Tgene | >SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 252_272 | 224 | 314 | Transmembrane | Helical |
Tgene | >SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 275_295 | 224 | 314 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >YEATS4 | chr12:69759664 | chr12:69152937 | ENST00000247843 | + | 4 | 7 | 178_226 | 111 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | >YEATS4 | chr12:69759664 | chr12:69152937 | ENST00000247843 | + | 4 | 7 | 22_126 | 111 | 228 | Domain | YEATS |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 77_82 | 224 | 314 | Compositional bias | Note=Poly-Leu |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 126_143 | 224 | 314 | Transmembrane | Helical |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 153_173 | 224 | 314 | Transmembrane | Helical |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 17_37 | 224 | 314 | Transmembrane | Helical |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 187_206 | 224 | 314 | Transmembrane | Helical |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 40_60 | 224 | 314 | Transmembrane | Helical |
Tgene | SLC35E3 | chr12:69759664 | chr12:69152937 | ENST00000398004 | + | 2 | 5 | 77_97 | 224 | 314 | Transmembrane | Helical |
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FusionGeneSequence for YEATS4_SLC35E3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_YEATS4_ENST00000247843_chr12_69759664_+_SLC35E3_ENST00000398004_chr12_69152937_+_201aa MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITE TGWGEFEIIIKIFFIDPNERPLMVLLSGVIAFMVNLSIYWIIGNTSPVTYNMFGHFKFCITLFGGYVLFKDPLSINQALGILCTLFGILA |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_YEATS4_ENST00000247843_chr12_69759664_+_SLC35E3_ENST00000398004_chr12_69152937_+_603nt ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTCTTATGGTGCTGCTATCTGGAGTAATA GCTTTCATGGTGAACTTATCAATTTATTGGATCATTGGGAACACTTCACCTGTCACCTATAACATGTTCGGACACTTCAAGTTCTGCATT ACTTTATTCGGAGGATATGTTTTATTTAAGGATCCACTGTCCATTAATCAGGCCCTTGGCATTTTATGTACATTATTTGGCATTCTCGCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_YEATS4_ENST00000247843_chr12_69759664_+_SLC35E3_ENST00000398004_chr12_69152937_+_4673nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTCTTATGGTGCTGCTATCTGGAGTAATA GCTTTCATGGTGAACTTATCAATTTATTGGATCATTGGGAACACTTCACCTGTCACCTATAACATGTTCGGACACTTCAAGTTCTGCATT ACTTTATTCGGAGGATATGTTTTATTTAAGGATCCACTGTCCATTAATCAGGCCCTTGGCATTTTATGTACATTATTTGGCATTCTCGCC TATACCCACTTTAAGCTCAGTGAACAGGAAGGAAGTAGGAGTAAACTGGCACAACGTCCTTAATTGGGTTTTTGTGGAGAAAAGAATGTT GTCCCAAGAAGATAAAAAATATTGTTAAGTGTGCAAGTTATTAAAAAAAAAAAATTGGGCCAGGCACGGTGGCTCACGCCTGTAATCCCA GCACTTTGGGAGGCCAAGGCCAGCGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCAACTAAT AATACAAAATTAGCCAGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGC GGCGGTTGCAGTGAGCCGAGATCGTACCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCCATTTCAAAAAAAAAAAATTGGTGACA GACTCAATGATGGAATGATTTGTCGGAATTAACACAAAGCAGATTTTATTCATATAATGACTTTTTTTTAAGAGTCTCTTTTTTAAAAAA ACTTAATTCTCTAAAACCGAAATGGTTCATGCTTCTTTTTAAAAATGATTGTATAAAATGTATGGAATGGTTAGCCTGGTGTGGTGGTGC ACACCTGTAATCCCAGCTACTTGGGAGACTGAGACATGAGAATCGCTTGAGCCTGGGAGGCGGAGGTTGCAATGAGCCAAGATCGTACCA CTGCACTCCAGCCTGGGCGACAGAGCAAGACACTGTCTCTCTCTCTCTCTCCATATATATATGTGTGTGTGTGTATATATATATATATGT GTGTGTGTGTGTGTGTATACATATATACACATATATACACACACACATACATATACATGTGTATATATATACCATCCCATATATATGTGG GATATATATATATATATATATGGATATGGTTATATATATGGGATGGTTTGGTTGGTCCCAGCAAAGTATATGAAAATTAAAGTTCTGTGA TAATGACAAAGGAATTGCTGTTACTGTACTGCAAATATGCTGTGGGTTCTCGGTGTTCAAACTCTTCTAAGGAAGGACACACAGTAGCTC TCTGCTTGCTGATAGATGGTTTCCCAGTGTGAGATTTGTTATTTTGATCAGAGTATTCAAATCAGAATTTAAATCTAGTGTTTCTATTTT AGTTTAGCTTCCTGATTTATATAAATGAAATCTCATTTATAAAGTATAATAAAGATGACTGTAAGACAAAATCCAATTCTAAAAGTATGA TTTTTTTCTAGTAGAAAATTGATGTAAGAAATCATACATTATTCATACATTTATAGGTCATCTCTTTGAGTTTTCAGTGAACTATAGAAA CTATATGGAGTTAAAAAACAAAACGGCAGCCAATCTCAGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGTTGAGGCAGGCAGATCA CCTGAGGTTGGGAGTTCAAGACCAGTCTGACCAACATGGAGGAATCCCGTCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCACA TGCCTGTAATCCCAGCTGCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGTGGTGAGCCGAGATCATGCCAT TGCTCTCCAGCCTGGGCAACAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATAGCCCTATGTTTAAATGGCTCAAAGAAAAGAC TATAAATGGAATTGAACATGTTTGTTAGCTGTTTGAGCATTTTATATTGGTAAATTTTTTATTTTCTTATTTTTTGTCTTACAGTCGACC AGGCTGGAATGCAGTGGCACAATCATGGCTCACTGCAGCCTCAGCCTCCTGGGCTCAAGCAATCCTCCTGCCTCAACCTCCCCAGTAGCT GGGACTACAGGTGCACACCAACATACCTGGCTGATTTTTATATTTTTTGTAGAGACAGAGTTTTGCCATGTTGCTCAGGCTGATCTCAAA CTCTTGAGCTCAAGCCATCTGTCTGCCTCAGCCTCTCGAAGTGCTGGGATTACAGGCCTGAGCCACCACACCTGGCCAGTAATTTCTTAA TCCTACCTCCCTGCTTCTATTGCCTAGCCCGTACATTTGAGGCTTCCATGGAGCTTTCTGTGGTACTGAAACACTTGGAGTGAACTGCAA ACTTGGAGTGAACTACATCCAACCTTTCTAAGGTGGCTGGGGAAAATTCTTGTACAGCAAGTTGGGACAAAATAGCCATATAGAAACAGC CATATAAGATCCCAATATAGAAAAATTGGGATATTAGAGGAAATACATGATTTCCATTTATGGAGTGCTACATGTTTGCAAAATGTATTT CTGCTTTTCATCTTCTTGACATCTGAATATTAAAAGCAGTTGTTGATAATTTCATATAATAAATTGAGACATATCATTACTCTTGTAATA ATTCATTTTCTAAATGTTATTTATCAACTTTCATGGAGAAAACAACTCTTAGGAGAACAAAGACCAGCCCGGGCAACATGGCAAAACCCT GTCTGCAAAAAATACAAAAATTAGCCGGGCCTAGTGGCACGTGCCTGTAGCTCCATCTACTCAGGAGGCTGAGGTGGGAGGATTGCTTGA GCCCAGAAGATGCAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTTCAGCCTGGGCGACAGACTGGACTCTGTCTCGGGAAAAAAAAA AAAAAAAAAAGGGAAGAGCGACAAAATATACCTTTTGATAAGACAGTAAATTTTATGTTTTGTGTTTTTTAACACAATAAAAATATATAT ACACACATATAATATACCTTTGGGGTTTTTAGGATTTTTTTTTCCTGGACTCTGAAATGAGAAGCCTCGCTGAAAATCTGTTTTGGAGAA TTCCAGTTTGTCAGTCAGTCTCTTGTGTAATTAGTACGTGTGGCTTCCTTCTTTGTTTTAAATATTCTTTGGTTCTTCTCATTTTACAAA GATATATATTTTTTGTGCTAAGGACAGAGCAATTAGTTTTTACCAGATAAGCCTCGGGTATTATGTTTGTCTAAGAAACATTCTCTGTGT ATGTTTAAATTGTAATTATTTCCCAAAAGCTGAGGAAAATGTTTCAGCACAGTGAGGATTTGACGTCTGCACTGAGAACAGCTGAGTTTA TTTGTGCCATTTAGAAATTCGTAACTGTAGGCTGGGCGCAGTGGCTTACGCCTATAATCCCAGCACTTTGAGAGGCCAAGGCGGGTGGAT CACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCGAAACACTGTCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGC GGGCGCCTGTAATTCCAGCTACTCGGGAGGCTGAGACAGGAGAATCACTTGAACCAGGGAGTCGGAGGTTGCAGTGAGCCGAGACTGCGC CATTGCACACCAGCCTGGGTGACGAGAGTGAAACTCTGTCTCAAAAAAAGAAAAAAAAAAAGAAATTTTTAACCGTAAATAGAACTTGGG GAGGGTGTTATATAATATATGTGTCAGTAGGAAGGCAGTAAGAAGATTGGAGTAAGACAGGATGGGGTTACATGTATATAAATGAATAAA ATAAGTACTGCTAAAACTTGAGTCTGATAAACTTTTTTGCCCCGAAGATAATCATCCCACTGAAAAGAAAACTCTGGGGAAAATATGCCA GATACTAGGACCAAGCACGGAGACAAACCAGATACAGTGCTTTCAAAGAAAACATGCTTGCTGTCCTTTGTTACCAGTGTAATTGTAATT |
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FusionGenePPI for YEATS4_SLC35E3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YEATS4 | TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN | SLC35E3 | BAG3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | YEATS4 | chr12:69759664 | chr12:69152937 | ENST00000247843 | + | 4 | 7 | 163_227 | 111 | 228 | MLLT10 |
Hgene | YEATS4 | chr12:69759664 | chr12:69152937 | ENST00000247843 | + | 4 | 7 | 168_227 | 111 | 228 | TACC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YEATS4_SLC35E3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS4_SLC35E3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |