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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 42318

FusionGeneSummary for YEATS4_MARS

check button Fusion gene summary
Fusion gene informationFusion gene name: YEATS4_MARS
Fusion gene ID: 42318
HgeneTgene
Gene symbol

YEATS4

MARS

Gene ID

8089

84174

Gene nameYEATS domain containing 4Src like adaptor 2
Synonyms4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9C20orf156|MARS|SLAP-2|SLAP2
Cytomap

12q15

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionYEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1src-like-adapter 2Src-like adapter protein-2modulator of antigen receptor signaling
Modification date2018051920180523
UniProtAcc

O95619

P56192

Ensembl transtripts involved in fusion geneENST00000247843, ENST00000548020, 
ENST00000262027, ENST00000315473, 
ENST00000447721, 
Fusion gene scores* DoF score13 X 4 X 8=41611 X 11 X 4=484
# samples 1415
** MAII scorelog2(14/416*10)=-1.57115670119613
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/484*10)=-1.69004454677871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: YEATS4 [Title/Abstract] AND MARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneYEATS4

GO:0043967

histone H4 acetylation

14966270

HgeneYEATS4

GO:0043968

histone H2A acetylation

14966270

TgeneMARS

GO:0000122

negative regulation of transcription by RNA polymerase II

11696592

TgeneMARS

GO:0050849

negative regulation of calcium-mediated signaling

11696592


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-06-0138-01AYEATS4chr12

69764755

+MARSchr12

57905481

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000247843ENST00000262027YEATS4chr12

69764755

+MARSchr12

57905481

+
Frame-shitENST00000247843ENST00000315473YEATS4chr12

69764755

+MARSchr12

57905481

+
5CDS-3UTRENST00000247843ENST00000447721YEATS4chr12

69764755

+MARSchr12

57905481

+
Frame-shitENST00000548020ENST00000262027YEATS4chr12

69764755

+MARSchr12

57905481

+
Frame-shitENST00000548020ENST00000315473YEATS4chr12

69764755

+MARSchr12

57905481

+
5CDS-3UTRENST00000548020ENST00000447721YEATS4chr12

69764755

+MARSchr12

57905481

+

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FusionProtFeatures for YEATS4_MARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
YEATS4

O95619

MARS

P56192

Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. Catalyzes the specific attachment of an amino acid toits cognate tRNA in a 2 step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. {ECO:0000269|PubMed:11714285}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for YEATS4_MARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for YEATS4_MARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
YEATS4TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRNMARSMCC, GIPC1, PRKAB1, ILK, BRF2, MYC, HDAC5, RPS27, TNNT1, CDK9, FBXO25, CUL3, CUL1, IARS, DARS, AIMP1, QARS, EPRS, LARS, KARS, RARS, AIMP2, EEF1E1, ACAT1, CCT3, FN1, VCAM1, ITGA4, EGFR, CASK, FBXO6, EIF2S1, RPL13, RPL27A, RPLP0, HUWE1, CUL7, CCDC8, RNF2, ESR1, SDCBP, EEA1, GARS, GFPT1, HARS, CIAPIN1, HK2, HSP90B1, PIN4, RCC2, XPNPEP1, NAA20, NMT1, OXSR1, TRMT6, TRMT61A, TXLNA, VARS, NTRK1, PKN2, CRY1, CRY2, MCM2, LENG1, ZNF746, CYLD, COQ2, DLST, PDHA1, FOXA1, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for YEATS4_MARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for YEATS4_MARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneYEATS4C0023827liposarcoma1CTD_human
TgeneMARSC4084821CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2U2ORPHANET;UNIPROT
TgeneMARSC4225400INTERSTITIAL LUNG AND LIVER DISEASE2ORPHANET;UNIPROT