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Fusion gene ID: 42312 |
FusionGeneSummary for YEATS2_TPRG1 |
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Fusion gene information | Fusion gene name: YEATS2_TPRG1 | Fusion gene ID: 42312 | Hgene | Tgene | Gene symbol | YEATS2 | TPRG1 | Gene ID | 55689 | 285386 |
Gene name | YEATS domain containing 2 | tumor protein p63 regulated 1 | |
Synonyms | - | FAM79B | |
Cytomap | 3q27.1 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | YEATS domain-containing protein 2 | tumor protein p63-regulated gene 1 proteinfamily with sequence similarity 79, member B | |
Modification date | 20180519 | 20180403 | |
UniProtAcc | Q9ULM3 | Q6ZUI0 | |
Ensembl transtripts involved in fusion gene | ENST00000305135, | ENST00000433971, ENST00000345063, ENST00000488841, | |
Fusion gene scores | * DoF score | 11 X 7 X 6=462 | 12 X 6 X 6=432 |
# samples | 11 | 13 | |
** MAII score | log2(11/462*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/432*10)=-1.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: YEATS2 [Title/Abstract] AND TPRG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | YEATS2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 18838386 |
Hgene | YEATS2 | GO:0043966 | histone H3 acetylation | 18838386 |
Hgene | YEATS2 | GO:0045892 | negative regulation of transcription, DNA-templated | 18838386 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-46-3767-01A | YEATS2 | chr3 | 183495488 | + | TPRG1 | chr3 | 188925165 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000305135 | ENST00000433971 | YEATS2 | chr3 | 183495488 | + | TPRG1 | chr3 | 188925165 | + |
5CDS-5UTR | ENST00000305135 | ENST00000345063 | YEATS2 | chr3 | 183495488 | + | TPRG1 | chr3 | 188925165 | + |
5CDS-intron | ENST00000305135 | ENST00000488841 | YEATS2 | chr3 | 183495488 | + | TPRG1 | chr3 | 188925165 | + |
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FusionProtFeatures for YEATS2_TPRG1 |
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Hgene | Tgene |
YEATS2 | TPRG1 |
Chromatin reader component of the ATAC complex, acomplex with histone acetyltransferase activity on histones H3 andH4. YEATS2 specifically recognizes and binds histone H3crotonylated at 'Lys-27' (H3K27cr) (PubMed:27103431).Crotonylation marks active promoters and enhancers and confersresistance to transcriptional repressors (PubMed:27103431).{ECO:0000269|PubMed:18838386, ECO:0000269|PubMed:19103755,ECO:0000269|PubMed:27103431}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for YEATS2_TPRG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for YEATS2_TPRG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
YEATS2 | RAD21, TFAP4, ZZZ3, UBAP2L, CSRP2BP, KAT2A, KAT2B, MAP3K7, TADA3, TADA2A, MBIP, WDR5, CCDC101, DR1, POLE3, POLE4, SNRNP200, NXF1, MAGEA10, PSME3, RFPL4B, BCAT1, TSSC1, CARD8, PSMC3, TBP, CEP162, CEP120, CDK2, CDC23, NANOG, POU5F1, IKZF5, SPERT, CDH19, LMO2, CCBL1, TP53INP1, IL17RA, TRIM25, TXNIP | TPRG1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for YEATS2_TPRG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS2_TPRG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |