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Fusion gene ID: 42314 |
FusionGeneSummary for YEATS4_AGAP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: YEATS4_AGAP2 | Fusion gene ID: 42314 | Hgene | Tgene | Gene symbol | YEATS4 | AGAP2 | Gene ID | 8089 | 116986 |
| Gene name | YEATS domain containing 4 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | |
| Synonyms | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | CENTG1|GGAP2|PIKE | |
| Cytomap | 12q15 | 12q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2GTP-binding and GTPase activating protein 2centaurin, gamma 1cnt-g1phosphatidylinositol 3-kinase enhancerphosphoinosi | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | O95619 | Q99490 | |
| Ensembl transtripts involved in fusion gene | ENST00000247843, ENST00000548020, | ENST00000257897, ENST00000547588, | |
| Fusion gene scores | * DoF score | 13 X 4 X 8=416 | 5 X 4 X 2=40 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/416*10)=-1.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: YEATS4 [Title/Abstract] AND AGAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| Hgene | YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
| Tgene | AGAP2 | GO:0042177 | negative regulation of protein catabolic process | 18374643 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A2IZ-01A | YEATS4 | chr12 | 69759664 | + | AGAP2 | chr12 | 58127956 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000247843 | ENST00000257897 | YEATS4 | chr12 | 69759664 | + | AGAP2 | chr12 | 58127956 | - |
| In-frame | ENST00000247843 | ENST00000547588 | YEATS4 | chr12 | 69759664 | + | AGAP2 | chr12 | 58127956 | - |
| intron-3CDS | ENST00000548020 | ENST00000257897 | YEATS4 | chr12 | 69759664 | + | AGAP2 | chr12 | 58127956 | - |
| intron-3CDS | ENST00000548020 | ENST00000547588 | YEATS4 | chr12 | 69759664 | + | AGAP2 | chr12 | 58127956 | - |
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FusionProtFeatures for YEATS4_AGAP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| YEATS4 | AGAP2 |
| Component of the NuA4 histone acetyltransferase (HAT)complex which is involved in transcriptional activation of selectgenes principally by acetylation of nucleosomal histones H4 andH2A. This modification may both alter nucleosome - DNAinteractions and promote interaction of the modified histones withother proteins which positively regulate transcription. Thiscomplex may be required for the activation of transcriptionalprograms associated with oncogene and proto-oncogene mediatedgrowth induction, tumor suppressor mediated growth arrest andreplicative senescence, apoptosis, and DNA repair. NuA4 may alsoplay a direct role in DNA repair when recruited to sites of DNAdamage. {ECO:0000269|PubMed:14966270}. | GTPase-activating protein (GAP) for ARF1 and ARF5, whichalso shows strong GTPase activity. Isoform 1 participates in theprevention of neuronal apoptosis by enhancing PI3 kinase activity.It aids the coupling of metabotropic glutamate receptor 1 (GRM1)to cytoplasmic PI3 kinase by interacting with Homer scaffoldingproteins, and also seems to mediate anti-apoptotic effects of NGFby activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3kinase but may protect cells from apoptosis by stimulating Akt. Italso regulates the adapter protein 1 (AP-1)-dependent traffickingof proteins in the endosomal system. It seems to be oncogenic. Itis overexpressed in cancer cells, prevents apoptosis and promotescancer cell invasion. {ECO:0000269|PubMed:12640130,ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108,ECO:0000269|PubMed:16079295}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 676_910 | 131 | 837 | Domain | PH |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 931_1051 | 131 | 837 | Domain | Arf-GAP |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 413_420 | 131 | 837 | Nucleotide binding | GTP |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 457_461 | 131 | 837 | Nucleotide binding | GTP |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 515_518 | 131 | 837 | Nucleotide binding | GTP |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 405_572 | 131 | 837 | Region | Note=G domain |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 1090_1119 | 131 | 837 | Repeat | Note=ANK 1 |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 1123_1152 | 131 | 837 | Repeat | Note=ANK 2 |
| Tgene | >AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 946_969 | 131 | 837 | Zinc finger | C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >YEATS4 | chr12:69759664 | chr12:58127956 | ENST00000247843 | + | 4 | 7 | 178_226 | 111 | 228 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >YEATS4 | chr12:69759664 | chr12:58127956 | ENST00000247843 | + | 4 | 7 | 22_126 | 111 | 228 | Domain | YEATS |
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FusionGeneSequence for YEATS4_AGAP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000257897_chr12_58127956_-_817aa MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARTFGKKREEDGHTHQWTVTVKPTRNEDMSATVKKIQFKLHESTGNPLRVVTKPPTEITE TGWGEFEIIIKIFFIDPNERPFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALC ADMKRCSYTETCATTGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAE AAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKTVTLSSNGFLLYHPSIND YIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARA LSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCC ESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDT ANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLH LAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRAD >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000547588_chr12_58127956_-_837aa MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARTFGKKREEDGHTHQWTVTVKPTRNEDMSATVKKIQFKLHESTGNPLRVVTKPPTEITE TGWGEFEIIIKIFFIDPNERPFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALC ADMKRCSYTETCATTGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAE AAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKTVTLSSNGFLLYHPSIND YIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARA LSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNITKAEENFEFLIVSSTGQTWHFEAASFE ERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSL DLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAH ARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000257897_chr12_58127956_-_2451nt ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTTTCTCAGGCTGGGCAGATGCTGTGATC TTCGTCTTCAGCCTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGA GGCCTGGCCTTGGCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGC GCGGACATGAAACGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTG GTGACCTTGCGCAAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCT GGCCAGGCTAGTAACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAG GCAGCTGCAGTGGCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGT GACTCCGAGAAACGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGA AGTGGCAATTCCTTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGAT TACATCCACAGTACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCC TTTGGCCCCTCAGCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCA AGCCCTAGCCCCAGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCC CTCAGCACGGACTGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAA AAATTGACAACACCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGAGGAAAACTTTGAGTTCCTGATCGTGTCCAGCACGGGTCAG ACGTGGCACTTTGAGGCAGCCAGTTTTGAGGAGCGGGATGCCTGGGTCCAGGCCATCGAGAGTCAGATCCTAGCCAGTCTGCAATGCTGT GAGAGCAGCAAGGTCAAGCTGCGCACAGACAGCCAAAGCGAGGCCGTGGCCATCCAGGCGATCCGGAACGCCAAGGGGAATTCAATCTGC GTGGACTGCGGGGCCCCCAACCCCACGTGGGCCAGCTTGAACCTGGGCGCCCTCATCTGCATCGAGTGTTCTGGCATCCACCGCAACCTG GGCACACACCTGTCCCGCGTTCGCTCGCTGGACTTGGACGACTGGCCACGGGAGCTGACCCTGGTGCTGACGGCTATTGGCAACGACACG GCCAACCGCGTGTGGGAAAGCGACACGCGAGGCCGTGCCAAGCCCTCGCGGGACTCTTCGCGGGAGGAGCGCGAGTCGTGGATTCGCGCC AAGTACGAGCAGCTACTGTTCCTGGCGCCGCTGAGCACCTCGGAGGAGCCGCTGGGCCGCCAGCTGTGGGCCGCCGTGCAGGCCCAGGAC GTGGCTACCGTTCTCCTGCTTTTGGCCCATGCGCGACACGGGCCGCTCGACACCAGCGTAGAGGACCCACAGCTGCGCTCCCCACTCCAC CTGGCGGCCGAGCTCGCCCACGTCGTCATCACGCAACTGCTGCTGTGGTACGGCGCGGACGTGGCGGCCCGTGACGCCCAGGGCCGCACG GCGCTGTTCTACGCCCGCCAGGCTGGAAGCCAGCTGTGCGCCGACATCCTTCTCCAGCACGGCTGCCCGGGTGAGGGCGGCAGCGCGGCC ACCACGCCCAGCGCGGCCACCACGCCCAGCATCACCGCCACGCCCAGCCCCCGCCGCCGGAGCAGCGCCGCTAGCGTGGGCCGCGCCGAC >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000547588_chr12_58127956_-_2511nt ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTTTCTCAGGCTGGGCAGATGCTGTGATC TTCGTCTTCAGCCTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGA GGCCTGGCCTTGGCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGC GCGGACATGAAACGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTG GTGACCTTGCGCAAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCT GGCCAGGCTAGTAACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAG GCAGCTGCAGTGGCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGT GACTCCGAGAAACGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGA AGTGGCAATTCCTTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGAT TACATCCACAGTACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCC TTTGGCCCCTCAGCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCA AGCCCTAGCCCCAGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCC CTCAGCACGGACTGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAA AAATTGACAACACCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGCCAAGCGCAAAATGTGGAAACTAAAATCCTTTGGTAGTTTA AGAAATATTTATAAAGCAGAGGAAAACTTTGAGTTCCTGATCGTGTCCAGCACGGGTCAGACGTGGCACTTTGAGGCAGCCAGTTTTGAG GAGCGGGATGCCTGGGTCCAGGCCATCGAGAGTCAGATCCTAGCCAGTCTGCAATGCTGTGAGAGCAGCAAGGTCAAGCTGCGCACAGAC AGCCAAAGCGAGGCCGTGGCCATCCAGGCGATCCGGAACGCCAAGGGGAATTCAATCTGCGTGGACTGCGGGGCCCCCAACCCCACGTGG GCCAGCTTGAACCTGGGCGCCCTCATCTGCATCGAGTGTTCTGGCATCCACCGCAACCTGGGCACACACCTGTCCCGCGTTCGCTCGCTG GACTTGGACGACTGGCCACGGGAGCTGACCCTGGTGCTGACGGCTATTGGCAACGACACGGCCAACCGCGTGTGGGAAAGCGACACGCGA GGCCGTGCCAAGCCCTCGCGGGACTCTTCGCGGGAGGAGCGCGAGTCGTGGATTCGCGCCAAGTACGAGCAGCTACTGTTCCTGGCGCCG CTGAGCACCTCGGAGGAGCCGCTGGGCCGCCAGCTGTGGGCCGCCGTGCAGGCCCAGGACGTGGCTACCGTTCTCCTGCTTTTGGCCCAT GCGCGACACGGGCCGCTCGACACCAGCGTAGAGGACCCACAGCTGCGCTCCCCACTCCACCTGGCGGCCGAGCTCGCCCACGTCGTCATC ACGCAACTGCTGCTGTGGTACGGCGCGGACGTGGCGGCCCGTGACGCCCAGGGCCGCACGGCGCTGTTCTACGCCCGCCAGGCTGGAAGC CAGCTGTGCGCCGACATCCTTCTCCAGCACGGCTGCCCGGGTGAGGGCGGCAGCGCGGCCACCACGCCCAGCGCGGCCACCACGCCCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000257897_chr12_58127956_-_4062nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTTTCTCAGGCTGGGCAGATGCTGTGATC TTCGTCTTCAGCCTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGA GGCCTGGCCTTGGCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGC GCGGACATGAAACGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTG GTGACCTTGCGCAAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCT GGCCAGGCTAGTAACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAG GCAGCTGCAGTGGCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGT GACTCCGAGAAACGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGA AGTGGCAATTCCTTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGAT TACATCCACAGTACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCC TTTGGCCCCTCAGCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCA AGCCCTAGCCCCAGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCC CTCAGCACGGACTGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAA AAATTGACAACACCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGAGGAAAACTTTGAGTTCCTGATCGTGTCCAGCACGGGTCAG ACGTGGCACTTTGAGGCAGCCAGTTTTGAGGAGCGGGATGCCTGGGTCCAGGCCATCGAGAGTCAGATCCTAGCCAGTCTGCAATGCTGT GAGAGCAGCAAGGTCAAGCTGCGCACAGACAGCCAAAGCGAGGCCGTGGCCATCCAGGCGATCCGGAACGCCAAGGGGAATTCAATCTGC GTGGACTGCGGGGCCCCCAACCCCACGTGGGCCAGCTTGAACCTGGGCGCCCTCATCTGCATCGAGTGTTCTGGCATCCACCGCAACCTG GGCACACACCTGTCCCGCGTTCGCTCGCTGGACTTGGACGACTGGCCACGGGAGCTGACCCTGGTGCTGACGGCTATTGGCAACGACACG GCCAACCGCGTGTGGGAAAGCGACACGCGAGGCCGTGCCAAGCCCTCGCGGGACTCTTCGCGGGAGGAGCGCGAGTCGTGGATTCGCGCC AAGTACGAGCAGCTACTGTTCCTGGCGCCGCTGAGCACCTCGGAGGAGCCGCTGGGCCGCCAGCTGTGGGCCGCCGTGCAGGCCCAGGAC GTGGCTACCGTTCTCCTGCTTTTGGCCCATGCGCGACACGGGCCGCTCGACACCAGCGTAGAGGACCCACAGCTGCGCTCCCCACTCCAC CTGGCGGCCGAGCTCGCCCACGTCGTCATCACGCAACTGCTGCTGTGGTACGGCGCGGACGTGGCGGCCCGTGACGCCCAGGGCCGCACG GCGCTGTTCTACGCCCGCCAGGCTGGAAGCCAGCTGTGCGCCGACATCCTTCTCCAGCACGGCTGCCCGGGTGAGGGCGGCAGCGCGGCC