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Fusion gene ID: 42317 |
FusionGeneSummary for YEATS4_LYZ |
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Fusion gene information | Fusion gene name: YEATS4_LYZ | Fusion gene ID: 42317 | Hgene | Tgene | Gene symbol | YEATS4 | LYZ | Gene ID | 8089 | 4069 |
Gene name | YEATS domain containing 4 | lysozyme | |
Synonyms | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | LYZF1|LZM | |
Cytomap | 12q15 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O95619 | P61626 | |
Ensembl transtripts involved in fusion gene | ENST00000247843, ENST00000548020, | ENST00000261267, ENST00000549690, ENST00000548839, | |
Fusion gene scores | * DoF score | 13 X 4 X 8=416 | 26 X 11 X 9=2574 |
# samples | 14 | 30 | |
** MAII score | log2(14/416*10)=-1.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(30/2574*10)=-3.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YEATS4 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
Hgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
Tgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
Tgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
Tgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-BT-A0S7-01A | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
TCGA | RV | LIHC | TCGA-BC-A3KF-01A | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
TCGA | RV | STAD | TCGA-BR-8289-01A | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000247843 | ENST00000261267 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
Frame-shift | ENST00000247843 | ENST00000549690 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
Frame-shift | ENST00000247843 | ENST00000548839 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
intron-3CDS | ENST00000548020 | ENST00000261267 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
intron-3CDS | ENST00000548020 | ENST00000549690 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
intron-3CDS | ENST00000548020 | ENST00000548839 | YEATS4 | chr12 | 69759664 | + | LYZ | chr12 | 69743888 | + |
In-frame | ENST00000247843 | ENST00000261267 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
In-frame | ENST00000247843 | ENST00000549690 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
Frame-shift | ENST00000247843 | ENST00000548839 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
In-frame | ENST00000548020 | ENST00000261267 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
In-frame | ENST00000548020 | ENST00000549690 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
Frame-shift | ENST00000548020 | ENST00000548839 | YEATS4 | chr12 | 69764755 | + | LYZ | chr12 | 69743888 | + |
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FusionProtFeatures for YEATS4_LYZ |
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Hgene | Tgene |
YEATS4 | LYZ |
Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. | Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | YEATS4 | chr12:69764755 | chr12:69743888 | ENST00000247843 | + | 6 | 7 | 22_126 | 171 | 228 | Domain | YEATS |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >YEATS4 | chr12:69764755 | chr12:69743888 | ENST00000247843 | + | 6 | 7 | 178_226 | 171 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for YEATS4_LYZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YEATS4_LYZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YEATS4 | TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN | LYZ | KHK, LRRK1, NME2, LTF, PARP11, USP1, USP25, CUL4B, CDK2, COPS6, CLU, GRK5, CRK, SMAD6, STAU1, AURKA, CEP57, NEDD1, TP53, FUS, RPS6KB2, NTRK1, MCM2, CRYAB, DDX31, FRMD1, HBM, SNX27, WWOX, CYLD, CDK1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | YEATS4 | chr12:69764755 | chr12:69743888 | ENST00000247843 | + | 6 | 7 | 163_227 | 171 | 228 | MLLT10 |
Hgene | YEATS4 | chr12:69764755 | chr12:69743888 | ENST00000247843 | + | 6 | 7 | 168_227 | 171 | 228 | TACC1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YEATS4_LYZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS4_LYZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |
Tgene | LYZ | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;UNIPROT |