ACCACGCCCAGCGCGGCCACCACGCCCAGCATCACCGCCACGCCCAGCCCCCGCCGCCGGAGCAGCGCCGCTAGCGTGGGCCGCGCCGAC GCCCCGGTTGCGCTGGTATAGTTGCCCAGCGGGAGAGACACCCCCATCCCCACGCGGGCCGGGCACGACCACACCGGGCGGACCGCTGGA CAGACGCACCCACTCACCTCTCCGATCCGCACCCCGCCCCACGGGAGCACTTCCTACCCCCACGAGGGCACAGCCCCCACGCCTTCCAGA AGACACAAACTCACCTCCCTCTCCCCAACGAGGCATGGAGACCCCAGCTCAACACGCCCCCTCTCCATTGTTTCCACACTCGGATTGCTC TGGGTCTACCCGCTCGGGGTTCGCGGAAGGGGAGGTCCCCAGCGGTACGGGCTCCTAGGCGCTTGGACATGCCCGCTTGTGCCCCCTAGG GGCGGAAAGAAGACCCGGTCCTGCCCGAGCTCAACAATCCCAGGGCGGGAGCCCATACCCAGGCTGGCTCCTGGGGCGACGCCACGCCAG AGGGAGGGTTTAGTACATGGGAGGGCTAGCCCCGGGACTTGGGGCCAATACGGAAACCCTACCCCTTCCATGCTCATCTCACTGCCCAGT GAAGGGGGCAAGGGCAGCGAGGGGCAGGACCCCTGCTGCTCATGGGGGTGGGGGTTCCCAACCCTTTCCGTGAAAGGGACCGTGAGTAGT GGAAACCAGGACGTCCCCTACACCTACCCATGGGTGGAAGCTAAAGAGTCCGGGGGGAACCAAGAGCCTGGGTCCCTCCCACTACTATCT TGGGAGGGAGAAGGGATGGAGCAGGAGCGGGCTAAGAGGGCTGCGGGGGCCTTGTAATTTATTGCTTTGTTCCCCAACATGGGGATGGGG GCGGGCAGGGGCGTGGGGAGGGCGTTTTGGGGTAGGGGAAGCCCAGGGTGGGCAGGGGGTGGGTTGGGGTGGGGGTGCTCTCGGGTTGTG TCTGTGACCGTGACTGCGTACCTGTGACTGTGCAGCGCCCGTGGTGATCTGGGGTAGGGGGCACCCCTACAGTGGGACCCCTCCCCCATT ATTCTTTCTGTCCAGCCCCTCCCTCCCACTGGAGCAGCTCCAGAGCCATTCCTCACCCCCGTGACCTCTCCCAGCCAGGGCTGAGAGGAT TCGAGGTGGCTGGGAGGGTTTCCAGGCCCCCTGCCCCTTCCCCACAAACTGGGTGATAGGGCGGACTTACCTGGCCCAGCCCTGCCTCCC TCAGCCAACCCAGCCCTTGGGCTGTCTGTGTCAGTGGTTTCCGGTCTTTTTTTTTTTTTTTTTTTCTGGCTAAAATAGTTTGCAAAGGAC CAGGTAATTGGGGAGGGGAGAGAGGTGGGGGCAAGGGGGAAATGCCCCCCCATCTCCTTGGAGGCAGTGGTGTGAATCTTCTTCAACAGC >In-frame_YEATS4_ENST00000247843_chr12_69759664_+_AGAP2_ENST00000547588_chr12_58127956_-_2781nt CGCGAGCCCGTTGCGCCTGCGCGCGGTGCGGCCGTCGCCCCTCTTTTCGCGGCGTTCTCCACCTGCGCGGGCCTGAATGGCCTTCAGGAG CACAGTCGGCCTGAGGAGTTGACGGTTACTCACCGCCGTGAGCCCAAGTAACTCGCCCTCCTTCGGCTAGAAACCCTCCGCCTGGGCCCG CGCGACAGGAGCGCGGTCTCTGAGGGGAGCGGCGACCCCGCCAGCCCCGGTCTCTTTCCCTGGCGGCGGCGGCTTCTTCCGTGGGACAAT ATGTTCAAGAGAATGGCCGAATTTGGGCCTGACTCCGGCGGGAGAGTAAAGGGTGTTACTATCGTTAAACCAATAGTTTACGGTAATGTT GCTCGGTATTTTGGAAAGAAAAGAGAAGAAGATGGGCACACTCATCAGTGGACAGTATATGTGAAACCATATAGAAATGAGGATATGTCA GCATATGTGAAGAAAATCCAGTTTAAATTACATGAAAGCTATGGCAATCCTTTAAGAGTTGTTACTAAACCTCCATATGAAATTACTGAA ACAGGATGGGGTGAATTCGAAATAATCATCAAAATATTTTTCATTGACCCTAATGAAAGACCTTTCTCAGGCTGGGCAGATGCTGTGATC TTCGTCTTCAGCCTGGAGGATGAGAACAGTTTCCAGGCTGTGAGCCGTCTCCATGGGCAGCTGAGTTCCCTTCGCGGGGAGGGACGAGGA GGCCTGGCCTTGGCACTGGTGGGGACACAAGACAGGATCAGTGCTTCCTCCCCTCGGGTGGTGGGAGATGCTCGTGCCAGAGCTCTGTGC GCGGACATGAAACGCTGCAGCTACTATGAGACTTGTGCAACCTATGGGCTCAATGTGGATCGGGTCTTCCAGGAGGTGGCCCAGAAGGTG GTGACCTTGCGCAAGCAGCAACAGCTTCTGGCTGCCTGCAAGTCCCTGCCCAGCTCCCCAAGCCACTCAGCTGCATCCACTCCGGTAGCT GGCCAGGCTAGTAACGGGGGCCACACTAGCGACTACTCTTCTTCCCTCCCGTCCTCACCGAATGTTGGTCACCGGGAGCTCCGAGCCGAG GCAGCTGCAGTGGCTGGATTGAGCACCCCAGGGTCCCTGCACCGGGCAGCCAAGCGCAGGACCAGCCTTTTTGCGAATCGTCGGGGTAGT GACTCCGAGAAACGAAGCTTGGATAGTCGGGGAGAGACAACAGGGAGTGGGCGAGCCATCCCCATCAAACAGAGCTTCCTACTAAAACGA AGTGGCAATTCCTTGAACAAAGAATGGAAGAAGAAATATGTAACCCTGTCCAGTAATGGCTTTCTACTCTACCACCCCAGTATTAACGAT TACATCCACAGTACCCACGGCAAGGAGATGGACTTGCTGCGAACAACAGTCAAAGTCCCGGGCAAGCGGCCCCCGAGGGCCATCTCTGCC TTTGGCCCCTCAGCCAGCATTAACGGGCTCGTCAAGGACATGAGCACTGTCCAGATGGGTGAAGGCCTGGAAGCCACTACTCCCATGCCA AGCCCTAGCCCCAGCCCCAGTTCCCTGCAGCCACCACCAGATCAGACATCCAAACACCTGCTGAAGCCAGACCGGAATTTGGCCCGAGCC CTCAGCACGGACTGTACCCCATCTGGAGACCTGAGCCCCCTGAGTCGGGAACCCCCTCCTTCTCCCATGGTGAAGAAGCAGAGGAGGAAA AAATTGACAACACCATCCAAGACTGAAGGCTCGGCTGGGCAGGCTGAAGCCAAGCGCAAAATGTGGAAACTAAAATCCTTTGGTAGTTTA AGAAATATTTATAAAGCAGAGGAAAACTTTGAGTTCCTGATCGTGTCCAGCACGGGTCAGACGTGGCACTTTGAGGCAGCCAGTTTTGAG GAGCGGGATGCCTGGGTCCAGGCCATCGAGAGTCAGATCCTAGCCAGTCTGCAATGCTGTGAGAGCAGCAAGGTCAAGCTGCGCACAGAC AGCCAAAGCGAGGCCGTGGCCATCCAGGCGATCCGGAACGCCAAGGGGAATTCAATCTGCGTGGACTGCGGGGCCCCCAACCCCACGTGG GCCAGCTTGAACCTGGGCGCCCTCATCTGCATCGAGTGTTCTGGCATCCACCGCAACCTGGGCACACACCTGTCCCGCGTTCGCTCGCTG GACTTGGACGACTGGCCACGGGAGCTGACCCTGGTGCTGACGGCTATTGGCAACGACACGGCCAACCGCGTGTGGGAAAGCGACACGCGA GGCCGTGCCAAGCCCTCGCGGGACTCTTCGCGGGAGGAGCGCGAGTCGTGGATTCGCGCCAAGTACGAGCAGCTACTGTTCCTGGCGCCG CTGAGCACCTCGGAGGAGCCGCTGGGCCGCCAGCTGTGGGCCGCCGTGCAGGCCCAGGACGTGGCTACCGTTCTCCTGCTTTTGGCCCAT GCGCGACACGGGCCGCTCGACACCAGCGTAGAGGACCCACAGCTGCGCTCCCCACTCCACCTGGCGGCCGAGCTCGCCCACGTCGTCATC ACGCAACTGCTGCTGTGGTACGGCGCGGACGTGGCGGCCCGTGACGCCCAGGGCCGCACGGCGCTGTTCTACGCCCGCCAGGCTGGAAGC CAGCTGTGCGCCGACATCCTTCTCCAGCACGGCTGCCCGGGTGAGGGCGGCAGCGCGGCCACCACGCCCAGCGCGGCCACCACGCCCAGC |
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FusionGenePPI for YEATS4_AGAP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| YEATS4 | TACC1, TACC2, NUMA1, CEP162, PFDN1, MLLT10, SMARCB1, ING3, RUVBL2, RUVBL1, MRGBP, KAT5, DMAP1, H2AFZ, MYCN, KDM1A, FRMD4A, RNF8, MYC, VIM, UBTF, BRD3, TFAP2B, LYN, HECW2, PLAC1, FOXR1, FOXR2, MORF4L1, FOSL2, FOS, GRAMD3, HIST1H2BA, EP400, FUS, MEAF6, EPC1, EPC2, SRCAP, TRRAP, BRD8, VPS72, SUGP1, HDGFRP2, MYO18A, SNX16, ACTL6B, MBTD1, UPF3B, ACTR6, GABPA, WEE1, MORF4L2, JAZF1, ZNHIT1, C12orf43, FBXO34, AGGF1, LENG1, POLDIP3, ANP32A, HIST1H2BG, MED23, XPO1, ACTL6A, COX6B1, ECHS1, FANCD2, MTOR, JUP, KRT2, KRT5, MLLT6, NFKBIE, PPM1G, S100A6, ATXN2, STIL, PTTG1, SNUPN, ZNF292, POLE3, WHSC1L1, PRPF40A, ZNF687, TSPYL2, KLF16, DOT1L, MICALL1, GPRIN1, CDYL2, PTGR2, EME1, ESCO2, REEP3, KPRP, MAX, FOXO6, POU5F1, MTMR7, PPP2R2D, TPH1, MYCL, P4HA3, ACTBL2, PKN3, NCKAP5L, TFPT, CCHCR1, TUFT1, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, GIT2, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, RPRD1A, ARNTL, RABGEF1, NUF2, THAP11, VPS51, TSSC1, RABEP1, STRN | AGAP2 | HOMER1, EPB41L1, PIK3R1, NF2, MPRIP, GRIP1, GRIA2, CDC42, RAC1, RAC2, RHOA, ARF1, AKT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 267_390 | 131 | 837 | PLCG1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | YEATS4 | chr12:69759664 | chr12:58127956 | ENST00000247843 | + | 4 | 7 | 163_227 | 111 | 228 | MLLT10 |
| Hgene | YEATS4 | chr12:69759664 | chr12:58127956 | ENST00000247843 | + | 4 | 7 | 168_227 | 111 | 228 | TACC1 |
| Tgene | AGAP2 | chr12:69759664 | chr12:58127956 | ENST00000257897 | - | 3 | 18 | 1_23 | 131 | 837 | EPB41L1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YEATS4_AGAP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS4_AGAP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |
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